PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus HMI1 CMR1 22199229 biogrid exp PUS4 HMI1 i2d exp DPM1 HMI1 i2d exp APT1 HMI1 i2d exp HHF1, HHF2 HMI1 22199229 biogrid exp CBF5 HMI1 i2d exp ERB1 HMI1 i2d exp HMT1 HMI1 22997150 biogrid exp ALG5 HMI1 i2d exp APT2 HMI1 i2d exp MDL2 HMI1 11283351 i2d,mint,intact,dip exp NAM7 HMI1 18087042 biogrid exp CYK3 HMI1 19841731 mint,intact exp MIP1 HMI1 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P33311 Q12039 - 11283351 - X 2 Q12510 Q12039 affinity chromatography technology 22199229 physical association X 2 Q12039 P02309 affinity chromatography technology 22199229 physical association X 2 Q12039 P02309 affinity chromatography technology 22199229 physical association X 2 P38074 Q12039 affinity chromatography technology 22997150 physical association X 2 P33311 Q12039 two hybrid pooling approach 11283351 physical association X 2 P33311 Q12039 two hybrid fragment pooling approach 11283351 physical association X 2 Q07533 Q12039 inferred by author 19841731 direct interaction X 2 P33311 Q12039 two hybrid 11283351 - X 2

PPI - HINT Gene A Gene B PMID Method Quality MDL2 HMI1 11283351,11283351,11283351 0018,0399,0398 HT HHF1|HHF2 HMI1 22199229 0004 HT HMT1 HMI1 22997150 0004 LC CYK3 HMI1 19841731 0363 LC HMI1 CMR1 22199229 0004 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q12039 Q07533 HMI1 CYK3 0.183 19841731 Q12039 P38074 HMI1 HMT1 0.126 22997150 Q12039 P30771 HMI1 NAM7 0.126 18087042 Q12039 P33311 HMI1 MDL2 0.236 11283351