PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus SSB2 MDY2 23332755 biogrid exp BNI1 MDY2 24133141 biogrid exp AAP1 MDY2 16554755 biogrid,mint,intact exp CDD1 MDY2 18719252 biogrid,intact exp SSA1 MDY2 20850366,23217712 biogrid,intact exp UPF0303 protein YBR137W MDY2 20850366,16554755 biogrid,i2d,mint,intact exp HMT1 MDY2 22997150 biogrid exp SPT15 MDY2 12052880 biogrid exp SRO9 MDY2 22271760 biogrid exp GET4 MDY2 20850366,16554755,16702403,20554915,23285234,22190685,20106980,24727835 biogrid,i2d,mint,intact,dip exp HSP104 MDY2 20850366 biogrid exp PAB1 MDY2 23285234 biogrid exp CIA1 MDY2 14690591,11805837 biogrid,mint,intact,dip exp TUB1 MDY2 20722039 biogrid exp GIS2 MDY2 21277287 biogrid exp SEC22 MDY2 20850366 biogrid exp NAB2 MDY2 19840948 biogrid exp NUP116 MDY2 11283351, 23023127 i2d,mint,intact,dip exp, pred RNQ1 MDY2 18719252, 23023127 biogrid,intact exp, pred GET3 MDY2 20554915,19325107,20850366,20106980,11283351,23203805,18719252, 23023127 biogrid,i2d,mint,intact,dip exp, pred NIP100 MDY2 20722039,16554755, 23023127 biogrid,i2d,mint,intact exp, pred SGT2 MDY2 20850366,21619481,23142665,17441508,11283351,24100326,21832041,16554755,18719252,23297211,23285234,10688190,20106980,20093466, 23023127 biogrid,i2d,mint,intact,dip exp, pred ENT2 MDY2 18719252, 23023127 biogrid,intact exp, pred SUA7 MDY2 11283351, 23023127 i2d,mint,intact,dip exp, pred YDJ1 MDY2 17441508, 23023127 biogrid,intact exp, pred UBX4 MDY2 23023127 pred MYO3 MDY2 23023127 pred EDE1 MDY2 23023127 pred PAN1 MDY2 23023127 pred FUS1 MDY2 23023127 pred MYO5 MDY2 23023127 pred SCP160 MDY2 23023127 pred UBC4 MDY2 23023127 pred ABP1 MDY2 23023127 pred UBC9 MDY2 23023127 pred SWA2 MDY2 23023127 pred DSK2 MDY2 23023127 pred BEM1 MDY2 23023127 pred CUE5 MDY2 23023127 pred SLA1 MDY2 23023127 pred UBI4 MDY2 23023127 pred CUE4 MDY2 23023127 pred CDC24 MDY2 23023127 pred MDY2 HUB1 23023127 pred SHP1 MDY2 23023127 pred MDY2 LAS17 23023127 pred UBC5 MDY2 23023127 pred UBC13 MDY2 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q12285 Q12118 - 11283351 - X 2 Q12285 Q12118 - 10688190 - X 2 Q02630 Q12285 - 11283351 - X 2 Q12154 Q12285 - 11283351 - X 2 Q12285 - 11805837 - C 6 Q05583 Q12285 - 11805837 - X 2 P29055 Q12285 - 11283351 - X 2 P04147 Q12285 affinity chromatography technology 23285234 physical association X 2 P04147 Q12285 affinity chromatography technology 23285234 physical association X 2 Q12285 Q12118 affinity chromatography technology 17441508 physical association X 2 Q12285 Q12118 two hybrid 17441508 direct interaction X 2 Q12285 Q12118 biochemical 17441508 association X 2 Q12285 P25491 affinity chromatography technology 17441508 physical association X 2 Q12285 P25491 biochemical 17441508 association X 2 Q12285 Q12118 pull down 23142665 direct interaction X 2 Q12285 Q12118 x-ray crystallography 23142665 association X 2 Q12285 Q12118 affinity chromatography technology 23285234 physical association X 2 Q12285 Q12118 pull down 23297211 direct interaction X 2 Q12285 Q12118 x-ray crystallography 24100326 association X 2 Q12285 Q12118 affinity chromatography technology 16554755 physical association X 2 Q12285 Q12118 two hybrid 18719252 direct interaction X 2 Q12285 Q05785 two hybrid 18719252 direct interaction X 2 Q12285 Q12118 affinity chromatography technology 20093466 physical association X 2 Q12285 Q12118 two hybrid 20106980 direct interaction X 2 Q12285 Q12118 affinity chromatography technology 20106980 physical association X 2 Q12285 P31539 affinity chromatography technology 20850366 physical association X 2 Q12285 Q12118 affinity chromatography technology 20850366 physical association X 2 Q12285 Q12118 affinity chromatography technology 21619481 physical association X 2 Q12285 Q12118 affinity chromatography technology 21619481 physical association X 2 Q12285 Q12118 affinity chromatography technology 21832041 physical association X 2 Q12285 Q12118 two hybrid 10688190 direct interaction X 2 P13393 Q12285 affinity chromatography technology 12052880 physical association X 2 Q12154 Q12285 two hybrid 18719252 direct interaction X 2 Q12154 Q12285 pull down 20106980 direct interaction X 2 Q12154 Q12285 two hybrid 20106980 direct interaction X 2 Q12154 Q12285 affinity chromatography technology 19325107 physical association X 2 Q12154 Q12285 affinity chromatography technology 20850366 physical association X 2 Q12154 Q12285 affinity chromatography technology 20554915 physical association X 2 Q12154 Q12285 affinity chromatography technology 20554915 physical association X 2 P40150 Q12285 biochemical 23332755 association X 2 P37898 Q12285 affinity chromatography technology 16554755 physical association X 2 P38276 Q12285 affinity chromatography technology 16554755 physical association X 2 P38276 Q12285 affinity chromatography technology 20850366 physical association X 2 Q12285 Q12125 affinity chromatography technology 23285234 physical association X 2 Q12285 O43765 pull down 23533635 direct interaction X 2 Q12285 Q12125 affinity chromatography technology 16554755 physical association X 2 Q12285 Q12125 affinity chromatography technology 16702403 physical association X 2 Q12285 Q12125 affinity chromatography technology 16702403 physical association X 2 Q12285 Q12125 pull down 20106980 direct interaction X 2 Q12285 Q12125 two hybrid 20106980 direct interaction X 2 Q12285 Q12125 affinity chromatography technology 20106980 physical association X 2 Q12285 Q12125 affinity chromatography technology 20106980 physical association X 2 Q12285 Q12125 x-ray crystallography 20106980 association X 2 Q12285 Q12125 two hybrid 20106980 direct interaction X 2 Q12285 Q12125 affinity chromatography technology 20850366 physical association X 2 Q12285 Q12125 affinity chromatography technology 20850366 physical association X 2 Q12285 Q12125 x-ray crystallography 20554915 association X 2 Q12285 Q12125 pull down 22190685 direct interaction X 2 P09733 Q12285 affinity chromatography technology 20722039 physical association X 2 P09733 Q12285 affinity chromatography technology 20722039 physical association X 2 P22214 Q12285 affinity chromatography technology 20850366 physical association X 2 P53849 Q12285 affinity chromatography technology 21277287 physical association X 2 Q05583 Q12285 affinity chromatography technology 11805837 physical association X 2 P33420 Q12285 affinity chromatography technology 16554755 physical association X 2 P33420 Q12285 affinity chromatography technology 20722039 physical association X 2 P33420 Q12285 affinity chromatography technology 20722039 physical association X 2 P25367 Q12285 two hybrid 18719252 direct interaction X 2 P10591 Q12285 affinity chromatography technology 20850366 physical association X 2 P38074 Q12285 affinity chromatography technology 22997150 physical association X 2 Q06549 Q12285 two hybrid 18719252 direct interaction X 2 Q12285 anti tag coimmunoprecipitation 11805837 - C 20 Q12285 Q12118 two hybrid pooling approach 11283351 physical association X 2 Q12285 Q12118 two hybrid 10688190 physical association X 2 Q02630 Q12285 two hybrid pooling approach 11283351 physical association X 2 Q12154 Q12285 two hybrid pooling approach 11283351 physical association X 2 Q12285 anti tag coimmunoprecipitation 11805837 - C 6 Q12285 molecular sieving 24727835 physical association C 3 Q12285 x-ray crystallography 24727835 physical association C 3 Q12285 Q12125 ion exchange chromatography 24727835 direct interaction X 2 Q12285 Q12125 molecular sieving 24727835 direct interaction X 2 Q05583 Q12285 anti tag coimmunoprecipitation 11805837 physical association X 2 P29055 Q12285 two hybrid pooling approach 11283351 physical association X 2 Q12285 pull down 23217712 association C 317 Q12285 anti bait coimmunoprecipitation 17441508 physical association C 3 Q12285 inferred by author 16554755 association C 6 Q12285 anti bait coimmunoprecipitation 17441508 physical association C 7 Q12285 Q12118 two hybrid 10688190 physical association X 2 Q12285 Q12118 two hybrid fragment pooling approach 11283351 physical association X 2 Q12285 Q12118 tandem affinity purification 16554755 physical association X 2 Q12285 Q12118 tandem affinity purification 16554755 physical association X 2 Q12285 Q12118 pull down 17441508 direct interaction X 2 Q12285 Q12118 two hybrid 17441508 physical association X 2 Q12285 P25491 pull down 17441508 physical association X 2 Q12285 Q12118 pull down 17441508 physical association X 2 Q12285 Q05785 two hybrid 18719252 physical association X 2 Q12285 Q12118 two hybrid 18719252 physical association X 2 Q12285 Q12118 two hybrid 20106980 physical association X 2 Q02630 Q12285 two hybrid fragment pooling approach 11283351 physical association X 2 Q12154 Q12285 two hybrid fragment pooling approach 11283351 physical association X 2 Q12154 Q12285 two hybrid 18719252 physical association X 2 P37898 Q12285 tandem affinity purification 16554755 physical association X 2 P37898 Q12285 tandem affinity purification 16554755 physical association X 2 Q12285 anti tag coimmunoprecipitation 11805837 association C 6 Q12285 anti bait coimmunoprecipitation 20106980 physical association C 3 Q12285 two hybrid 20106980 physical association C 3 Q12285 two hybrid 20106980 physical association C 3 P38276 Q12285 tandem affinity purification 16554755 physical association X 2 Q12285 Q12125 tandem affinity purification 16554755 physical association X 2 Q12285 Q12125 tandem affinity purification 16554755 physical association X 2 Q12285 Q12125 two hybrid 20106980 physical association X 2 Q12285 Q12125 anti bait coimmunoprecipitation 20106980 physical association X 2 Q12285 Q12125 anti bait coimmunoprecipitation 20106980 physical association X 2 Q12285 Q12125 pull down 20106980 physical association X 2 Q12285 Q12125 x-ray crystallography 20106980 direct interaction X 2 Q12285 Q12125 pull down 20106980 direct interaction X 2 Q12285 Q12125 two hybrid 20106980 physical association X 2 Q05583 Q12285 anti tag coimmunoprecipitation 11805837 physical association X 2 Q05583 Q12285 two hybrid array 14690591 physical association X 2 P33420 Q12285 tandem affinity purification 16554755 physical association X 2 P33420 Q12285 tandem affinity purification 16554755 physical association X 2 P29055 Q12285 two hybrid fragment pooling approach 11283351 physical association X 2 P25367 Q12285 two hybrid 18719252 physical association X 2 Q06549 Q12285 two hybrid 18719252 physical association X 2 Q12285 Q12118 two hybrid 10688190 - X 2 Q12285 Q12118 two hybrid 11283351 - X 2 Q02630 Q12285 two hybrid 11283351 - X 2 Q12154 Q12285 two hybrid 11283351 - X 2 Q12285 mass spectrometry studies of complexes 11805837 - C 7 P29055 Q12285 two hybrid 11283351 - X 2

PPI - HINT Gene A Gene B PMID Method Quality RNQ1 MDY2 18719252 0018 HT YDJ1 MDY2 17441508,17441508,17441508,17441508 0004,0401,0006,0096 LC SUA7 MDY2 11283351,11283351,11283351 0018,0399,0398 HT SSB2 MDY2 23332755 0401 LC NUP116 MDY2 11283351,11283351,11283351 0018,0399,0398 HT CIA1 MDY2 14690591 0397 LC ENT2 MDY2 18719252 0018 HT CDD1 MDY2 18719252 0018 HT SGT2 MDY2 24100326,20106980,17441508,23297211,17441508,23297211,11283351,23142665,17441508,10688190,10688190,23142665,11283351,18719252,17441508,20106980,17441508,11283351 0114,0018,0018,0114,0004,0096,0398,0096,0096,0397,0018,0114,0399,0018,0401,0004,0006,0018 LC,HT GET4 MDY2 20106980,20106980,20106980,20554915,20106980,26451041,24727835,20106980,24727835 0018,0004,0114,0114,0006,0114,0071,0096,0226 LC GET3 MDY2 18719252,11283351,11283351,20106980,11283351,20106980,20106980 0018,0018,0399,0018,0398,0006,0096 HT,LC MDY2 MDY2 22262836,23142665 0114,0114 LC PAB1 MDY2 23285234 0004 LC TUB1 MDY2 20722039 0004 LC SSA1 MDY2 23217712,20850366 0096,0004 LC SPT15 MDY2 12052880 0004 LC SEC22 MDY2 20850366 0004 LC YDJ1 MDY2 17441508,17441508,17441508,17441508 0004,0401,0006,0096 LC HSP104 MDY2 20850366 0004 LC NAB2 MDY2 19840948 0004 LC NIP100 MDY2 20722039,16554755,16554755 0004,0676,0004 LC,HT AAP1 MDY2 16554755,16554755 0676,0004 HT HMT1 MDY2 22997150 0004 LC P38276 MDY2 20850366,16554755,16554755 0004,0676,0004 LC,HT SSB2 MDY2 23332755 0401 LC BNI1 MDY2 24133141 0096 LC INO80 MDY2 26656161 0004 LC GIS2 MDY2 21277287 0004 LC CIA1 MDY2 11805837,11805837 0004,0007 HT SGT2 MDY2 21832041,23285234,20106980,17441508,23297211,17441508,23297211,23142665,20093466,17441508,16554755,23142665,21619481,20850366,16554755,17441508,20106980,17441508 0004,0004,0018,0018,0114,0004,0096,0096,0004,0096,0676,0114,0004,0004,0004,0401,0004,0006 LC,HT GET4 MDY2 20106980,23285234,16554755,20106980,20106980,20106980,20850366,16702403,20106980,16554755,22190685,16554755 0018,0004,0676,0004,0114,0006,0004,0004,0096,0363,0096,0004 LC,HT GET3 MDY2 20850366,20106980,20106980,20554915,20106980,23203805,19325107 0004,0018,0006,0004,0096,0428,0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q12285 P53115 MDY2 INO80 0.21 26656161 Q12285 O43765 MDY2 SGTA 0.309 23533635 Q12285 P04147 MDY2 PAB1 0.376 23285234 Q12285 P09733 MDY2 TUB1 0.376 20722039 Q12285 P10591 MDY2 SSA1 0.309 23217712,20850366 Q12285 P22214 MDY2 SEC22 0.21 20850366 Q12285 P25367 MDY2 RNQ1 0.332 18719252 Q12285 P31539 MDY2 HSP104 0.21 20850366 Q12285 Q02630 MDY2 NUP116 0.21 11283351 Q12285 Q12154 MDY2 GET3 0.946 20106980,19325107,20554915,18719252,23203805,11283351,20850366 Q12285 P25567 MDY2 SRO9 0.126 22271760 Q12285 Q12118 MDY2 SGT2 0.995 10688190,20106980,17441508,16554755,21619481,23285234,23142665,20850366,23297211,18719252,20093466,24100326,11283351,21832041 Q12285 Q05785 MDY2 ENT2 0.332 18719252 Q12285 P25491 MDY2 YDJ1 0.376 17441508 Q12285 Q06549 MDY2 CDD1 0.332 18719252 Q12285 Q12125 MDY2 GET4 0.994 20106980,22190685,20554915,16554755,23285234,20850366 Q12285 P29055 MDY2 SUA7 0.236 11283351 Q12285 P37898 MDY2 AAP1 0.332 16554755 Q12285 P38074 MDY2 HMT1 0.126 22997150 Q12285 P38276 MDY2 P38276 0.396 16554755,20850366 Q12285 P32505 MDY2 NAB2 0.126 19840948 Q12285 P33420 MDY2 NIP100 0.523 16554755,20722039 Q12285 P40150 MDY2 SSB2 0.126 23332755 Q12285 P41832 MDY2 BNI1 0.183 24133141 Q12285 P53849 MDY2 GIS2 0.126 21277287 Q12285 Q05583 MDY2 CIA1 0.454 11805837,14690591