PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus PUF3 TFC7 26493364 biogrid exp RPO21 TFC7 23569204 biogrid exp RIM13 TFC7 22615397,18467557 biogrid,i2d,mint,intact exp SRO9 TFC7 22271760 biogrid exp TFC7 NCB2 i2d exp ASF1 TFC7 21179020 intact exp SET3 TFC7 21179020 intact exp SSA2 TFC7 16429126,19536198 intact exp SPT10 TFC7 25228766 biogrid exp HTB1 TFC7 21179020 intact exp COP1 TFC7 i2d exp HSP10 TFC7 19536198,18467557 biogrid,i2d,mint,intact exp SSB1 TFC7 19536198 intact exp PGK1 TFC7 11283351 i2d,mint,intact,dip exp CCT8 TFC7 19536198 intact exp TFC7 RLF2 21179020 intact exp IDI1 TFC7 18467557 biogrid,i2d,mint,intact exp COX14 TFC7 11283351 i2d,mint,intact,dip exp RPN6 TFC7 i2d exp TOM71 TFC7 11283351 i2d,mint,intact,dip exp SSA1 TFC7 19536198 biogrid,intact exp CDC28 TFC7 24019491 biogrid exp TFC1 TFC7 11604518,14759368,11805826,16429126,9584160,17409385,16554755, 23023127 biogrid,i2d,mint,intact,dip exp, pred CDC39 TFC7 11805826,16429126, 23023127 biogrid,mint,intact,dip exp, pred TFC8 TFC7 16429126, 23023127 biogrid,intact exp, pred PHO85 TFC7 16319894, 23023127 biogrid,i2d exp, pred NHP6B TFC7 11805826,16429126, 23023127 biogrid,mint,intact,dip exp, pred SUA7 TFC7 11283351, 23023127 i2d,mint,intact,dip exp, pred TFC4 TFC7 16429126,8617241,9584160,16554755, 23023127 biogrid,i2d,mint,intact,dip exp, pred RSC4 TFC7 21179020, 23023127 intact exp, pred YKU80 TFC7 11805837, 23023127 biogrid,mint,intact,dip exp, pred TFC3 TFC7 16429126,9584160,16554755, 23023127 biogrid,i2d,mint,intact exp, pred ATP22 TFC7 18467557, 23023127 biogrid,i2d,mint,intact exp, pred NAB2 TFC7 19840948, 23023127 biogrid exp, pred TFC6 TFC7 16429126,16554755, 23023127 biogrid,i2d,mint,intact exp, pred IFH1 TFC7 23023127 pred RPC53 TFC7 23023127 pred RPC25 TFC7 23023127 pred BDP1 TFC7 23023127 pred SPT15 TFC7 23023127 pred BRF1 TFC7 23023127 pred PZF1 TFC7 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q12415 - 11805826 - C 18 Q12415 - 14759368 - C 4 P00560 Q12415 - 11283351 - X 2 P29055 Q12415 - 11283351 - X 2 Q12415 - 11805826 - C 7 Q12415 - 11805826 - C 9 Q12415 - 11805837 - C 32 Q12415 - 2052571 - C 6 Q12415 - 15044803 - C 6 P32367 Q12415 - 9584160 - X 2 P38825 Q12415 - 11283351 - X 2 P39103 Q12415 - 11283351 - X 2 P38910 Q12415 protein complementation assay 18467557 direct interaction X 2 P15496 Q12415 protein complementation assay 18467557 direct interaction X 2 P50273 Q12415 protein complementation assay 18467557 direct interaction X 2 Q06339 Q12415 affinity chromatography technology 16554755 physical association X 2 Q06339 Q12415 affinity chromatography technology 16429126 physical association X 2 Q06339 Q12415 affinity chromatography technology 17200106 physical association X 2 P17157 Q12415 enzymatic study 16319894 direct interaction X 2 Q03792 Q12415 protein complementation assay 18467557 direct interaction X 2 Q03792 Q12415 protein complementation assay 22615397 direct interaction X 2 Q12308 Q12415 affinity chromatography technology 16429126 physical association X 2 Q12308 Q12415 affinity chromatography technology 16429126 physical association X 2 Q12308 Q12415 affinity chromatography technology 17200106 physical association X 2 Q04437 Q12415 affinity chromatography technology 11805837 physical association X 2 P11633 Q12415 affinity chromatography technology 11805826 physical association X 2 P00546 Q12415 protein complementation assay 24019491 direct interaction X 2 Q12415 P34111 affinity chromatography technology 9584160 physical association X 2 Q12415 P04050 enzymatic study 23569204 direct interaction X 2 Q12415 Q12306 affinity chromatography technology 23935535 physical association X 2 Q12415 P34111 affinity chromatography technology 16554755 physical association X 2 Q12415 P34111 affinity chromatography technology 16429126 physical association X 2 Q12415 P34111 affinity chromatography technology 17200106 physical association X 2 P35208 Q12415 affinity chromatography technology 25228766 physical association X 2 P33339 Q12415 two hybrid 8617241 direct interaction X 2 P33339 Q12415 affinity chromatography technology 9584160 physical association X 2 P33339 Q12415 affinity chromatography technology 16554755 physical association X 2 P33339 Q12415 affinity chromatography technology 16429126 physical association X 2 P33339 Q12415 affinity chromatography technology 17200106 physical association X 2 P32367 Q12415 two hybrid 9584160 direct interaction X 2 P32367 Q12415 pull down 9584160 direct interaction X 2 P32367 Q12415 affinity chromatography technology 9584160 physical association X 2 P32367 Q12415 biochemical 9584160 colocalization X 2 P32367 Q12415 affinity chromatography technology 16554755 physical association X 2 P32367 Q12415 affinity chromatography technology 16429126 physical association X 2 P32367 Q12415 affinity chromatography technology 16429126 physical association X 2 P32367 Q12415 affinity chromatography technology 17200106 physical association X 2 P32367 Q12415 two hybrid 11604518 direct interaction X 2 P32367 Q12415 two hybrid 17409385 direct interaction X 2 P32367 Q12415 affinity chromatography technology 14759368 physical association X 2 P32367 Q12415 affinity chromatography technology 11805826 physical association X 2 P25655 Q12415 affinity chromatography technology 11805826 physical association X 2 P10591 Q12415 affinity chromatography technology 19536198 physical association X 2 P10591 Q12415 affinity chromatography technology 19536198 physical association X 2 Q12415 tandem affinity purification 11805826 - C 18 Q12415 inferred by author 11805826 physical association C 26 Q12415 inferred by author 11805826 physical association C 28 P00560 Q12415 two hybrid pooling approach 11283351 physical association X 2 P29055 Q12415 two hybrid pooling approach 11283351 physical association X 2 Q04437 Q12415 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12415 inferred by author 11805826 physical association C 7 Q12415 tandem affinity purification 11805826 physical association C 7 Q12415 tandem affinity purification 11805826 - C 9 Q12415 anti tag coimmunoprecipitation 11805837 - C 32 Q12415 anti tag coimmunoprecipitation 11805837 - C 69 P33339 Q12415 two hybrid 8617241 physical association X 2 P32367 Q12415 tandem affinity purification 11805826 physical association X 2 P32367 Q12415 filter binding 9584160 physical association X 2 P32367 Q12415 affinity chromatography technology 9584160 physical association X 2 P32367 Q12415 two hybrid 9584160 physical association X 2 P32367 Q12415 coimmunoprecipitation 9584160 physical association X 2 P25655 Q12415 tandem affinity purification 11805826 physical association X 2 P38825 Q12415 two hybrid pooling approach 11283351 physical association X 2 Q12415 tandem affinity purification 11805826 physical association X 2 P39103 Q12415 two hybrid pooling approach 11283351 physical association X 2 Q12415 tandem affinity purification 21179020 association C 140 Q12415 tandem affinity purification 16429126 association C 9 Q12415 tandem affinity purification 21179020 association C 106 Q12415 tandem affinity purification 16429126 association C 13 Q12415 tandem affinity purification 21179020 association C 193 Q12415 tandem affinity purification 11805826 association C 18 Q12415 tandem affinity purification 21179020 association C 107 Q12415 tandem affinity purification 16429126 association C 24 Q12415 tandem affinity purification 21179020 association C 121 P38910 Q12415 dihydrofolate reductase reconstruction 18467557 physical association X 2 P38910 Q12415 tandem affinity purification 19536198 association X 2 P15496 Q12415 dihydrofolate reductase reconstruction 18467557 physical association X 2 P00560 Q12415 two hybrid fragment pooling approach 11283351 physical association X 2 P50273 Q12415 dihydrofolate reductase reconstruction 18467557 physical association X 2 Q06339 Q12415 tandem affinity purification 16554755 physical association X 2 Q06339 Q12415 tandem affinity purification 16554755 physical association X 2 Q06339 Q12415 tandem affinity purification 16554755 physical association X 2 Q06339 Q12415 tandem affinity purification 16554755 physical association X 2 Q06339 Q12415 tandem affinity purification 16554755 physical association X 2 Q06339 Q12415 tandem affinity purification 16554755 physical association X 2 Q03792 Q12415 dihydrofolate reductase reconstruction 18467557 physical association X 2 P29055 Q12415 two hybrid fragment pooling approach 11283351 physical association X 2 Q12415 tandem affinity purification 11805826 association C 8 Q12415 tandem affinity purification 16429126 association C 7 Q12415 tandem affinity purification 11805826 association C 10 Q12415 anti tag coimmunoprecipitation 11805837 association C 49 Q12415 tandem affinity purification 16429126 association C 6 Q12415 inferred by author 16429126 physical association C 6 Q12415 inferred by author 16554755 association C 6 P10592 Q12415 tandem affinity purification 19536198 association X 2 P11484 Q12415 tandem affinity purification 19536198 association X 2 Q12415 P34111 tandem affinity purification 16554755 physical association X 2 Q12415 P34111 tandem affinity purification 16554755 physical association X 2 Q12415 P34111 tandem affinity purification 16554755 physical association X 2 Q12415 P34111 tandem affinity purification 16554755 physical association X 2 Q12415 P34111 tandem affinity purification 16554755 physical association X 2 Q12415 P34111 tandem affinity purification 16554755 physical association X 2 Q12415 P34111 tandem affinity purification 16554755 physical association X 2 Q12415 P34111 tandem affinity purification 16554755 physical association X 2 Q12415 P34111 tandem affinity purification 16554755 physical association X 2 Q12415 P34111 tandem affinity purification 16554755 physical association X 2 Q12415 P34111 tandem affinity purification 16554755 physical association X 2 Q12415 P34111 tandem affinity purification 16554755 physical association X 2 Q12415 P47079 tandem affinity purification 19536198 association X 2 P33339 Q12415 tandem affinity purification 16554755 physical association X 2 P33339 Q12415 tandem affinity purification 16554755 physical association X 2 P33339 Q12415 tandem affinity purification 16554755 physical association X 2 P33339 Q12415 tandem affinity purification 16554755 physical association X 2 P33339 Q12415 tandem affinity purification 16554755 physical association X 2 P33339 Q12415 tandem affinity purification 16554755 physical association X 2 P33339 Q12415 tandem affinity purification 16554755 physical association X 2 P33339 Q12415 tandem affinity purification 16554755 physical association X 2 P32367 Q12415 anti tag coimmunoprecipitation 14759368 physical association X 2 P32367 Q12415 tandem affinity purification 16554755 physical association X 2 P32367 Q12415 tandem affinity purification 16554755 physical association X 2 P32367 Q12415 tandem affinity purification 16554755 physical association X 2 P32367 Q12415 tandem affinity purification 16554755 physical association X 2 P32367 Q12415 tandem affinity purification 16554755 physical association X 2 P32367 Q12415 tandem affinity purification 16554755 physical association X 2 P32367 Q12415 tandem affinity purification 16554755 physical association X 2 P32367 Q12415 tandem affinity purification 16554755 physical association X 2 P32367 Q12415 tandem affinity purification 16554755 physical association X 2 P38825 Q12415 two hybrid fragment pooling approach 11283351 physical association X 2 P39103 Q12415 two hybrid fragment pooling approach 11283351 physical association X 2 P10591 Q12415 tandem affinity purification 19536198 association X 2 P10591 Q12415 tandem affinity purification 19536198 association X 2 Q12415 mass spectrometry studies of complexes 11805826 - C 9 Q12415 mass spectrometry studies of complexes 11805826 - C 32 Q12415 confirmational text mining - - C 5 P00560 Q12415 two hybrid 11283351 - X 2 P29055 Q12415 two hybrid 11283351 - X 2 Q12415 mass spectrometry studies of complexes 11805837 - C 33 P32367 Q12415 coimmunoprecipitation 9584160 - X 2 P38825 Q12415 two hybrid 11283351 - X 2 P39103 Q12415 two hybrid 11283351 - X 2

PPI - HINT Gene A Gene B PMID Method Quality CDC28 TFC7 24019491 0090 LC PGK1 TFC7 11283351,11283351,11283351 0018,0399,0398 HT RPO21 TFC7 23569204 0415 LC IDI1 TFC7 18467557,18467557 0111,0090 HT PHO85 TFC7 16319894 0415 LC SUA7 TFC7 11283351,11283351,11283351 0018,0399,0398 HT TFC1 TFC7 9584160,9584160,9584160,9584160,9584160,9584160,11604518,17409385,9584160,9584160 0004,0047,0018,0096,0401,0019,0018,0018,0049,0045 LC TFC4 TFC7 8617241 0018 LC TOM71 TFC7 11283351,11283351,11283351 0018,0399,0398 HT HSP10 TFC7 18467557,18467557 0111,0090 HT COX14 TFC7 11283351,11283351,11283351 0018,0399,0398 HT ATP22 TFC7 18467557,18467557 0111,0090 HT RIM13 TFC7 18467557,18467557,22615397 0111,0090,0090 HT,LC HTB1 TFC7 21179020 0676 HT SSA1 TFC7 19536198,19536198 0004,0676 HT SSA2 TFC7 19536198,16429126 0676,0676 HT SSB1 TFC7 19536198 0676 HT NHP6B TFC7 11805826,16429126,11805826,11805826 0004,0676,0007,0676 HT CDC39 TFC7 11805826,16429126,11805826,11805826 0004,0676,0007,0676 HT TFC1 TFC7 14759368,9584160,9584160,17200106,9584160,9584160,9584160,9584160,16429126,16554755,16554755,16429126,11805826,14759368,16554755,16429126,9584160,11805826,11805826,9584160 0007,0004,0047,0004,0018,0096,0401,0019,0363,0363,0676,0676,0004,0004,0004,0004,0049,0676,0007,0045 HT,LC ASF1 TFC7 21179020 0676 HT NAB2 TFC7 19840948 0004 LC TFC4 TFC7 16554755,16429126,9584160,17200106,16429126,16554755 0676,0004,0004,0004,0676,0004 HT,LC TFC3 TFC7 16554755,16429126,9584160,17200106,16429126,16554755 0676,0004,0004,0004,0676,0004 HT,LC SPT10 TFC7 25228766 0004 HT SET3 TFC7 21179020 0676 HT HSP10 TFC7 19536198 0676 HT CCT8 TFC7 19536198 0676 HT RSC4 TFC7 21179020 0676 HT YKU80 TFC7 11805837,11805837 0004,0007 HT TFC6 TFC7 16429126,17200106,16429126,16554755,16554755 0004,0004,0676,0676,0004 HT TFC8 TFC7 17200106,16429126,16429126 0004,0676,0004 HT TFC7 RLF2 21179020 0676 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q12415 Q04437 TFC7 YKU80 0.21 11805837 Q12415 Q12308 TFC7 TFC8 0.236 16429126 Q12415 P04050 TFC7 RPO21 0.309 23569204 Q12415 P11484 TFC7 SSB1 0.126 19536198 Q12415 P11633 TFC7 NHP6B 0.416 11805826,16429126 Q12415 P15496 TFC7 IDI1 0.126 18467557 Q12415 P29055 TFC7 SUA7 0.21 11283351 Q12415 P33339 TFC7 TFC4 0.659 16554755,8617241,16429126,9584160 Q12415 P38825 TFC7 TOM71 0.21 11283351 Q12415 Q03792 TFC7 RIM13 0.126 18467557 Q12495 Q12415 RLF2 TFC7 0.126 21179020 Q12415 P25567 TFC7 SRO9 0.126 22271760 Q12415 P25655 TFC7 CDC39 0.286 11805826,16429126 Q12415 P00546 TFC7 CDC28 0.309 24019491 Q12415 P00560 TFC7 PGK1 0.21 11283351 Q12415 P10591 TFC7 SSA1 0.332 19536198 Q12415 P02293 TFC7 HTB1 0.126 21179020 Q12415 Q06339 TFC7 TFC6 0.416 16554755,16429126 Q12415 P10592 TFC7 SSA2 0.236 16429126,19536198 Q12415 P34111 TFC7 TFC3 0.539 16554755,16429126,9584160 Q12415 P38910 TFC7 HSP10 0.236 18467557,19536198 Q12415 P32367 TFC7 TFC1 0.958 11805826,16429126,9584160,14759368,16554755,17409385,11604518 Q12415 P32447 TFC7 ASF1 0.126 21179020 Q12415 P32505 TFC7 NAB2 0.126 19840948 Q12415 P39103 TFC7 COX14 0.236 11283351 Q12415 P36124 TFC7 SET3 0.126 21179020 Q12415 P47079 TFC7 CCT8 0.126 19536198 Q12415 P50273 TFC7 ATP22 0.286 18467557 Q12415 Q02206 TFC7 RSC4 0.126 21179020 Q12415 P17157 TFC7 PHO85 0.183 16319894 Q12415 Q07807 TFC7 PUF3 0.126 26493364