PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus LYS1 RUP1 18719252 biogrid,intact exp SSB1 RUP1 19536198 intact exp WWM1 RUP1 i2d exp HSE1 RUP1 17079730 biogrid exp SSA2 RUP1 16429126,19536198 intact exp LSM12 RUP1 i2d exp SSZ1 RUP1 19536198 intact exp SSA1 RUP1 19536198 intact exp NOP13 RUP1 16429126 intact exp HDA1 RUP1 16554755 biogrid,i2d,mint,intact exp NPR2 RUP1 10688190 biogrid,i2d,mint,intact,dip exp CDC34 RUP1 i2d exp HDA2 RUP1 i2d exp SSB2 RUP1 23332755,19536198 biogrid,intact exp SSE1 RUP1 19536198 intact exp BUL1 RUP1 16554755 intact exp CCT3 RUP1 19536198 intact exp RPL40A RUP1 16007098 dip exp ERJ5 RUP1 19536198 intact exp ALK2 RUP1 i2d exp MLC1 RUP1 i2d exp Uncharacterized protein YGR126W RUP1 i2d exp NAM7 RUP1 18087042 biogrid exp TUB1 RUP1 i2d exp RSP5 RUP1 16429126,15933713,19165343,16554755, 23023127 biogrid,i2d,mint,intact exp, pred FRA1 RUP1 16554755, 23023127 biogrid,i2d,mint,intact exp, pred RVS167 RUP1 16554755, 23023127 biogrid,i2d,mint,intact exp, pred HUA1 RUP1 10688190,17079730, 23023127 biogrid,i2d,mint,intact,dip exp, pred UBP2 RUP1 20826334,16429126,15933713,19165343,16554755,18719252, 23023127 biogrid,i2d,mint,intact exp, pred CDC73 RUP1 16554755, 23023127 biogrid,i2d,mint,intact exp, pred UBP14 RUP1 23023127 pred UBX7 RUP1 23023127 pred RUP1 HUB1 23023127 pred UBI4 RUP1 23023127 pred RUP1 SMT3 23023127 pred CUE2 RUP1 23023127 pred CUE5 RUP1 23023127 pred CUE1 RUP1 23023127 pred DSK2 RUP1 23023127 pred RAD23 RUP1 23023127 pred UBX3 RUP1 23023127 pred SHP1 RUP1 23023127 pred RUB1 RUP1 23023127 pred UBX5 RUP1 23023127 pred UBP6 RUP1 23023127 pred ATG12 RUP1 23023127 pred CDC31 RUP1 23023127 pred UBX4 RUP1 23023127 pred RUP1 MEX67 23023127 pred UBX6 RUP1 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q12242 - 15933713 - C 3 Q12242 P40325 - 10688190 - X 2 Q12242 Q01476 - 15933713 - X 2 P39940 Q12242 - 15933713 - X 2 P39923 Q12242 - 10688190 - X 2 P38998 Q12242 two hybrid 18719252 direct interaction X 2 Q06697 Q12242 affinity chromatography technology 16554755 physical association X 2 Q12242 Q01476 affinity chromatography technology 15933713 physical association X 2 Q12242 Q01476 pull down 15933713 direct interaction X 2 Q12242 Q01476 affinity chromatography technology 16554755 physical association X 2 Q12242 Q01476 affinity chromatography technology 16429126 physical association X 2 Q12242 Q01476 affinity chromatography technology 16429126 physical association X 2 Q12242 P40325 affinity chromatography technology 17079730 physical association X 2 Q12242 Q01476 affinity chromatography technology 17200106 physical association X 2 Q12242 Q01476 two hybrid 18719252 direct interaction X 2 Q12242 Q01476 affinity chromatography technology 19165343 physical association X 2 Q12242 Q01476 affinity chromatography technology 19165343 physical association X 2 Q12242 Q01476 affinity chromatography technology 20826334 physical association X 2 Q12242 P40325 two hybrid 10688190 direct interaction X 2 P39940 Q12242 affinity chromatography technology 15933713 physical association X 2 P39940 Q12242 pull down 15933713 direct interaction X 2 P39940 Q12242 affinity chromatography technology 16554755 physical association X 2 P39940 Q12242 affinity chromatography technology 17200106 physical association X 2 P39940 Q12242 affinity chromatography technology 19165343 physical association X 2 P0CG63 Q12242 affinity chromatography technology 23749301 physical association X 2 P0CG63 Q12242 biochemical 23583075 association X 2 P0CG63 Q12242 affinity chromatography technology 19722269 physical association X 2 Q12242 P39743 affinity chromatography technology 16554755 physical association X 2 P38753 Q12242 affinity chromatography technology 17079730 physical association X 2 P40150 Q12242 biochemical 23332755 association X 2 P53973 Q12242 affinity chromatography technology 16554755 physical association X 2 P39923 Q12242 two hybrid 10688190 direct interaction X 2 Q07825 Q12242 affinity chromatography technology 16554755 physical association X 2 Q12242 two hybrid 10688190 physical association X 2 Q12242 P40325 two hybrid 10688190 physical association X 2 Q12242 P05759 pull down 16007098 direct interaction X 2 Q12242 inferred by author 16429126 physical association C 4 Q12242 tandem affinity purification 16429126 association C 44 P32589 Q12242 tandem affinity purification 19536198 association X 2 P39077 Q12242 tandem affinity purification 19536198 association X 2 P38998 Q12242 two hybrid 18719252 physical association X 2 Q06697 Q12242 tandem affinity purification 16554755 physical association X 2 Q06697 Q12242 tandem affinity purification 16554755 physical association X 2 Q06697 Q12242 tandem affinity purification 16554755 physical association X 2 Q06697 Q12242 tandem affinity purification 16554755 physical association X 2 Q06697 Q12242 tandem affinity purification 16554755 physical association X 2 Q12242 P40325 two hybrid 10688190 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 tandem affinity purification 16554755 physical association X 2 Q12242 Q01476 two hybrid 18719252 physical association X 2 P10591 Q12242 tandem affinity purification 19536198 association X 2 P38788 Q12242 tandem affinity purification 19536198 association X 2 P39940 Q12242 tandem affinity purification 16554755 physical association X 2 P39940 Q12242 tandem affinity purification 16554755 physical association X 2 P39940 Q12242 tandem affinity purification 16554755 physical association X 2 P39940 Q12242 tandem affinity purification 16554755 physical association X 2 P39940 Q12242 tandem affinity purification 16554755 physical association X 2 P39940 Q12242 tandem affinity purification 16554755 physical association X 2 P39940 Q12242 tandem affinity purification 16554755 physical association X 2 Q12242 tandem affinity purification 16429126 association C 5 Q12242 inferred by author 16554755 association C 7 Q12242 tandem affinity purification 16429126 association C 3 P10592 Q12242 tandem affinity purification 19536198 association X 2 P11484 Q12242 tandem affinity purification 19536198 association X 2 Q12242 P39743 tandem affinity purification 16554755 physical association X 2 Q12242 P39743 tandem affinity purification 16554755 physical association X 2 P40150 Q12242 tandem affinity purification 19536198 association X 2 P43613 Q12242 tandem affinity purification 19536198 association X 2 P53973 Q12242 tandem affinity purification 16554755 physical association X 2 P53973 Q12242 tandem affinity purification 16554755 physical association X 2 P39923 Q12242 two hybrid 10688190 physical association X 2 Q07825 Q12242 tandem affinity purification 16554755 physical association X 2 Q12242 P40325 two hybrid 10688190 - X 2 P39923 Q12242 two hybrid 10688190 - X 2

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q12242 P11484 RUP1 SSB1 0.126 19536198 Q12242 P39077 RUP1 CCT3 0.126 19536198 Q12242 P10591 RUP1 SSA1 0.126 19536198 Q12242 P39940 RUP1 RSP5 0.748 15933713,16429126,26508657,16554755,19165343 Q12242 P10592 RUP1 SSA2 0.236 16429126,19536198 Q12242 P40150 RUP1 SSB2 0.236 23332755,19536198 Q12242 Q01476 RUP1 UBP2 0.911 15933713,16429126,18719252,16554755,20826334,19165343 Q12242 P30771 RUP1 NAM7 0.126 18087042 Q12242 P38788 RUP1 SSZ1 0.126 19536198 Q12242 P32589 RUP1 SSE1 0.126 19536198 Q12242 P38998 RUP1 LYS1 0.332 18719252 Q12242 P39743 RUP1 RVS167 0.236 16554755 Q12242 P39923 RUP1 NPR2 0.332 10688190 Q12242 P40325 RUP1 HUA1 0.332 10688190 Q12242 P43613 RUP1 ERJ5 0.126 19536198 Q12242 P48524 RUP1 BUL1 0.126 16554755 Q12242 Q06697 RUP1 CDC73 0.332 16554755 Q12242 P53883 RUP1 NOP13 0.126 16429126 Q12242 P53973 RUP1 HDA1 0.236 16554755 Q12242 Q07825 RUP1 FRA1 0.126 16554755