PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus NDL1 ULS1 22875988 biogrid exp SSE1 ULS1 19536198 intact exp PRP9 ULS1 9207794 biogrid,i2d,dip exp CBF5 ULS1 i2d exp BIK1 ULS1 23034179 biogrid exp CDC11 ULS1 18603780 biogrid exp HPR1 ULS1 16554755 biogrid,i2d,mint,intact exp PAC1 ULS1 23034179 biogrid exp NOP2 ULS1 11805837 biogrid,mint,intact,dip exp SLX5 ULS1 23550137 biogrid exp YDJ1 ULS1 19536198 intact exp CDC14 ULS1 21127052 biogrid exp KAR9 ULS1 18832349 biogrid exp ULS1 ULS1 9271422 intact exp BNR1 ULS1 22875988 biogrid exp ULS1 TIF6 11805837 biogrid,mint,intact,dip exp SLX8 ULS1 23550137 biogrid exp SPP382 ULS1 14690591 intact exp DCP2 ULS1 i2d exp CDC3 ULS1 18603780,22875988 biogrid exp HHF1, HHF2 ULS1 i2d exp HSP78 ULS1 19536198 intact exp SSA3 ULS1 19536198 intact exp UBC4 ULS1 17728242 biogrid exp MOT1 ULS1 18596064 biogrid exp SRT1 ULS1 i2d exp HTB2 ULS1 i2d exp COY1 ULS1 22875988 biogrid exp ATG7 ULS1 11805837 biogrid,mint,intact,dip exp ECM10 ULS1 19536198 intact exp SSB2 ULS1 19536198 intact exp KAP95 ULS1 i2d exp ULS1 ELG1 21869594 biogrid exp EBP2 ULS1 18603780 biogrid exp BIM1 ULS1 18832349 biogrid exp CPR7 ULS1 16554755 intact exp SSA2 ULS1 19536198 biogrid,intact exp PUF3 ULS1 26493364 biogrid exp SSA1 ULS1 19536198 intact exp SSB1 ULS1 19536198 biogrid,intact exp ALY2 ULS1 i2d exp HOF1 ULS1 19841731 biogrid,mint,intact exp SIS1 ULS1 19536198 intact exp DMC1 ULS1 9335591, 23023127 biogrid,i2d,dip exp, pred ULS1 SMT3 23122649,17728242,11283351,15590687, 23023127 biogrid,i2d,mint,intact,dip exp, pred PIN3 ULS1 19841731, 23023127 biogrid,mint,intact exp, pred SIR4 ULS1 9271422, 23023127 biogrid,intact,dip exp, pred LSM2 ULS1 10900456, 23023127 biogrid,i2d,mint,intact,dip exp, pred MFT1 ULS1 16554755, 23023127 biogrid,i2d,mint,intact exp, pred THO2 ULS1 16554755, 23023127 biogrid,i2d,mint,intact exp, pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q08562 - 11805837 - C 4 P25453 Q08562 - 9335591 - X 2 P38203 Q08562 - 10900456 - X 2 P19736 Q08562 - 9207794 - X 2 Q12306 Q08562 - 11283351 - X 2 Q00684 Q08562 affinity chromatography technology 21127052 physical association X 2 P33441 Q08562 affinity chromatography technology 16554755 physical association X 2 P40072 Q08562 two hybrid 23550137 direct interaction X 2 P32333 Q08562 affinity chromatography technology 18596064 physical association X 2 P38862 Q08562 affinity chromatography technology 11805837 physical association X 2 P11484 Q08562 affinity chromatography technology 19536198 physical association X 2 P11484 Q08562 affinity chromatography technology 19536198 physical association X 2 P25453 Q08562 two hybrid 9335591 direct interaction X 2 P38203 Q08562 two hybrid 10900456 direct interaction X 2 P32526 Q08562 two hybrid 18832349 direct interaction X 2 Q12050 Q08562 two hybrid 21869594 direct interaction X 2 P40450 Q08562 two hybrid 22875988 direct interaction X 2 P32458 Q08562 two hybrid 18603780 direct interaction X 2 P36049 Q08562 two hybrid 18603780 direct interaction X 2 Q12522 Q08562 affinity chromatography technology 11805837 physical association X 2 P53552 Q08562 affinity chromatography technology 16554755 physical association X 2 P34237 Q08562 two hybrid 22875988 direct interaction X 2 P32828 Q08562 two hybrid 23550137 direct interaction X 2 P32828 Q08562 affinity chromatography technology 23550137 physical association X 2 P17629 Q08562 affinity chromatography technology 16554755 physical association X 2 P10592 Q08562 affinity chromatography technology 19536198 physical association X 2 P10592 Q08562 affinity chromatography technology 19536198 physical association X 2 P39946 Q08562 two hybrid 23034179 direct interaction X 2 Q06449 Q08562 two hybrid 19841731 direct interaction X 2 P40013 Q08562 two hybrid 18832349 direct interaction X 2 P15731 Q08562 affinity chromatography technology 17728242 physical association X 2 P19736 Q08562 two hybrid 9207794 direct interaction X 2 P11978 Q08562 two hybrid 9271422 direct interaction X 2 Q06568 Q08562 two hybrid 22875988 direct interaction X 2 P40991 Q08562 affinity chromatography technology 11805837 physical association X 2 Q12306 Q08562 two hybrid 15590687 direct interaction X 2 Q12306 Q08562 affinity chromatography technology 15590687 physical association X 2 Q12306 Q08562 affinity chromatography technology 23935535 physical association X 2 Q12306 Q08562 unspecified method 23122649 direct interaction X 2 Q12306 Q08562 pull down 17728242 direct interaction X 2 Q12306 Q08562 two hybrid 17728242 direct interaction X 2 Q12306 Q08562 affinity chromatography technology 15326169 physical association X 2 Q05080 Q08562 two hybrid 19841731 direct interaction X 2 P11709 Q08562 two hybrid 23034179 direct interaction X 2 P32457 Q08562 two hybrid 22875988 direct interaction X 2 P32457 Q08562 two hybrid 18603780 direct interaction X 2 Q08562 anti tag coimmunoprecipitation 11805837 - C 4 P38862 Q08562 anti tag coimmunoprecipitation 11805837 physical association X 2 P25453 Q08562 two hybrid 9335591 physical association X 2 P38203 Q08562 two hybrid 10900456 physical association X 2 Q12522 Q08562 anti tag coimmunoprecipitation 11805837 physical association X 2 P19736 Q08562 two hybrid 9207794 physical association X 2 P11978 Q08562 two hybrid 9271422 physical association X 2 P40991 Q08562 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12306 Q08562 two hybrid pooling approach 11283351 physical association X 2 Q08562 anti tag coimmunoprecipitation 11805837 association C 4 P32589 Q08562 tandem affinity purification 19536198 association X 2 P33441 Q08562 tandem affinity purification 16554755 physical association X 2 P25294 Q08562 tandem affinity purification 19536198 association X 2 P11484 Q08562 tandem affinity purification 19536198 association X 2 P11484 Q08562 tandem affinity purification 19536198 association X 2 P25491 Q08562 tandem affinity purification 19536198 association X 2 P09435 Q08562 tandem affinity purification 19536198 association X 2 P38203 Q08562 two hybrid 10900456 physical association X 2 P40150 Q08562 tandem affinity purification 19536198 association X 2 P53552 Q08562 tandem affinity purification 16554755 physical association X 2 P39987 Q08562 tandem affinity purification 19536198 association X 2 P17629 Q08562 tandem affinity purification 16554755 physical association X 2 Q08562 inferred by author 16554755 association C 13 P10592 Q08562 tandem affinity purification 19536198 association X 2 P10592 Q08562 tandem affinity purification 19536198 association X 2 Q08562 Q08562 two hybrid 9271422 physical association X 2 Q06449 Q08562 two hybrid pooling approach 19841731 physical association X 2 P11978 Q08562 two hybrid 9271422 physical association X 2 P33416 Q08562 tandem affinity purification 19536198 association X 2 Q06411 Q08562 two hybrid array 14690591 physical association X 2 Q12306 Q08562 two hybrid fragment pooling approach 11283351 physical association X 2 Q05080 Q08562 two hybrid pooling approach 19841731 physical association X 2 P10591 Q08562 tandem affinity purification 19536198 association X 2 P25453 Q08562 two hybrid 9335591 - X 2 P38203 Q08562 two hybrid 10900456 - X 2 Q06340 Q08562 interaction detection method 14764870 - X 2 Q08562 mass spectrometry studies of complexes 11805837 - C 5 Q08562 mass spectrometry studies of complexes 11805837 - C 5 P19736 Q08562 two hybrid 9207794 - X 2 Q12306 Q08562 two hybrid 11283351 - X 2

PPI - HINT Gene A Gene B PMID Method Quality BIK1 ULS1 23034179 0018 LC SIR4 ULS1 9271422 0018 LC PRP9 ULS1 9207794 0018 HT DMC1 ULS1 9335591 0018 LC CDC3 ULS1 18603780,22875988 0018,0018 LC,HT CDC11 ULS1 18603780 0018 LC KAR9 ULS1 18832349 0018 LC SLX5 ULS1 23550137,23550137 0018,0004 LC COY1 ULS1 22875988 0018 HT EBP2 ULS1 18603780 0018 LC LSM2 ULS1 10900456 0018 HT PAC1 ULS1 23034179 0018 LC BIM1 ULS1 18832349 0018 LC SLX8 ULS1 23550137 0018 LC BNR1 ULS1 22875988 0018 HT HOF1 ULS1 19841731,19841731 0398,0018 HT SPP382 ULS1 14690591 0397 LC PIN3 ULS1 19841731,19841731 0398,0018 HT NDL1 ULS1 22875988 0018 HT ULS1 ULS1 9271422 0018 LC ULS1 ELG1 21869594 0018 LC ULS1 SMT3 17728242,17728242,11283351,15590687,11283351,15590687,17728242,11283351 0018,0004,0018,0004,0398,0018,0096,0399 LC,HT SSA3 ULS1 19536198 0676 HT SSA1 ULS1 19536198 0676 HT SSA2 ULS1 19536198,19536198 0004,0676 HT SSB1 ULS1 19536198,19536198 0004,0676 HT UBC4 ULS1 17728242 0004 LC HPR1 ULS1 16554755,16554755 0676,0004 HT SIS1 ULS1 19536198 0676 HT YDJ1 ULS1 19536198 0676 HT MOT1 ULS1 18596064 0004 LC SSE1 ULS1 19536198 0676 HT SLX5 ULS1 23550137,23550137 0018,0004 LC HSP78 ULS1 19536198 0676 HT MFT1 ULS1 16554755,16554755 0676,0004 HT ATG7 ULS1 11805837,11805837 0004,0007 HT ECM10 ULS1 19536198 0676 HT SSB2 ULS1 19536198 0676 HT NOP2 ULS1 11805837,11805837 0004,0007 HT CPR7 ULS1 16554755 0363 HT THO2 ULS1 16554755,16554755 0676,0004 HT CDC14 ULS1 21127052 0004 LC ULS1 SMT3 17728242,17728242,15590687,15326169,15590687,17728242 0018,0004,0004,0004,0018,0096 LC ULS1 TIF6 11805837,11805837 0004,0007 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q08562 P15731 ULS1 UBC4 0.21 17728242 Q12050 Q08562 ELG1 ULS1 0.309 21869594 Q12306 Q08562 SMT3 ULS1 0.78 11283351,17728242,15590687,23122649 Q08562 P25294 ULS1 SIS1 0.126 19536198 Q08562 P10592 ULS1 SSA2 0.332 19536198 Q08562 P11709 ULS1 BIK1 0.309 23034179 Q08562 P09435 ULS1 SSA3 0.126 19536198 Q08562 P11484 ULS1 SSB1 0.416 19536198 Q08562 P53552 ULS1 THO2 0.236 16554755 Q08562 P17629 ULS1 HPR1 0.236 16554755 Q08562 P32828 ULS1 SLX5 0.454 23550137 Q08562 P32333 ULS1 MOT1 0.126 18596064 Q08562 P32457 ULS1 CDC3 0.309 18603780 Q08562 P32458 ULS1 CDC11 0.309 18603780 Q08562 P38862 ULS1 ATG7 0.332 11805837 Q08562 P32526 ULS1 KAR9 0.309 18832349 Q08562 P39946 ULS1 PAC1 0.309 23034179 Q08562 P33416 ULS1 HSP78 0.126 19536198 Q08562 P33441 ULS1 MFT1 0.236 16554755 Q08562 P40013 ULS1 BIM1 0.309 18832349 Q08562 P40150 ULS1 SSB2 0.126 19536198 Q08562 P40991 ULS1 NOP2 0.332 11805837 Q08562 P36049 ULS1 EBP2 0.309 18603780 Q08562 P47103 ULS1 CPR7 0.126 16554755 Q12522 Q08562 TIF6 ULS1 0.332 11805837 Q08562 Q00684 ULS1 CDC14 0.126 21127052 Q08562 Q05080 ULS1 HOF1 0.286 19841731 Q08562 P10591 ULS1 SSA1 0.126 19536198 Q08562 P11978 ULS1 SIR4 0.309 9271422 Q08562 P19736 ULS1 PRP9 0.033 9207794 Q08562 P25453 ULS1 DMC1 0.332 9335591 Q08562 P25491 ULS1 YDJ1 0.126 19536198 Q08562 P32589 ULS1 SSE1 0.126 19536198 Q08562 P38203 ULS1 LSM2 0.354 10900456 Q08562 P39987 ULS1 ECM10 0.126 19536198 Q08562 P40072 ULS1 SLX8 0.309 23550137 Q08562 Q06411 ULS1 SPP382 0.126 14690591 Q08562 Q06449 ULS1 PIN3 0.376 19841731