PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus STE4 NAB2 19840948 biogrid exp STE4 CCT8 11805837 dip exp SBP1 STE4 23222640 biogrid exp CIT1 STE4 11805837 dip exp STE4 SSB2 23332755,19536198 biogrid,intact exp SSB1 STE4 11805837 dip exp STE4 STV1 22875988 biogrid exp STE4 DSE1 19820940 biogrid exp STE4 ALD4 11805837 dip exp STE4 CCT2 11805837 biogrid,mint,intact,dip exp STE4 CCT7 11805837 dip exp STE4 SSO1 22875988 biogrid exp MET6 STE4 11805837 dip exp SSA1 STE4 19536198 intact exp STE4 GCD11 11805837 biogrid,mint,intact,dip exp GAL10 STE4 11805837 dip exp STE4 CCT6 11805837 biogrid,mint,intact,dip exp STE4 HSP60 11805837 dip exp STE4 Uncharacterized protein YHR033W 11805837 biogrid,mint,intact,dip exp STE4 CCT4 11805837 dip exp LEU2 STE4 11805837 dip exp STE4 AIR1 16554755 intact exp STE2 STE4 11287148,10664449 biogrid,i2d exp PGI1 STE4 11805837 dip exp TIF1, TIF2 STE4 11805837 dip exp STE4 PGM2 11805837 biogrid,intact,dip exp STE4 Putative proline--tRNA ligase YHR020W 11805837 dip exp TEF1, TEF2 STE4 11805837 dip exp STE4 MTR4 16554755 biogrid,i2d,mint,intact exp GFA1 STE4 11805837 dip exp STE4 PUF3 26493364 biogrid exp SAM1 STE4 11805837 dip exp ENO1 STE4 11805837 dip exp STE4 YAF9 22875988 biogrid exp STE4 GUS1 11805837 dip exp STE4 SCJ1 11805837 dip exp STE4 NUF2 22875988 biogrid exp INO1 STE4 11805837 dip exp SSA3 STE4 11805837 dip exp SSC1 STE4 11805837 dip exp STE4 CTS1 i2d exp STE4 GND1 11805837 dip exp STE4 SAH1 11805837 dip exp VMA2 STE4 16429126,11805837 intact,dip exp STE4 ADE17 11805837 biogrid,intact,dip exp SSA2 STE4 16429126 intact exp HSC82 STE4 11805837 dip exp PDC1 STE4 11805837 dip exp STE4 RNQ1 11805837 biogrid,mint,intact,dip exp STE4 RPT1 16429126 intact exp STE4 RPN3 16429126 intact exp HSP82 STE4 11805837 dip exp STE4 MRP4 11283351 i2d,mint,intact,dip exp STE4 KIN3 22875988 biogrid exp SEC53 STE4 11805837 biogrid,intact,dip exp STE4 RPT6 11805837 dip exp HSP26 STE4 11805837 dip exp GAL1 STE4 11805837 dip exp URA2 STE4 16429126 intact exp STE4 SHM2 11805837 dip exp TDH1 STE4 11805837 dip exp STE4 CCT5 11805837 biogrid,mint,intact,dip exp, ortho TCP1 STE4 11805837 biogrid,mint,intact,dip exp, ortho STE4 CCT3 11805837 biogrid,mint,intact,dip exp, ortho STE4 STE50 9148934,8793874, 23023127 biogrid,i2d exp, pred STE4 ARP2 11805837, 23023127 biogrid,mint,intact,dip exp, pred STE4 SYG1 7592711, 23023127 biogrid,i2d,dip exp, pred STE4 PLP1 10749875, 23023127 biogrid,intact,dip exp, pred GPA1 STE4 16429126,8164677,19820940,8702760,11283351,11805837,9832519,11394869,19445518,8417317,8942643,8649369,10664449,10749875,17978098,9671029,15197187,16839886,9604890, 23023127 biogrid,i2d,mint,intact,dip exp, pred CDC24 STE4 7565673,10087263,9428768,15657049,9822386, 23023127 biogrid,i2d,intact,dip exp, pred FUS3 STE4 15020407, 23023127 i2d,mint,intact exp, pred STE4 STE5 9428767,10481914,17289571,9335587,9501067,9832519,7667635,15657049,9311911,7851759, 23023127 biogrid,i2d,mint,intact,dip exp, pred STE4 YDJ1 19536198,11805837, 23023127 intact,dip exp, pred STE4 ATG16 11283351, 23023127 i2d,mint,intact,dip exp, pred STE4 CLA4 9428767, 23023127 i2d,intact exp, pred RHO1 STE4 12660244, 23023127 biogrid exp, pred STE4 PLP2 10749875, 23023127 biogrid,intact,dip exp, pred STE4 STE4 16839886, 23023127 intact exp, pred STE4 AKR1 16429126,8524293,8649369, 23023127 biogrid,i2d,mint,intact,dip exp, pred STE4 AHA1 11805837, 23023127 biogrid,mint,intact,dip exp, pred STE4 FAR1 10087263,9822386, 23023127 biogrid,i2d,mint,intact,dip exp, pred STE4 RSP5 21685393, 23023127 biogrid exp, pred STE4 STE20 10359756,9428767, 23023127 biogrid,i2d,intact exp, pred STE4 STE11 23023127 i2d exp, pred STE4 ACT1 11805837, 23023127 dip exp, pred STE4 STE18 12660244,8417317,11283351,8649369,8995254,11557045,10087263,10688190,9832519, 23023127 biogrid,i2d,mint,intact,dip exp, pred STE4 RPN1 ortho STE4 GIM5 ortho STE4 CKB2 ortho STE4 MVD1 ortho STE4 MEU1 ortho STE4 Putative alanyl-tRNA editing protein alaX, AlaX, AlaXp, AlaXp-II ortho STE4 RFA1 ortho STE4 RPN10 ortho STE4 TOR2 ortho STE4 MCM2 ortho STI1 STE4 ortho STE4 MFA1 23023127 pred STE4 CDC12 23023127 pred SPS1 STE4 23023127 pred RSR1 STE4 23023127 pred STE4 PKC1 23023127 pred RHO2 STE4 23023127 pred SST2 STE4 23023127 pred PBS2 STE4 23023127 pred STE4 CDC20 23023127 pred RAS1 STE4 23023127 pred KSS1 STE4 23023127 pred STE4 SSK2 23023127 pred STE4 SLN1 23023127 pred STE4 RGS2 23023127 pred STE4 YCK2 23023127 pred STE4 SOK2 23023127 pred STE3 STE4 23023127 pred TPM1 STE4 23023127 pred STE4 CDC11 23023127 pred CAP2 STE4 23023127 pred STE6 STE4 23023127 pred STE2 STE4 23023127 pred RAS2 STE4 23023127 pred STE4 IRE1 23023127 pred STE4 MKK2 23023127 pred SEC4 STE4 23023127 pred STE4 YCK1 23023127 pred STE4 BEM1 23023127 pred FUS1 STE4 23023127 pred STE4 CDC55 23023127 pred STE4 SHO1 23023127 pred MSI1 STE4 23023127 pred STE4 RHO3 23023127 pred STE4 CDC42 23023127 pred STE4 ASC1 23023127 pred GPA2 STE4 23023127 pred STE4 CDC10 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P18851 - 11805837 - C 4 P16892 P18851 - - - X 2 P18851 - 10664449 - X 2 P32917 P18851 - 9428767 - X 2 P32917 P18851 - 7667635 - X 2 P32917 P18851 - 9311911 - X 2 P18851 P40528 - 7592711 - X 2 P11433 P18851 - 10087263,7565673 - X 2 P11433 P18851 - 9428768 - X 2 P48562 P18851 - 9428767 - X 2 Q03497 P18851 - 9428767 - X 2 P08539 P18851 - 11283351 - X 2 P08539 P18851 - 8417317 - X 2 P08539 P18851 - 8887662 - X 2 P08539 P18851 - 9671029 - X 2 P08539 P18851 - 10664449 - X 2 P08539 P18851 - 10664449 - X 2 Q03818 P18851 - 11283351 - X 2 P18851 - 11805837 - C 12 P29029 P18851 - 10664449 - X 2 P39010 P18851 - 8649369 - X 2 P39010 P18851 - 8524293 - X 2 P32902 P18851 - 11283351 - X 2 P18851 P18852 - 8417317 - X 2 P18851 P18852 - 10688190 - X 2 P18851 P18852 - 11283351 - X 2 P18851 P21268 - 9822386 - X 2 P18851 P18852 - 8417317 - X 2 P25344 P18851 - 9024634 - X 2 D6VTK4 P18851 two hybrid 11287148 direct interaction X 2 D6VTK4 P18851 two hybrid 10664449 direct interaction X 2 P32917 P18851 affinity chromatography technology 9501067 physical association X 2 P32917 P18851 affinity chromatography technology 9428767 physical association X 2 P32917 P18851 affinity chromatography technology 7667635 physical association X 2 P32917 P18851 two hybrid 9832519 direct interaction X 2 P32917 P18851 two hybrid 7667635 direct interaction X 2 P32917 P18851 two hybrid 7667635 direct interaction X 2 P32917 P18851 affinity chromatography technology 9335587 physical association X 2 P32917 P18851 affinity chromatography technology 9311911 physical association X 2 P32917 P18851 affinity chromatography technology 10481914 physical association X 2 P32917 P18851 affinity chromatography technology 15657049 physical association X 2 P38009 P18851 affinity chromatography technology 11805837 physical association X 2 P22209 P18851 two hybrid 22875988 direct interaction X 2 P37012 P18851 affinity chromatography technology 11805837 physical association X 2 P38690 P18851 affinity chromatography technology 11805837 physical association X 2 P18851 P33895 two hybrid 22875988 direct interaction X 2 P18851 P40528 two hybrid 7592711 direct interaction X 2 P18851 Q04004 pull down 10749875 direct interaction X 2 P18851 P12612 affinity chromatography technology 11805837 physical association X 2 P11433 P18851 pull down 10087263 direct interaction X 2 P11433 P18851 pull down 9428768 direct interaction X 2 P11433 P18851 two hybrid 10087263 direct interaction X 2 P11433 P18851 two hybrid 9428768 direct interaction X 2 P11433 P18851 two hybrid 9822386 direct interaction X 2 P11433 P18851 two hybrid 7565673 direct interaction X 2 P11433 P18851 affinity chromatography technology 15657049 physical association X 2 P32481 P18851 affinity chromatography technology 11805837 physical association X 2 P07283 P18851 affinity chromatography technology 11805837 physical association X 2 P25367 P18851 affinity chromatography technology 11805837 physical association X 2 Q03497 P18851 affinity chromatography technology 9428767 physical association X 2 Q03497 P18851 pull down 9428767 direct interaction X 2 Q03497 P18851 affinity chromatography technology 10359756 physical association X 2 Q12017 P18851 pull down 10749875 direct interaction X 2 P39076 P18851 affinity chromatography technology 11805837 physical association X 2 P08539 P18851 affinity chromatography technology 8417317 physical association X 2 P08539 P18851 affinity chromatography technology 11394869 physical association X 2 P08539 P18851 two hybrid 9832519 direct interaction X 2 P08539 P18851 two hybrid 9671029 direct interaction X 2 P08539 P18851 two hybrid 10664449 direct interaction X 2 P08539 P18851 pull down 8702760 direct interaction X 2 P08539 P18851 affinity chromatography technology 8702760 physical association X 2 P08539 P18851 two hybrid 9604890 direct interaction X 2 P08539 P18851 affinity chromatography technology 15197187 physical association X 2 P08539 P18851 pull down 10749875 direct interaction X 2 P08539 P18851 two hybrid 8649369 direct interaction X 2 P08539 P18851 two hybrid 8164677 direct interaction X 2 P08539 P18851 biochemical 8942643 association X 2 P08539 P18851 affinity chromatography technology 16839886 physical association X 2 P08539 P18851 two hybrid 11283351 direct interaction X 2 P08539 P18851 two hybrid 19820940 direct interaction X 2 P08539 P18851 affinity chromatography technology 19445518 physical association X 2 P08539 P18851 two hybrid 17978098 direct interaction X 2 P08539 P18851 affinity chromatography technology 17978098 physical association X 2 P08539 P18851 affinity chromatography technology 11805837 physical association X 2 P47047 P18851 affinity chromatography technology 16554755 physical association X 2 P32867 P18851 two hybrid 22875988 direct interaction X 2 P06780 P18851 affinity chromatography technology 12660244 physical association X 2 P39077 P18851 affinity chromatography technology 11805837 physical association X 2 P39010 P18851 two hybrid 8524293 direct interaction X 2 P39010 P18851 two hybrid 8649369 direct interaction X 2 P39010 P18851 affinity chromatography technology 16429126 physical association X 2 P39010 P18851 affinity chromatography technology 16429126 physical association X 2 P39010 P18851 affinity chromatography technology 17200106 physical association X 2 P0CG63 P18851 affinity chromatography technology 23749301 physical association X 2 P0CG63 P18851 affinity chromatography technology 21685393 physical association X 2 P0CG63 P18851 affinity chromatography technology 21427232 physical association X 2 P0CG63 P18851 affinity chromatography technology 22106047 physical association X 2 P32381 P18851 affinity chromatography technology 11805837 physical association X 2 P18851 P53930 two hybrid 22875988 direct interaction X 2 P18851 P18852 affinity chromatography technology 8417317 physical association X 2 P18851 P21268 affinity chromatography technology 9822386 physical association X 2 P18851 P18852 affinity chromatography technology 8995254 physical association X 2 P18851 P18852 affinity chromatography technology 12660244 physical association X 2 P18851 P21268 pull down 10087263 direct interaction X 2 P18851 P21268 two hybrid 9822386 direct interaction X 2 P18851 P18852 two hybrid 9832519 direct interaction X 2 P18851 P18852 two hybrid 8649369 direct interaction X 2 P18851 P18852 two hybrid 11283351 direct interaction X 2 P18851 P40077 affinity chromatography technology 19820940 physical association X 2 P18851 P18852 protein complementation assay 11557045 direct interaction X 2 P18851 P40413 affinity chromatography technology 11805837 physical association X 2 P18851 P18852 two hybrid 10688190 direct interaction X 2 P39079 P18851 affinity chromatography technology 11805837 physical association X 2 P25344 P18851 two hybrid 9148934 direct interaction X 2 P25344 P18851 two hybrid 8793874 direct interaction X 2 P40150 P18851 biochemical 23332755 association X 2 Q12449 P18851 affinity chromatography technology 11805837 physical association X 2 P37296 P18851 two hybrid 22875988 direct interaction X 2 P39940 P18851 affinity chromatography technology 21685393 physical association X 2 P39940 P18851 enzymatic study 21685393 direct interaction X 2 P18851 anti tag coimmunoprecipitation 11805837 - C 50 P39954 P18851 anti tag coimmunoprecipitation 11805837 physical association X 2 P00360 P18851 anti tag coimmunoprecipitation 11805837 physical association X 2 P38708 P18851 anti tag coimmunoprecipitation 11805837 physical association X 2 P32917 P18851 coimmunoprecipitation 9335587 physical association X 2 P32917 P18851 coimmunoprecipitation 9311911 physical association X 2 P32917 P18851 two hybrid 9311911 physical association X 2 P32917 P18851 coimmunoprecipitation 9335587 physical association X 2 P04385 P18851 anti tag coimmunoprecipitation 11805837 physical association X 2 P38009 P18851 anti tag coimmunoprecipitation 11805837 physical association X 2 P37012 P18851 anti tag coimmunoprecipitation 11805837 physical association X 2 P10081 P18851 anti tag coimmunoprecipitation 11805837 physical association X 2 P38690 P18851 anti tag coimmunoprecipitation 11805837 physical association X 2 P00924 P18851 anti tag coimmunoprecipitation 11805837 physical association X 2 P18851 P60010 anti tag coimmunoprecipitation 11805837 physical association X 2 P18851 P46367 anti tag coimmunoprecipitation 11805837 physical association X 2 P18851 P47079 anti tag coimmunoprecipitation 11805837 physical association X 2 P18851 P02994 anti tag coimmunoprecipitation 11805837 physical association X 2 P18851 Q04004 affinity chromatography technology 10749875 physical association X 2 P18851 P12612 anti tag coimmunoprecipitation 11805837 physical association X 2 P18851 P40528 two hybrid 7592711 physical association X 2 P14742 P18851 anti tag coimmunoprecipitation 11805837 physical association X 2 P11433 P18851 affinity chromatography technology 9428768 physical association X 2 P11433 P18851 two hybrid 9428768 physical association X 2 P11433 P18851 two hybrid 7565673 physical association X 2 P32481 P18851 anti tag coimmunoprecipitation 11805837 physical association X 2 P04173 P18851 anti tag coimmunoprecipitation 11805837 physical association X 2 P07283 P18851 anti tag coimmunoprecipitation 11805837 physical association X 2 P25367 P18851 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12017 P18851 affinity chromatography technology 10749875 physical association X 2 P05694 P18851 anti tag coimmunoprecipitation 11805837 physical association X 2 P39076 P18851 anti tag coimmunoprecipitation 11805837 physical association X 2 P08539 P18851 anti tag coimmunoprecipitation 11805837 physical association X 2 P08539 P18851 two hybrid 8649369 physical association X 2 P08539 P18851 two hybrid 8164677 physical association X 2 P08539 P18851 affinity chromatography technology 10749875 physical association X 2 P08539 P18851 genetic interference 8417317 physical association X 2 P08539 P18851 two hybrid pooling approach 11283351 physical association X 2 Q03818 P18851 two hybrid pooling approach 11283351 physical association X 2 P0CS90 P18851 anti tag coimmunoprecipitation 11805837 physical association X 2 P18851 anti tag coimmunoprecipitation 11805837 - C 15 P19882 P18851 anti tag coimmunoprecipitation 11805837 physical association X 2 P06169 P18851 anti tag coimmunoprecipitation 11805837 physical association X 2 P39077 P18851 anti tag coimmunoprecipitation 11805837 physical association X 2 P11484 P18851 anti tag coimmunoprecipitation 11805837 physical association X 2 P15108 P18851 anti tag coimmunoprecipitation 11805837 physical association X 2 P39010 P18851 two hybrid 8524293 physical association X 2 P32381 P18851 anti tag coimmunoprecipitation 11805837 physical association X 2 P11986 P18851 anti tag coimmunoprecipitation 11805837 physical association X 2 P02829 P18851 anti tag coimmunoprecipitation 11805837 physical association X 2 P04397 P18851 anti tag coimmunoprecipitation 11805837 physical association X 2 P32902 P18851 two hybrid pooling approach 11283351 physical association X 2 P18851 P18852 genetic interference 8417317 physical association X 2 P18851 P18852 two hybrid 10688190 physical association X 2 P18851 P18852 two hybrid pooling approach 11283351 physical association X 2 P18851 P00890 anti tag coimmunoprecipitation 11805837 physical association X 2 P18851 P15992 anti tag coimmunoprecipitation 11805837 physical association X 2 P18851 P37291 anti tag coimmunoprecipitation 11805837 physical association X 2 P18851 P09435 anti tag coimmunoprecipitation 11805837 physical association X 2 P18851 P16140 anti tag coimmunoprecipitation 11805837 physical association X 2 P18851 P25491 anti tag coimmunoprecipitation 11805837 physical association X 2 P18851 P40413 anti tag coimmunoprecipitation 11805837 physical association X 2 P18851 P21268 coimmunoprecipitation 10087263 physical association X 2 P18851 P21268 two hybrid 10087263 physical association X 2 P38720 P18851 anti tag coimmunoprecipitation 11805837 physical association X 2 P39078 P18851 anti tag coimmunoprecipitation 11805837 physical association X 2 P18851 anti tag coimmunoprecipitation 11805837 physical association X 2 P39079 P18851 anti tag coimmunoprecipitation 11805837 physical association X 2 P46655 P18851 anti tag coimmunoprecipitation 11805837 physical association X 2 Q01939 P18851 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12449 P18851 anti tag coimmunoprecipitation 11805837 physical association X 2 P10659 P18851 anti tag coimmunoprecipitation 11805837 physical association X 2 P42943 P18851 anti tag coimmunoprecipitation 11805837 physical association X 2 P12709 P18851 anti tag coimmunoprecipitation 11805837 physical association X 2 P18851 anti tag coimmunoprecipitation 11805837 association C 4 P18851 inferred by author 16554755 association C 8 P16892 P18851 two hybrid 15020407 physical association X 2 P32917 P18851 anti tag coimmunoprecipitation 17289571 physical association X 2 P32917 P18851 anti tag coimmunoprecipitation 9428767 physical association X 2 Q61036 P18851 pull down 9428767 physical association X 2 P18851 Q04004 pull down 10749875 physical association X 2 P0CI39 P18851 two hybrid 10664449 physical association X 2 P0CI39 P18851 cosedimentation through density gradient 8756677 colocalization X 2 P48562 P18851 pull down 9428767 physical association X 2 Q03497 P18851 pull down 9428767 physical association X 2 Q03497 P18851 anti tag coimmunoprecipitation 9428767 physical association X 2 Q03497 P18851 pull down 9428767 physical association X 2 Q12017 P18851 pull down 10749875 physical association X 2 P08539 P18851 two hybrid 10664449 physical association X 2 P08539 P18851 pull down 10749875 physical association X 2 P08539 P18851 two hybrid fragment pooling approach 11283351 physical association X 2 P08539 P18851 tandem affinity purification 16839886 physical association X 2 P08539 P18851 tandem affinity purification 16839886 physical association X 2 P08539 P18851 two hybrid 8164677 physical association X 2 P08539 P18851 two hybrid 8417317 physical association X 2 P10591 P18851 tandem affinity purification 19536198 association X 2 Q03818 P18851 two hybrid fragment pooling approach 11283351 physical association X 2 P47047 P18851 tandem affinity purification 16554755 physical association X 2 P47047 P18851 tandem affinity purification 16554755 physical association X 2 P47047 P18851 tandem affinity purification 16554755 physical association X 2 P47047 P18851 tandem affinity purification 16554755 physical association X 2 P18851 tandem affinity purification 16429126 association C 8 P18851 tandem affinity purification 16429126 association C 14 P18851 anti tag coimmunoprecipitation 11805837 association C 12 P18851 inferred by author 16429126 physical association C 6 P39010 P18851 two hybrid 8524293 physical association X 2 P32902 P18851 two hybrid fragment pooling approach 11283351 physical association X 2 P18851 P21268 two hybrid 10087263 physical association X 2 P18851 P18852 two hybrid 10688190 physical association X 2 P18851 P18852 two hybrid fragment pooling approach 11283351 physical association X 2 P18851 P18851 tandem affinity purification 16839886 physical association X 2 P18851 P25491 tandem affinity purification 19536198 association X 2 P18851 P18852 two hybrid 8417317 physical association X 2 P40150 P18851 tandem affinity purification 19536198 association X 2 P18851 mass spectrometry studies of complexes 11805837 - C 16 P18851 mass spectrometry studies of complexes 11805837 - C 16 D6VTK4 P18851 two hybrid 10664449 - X 2 P32917 P18851 coimmunoprecipitation 7667635 - X 2 P32917 P18851 copurification 7667635 - X 2 P32917 P18851 two hybrid 7667635 - X 2 P32917 P18851 coimmunoprecipitation 9311911 - X 2 P32917 P18851 interaction detection method 9335587 - X 2 P18851 P40528 two hybrid - - X 2 P18851 P40528 two hybrid 7592711 - X 2 P11433 P18851 two hybrid 10087263,7565673 - X 2 P11433 P18851 two hybrid 7565673,9822386 - X 2 P11433 P18851 coimmunoprecipitation 9428768 - X 2 P11433 P18851 coimmunoprecipitation 9428768,9822386 - X 2 P08539 P18851 two hybrid 11283351 - X 2 P08539 P18851 two hybrid 9671029 - X 2 P08539 P18851 two hybrid 8887662 - X 2 P08539 P18851 two hybrid 10664449 - X 2 Q03818 P18851 two hybrid 11283351 - X 2 P23561 P18851 two hybrid 9632790 - X 2 P18851 confirmational text mining - - C 3 P29029 P18851 two hybrid 10664449 - X 2 P39010 P18851 two hybrid 8524293 - X 2 P32902 P18851 two hybrid 11283351 - X 2 P18851 P21268 coimmunoprecipitation 10087263,9822386 - X 2 P18851 P18852 two hybrid 10688190 - X 2 P18851 P18852 two hybrid 11283351 - X 2 P18851 P18852 two hybrid 8417317 - X 2 P25344 P18851 two hybrid 9024634 - X 2

PPI - HINT Gene A Gene B PMID Method Quality STE2 STE4 10664449,11287148 0018,0018 LC GPA1 STE4 10664449,8887662,9604890,17978098,8942643,8417317,8649369,17978098,9832519,8417317,11283351,19820940,8164677,11283351,11283351,9671029 0018,0018,0018,0018,0401,0018,0018,0004,0018,0004,0398,0018,0018,0399,0018,0018 LC,HT STE2 STE4 8756677,10664449 0029,0018 LC CDC24 STE4 9428768,7565673,7565673,9822386,10087263,10087263,9428768,9822386,10087263,9428768,9428768 0096,0004,0018,0018,0004,0018,0004,0019,0096,0018,0019 LC FUS3 STE4 15020407 0018 LC STE4 STE18 8649369,9832519,8417317,11283351,11283351,11283351,10087263,11557045,10688190,8417317,10688190 0018,0018,0004,0018,0399,0398,0018,0090,0397,0018,0018 LC,HT STE4 FAR1 10087263,9822386,10087263,9822386,10087263,9822386 0018,0018,0019,0019,0096,0004 LC STE4 KIN3 22875988 0018 HT STE4 STE11 9632790 0018 LC STE4 STE50 8793874,9148934,9024634 0018,0018,0018 LC STE4 CTS1 10664449 0018 LC STE4 SSO1 22875988 0018 HT STE4 MRP4 11283351,11283351,11283351 0018,0399,0398 HT STE4 STE5 9311911,9311911,7667635,7667635,9832519,9428767,9335587,9428767,9335587,7851759,7667635,9311911,7667635,9428767 0004,0019,0004,0025,0018,0007,0019,0004,0004,0019,0018,0018,0019,0019 LC STE4 NUF2 22875988 0018 HT STE4 STV1 22875988 0018 HT STE4 AKR1 8649369,8524293 0018,0018 LC STE4 RSP5 21685393,21685393 0004,0415 LC STE4 SSB2 23332755 0401 LC STE4 SYG1 7592711 0018 LC STE4 YAF9 22875988 0018 HT STE4 STE20 9428767,9428767,9428767,9428767 0096,0004,0019,0007 LC STE4 ATG16 11283351,11283351,11283351 0018,0399,0398 HT TDH1 STE4 11805837 0007 HT CIT1 STE4 11805837 0007 HT ENO1 STE4 11805837 0007 HT HSP82 STE4 11805837 0007 HT TEF1|TEF2 STE4 11805837 0007 HT LEU2 STE4 11805837 0007 HT GAL1 STE4 11805837 0007 HT GAL10 STE4 11805837 0007 HT MET6 STE4 11805837 0007 HT PDC1 STE4 11805837 0007 HT RHO1 STE4 12660244 0004 LC ADR1 STE4 11805837,11805837 0004,0007 HT URA2 STE4 16429126 0676 HT SEC53 STE4 11805837,11805837 0004,0007 HT GPA1 STE4 16839886,11805837,10749875,17978098,8942643,8417317,16839886,17978098,8417317,10749875,16429126,19445518,11394869,8702760,15197187,11805837,8702760 0676,0004,0004,0018,0401,0018,0004,0004,0004,0096,0676,0004,0004,0004,0004,0007,0096 LC,HT SSA3 STE4 11805837 0007 HT UBI4 STE4 21685393,22106047 0004,0004 LC SSC1 STE4 11805837 0007 HT TIF1|TIF2 STE4 11805837 0007 HT SSA1 STE4 19536198 0676 HT SSA2 STE4 16429126 0676 HT SAM1 STE4 11805837 0007 HT CDC24 STE4 15657049,9428768,7565673,7565673,10087263,10087263,9428768,10087263,9428768,9428768 0004,0096,0004,0018,0004,0018,0004,0096,0018,0019 LC SSB1 STE4 11805837 0007 HT INO1 STE4 11805837 0007 HT TCP1 STE4 11805837,11805837 0004,0007 HT PGI1 STE4 11805837 0007 HT GFA1 STE4 11805837 0007 HT HSC82 STE4 11805837 0007 HT HSP26 STE4 11805837 0007 HT VMA2 STE4 16429126,11805837 0676,0007 HT STE4 STE4 16839886 0676 LC STE4 STE18 8995254,8417317,12660244,8417317 0004,0004,0004,0018 LC STE4 HSP60 11805837 0007 HT STE4 FAR1 10087263,9822386,10087263,9822386,10087263,9822386 0018,0018,0019,0019,0096,0004 LC STE4 SCJ1 11805837 0007 HT STE4 RNQ1 11805837,11805837 0004,0007 HT STE4 YDJ1 19536198,11805837 0676,0007 HT STE4 ARP2 11805837,11805837 0004,0007 HT STE4 GCD11 11805837,11805837 0004,0007 HT STE4 NAB2 19840948 0004 LC STE4 STE5 9311911,9311911,17289571,7667635,7667635,9428767,10481914,9335587,15657049,9501067,9428767,9335587,7667635,9311911,7667635,9428767 0004,0019,0007,0004,0025,0007,0004,0019,0004,0004,0004,0004,0018,0018,0019,0019 LC STE4 RPT1 16429126 0676 HT STE4 PGM2 11805837,11805837 0004,0007 HT STE4 SHM2 11805837 0007 HT STE4 ADE17 11805837,11805837 0004,0007 HT STE4 P38690 11805837,11805837 0004,0007 HT STE4 P38708 11805837 0007 HT STE4 GND1 11805837 0007 HT STE4 AKR1 16429126,17200106,16429126,16429126 0676,0004,0004,0363 HT STE4 CCT2 11805837,11805837 0004,0007 HT STE4 CCT3 11805837,11805837 0004,0007 HT STE4 CCT4 11805837 0007 HT STE4 CCT6 11805837,11805837 0004,0007 HT STE4 RSP5 21685393,21685393 0004,0415 LC STE4 SAH1 11805837 0007 HT STE4 RPN3 16429126 0676 HT STE4 DSE1 19820940 0004 LC STE4 SSB2 19536198,23332755 0676,0401 HT,LC STE4 CCT5 11805837,11805837 0004,0007 HT STE4 AIR1 16554755 0363 HT STE4 CCT7 11805837 0007 HT STE4 ALD4 11805837 0007 HT STE4 GUS1 11805837 0007 HT STE4 MTR4 16554755,16554755 0676,0004 HT STE4 CCT8 11805837 0007 HT STE4 CLA4 9428767,9428767 0096,0004 LC STE4 ACT1 11805837 0007 HT STE4 RPT6 11805837 0007 HT STE4 STE20 9428767,10359756,9428767,9428767,9428767 0096,0004,0004,0019,0007 LC STE4 PLP1 10749875,10749875 0096,0004 LC STE4 PLP2 10749875,10749875 0096,0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P18851 P15992 STE4 HSP26 0.126 11805837 P25303 P18851 SCJ1 STE4 0.126 11805837 P18851 P10080 STE4 SBP1 0.126 23222640 P18851 P10081 STE4 TIF2 0.126 11805837 P18851 P10591 STE4 SSA1 0.126 19536198 P18851 P00890 STE4 CIT1 0.126 11805837 P18851 P00924 STE4 ENO1 0.126 11805837 P18851 P12398 STE4 SSC1 0.126 11805837 P18851 P02994 STE4 TEF2 0.126 11805837 P18851 P12709 STE4 PGI1 0.126 11805837 P18851 P09435 STE4 SSA3 0.126 11805837 P18851 P00360 STE4 TDH1 0.126 11805837 P18851 P04173 STE4 LEU2 0.126 11805837 P18851 P04385 STE4 GAL1 0.126 11805837 P18851 P04397 STE4 GAL10 0.126 11805837 P18851 P05694 STE4 MET6 0.126 11805837 P18851 P06169 STE4 PDC1 0.126 11805837 P18851 P0CI39 STE4 STE2 0.396 10664449,8756677 P18852 P18851 STE18 STE4 0.848 10688190,9832519,11283351,11557045,10087263 P21268 P18851 FAR1 STE4 0.554 10087263 P25344 P18851 STE50 STE4 0.523 9148934,8793874 P32917 P18851 STE5 STE4 0.794 9311911,9335587,9428767,9832519,7667635,17289571 P39940 P18851 RSP5 STE4 0.454 21685393 P40150 P18851 SSB2 STE4 0.236 23332755,19536198 P18851 P08539 STE4 GPA1 0.989 11805837,16839886,9832519,9604890,10749875,17978098,8942643,16429126,8649369,10664449,8164677,11283351,19445518,15197187 P32381 P18851 ARP2 STE4 0.236 11805837 P38708 P18851 P38708 STE4 0.126 11805837 P32505 P18851 NAB2 STE4 0.126 19840948 P39076 P18851 CCT2 STE4 0.236 11805837 P39078 P18851 CCT4 STE4 0.126 11805837 P39079 P18851 CCT6 STE4 0.236 11805837 P32902 P18851 MRP4 STE4 0.236 11283351 P40413 P18851 CCT5 STE4 0.236 11805837 P40507 P18851 AIR1 STE4 0.126 16554755 P40528 P18851 SYG1 STE4 0.309 7592711 P46367 P18851 ALD4 STE4 0.126 11805837 P46655 P18851 GUS1 STE4 0.126 11805837 P48562 P18851 CLA4 STE4 0.21 9428767 P18851 P02829 STE4 HSP82 0.126 11805837 P18851 P07259 STE4 URA2 0.126 16429126 P18851 P07283 STE4 SEC53 0.286 11805837 P18851 P10592 STE4 SSA2 0.126 16429126 P18851 P10659 STE4 SAM1 0.126 11805837 P18851 P11433 STE4 CDC24 0.74 10087263,9822386,9428768,7565673 P18851 P11484 STE4 SSB1 0.126 11805837 P18851 P11986 STE4 INO1 0.126 11805837 P18851 P12612 STE4 TCP1 0.236 11805837 P18851 P14742 STE4 GFA1 0.126 11805837 P18851 P16140 STE4 VMA2 0.21 16429126,11805837 P18851 P18851 STE4 STE4 0.236 16839886 P19882 P18851 HSP60 STE4 0.126 11805837 P25367 P18851 RNQ1 STE4 0.236 11805837 P25491 P18851 YDJ1 STE4 0.236 11805837,19536198 P32481 P18851 GCD11 STE4 0.21 11805837 P33299 P18851 RPT1 STE4 0.126 16429126 P37012 P18851 PGM2 STE4 0.286 11805837 P37291 P18851 SHM2 STE4 0.126 11805837 P38009 P18851 ADE17 STE4 0.286 11805837 P38690 P18851 P38690 STE4 0.21 11805837 P38720 P18851 GND1 STE4 0.126 11805837 P39010 P18851 AKR1 STE4 0.539 8524293,16429126 P39077 P18851 CCT3 STE4 0.21 11805837 P39954 P18851 SAH1 STE4 0.126 11805837 P40016 P18851 RPN3 STE4 0.126 16429126 P47047 P18851 MTR4 STE4 0.332 16554755 P47079 P18851 CCT8 STE4 0.126 11805837 P60010 P18851 ACT1 STE4 0.126 11805837 Q03818 P18851 ATG16 STE4 0.236 11283351 Q04004 P18851 PLP1 STE4 0.332 10749875 Q12017 P18851 PLP2 STE4 0.309 10749875 Q12449 P18851 AHA1 STE4 0.21 11805837 Q61036 P18851 PAK3 STE4 0.21 9428767 P42943 P18851 CCT7 STE4 0.126 11805837 Q01939 P18851 RPT6 STE4 0.126 11805837 P18851 P15108 STE4 HSC82 0.126 11805837 Q03497 P18851 STE20 STE4 0.507 9428767 Q07807 P18851 PUF3 STE4 0.126 26493364 P18851 P16892 STE4 FUS3 0.309 15020407