PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus KRR1 WTM2 18719252 biogrid,intact exp PCF11 WTM2 14690591 intact exp SSB1 WTM2 19536198 intact exp SRP1 WTM2 18719252 biogrid,intact exp CCT6 WTM2 11805837 biogrid,mint,intact,dip exp RPL39 WTM2 18719252 biogrid,intact exp SRO9 WTM2 22271760 biogrid exp NUP1 WTM2 10688190 mint,intact,dip exp HSC82 WTM2 19536198 intact exp PEX13 WTM2 19841731 mint,intact exp WTM2 SAS5 16429126 intact exp KAP122 WTM2 16432237 biogrid exp PSA1 WTM2 16429126 intact exp PTK2 WTM2 16319894 biogrid,i2d exp PUF3 WTM2 23409723 biogrid exp ADH1 WTM2 16429126 intact exp ATP2 WTM2 11805837 dip exp PSE1 WTM2 10688190 biogrid,i2d,mint,intact,dip exp HSP26 WTM2 11805837 dip exp WTM2 HSP42 11805837 dip exp RVB1 WTM2 11805837 biogrid,intact,dip exp RNR2 WTM2 16432237,16452505,11805837 biogrid,mint,intact,dip exp WTM2 RVB2 11805837 dip exp TUB1 WTM2 11805837 dip exp SSB2 WTM2 23332755 biogrid exp RPP1A WTM2 11283351 i2d,mint,intact,dip exp Broad-specificity phosphatase YOR283W WTM2 18719252,11805837 biogrid,intact,dip exp HSP82 WTM2 15879519 biogrid,i2d,intact exp RNR4 WTM2 16432237,16452505,18719252,11805837, 23023127 biogrid,intact,dip exp, pred CKA1 WTM2 11805837, 23023127 biogrid,intact,dip exp, pred WTM2 WTM1 9234739,18719252,11805837, 23023127 biogrid,mint,intact,dip exp, pred WTM2 WTM2 22615397,9234739,18467557,18719252, 23023127 biogrid,i2d,mint,intact exp, pred TEM1 WTM2 10688190, 23023127 biogrid,i2d,mint,intact,dip exp, pred BUD14 WTM2 19841731, 23023127 biogrid,mint,intact exp, pred UME1 WTM2 23023127 pred RIM15 WTM2 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q12206 - 11805837 - C 6 Q12206 - 11805837 - C 33 Q12206 - 11805837 - C 3 P38987 Q12206 - 10688190 - X 2 Q12206 P02829 - 15879519 - X 2 Q12206 P32337 - 10688190 - X 2 Q12206 P05318 - 11283351 - X 2 Q12206 - 11805837 - C 5 Q12206 P09938 - 11805837 - X 2 P38987 Q12206 two hybrid 10688190 direct interaction X 2 P39079 Q12206 affinity chromatography technology 11805837 physical association X 2 Q12206 P02829 two hybrid 15879519 direct interaction X 2 Q12206 P47116 enzymatic study 16319894 direct interaction X 2 Q12206 P25586 two hybrid 18719252 direct interaction X 2 Q12206 Q02821 two hybrid 18719252 direct interaction X 2 Q12206 Q12040 two hybrid 18719252 direct interaction X 2 Q12206 Q12040 affinity chromatography technology 11805837 physical association X 2 Q12206 P15790 affinity chromatography technology 11805837 physical association X 2 Q12206 P32337 two hybrid 10688190 direct interaction X 2 P49723 Q12206 affinity chromatography technology 16452505 physical association X 2 P49723 Q12206 biochemical 16432237 association X 2 P49723 Q12206 two hybrid 18719252 direct interaction X 2 Q12363 Q12206 affinity chromatography technology 9234739 physical association X 2 Q12363 Q12206 affinity chromatography technology 9234739 physical association X 2 Q12363 Q12206 two hybrid 9234739 direct interaction X 2 Q12363 Q12206 two hybrid 18719252 direct interaction X 2 Q12363 Q12206 affinity chromatography technology 11805837 physical association X 2 Q12363 Q12206 affinity chromatography technology 11805837 physical association X 2 Q12206 Q12206 affinity chromatography technology 9234739 physical association X 2 Q12206 Q12206 two hybrid 9234739 direct interaction X 2 Q12206 P40150 biochemical 23332755 association X 2 Q12206 P09938 affinity chromatography technology 16452505 physical association X 2 Q12206 P09938 affinity chromatography technology 16432237 physical association X 2 Q12206 P09938 biochemical 16432237 association X 2 Q12206 P32767 imaging technique 16432237 colocalization X 2 Q12206 Q12206 protein complementation assay 18467557 direct interaction X 2 Q12206 P04650 two hybrid 18719252 direct interaction X 2 Q12206 Q12206 two hybrid 18719252 direct interaction X 2 Q12206 P27637 two hybrid 19841731 direct interaction X 2 Q12206 Q03940 affinity chromatography technology 11805837 physical association X 2 Q12206 P09938 affinity chromatography technology 11805837 physical association X 2 Q12206 Q12206 protein complementation assay 22615397 direct interaction X 2 Q12206 anti tag coimmunoprecipitation 11805837 - C 60 Q12206 anti tag coimmunoprecipitation 11805837 - C 12 Q12206 anti tag coimmunoprecipitation 11805837 - C 6 Q12206 anti tag coimmunoprecipitation 11805837 - C 12 Q12464 Q12206 anti tag coimmunoprecipitation 11805837 physical association X 2 P38987 Q12206 two hybrid 10688190 physical association X 2 P39079 Q12206 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12206 P05318 two hybrid pooling approach 11283351 physical association X 2 Q12206 P00830 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12206 P15992 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12206 P15790 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12206 Q12040 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12206 P32337 two hybrid 10688190 physical association X 2 Q12206 anti tag coimmunoprecipitation 11805837 - C 50 Q12206 anti tag coimmunoprecipitation 16432237 - C 4 Q12206 anti tag coimmunoprecipitation 11805837 - C 6 P49723 Q12206 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12363 Q12206 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12363 Q12206 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12206 Q12329 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12206 P09733 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12206 Q03940 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12206 P09938 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12206 P09938 anti tag coimmunoprecipitation 16432237 physical association X 2 Q12206 P20676 two hybrid 10688190 physical association X 2 Q12206 anti tag coimmunoprecipitation 11805837 association C 6 Q12206 anti tag coimmunoprecipitation 11805837 association C 33 Q12206 anti tag coimmunoprecipitation 11805837 association C 3 P15108 Q12206 tandem affinity purification 19536198 association X 2 P38987 Q12206 two hybrid 10688190 physical association X 2 Q12206 P32337 two hybrid 10688190 physical association X 2 Q12206 P05318 two hybrid fragment pooling approach 11283351 physical association X 2 Q12206 P39081 two hybrid array 14690591 physical association X 2 Q12206 P02829 two hybrid array 15879519 physical association X 2 Q12206 Q99314 tandem affinity purification 16429126 physical association X 2 Q12206 Q12040 two hybrid 18719252 physical association X 2 Q12206 P25586 two hybrid 18719252 physical association X 2 Q12206 Q12206 two hybrid 18719252 physical association Y 1 Q12206 Q02821 two hybrid 18719252 physical association X 2 Q12206 P80667 inferred by author 19841731 direct interaction X 2 Q12206 anti tag coimmunoprecipitation 11805837 association C 5 Q12206 tandem affinity purification 16429126 association C 3 P49723 Q12206 two hybrid 18719252 physical association X 2 Q12363 Q12206 two hybrid 18719252 physical association X 2 Q12206 P20676 two hybrid 10688190 physical association X 2 Q12206 P09938 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12206 Q12206 dihydrofolate reductase reconstruction 18467557 physical association X 2 Q12206 P04650 two hybrid 18719252 physical association X 2 Q12206 P11484 tandem affinity purification 19536198 association X 2 Q12206 P27637 two hybrid array 19841731 physical association X 2 Q12206 mass spectrometry studies of complexes 11805837 - C 7 Q12206 mass spectrometry studies of complexes 11805837 - C 7 Q12206 mass spectrometry studies of complexes 11805837 - C 7 Q12206 mass spectrometry studies of complexes 11805837 - C 51 P38987 Q12206 two hybrid 10688190 - X 2 Q12206 P32337 two hybrid 10688190 - X 2 Q12206 P05318 two hybrid 11283351 - X 2

PPI - HINT Gene A Gene B PMID Method Quality HSP82 WTM2 15879519,15879519 0018,0397 HT RPL39 WTM2 18719252 0018 HT RPP1A WTM2 11283351,11283351,11283351 0018,0399,0398 HT RNR2 WTM2 16432237,16432237,16432237 0007,0004,0401 LC NUP1 WTM2 10688190 0018 HT KRR1 WTM2 18719252 0018 HT BUD14 WTM2 19841731,19841731 0397,0018 HT PSE1 WTM2 10688190,10688190 0397,0018 HT TEM1 WTM2 10688190,10688190 0397,0018 HT PCF11 WTM2 14690591 0397 LC SSB2 WTM2 23332755 0401 LC PTK2 WTM2 16319894 0415 LC RNR4 WTM2 18719252,16432237 0018,0401 HT,LC SRP1 WTM2 18719252 0018 HT Q12040 WTM2 18719252 0018 HT WTM2 WTM2 18719252,9234739,18467557,18467557,22615397,9234739 0018,0004,0111,0090,0090,0018 HT,LC WTM2 WTM1 18719252,9234739,9234739 0018,0004,0018 HT,LC ADH1 WTM2 16429126 0676 HT ATP2 WTM2 11805837 0007 HT TUB1 WTM2 11805837 0007 HT RNR2 WTM2 11805837,16452505,16432237,16432237,16432237,11805837 0004,0004,0007,0004,0401,0007 HT,LC SSB1 WTM2 19536198 0676 HT HSC82 WTM2 19536198 0676 HT CKA1 WTM2 11805837,11805837 0004,0007 HT HSP26 WTM2 11805837 0007 HT KAP122 WTM2 16432237 0428 LC CCT6 WTM2 11805837,11805837 0004,0007 HT SSB2 WTM2 23332755 0401 LC PSA1 WTM2 16429126 0676 HT RNR4 WTM2 16432237,11805837,16452505 0401,0007,0004 LC,HT PEX13 WTM2 19841731 0363 LC RVB1 WTM2 11805837,11805837 0004,0007 HT Q12040 WTM2 11805837,11805837 0004,0007 HT WTM2 WTM2 9234739,9234739 0004,0018 LC WTM2 HSP42 11805837 0007 HT WTM2 WTM1 11805837,9234739,9234739,11805837 0004,0004,0018,0007 HT,LC WTM2 RVB2 11805837 0007 HT WTM2 SAS5 16429126 0676 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q12206 P15790 WTM2 CKA1 0.236 11805837 Q12206 P00330 WTM2 ADH1 0.126 16429126 Q12206 P02829 WTM2 HSP82 0.286 15879519 Q12206 P04650 WTM2 RPL39 0.332 18719252 Q12206 P09733 WTM2 TUB1 0.126 11805837 Q12206 P11484 WTM2 SSB1 0.126 19536198 Q12206 P15108 WTM2 HSC82 0.126 19536198 Q12206 P20676 WTM2 NUP1 0.183 10688190 Q12206 P25586 WTM2 KRR1 0.332 18719252 Q12206 P32767 WTM2 KAP122 0.126 16432237 Q12206 P39081 WTM2 PCF11 0.126 14690591 Q12206 P41940 WTM2 PSA1 0.126 16429126 Q12206 Q12040 WTM2 Q12040 0.472 11805837,18719252 Q12329 Q12206 HSP42 WTM2 0.126 11805837 Q12363 Q12206 WTM1 WTM2 0.671 11805837,18719252,9234739 Q99314 Q12206 SAS5 WTM2 0.126 16429126 Q12206 P15992 WTM2 HSP26 0.126 11805837 Q12221 Q12206 PUF2 WTM2 0.126 26668354 Q12464 Q12206 RVB2 WTM2 0.126 11805837 Q12206 P25567 WTM2 SRO9 0.126 22271760 Q12206 P00830 WTM2 ATP2 0.126 11805837 Q12206 P05318 WTM2 RPP1A 0.21 11283351 Q12206 P09938 WTM2 RNR2 0.623 11805837,16432237,16452505 Q12206 Q02821 WTM2 SRP1 0.332 18719252 Q12206 Q12206 WTM2 WTM2 0.648 18719252,9234739,18467557 Q12206 P32337 WTM2 PSE1 0.332 10688190 Q12206 P38987 WTM2 TEM1 0.332 10688190 Q12206 P39079 WTM2 CCT6 0.236 11805837 Q12206 P27637 WTM2 BUD14 0.286 19841731 Q12206 P40150 WTM2 SSB2 0.126 23332755 Q12206 P47116 WTM2 PTK2 0.183 16319894 Q12206 P80667 WTM2 PEX13 0.332 19841731 Q12206 P49723 WTM2 RNR4 0.597 11805837,16432237,18719252,16452505 Q12206 P63279 WTM2 UBE2I 0.332 27107014 Q12206 Q03940 WTM2 RVB1 0.236 11805837