PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus TUB1 APC5 16429126 intact exp CDC28 APC5 16319894 biogrid exp SSA1 APC5 19536198 intact exp TEF1, TEF2 APC5 16429126 intact exp TUB2 APC5 16429126 intact exp SSB1 APC5 16429126,19536198 intact exp GZF3 APC5 17634282 biogrid exp FOB1 APC5 24361936 biogrid exp YEF3 APC5 16429126 biogrid,intact exp FMP52 APC5 16554755 biogrid,i2d,mint,intact exp BEM1 APC5 19841731 mint,intact exp ATP2 APC5 16429126 intact exp ADH1 APC5 16429126 intact exp MRP7 APC5 16554755 biogrid,i2d,mint,intact exp NAB2 APC5 19840948 biogrid exp OAF3 APC5 16554755 biogrid,i2d,mint,intact exp SSA2 APC5 16429126 intact exp DOC1 APC5 10318877,16429126,16554755,9469814, 23023127 biogrid,i2d,intact,dip exp, pred APC5 APC11 9469814, 23023127 biogrid,i2d,intact,dip exp, pred MND2 APC5 12477395,16429126,12609981,12574115, 23023127 biogrid,intact exp, pred CDC16 APC5 10318877,16429126,12402045,21186364,9469814,16364911,15649358,15060174,16275330,17406682,12574115,23751495,12887895,15797379, 23023127 biogrid,i2d,intact,dip exp, pred APC5 SWM1 12477395,16429126,15060174,12609981,12574115, 23023127 biogrid,intact exp, pred APC1 APC5 16429126,16481473,9469814, 23023127 biogrid,i2d,intact,dip exp, pred CDC27 APC5 16429126,12609981,16554755,9469814, 23023127 biogrid,i2d,mint,intact,dip exp, pred MLC1 APC5 16554755, 23023127 biogrid,i2d,mint,intact exp, pred CDC26 APC5 9469814, 23023127 i2d,intact,dip exp, pred APC5 APC2 16429126,15060174,16554755,9469814, 23023127 biogrid,i2d,mint,intact,dip exp, pred APC4 APC5 12477395,16429126,21307936,15060174,17634282,21186364,9469814, 23023127 biogrid,i2d,intact,dip exp, pred CDC23 APC5 16429126,16481473,16554755,9469814, 23023127 biogrid,i2d,mint,intact,dip exp, pred APC5 APC9 16429126,9469814, 23023127 biogrid,i2d,intact,dip exp, pred CDC20 APC5 23023127 pred PDS1 APC5 23023127 pred CDH1 APC5 23023127 pred UBC9 APC5 23023127 pred DUO1 APC5 23023127 pred CBF2 APC5 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q08683 - 15797379 - C 13 Q08683 - 15649358 - C 13 Q08683 - 15916961 - C 7 Q08683 - 9469814 - C 12 Q12440 Q08683 - 9469814 - X 2 Q08683 - 9469814 - X 2 Q12107 Q08683 - 9469814 - X 2 Q04601 Q08683 - 9469814 - X 2 P14724 Q08683 - 9469814 - X 2 Q08683 - 15044803 - C 11 Q12157 Q08683 - 9469814 - X 2 Q08683 P09798 - 9469814 - X 2 Q08683 P16522 - 9469814 - X 2 P53068 Q08683 - 9469814 - X 2 Q12440 Q08683 affinity chromatography technology 15060174 physical association X 2 Q12440 Q08683 affinity chromatography technology 9469814 physical association X 2 Q12440 Q08683 affinity chromatography technology 16554755 physical association X 2 Q12440 Q08683 affinity chromatography technology 16429126 physical association X 2 Q12440 Q08683 affinity chromatography technology 17200106 physical association X 2 Q08683 P40577 affinity chromatography technology 12609981 physical association X 2 Q08683 P40577 affinity chromatography technology 12574115 physical association X 2 Q08683 P40577 affinity chromatography technology 12477395 physical association X 2 Q08683 P53886 affinity chromatography technology 9469814 physical association X 2 Q08683 P40577 affinity chromatography technology 12609981 physical association X 2 Q08683 P53886 affinity chromatography technology 16481473 physical association X 2 Q08683 P53141 affinity chromatography technology 16554755 physical association X 2 Q08683 P12687 affinity chromatography technology 16554755 physical association X 2 Q08683 P53886 affinity chromatography technology 16429126 physical association X 2 Q08683 P16521 affinity chromatography technology 16429126 physical association X 2 Q08683 P40577 affinity chromatography technology 17200106 physical association X 2 Q08683 P53886 affinity chromatography technology 17200106 physical association X 2 Q08683 P00546 enzymatic study 16319894 direct interaction X 2 P36023 Q08683 affinity chromatography technology 16554755 physical association X 2 Q12107 Q08683 affinity chromatography technology 9469814 physical association X 2 Q12107 Q08683 affinity chromatography technology 16429126 physical association X 2 Q12107 Q08683 affinity chromatography technology 17200106 physical association X 2 Q04601 Q08683 affinity chromatography technology 15060174 physical association X 2 Q04601 Q08683 affinity chromatography technology 12477395 physical association X 2 Q04601 Q08683 affinity chromatography technology 9469814 physical association X 2 Q04601 Q08683 affinity chromatography technology 16429126 physical association X 2 Q04601 Q08683 affinity chromatography technology 17200106 physical association X 2 Q04601 Q08683 two hybrid 17634282 direct interaction X 2 Q04601 Q08683 two hybrid 17634282 direct interaction X 2 Q04601 Q08683 affinity chromatography technology 21186364 physical association X 2 Q04601 Q08683 x-ray crystallography 21307936 association X 2 Q04601 Q08683 pull down 21307936 direct interaction X 2 Q12157 Q08683 affinity chromatography technology 9469814 physical association X 2 P0CG63 Q08683 affinity chromatography technology 23793018 physical association X 2 Q12379 Q08683 affinity chromatography technology 12609981 physical association X 2 Q12379 Q08683 affinity chromatography technology 12574115 physical association X 2 Q12379 Q08683 affinity chromatography technology 15060174 physical association X 2 Q12379 Q08683 affinity chromatography technology 12477395 physical association X 2 Q12379 Q08683 affinity chromatography technology 12609981 physical association X 2 Q08683 P09798 affinity chromatography technology 12574115 physical association X 2 Q08683 P09798 affinity chromatography technology 10318877 physical association X 2 Q08683 P38042 affinity chromatography technology 12609981 physical association X 2 Q08683 P09798 affinity chromatography technology 12887895 physical association X 2 Q08683 P09798 affinity chromatography technology 12402045 physical association X 2 Q08683 P09798 affinity chromatography technology 15649358 physical association X 2 Q08683 P09798 affinity chromatography technology 15060174 physical association X 2 Q08683 P09798 affinity chromatography technology 9469814 physical association X 2 Q08683 P16522 affinity chromatography technology 9469814 physical association X 2 Q08683 P38042 affinity chromatography technology 9469814 physical association X 2 Q08683 O13329 two hybrid 24361936 direct interaction X 2 Q08683 P16522 affinity chromatography technology 16481473 physical association X 2 Q08683 P09798 affinity chromatography technology 23751495 physical association X 2 Q08683 P38042 affinity chromatography technology 16554755 physical association X 2 Q08683 P40008 affinity chromatography technology 16554755 physical association X 2 Q08683 P16522 affinity chromatography technology 16554755 physical association X 2 Q08683 P09798 affinity chromatography technology 16429126 physical association X 2 Q08683 P09798 affinity chromatography technology 16429126 physical association X 2 Q08683 P16522 affinity chromatography technology 16429126 physical association X 2 Q08683 P38042 affinity chromatography technology 16429126 physical association X 2 Q08683 P09798 affinity chromatography technology 16275330 physical association X 2 Q08683 P16522 affinity chromatography technology 16481473 physical association X 2 Q08683 P38042 affinity chromatography technology 17200106 physical association X 2 Q08683 P16522 affinity chromatography technology 17200106 physical association X 2 Q08683 P09798 affinity chromatography technology 17200106 physical association X 2 Q08683 P42944 two hybrid 17634282 direct interaction X 2 Q08683 P09798 affinity chromatography technology 17406682 physical association X 2 Q08683 P09798 affinity chromatography technology 15797379 physical association X 2 Q08683 P09798 affinity chromatography technology 21186364 physical association X 2 Q08683 P09798 affinity chromatography technology 16364911 physical association X 2 P53068 Q08683 affinity chromatography technology 10318877 physical association X 2 P53068 Q08683 affinity chromatography technology 9469814 physical association X 2 Q08683 pull down 21107322 - C 13 Q08683 tandem affinity purification 21107322 - C 12 Q08683 tandem affinity purification 21107322 - C 13 Q12440 Q08683 coimmunoprecipitation 9469814 physical association X 2 Q08683 coimmunoprecipitation 9469814 physical association X 2 Q08683 coimmunoprecipitation 9469814 physical association X 2 Q12107 Q08683 coimmunoprecipitation 9469814 physical association X 2 Q04601 Q08683 coimmunoprecipitation 9469814 physical association X 2 Q04601 Q08683 tandem affinity purification 21186364 physical association X 2 Q04601 Q08683 tandem affinity purification 21186364 physical association X 2 P14724 Q08683 coimmunoprecipitation 9469814 physical association X 2 Q08683 tandem affinity purification 21186364 - C 3 Q08683 tandem affinity purification 21186364 physical association C 11 Q08683 electron tomography 21186364 physical association C 11 Q08683 pull down 21107322 - C 14 Q12157 Q08683 coimmunoprecipitation 9469814 physical association X 2 Q08683 P09798 coimmunoprecipitation 9469814 physical association X 2 Q08683 P09798 tandem affinity purification 21107322 physical association X 2 Q08683 P09798 pull down 21107322 physical association X 2 Q08683 P09798 pull down 21107322 physical association X 2 Q08683 P09798 tandem affinity purification 21186364 physical association X 2 Q08683 P09798 tandem affinity purification 21107322 physical association X 2 Q08683 P09798 coimmunoprecipitation 10318877 physical association X 2 Q08683 P16522 coimmunoprecipitation 9469814 physical association X 2 Q08683 P38042 coimmunoprecipitation 9469814 physical association X 2 Q08683 anti tag coimmunoprecipitation 9469814 association C 9 Q08683 anti tag coimmunoprecipitation 9469814 association C 9 Q08683 anti tag coimmunoprecipitation 9469814 association C 9 Q08683 anti tag coimmunoprecipitation 9469814 association C 9 Q08683 anti tag coimmunoprecipitation 9469814 association C 9 Q08683 tandem affinity purification 16429126 association C 22 Q08683 affinity chromatography technology 12609981 association C 11 Q08683 affinity chromatography technology 12609981 association C 11 Q08683 inferred by author 16554755 association C 12 Q08683 tandem affinity purification 12477395 association C 13 Q08683 tandem affinity purification 12477395 association C 13 Q08683 tandem affinity purification 12477395 association C 13 Q08683 affinity chromatography technology 12609981 association C 13 Q08683 anti tag coimmunoprecipitation 9469814 association C 7 Q08683 anti tag coimmunoprecipitation 9469814 association C 10 Q08683 anti tag coimmunoprecipitation 9469814 association C 10 Q08683 anti tag coimmunoprecipitation 9469814 association C 10 Q08683 anti tag coimmunoprecipitation 9469814 association C 12 Q08683 anti tag coimmunoprecipitation 9469814 association C 12 Q08683 anti tag coimmunoprecipitation 9469814 association C 12 Q08683 anti tag coimmunoprecipitation 9469814 association C 12 Q08683 anti tag coimmunoprecipitation 9469814 association C 12 Q12440 Q08683 tandem affinity purification 16554755 physical association X 2 Q12440 Q08683 tandem affinity purification 16554755 physical association X 2 Q12440 Q08683 tandem affinity purification 16554755 physical association X 2 P10591 Q08683 tandem affinity purification 19536198 association X 2 Q08683 P40577 anti tag coimmunoprecipitation 12609981 physical association X 2 Q08683 P53141 tandem affinity purification 16554755 physical association X 2 Q08683 P12687 tandem affinity purification 16554755 physical association X 2 Q08683 P11484 tandem affinity purification 19536198 association X 2 Q08683 P29366 inferred by author 19841731 direct interaction X 2 P36023 Q08683 tandem affinity purification 16554755 physical association X 2 Q08683 tandem affinity purification 16429126 association C 19 Q08683 inferred by author 16429126 physical association C 9 Q08683 anti tag coimmunoprecipitation 9469814 association C 8 Q08683 anti tag coimmunoprecipitation 9469814 association C 8 Q08683 anti tag coimmunoprecipitation 9469814 association C 7 Q08683 anti tag coimmunoprecipitation 9469814 association C 7 Q12379 Q08683 anti tag coimmunoprecipitation 12609981 physical association X 2 Q08683 P40008 tandem affinity purification 16554755 physical association X 2 Q08683 P16522 tandem affinity purification 16554755 physical association X 2 Q08683 P38042 tandem affinity purification 16554755 physical association X 2 Q12440 Q08683 coimmunoprecipitation 9469814 - X 2 Q08683 P53886 coimmunoprecipitation 9469814 - X 2 Q12107 Q08683 coimmunoprecipitation 9469814 - X 2 Q04601 Q08683 coimmunoprecipitation 9469814 - X 2 P14724 Q08683 coimmunoprecipitation 9469814 - X 2 Q08683 confirmational text mining - - C 11 Q12157 Q08683 coimmunoprecipitation 9469814 - X 2 Q08683 P16522 coimmunoprecipitation 9469814 - X 2 Q08683 P09798 coimmunoprecipitation 9469814 - X 2 Q08683 P38042 coimmunoprecipitation 9469814 - X 2 P53068 Q08683 coimmunoprecipitation 9469814 - X 2

PPI - HINT Gene A Gene B PMID Method Quality FOB1 APC5 24361936 0018 LC CDC28 APC5 16319894 0415 LC CDC16 APC5 9469814,9469814,10318877,10318877,9469814 0004,0019,0019,0004,0007 LC CDC26 APC5 9469814,9469814 0019,0007 LC CDC23 APC5 9469814,9469814,9469814 0004,0019,0007 LC CDC27 APC5 9469814,9469814,9469814 0004,0019,0007 LC PDS1 APC5 16364911 0415 LC GZF3 APC5 17634282 0018 HT DOC1 APC5 9469814,9469814,9469814 0004,0019,0007 LC NRM1 APC5 21562221 0415 LC APC1 APC5 9469814,9469814,9469814 0004,0019,0007 LC YHP1 APC5 21562221 0415 LC APC4 APC5 9469814,21307936,17634282,21307936,9469814,9469814 0004,0114,0018,0096,0019,0007 LC,HT APC5 APC9 9469814,9469814,9469814 0004,0019,0007 LC APC5 APC11 9469814,9469814,9469814 0019,0007,0004 LC APC5 APC2 9469814,9469814,9469814 0004,0019,0007 LC ADH1 APC5 16429126 0676 HT ATP2 APC5 16429126 0676 HT TUB2 APC5 16429126 0676 HT TEF1|TEF2 APC5 16429126 0676 HT TUB1 APC5 16429126 0676 HT CDC16 APC5 23751495,17406682,15649358,21107322,12574115,17200106,9469814,12887895,12402045,9469814,10318877,15797379,21107322,16429126,10318877,21186364,15060174,16429126,21186364,16275330,16364911,9469814 0004,0004,0004,0096,0004,0004,0004,0004,0004,0019,0019,0004,0676,0676,0004,0676,0004,0004,0004,0004,0004,0007 LC,HT SSA1 APC5 19536198 0676 HT SSA2 APC5 16429126 0676 HT SSB1 APC5 19536198,16429126 0676,0676 HT MRP7 APC5 16554755,16554755 0676,0004 HT CDC26 APC5 9469814,9469814 0019,0007 LC YEF3 APC5 16429126,16429126 0676,0004 HT CDC23 APC5 16554755,9469814,16429126,17200106,16481473,9469814,16429126,9469814,16554755 0676,0004,0676,0004,0004,0019,0004,0007,0004 HT,LC BEM1 APC5 19841731 0363 LC NAB2 APC5 19840948 0004 LC OAF3 APC5 16554755,16554755 0676,0004 HT CDC27 APC5 12609981,16554755,9469814,16429126,17200106,9469814,16429126,9469814,16554755 0004,0676,0004,0676,0004,0019,0004,0007,0004 LC,HT FMP52 APC5 16554755,16554755 0676,0004 HT MND2 APC5 12477395,12609981,12477395,16429126,12574115,12609981,17200106 0676,0004,0004,0676,0004,0007,0004 LC,HT DOC1 APC5 16554755,9469814,16429126,10318877,9469814,9469814 0363,0004,0676,0004,0019,0007 HT,LC MLC1 APC5 16554755,16554755 0676,0004 HT CDH1 APC5 21107322 0004 LC APC1 APC5 9469814,16429126,17200106,16481473,9469814,16429126,9469814,16429126 0004,0676,0004,0004,0019,0004,0007,0363 LC,HT APC4 APC5 12477395,9469814,21307936,16429126,15060174,12477395,21186364,21307936,17200106,21186364,9469814,16429126,9469814 0676,0004,0114,0004,0004,0004,0004,0096,0004,0676,0019,0676,0007 LC,HT APC5 APC9 9469814,16429126,17200106,9469814,16429126,9469814 0004,0676,0004,0019,0004,0007 LC,HT APC5 APC11 9469814,9469814,9469814 0019,0007,0004 LC APC5 SWM1 12477395,12609981,12477395,16429126,15060174,12574115,12609981 0676,0004,0004,0676,0004,0004,0007 LC,HT APC5 APC2 16554755,9469814,16429126,15060174,17200106,9469814,16429126,9469814,16554755 0676,0004,0676,0004,0004,0019,0004,0007,0004 HT,LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q08683 Q04601 APC5 APC4 0.863 16429126,12477395,21307936,17634282,9469814,21186364 Q12107 Q08683 APC9 APC5 0.354 9469814,16429126 Q12157 Q08683 APC11 APC5 0.21 9469814 Q12440 Q08683 APC2 APC5 0.583 16554755,9469814,16429126 Q08683 P00546 APC5 CDC28 0.183 16319894 Q08683 P09798 APC5 CDC16 0.843 16275330,17406682,16429126,9469814,15797379,21186364,16364911,10318877,23751495 Q08683 P53141 APC5 MLC1 0.236 16554755 Q08683 P36023 APC5 OAF3 0.236 16554755 Q08683 P40577 APC5 MND2 0.472 12477395,16429126,12609981 Q08683 P40008 APC5 FMP52 0.236 16554755 Q08683 P29366 APC5 BEM1 0.183 19841731 Q08683 P38042 APC5 CDC27 0.539 16554755,9469814,16429126 Q08683 P32505 APC5 NAB2 0.126 19840948 Q08683 P14724 APC5 CDC26 0.126 9469814 Q08683 P16522 APC5 CDC23 0.61 16429126,16554755,9469814,16481473 Q08683 O13329 APC5 FOB1 0.309 24361936 Q08683 P00330 APC5 ADH1 0.126 16429126 Q08683 P00830 APC5 ATP2 0.126 16429126 Q08683 P02557 APC5 TUB2 0.126 16429126 Q08683 P02994 APC5 TEF2 0.126 16429126 Q08683 P09733 APC5 TUB1 0.126 16429126 Q08683 P10591 APC5 SSA1 0.126 19536198 Q08683 P10592 APC5 SSA2 0.126 16429126 Q08683 P11484 APC5 SSB1 0.236 16429126,19536198 Q08683 P12687 APC5 MRP7 0.236 16554755 Q08683 P16521 APC5 YEF3 0.126 16429126 Q08683 P40466 APC5 FKH1 0.21 27099939 Q08683 P42944 APC5 GZF3 0.183 17634282 Q08683 P53886 APC5 APC1 0.583 9469814,16481473,16429126 Q12379 Q08683 SWM1 APC5 0.472 12477395,16429126,12609981 Q08683 P53068 APC5 DOC1 0.523 16429126,10318877,16554755,9469814