PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus PKC1 PAC1 22875988 biogrid exp RPT5 PAC1 22875988 biogrid exp KIN3 PAC1 22875988 biogrid exp PAC1 GIM4 22875988 biogrid exp PAC1 HMS2 22875988 biogrid exp CIN8 PAC1 i2d exp PAC1 CTF19 22875988 biogrid exp WSS1 PAC1 23034179 biogrid exp PAC1 UBP2 22875988 biogrid exp PAC1 UBC7 14690591 intact exp PAC1 FMP27 22875988 biogrid exp DIA4 PAC1 22875988 biogrid exp WHI3 PAC1 18667435 biogrid exp MUM2 PAC1 22875988 biogrid exp PAC1 BNI1 i2d exp PAC1 ULS1 23034179 biogrid exp DYN1 PAC1 22939623,24916158,22875988,21571221 biogrid exp MRP8 PAC1 22875988 biogrid exp PAC1 RPN5 21289098 biogrid exp UBI4 PAC1 23034179 biogrid exp ENO1 PAC1 11805837 dip exp TDH1 PAC1 11805837 dip exp ARP2 PAC1 16554755 intact exp PAC1 YKE2 22875988 biogrid exp PAC1 NNF1 11087867,22875988 biogrid,i2d,mint,intact,dip exp PAC1 VPS60 22875988 biogrid exp PAC1 ECM11 22875988 biogrid exp PAC1 SMT3 23034179 biogrid exp PAC1 DAD4 22875988 biogrid exp STV1 PAC1 22875988 biogrid exp HSP60 PAC1 11805837 dip exp PAC1 STU2 17634282 biogrid exp PAC1 SPC25 22875988 biogrid exp PAC1 Uncharacterized protein YJL049W 22875988 biogrid exp KEL1 PAC1 11087867,22875988 biogrid,i2d,mint,intact,dip exp PAC1 NIS1 23034179 biogrid exp Uncharacterized protein YHR080C PAC1 22875988 biogrid exp SSD1 PAC1 22875988 biogrid exp END3 PAC1 22875988 biogrid exp YAP1 PAC1 22875988 biogrid exp PAC1 GTB1 22875988 biogrid exp PAC1 SRL2 22875988 biogrid exp PAC1 NFI1 23034179 biogrid exp NUF2 PAC1 22875988 biogrid exp PAC1 UBC9 23034179 biogrid exp PDC1 PAC1 11805837 dip exp PGM1 PAC1 11283351 i2d,mint,intact,dip exp SNF1 PAC1 21460040 biogrid exp PAC1 SSB2 23332755 biogrid exp HSP26 PAC1 11805837 dip exp PAC1 BIM1 i2d exp PAC1 RLF2 22875988 biogrid exp DAD2 PAC1 22875988 biogrid exp NAB2 PAC1 19840948 biogrid exp PAC1 VPS20 22875988 biogrid exp SWC3 PAC1 11087867,22875988 biogrid,i2d,mint,intact,dip exp PAC1 GIS2 21232131 biogrid exp PAC1 NST1 22875988 biogrid exp PAC1 VAB2 22875988 biogrid exp BIK1 PAC1 12620184, 23023127 biogrid,i2d exp, pred ARC40 PAC1 16554755, 23023127 biogrid,i2d,mint,intact exp, pred PAC1 Uncharacterized protein YEL023C 16554755, 23023127 biogrid,i2d,mint,intact exp, pred PAC1 NNF2 11087867, 23023127 biogrid,i2d,mint,intact,dip exp, pred CLN3 PAC1 10688190, 23023127 mint,intact,dip exp, pred PAC1 NDL1 10688190,15965467,11283351,22875988,18719252, 23023127 biogrid,i2d,mint,intact,dip exp, pred AME1 PAC1 11087867,22875988, 23023127 biogrid,i2d,mint,intact,dip exp, pred PAC1 NSE5 14690591, 23023127 biogrid,i2d,intact exp, pred TUB1 PAC1 17634282, 23023127 biogrid exp, pred PAC1 PAC1 22939623,15965467,22875988,18719252, 23023127 biogrid,i2d,intact exp, pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P39946 Q03718 - 14690591 - X 2 P39946 P39946 - 15965467 - X 2 P33401 P39946 - 11283351 - X 2 Q06568 P39946 - 11283351 - X 2 Q06568 P39946 - 15965467 - X 2 Q06568 P39946 - 10688190 - X 2 P39946 Q01476 two hybrid 22875988 direct interaction X 2 P39946 P39946 two hybrid 22875988 direct interaction X 2 P39946 P39946 two hybrid 18719252 direct interaction X 2 P39946 Q03718 two hybrid 14690591 direct interaction X 2 P39946 P39946 affinity chromatography technology 15965467 physical association X 2 P33895 P39946 two hybrid 22875988 direct interaction X 2 P33297 P39946 two hybrid 22875988 direct interaction X 2 P06782 P39946 pull down 21460040 direct interaction X 2 P24276 P39946 two hybrid 22875988 direct interaction X 2 P24583 P39946 two hybrid 22875988 direct interaction X 2 P24583 P39946 two hybrid 22875988 direct interaction X 2 P38800 P39946 two hybrid 22875988 direct interaction X 2 P38800 P39946 two hybrid 22875988 direct interaction X 2 P38853 P39946 two hybrid 22875988 direct interaction X 2 P38853 P39946 two hybrid 11087867 direct interaction X 2 P38853 P39946 two hybrid 11087867 direct interaction X 2 P0CG63 P39946 two hybrid 23034179 direct interaction X 2 P0CG63 P39946 affinity chromatography technology 23034179 physical association X 2 P38313 P39946 two hybrid 22875988 direct interaction X 2 P38313 P39946 two hybrid 22875988 direct interaction X 2 P38313 P39946 two hybrid 11087867 direct interaction X 2 Q12306 P39946 two hybrid 23034179 direct interaction X 2 Q12306 P39946 affinity chromatography technology 23034179 physical association X 2 P31376 P39946 two hybrid 22875988 direct interaction X 2 P31376 P39946 two hybrid 11087867 direct interaction X 2 P38705 P39946 two hybrid 22875988 direct interaction X 2 Q12495 P39946 two hybrid 22875988 direct interaction X 2 P38236 P39946 two hybrid 22875988 direct interaction X 2 P38236 P39946 two hybrid 22875988 direct interaction X 2 P39992 P39946 affinity chromatography technology 16554755 physical association X 2 Q04272 P39946 two hybrid 22875988 direct interaction X 2 P47175 P39946 two hybrid 22875988 direct interaction X 2 P37296 P39946 two hybrid 22875988 direct interaction X 2 P36022 P39946 two hybrid 22875988 direct interaction X 2 P36022 P39946 biochemical 22939623 colocalization X 2 P36022 P39946 pull down 24916158 direct interaction X 2 P36022 P39946 imaging technique 21571221 colocalization X 2 P53939 P39946 two hybrid 23034179 direct interaction X 2 P40003 P39946 two hybrid 22875988 direct interaction X 2 P40014 P39946 two hybrid 22875988 direct interaction X 2 P47048 P39946 two hybrid 22875988 direct interaction X 2 P39946 P35719 two hybrid 22875988 direct interaction X 2 P39946 Q08562 two hybrid 23034179 direct interaction X 2 P53253 P39946 two hybrid 11087867 direct interaction X 2 Q03390 P39946 two hybrid 22875988 direct interaction X 2 P09733 P39946 two hybrid 17634282 direct interaction X 2 P38328 P39946 affinity chromatography technology 16554755 physical association X 2 P53935 P39946 two hybrid 22875988 direct interaction X 2 P39013 P39946 two hybrid 22875988 direct interaction X 2 P22209 P39946 two hybrid 22875988 direct interaction X 2 P22209 P39946 two hybrid 22875988 direct interaction X 2 P36162 P39946 two hybrid 22875988 direct interaction X 2 Q06568 P39946 two hybrid 22875988 direct interaction X 2 Q06568 P39946 affinity chromatography technology 15965467 physical association X 2 Q06568 P39946 two hybrid 11283351 direct interaction X 2 Q06568 P39946 two hybrid 18719252 direct interaction X 2 Q06568 P39946 two hybrid 10688190 direct interaction X 2 Q12020 P39946 two hybrid 22875988 direct interaction X 2 P40005 P39946 two hybrid 22875988 direct interaction X 2 P40005 P39946 two hybrid 22875988 direct interaction X 2 P69851 P39946 two hybrid 22875988 direct interaction X 2 P19880 P39946 two hybrid 22875988 direct interaction X 2 P19880 P39946 two hybrid 22875988 direct interaction X 2 Q04924 P39946 two hybrid 22875988 direct interaction X 2 P47149 P39946 two hybrid 22875988 direct interaction X 2 P47149 P39946 two hybrid 22875988 direct interaction X 2 P47149 P39946 two hybrid 11087867 direct interaction X 2 P40150 P39946 biochemical 23332755 association X 2 Q12216 P39946 two hybrid 23034179 direct interaction X 2 Q06179 P39946 two hybrid 22875988 direct interaction X 2 Q12250 P39946 affinity chromatography technology 21289098 physical association X 2 Q04110 P39946 two hybrid 22875988 direct interaction X 2 P11709 P39946 two hybrid 12620184 direct interaction X 2 P52553 P39946 two hybrid 22875988 direct interaction X 2 P52553 P39946 two hybrid 22875988 direct interaction X 2 P46675 P39946 two hybrid 17634282 direct interaction X 2 P38838 P39946 two hybrid 23034179 direct interaction X 2 Q02732 P39946 two hybrid 22875988 direct interaction X 2 P50623 P39946 two hybrid 23034179 direct interaction X 2 P39946 P15992 anti tag coimmunoprecipitation 11805837 physical association X 2 P39946 two hybrid 11087867 physical association X 2 P19882 P39946 anti tag coimmunoprecipitation 11805837 physical association X 2 P06169 P39946 anti tag coimmunoprecipitation 11805837 physical association X 2 P38853 P39946 two hybrid 11087867 physical association X 2 P38313 P39946 two hybrid 11087867 physical association X 2 P33401 P39946 two hybrid pooling approach 11283351 physical association X 2 P13365 P39946 two hybrid 10688190 physical association X 2 P39946 anti tag coimmunoprecipitation 11805837 - C 6 P00360 P39946 anti tag coimmunoprecipitation 11805837 physical association X 2 P53253 P39946 two hybrid 11087867 physical association X 2 Q06568 P39946 two hybrid 10688190 physical association X 2 Q06568 P39946 two hybrid pooling approach 11283351 physical association X 2 P00924 P39946 anti tag coimmunoprecipitation 11805837 physical association X 2 P47149 P39946 two hybrid 11087867 physical association X 2 P39946 inferred by author 16554755 association C 8 P39946 Q03718 two hybrid array 14690591 physical association X 2 P38853 P39946 two hybrid 11087867 physical association X 2 P38853 P39946 two hybrid 11087867 physical association X 2 P38853 P39946 two hybrid 11087867 physical association X 2 P38313 P39946 two hybrid 11087867 physical association X 2 P33401 P39946 two hybrid fragment pooling approach 11283351 physical association X 2 P31376 P39946 two hybrid 11087867 physical association X 2 P39992 P39946 tandem affinity purification 16554755 physical association X 2 P13365 P39946 two hybrid 10688190 physical association X 2 P39946 P39946 two hybrid 18719252 physical association Y 1 P39946 P39946 cross-linking study 22939623 direct interaction Y 1 P39946 P39946 molecular sieving 22939623 direct interaction Y 1 P53253 P39946 two hybrid 11087867 physical association X 2 P38328 P39946 tandem affinity purification 16554755 physical association X 2 Q06568 P39946 two hybrid 10688190 physical association X 2 Q06568 P39946 two hybrid fragment pooling approach 11283351 physical association X 2 Q06568 P39946 two hybrid 18719252 physical association X 2 Q02159 P39946 two hybrid array 14690591 physical association X 2 P47149 P39946 two hybrid 11087867 physical association X 2 P47149 P39946 two hybrid 11087867 physical association X 2 P47149 P39946 two hybrid 11087867 physical association X 2 P53900 P39946 interaction detection method 14764870 - X 2 P53900 P39946 interaction detection method 14764870 - X 2 P40013 P39946 interaction detection method 11743205 - X 2 P40013 P39946 interaction detection method 14764870 - X 2 P40013 P39946 interaction detection method 11743205 - X 2 P38853 P39946 two hybrid 11087867 - X 2 P38853 P39946 two hybrid 11087867 - X 2 P41832 P39946 interaction detection method 11743205 - X 2 P41832 P39946 interaction detection method 11743205 - X 2 P41832 P39946 interaction detection method 14764870 - X 2 P38313 P39946 two hybrid 11087867 - X 2 P33401 P39946 two hybrid 11283351 - X 2 P31376 P39946 two hybrid 11087867 - X 2 P53086 P39946 interaction detection method 14764870 - X 2 P53086 P39946 interaction detection method 14764870 - X 2 P38860 P39946 interaction detection method 14764870 - X 2 P17119 P39946 interaction detection method 14764870 - X 2 P17119 P39946 interaction detection method 14764870 - X 2 P39960 P39946 interaction detection method 14764870 - X 2 P34756 P39946 interaction detection method 14764870 - X 2 P48363 P39946 interaction detection method 14764870 - X 2 P48363 P39946 interaction detection method 14764870 - X 2 P53253 P39946 two hybrid 11087867 - X 2 P50275 P39946 interaction detection method 14764870 - X 2 Q04493 P39946 interaction detection method 14764870 - X 2 Q04493 P39946 interaction detection method 14764870 - X 2 P53085 P39946 interaction detection method 14764870 - X 2 Q06568 P39946 two hybrid 10688190 - X 2 Q06568 P39946 two hybrid 11283351 - X 2 P32526 P39946 interaction detection method 14764870 - X 2 P32526 P39946 interaction detection method 14764870 - X 2 P27895 P39946 interaction detection method 14764870 - X 2 P27895 P39946 interaction detection method 14764870 - X 2 P27895 P39946 interaction detection method 9201714 - X 2 P40005 P39946 interaction detection method 14764870 - X 2 P40005 P39946 interaction detection method 14764870 - X 2 Q08756 P39946 interaction detection method 14764870 - X 2 P47149 P39946 two hybrid 11087867 - X 2 P47149 P39946 two hybrid 11087867 - X 2 Q08748 P39946 interaction detection method 14764870 - X 2 P28495 P39946 interaction detection method 14764870 - X 2 P19524 P39946 interaction detection method 14764870 - X 2 P52553 P39946 interaction detection method 14764870 - X 2 P52553 P39946 interaction detection method 14764870 - X 2

PPI - HINT Gene A Gene B PMID Method Quality TUB1 PAC1 17634282 0018 HT UBI4 PAC1 23034179 0018 LC BIK1 PAC1 12620184 0018 LC CLN3 PAC1 10688190 0018 HT YAP1 PAC1 22875988 0018 HT KIN3 PAC1 22875988 0018 HT SSD1 PAC1 22875988 0018 HT PKC1 PAC1 22875988 0018 HT SWC3 PAC1 11087867,22875988,11087867 0397,0018,0018 HT RPT5 PAC1 22875988 0018 HT PGM1 PAC1 11283351,11283351,11283351 0018,0399,0398 HT NUF2 PAC1 22875988 0018 HT MRP8 PAC1 22875988 0018 HT DYN1 PAC1 22939623,22875988 0401,0018 LC,HT DAD2 PAC1 22875988 0018 HT STV1 PAC1 22875988 0018 HT MUM2 PAC1 22875988 0018 HT AME1 PAC1 11087867,22875988,11087867 0397,0018,0018 HT DIA4 PAC1 22875988 0018 HT LAM4 PAC1 22875988 0018 HT WSS1 PAC1 23034179 0018 LC KEL1 PAC1 11087867,22875988,11087867 0397,0018,0018 HT END3 PAC1 22875988 0018 HT PAC1 PAC1 18719252,15965467,22939623,22939623,22875988,15965467 0018,0019,0030,0071,0018,0004 HT,LC PAC1 VAB2 22875988 0018 HT PAC1 GIM4 22875988 0018 HT PAC1 SPC25 22875988 0018 HT PAC1 SSB2 23332755 0401 LC PAC1 STU2 17634282 0018 HT PAC1 P47048 22875988 0018 HT PAC1 NNF1 11087867,22875988,11087867 0397,0018,0018 HT PAC1 HMS2 22875988 0018 HT PAC1 UBC9 23034179 0018 LC PAC1 YKE2 22875988 0018 HT PAC1 NNF2 11087867,11087867 0397,0018 HT PAC1 NST1 22875988 0018 HT PAC1 NIS1 23034179 0018 LC PAC1 DAD4 22875988 0018 HT PAC1 UBP2 22875988 0018 HT PAC1 UBC7 14690591 0397 LC PAC1 CTF19 22875988 0018 HT PAC1 VPS60 22875988 0018 HT PAC1 NSE5 14690591,14690591 0018,0397 LC PAC1 ECM11 22875988 0018 HT PAC1 VPS20 22875988 0018 HT PAC1 GTB1 22875988 0018 HT PAC1 FMP27 22875988 0018 HT PAC1 NDL1 18719252,15965467,11283351,11283351,11283351,10688190,15965467,10688190,22875988,15965467 0018,0019,0018,0399,0398,0018,0029,0397,0018,0004 HT,LC PAC1 ULS1 23034179 0018 LC PAC1 SRL2 22875988 0018 HT PAC1 NFI1 23034179 0018 LC PAC1 SMT3 23034179 0018 LC PAC1 RLF2 22875988 0018 HT TDH1 PAC1 11805837 0007 HT ENO1 PAC1 11805837 0007 HT PDC1 PAC1 11805837 0007 HT SNF1 PAC1 21460040 0096 LC HSP26 PAC1 11805837 0007 HT HSP60 PAC1 11805837 0007 HT ARP2 PAC1 16554755 0363 HT NAB2 PAC1 19840948 0004 LC DYN1 PAC1 22939623,24916158,21571221 0401,0096,0428 LC ARC40 PAC1 16554755,16554755 0676,0004 HT PAC1 PAC1 15965467,15965467 0019,0004 LC PAC1 P39992 16554755,16554755 0676,0004 HT PAC1 SSB2 23332755 0401 LC PAC1 NDL1 15965467,15965467,15965467 0019,0029,0004 LC PAC1 RPN5 21289098 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P39946 P24276 PAC1 SSD1 0.183 22875988 Q12250 P39946 RPN5 PAC1 0.126 21289098 P39946 P09733 PAC1 TUB1 0.183 17634282 P39946 P00924 PAC1 ENO1 0.126 11805837 P39946 P00360 PAC1 TDH1 0.126 11805837 P39946 P06169 PAC1 PDC1 0.126 11805837 P39946 P06782 PAC1 SNF1 0.183 21460040 Q06568 P39946 NDL1 PAC1 0.597 10688190,11283351,18719252 P39992 P39946 P39992 PAC1 0.236 16554755 Q5JR59 P39946 MTUS2 PAC1 0.332 27107014 Q14566 P39946 MCM6 PAC1 0.332 27107014 P39946 P36022 PAC1 DYN1 0.472 21571221,24916158,22939623 P39946 P39946 PAC1 PAC1 0.787 15965467,18719252,22939623 P39946 P31376 PAC1 SWC3 0.21 11087867 Q96HB5 P39946 CCDC120 PAC1 0.332 27107014 P39946 P38313 PAC1 AME1 0.332 22875988,11087867 P39946 P38328 PAC1 ARC40 0.236 16554755 P39946 P32381 PAC1 ARP2 0.126 16554755 P39946 P32505 PAC1 NAB2 0.126 19840948 P39946 P38853 PAC1 KEL1 0.332 11087867 P39946 P0CG63 PAC1 UBI4 0.309 23034179 P39946 P13365 PAC1 CLN3 0.21 10688190 P39946 P15992 PAC1 HSP26 0.126 11805837 P39946 P33401 PAC1 PGM1 0.236 11283351 P39946 P38838 PAC1 WSS1 0.309 23034179 P47149 P39946 NNF1 PAC1 0.332 22875988,11087867 P50623 P39946 UBC9 PAC1 0.309 23034179 P52553 P39946 YKE2 PAC1 0.183 22875988 P53253 P39946 NNF2 PAC1 0.21 11087867 P53939 P39946 NIS1 PAC1 0.309 23034179 Q02159 P39946 UBC7 PAC1 0.126 14690591 Q03718 P39946 NSE5 PAC1 0.126 14690591 Q08562 P39946 ULS1 PAC1 0.309 23034179 Q12216 P39946 NFI1 PAC1 0.309 23034179 Q12306 P39946 SMT3 PAC1 0.309 23034179 Q9UJV3 P39946 MID2 PAC1 0.332 27107014 P40150 P39946 SSB2 PAC1 0.126 23332755 P39946 P34761 PAC1 WHI3 0.183 18667435 P46675 P39946 STU2 PAC1 0.183 17634282 P39946 P19880 PAC1 YAP1 0.183 22875988 P39946 P19882 PAC1 HSP60 0.126 11805837 P53849 P39946 GIS2 PAC1 0.126 21232131 P39946 P22209 PAC1 KIN3 0.183 22875988