PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus YPD1 RAX1 18467557 biogrid,i2d,mint,intact exp UBC7 RAX1 14690591 intact exp GPA1 RAX1 16467474 biogrid,intact exp FLD1 RAX1 18719252 biogrid,intact exp NAM7 RAX1 18087042 biogrid exp HEK2 RAX1 18805955 biogrid exp HSP82 RAX1 19536198 intact exp WHI3 RAX1 18667435 biogrid exp BUD8 RAX1 15356260,17581861 biogrid exp PHO85 RAX1 16319894, 23023127 biogrid,i2d exp, pred Putative uncharacterized protein YGR259C RAX1 11283351, 23023127 i2d,mint,intact exp, pred RAX1 RAX2 15356260, 23023127 biogrid exp, pred BUD9 RAX1 15356260,17581861, 23023127 biogrid exp, pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q08760 - 11283351 - X 2 Q08760 P53226 affinity chromatography technology 15356260 physical association X 2 Q08760 P08539 affinity chromatography technology 16467474 physical association X 2 Q08760 P53226 affinity chromatography technology 17581861 physical association X 2 Q08760 Q07688 protein complementation assay 18467557 direct interaction X 2 Q08760 P17157 enzymatic study 16319894 direct interaction X 2 P0CG63 Q08760 affinity chromatography technology 23749301 physical association X 2 P0CG63 Q08760 affinity chromatography technology 23793018 physical association X 2 P0CG63 Q08760 affinity chromatography technology 22106047 physical association X 2 Q08760 Q12465 affinity chromatography technology 15356260 physical association X 2 Q08760 P41698 affinity chromatography technology 15356260 physical association X 2 Q08760 P41698 affinity chromatography technology 17581861 physical association X 2 Q08760 Q06058 two hybrid 18719252 direct interaction X 2 Q08760 Q02159 two hybrid array 14690591 physical association X 2 Q08760 P08539 affinity chromatography technology 16467474 physical association X 2 Q08760 Q07688 dihydrofolate reductase reconstruction 18467557 physical association X 2 Q08760 P53321 two hybrid fragment pooling approach 11283351 physical association X 2 Q08760 Q06058 two hybrid 18719252 physical association X 2 Q08760 P02829 tandem affinity purification 19536198 association X 2 Q08760 P53321 two hybrid 11283351 - X 2

PPI - HINT Gene A Gene B PMID Method Quality PHO85 RAX1 16319894 0415 LC P53321 RAX1 11283351,11283351,11283351 0018,0399,0398 HT UBC7 RAX1 14690591 0397 LC SEI1 RAX1 18719252 0018 HT YPD1 RAX1 18467557,18467557 0111,0090 HT HSP82 RAX1 19536198 0676 HT GPA1 RAX1 16467474 0004 LC UBI4 RAX1 22106047 0004 LC BUD8 RAX1 15356260,17581861 0004,0004 LC BUD9 RAX1 15356260,17581861 0004,0004 LC RAX1 RAX2 15356260 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q08760 P53321 RAX1 P53321 0.126 11283351 Q08760 P08539 RAX1 GPA1 0.21 16467474 Q08760 P30771 RAX1 NAM7 0.126 18087042 Q08760 P38199 RAX1 HEK2 0.126 18805955 Q08760 P34761 RAX1 WHI3 0.183 18667435 Q08760 P17157 RAX1 PHO85 0.183 16319894 Q08760 P02829 RAX1 HSP82 0.126 19536198 Q08760 P41698 RAX1 BUD8 0.21 17581861 Q08760 P53226 RAX1 BUD9 0.21 17581861 Q08760 Q02159 RAX1 UBC7 0.126 14690591 Q08760 Q06058 RAX1 FLD1 0.332 18719252 Q08760 Q07688 RAX1 YPD1 0.126 18467557