PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus CAB3 ULA1 14690591 intact exp TDH2 ULA1 16554755 biogrid,i2d,mint,intact exp SSA1 ULA1 16429126,19536198 intact exp BUD7 ULA1 16554755 intact exp NAB2 ULA1 19840948 biogrid exp SSE1 ULA1 19536198 intact exp VMA6 ULA1 11283351 i2d,mint,intact,dip exp SBP1 ULA1 23222640 biogrid exp FOL2 ULA1 11283351 i2d,mint,intact,dip exp SSA2 ULA1 19536198 intact exp LAP2 ULA1 i2d exp PPH22 ULA1 11805837 biogrid,mint,intact,dip exp SSB2 ULA1 23332755 biogrid exp CDC34 ULA1 i2d exp UBC12 ULA1 11805837, 23023127 biogrid,mint,intact,dip exp, pred ULA1 UBA3 20826334,11805826,16429126,10688190,11283351,9545234,18719252, 23023127 biogrid,i2d,mint,intact,dip exp, pred UBI4 ULA1 23023127 pred AOS1 ULA1 23023127 pred UBA2 ULA1 23023127 pred RUB1 ULA1 23023127 pred ULA1 DCN1 23023127 pred UBA1 ULA1 23023127 pred UBP6 ULA1 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q12059 P23595 - 11805837 - X 2 Q12059 Q99344 - 11805826 - X 2 Q12059 Q99344 - 15044803 - X 2 Q12059 P32366 - 11283351 - X 2 Q12059 Q99344 - 10688190 - X 2 Q12059 Q99344 - 11283351 - X 2 Q12059 P51601 - 11283351 - X 2 Q12059 P52491 - 11805837 - X 2 Q12059 Q99344 pull down 9545234 direct interaction X 2 Q12059 P00358 affinity chromatography technology 16554755 physical association X 2 Q12059 Q99344 affinity chromatography technology 16429126 physical association X 2 Q12059 Q99344 affinity chromatography technology 16429126 physical association X 2 Q12059 Q99344 affinity chromatography technology 17200106 physical association X 2 Q12059 Q99344 two hybrid 11283351 direct interaction X 2 Q12059 Q99344 two hybrid 18719252 direct interaction X 2 Q12059 Q99344 affinity chromatography technology 20826334 physical association X 2 Q12059 Q99344 affinity chromatography technology 11805826 physical association X 2 Q12059 P23595 affinity chromatography technology 11805837 physical association X 2 Q12059 Q99344 two hybrid 10688190 direct interaction X 2 Q12059 P40150 biochemical 23332755 association X 2 Q12059 P52491 affinity chromatography technology 11805837 physical association X 2 Q12059 anti tag coimmunoprecipitation 11805837 - C 5 Q12059 P51601 two hybrid pooling approach 11283351 physical association X 2 Q12059 P32366 two hybrid pooling approach 11283351 physical association X 2 Q12059 P23595 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12059 Q99344 two hybrid 10688190 physical association X 2 Q12059 Q99344 tandem affinity purification 11805826 physical association X 2 Q12059 Q99344 two hybrid pooling approach 11283351 physical association X 2 Q12059 Q99344 inferred by author 11805826 physical association X 2 Q12059 P52491 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12059 inferred by author 16554755 association C 4 Q12059 tandem affinity purification 16429126 association C 3 Q12059 tandem affinity purification 11805826 association C 3 P32589 Q12059 tandem affinity purification 19536198 association X 2 Q12059 Q99344 two hybrid 10688190 physical association X 2 Q12059 P32366 two hybrid fragment pooling approach 11283351 physical association X 2 Q12059 P51601 two hybrid fragment pooling approach 11283351 physical association X 2 Q12059 Q99344 two hybrid fragment pooling approach 11283351 physical association X 2 Q12059 P23595 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12059 P36076 two hybrid array 14690591 physical association X 2 Q12059 Q99344 tandem affinity purification 16429126 physical association X 2 Q12059 Q99344 inferred by author 16429126 physical association X 2 Q12059 P00358 tandem affinity purification 16554755 physical association X 2 Q12059 Q99344 two hybrid 18719252 physical association X 2 Q12059 P10591 tandem affinity purification 19536198 association X 2 Q12059 P52491 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12059 P10592 tandem affinity purification 19536198 association X 2 Q12059 mass spectrometry studies of complexes 11805837 - C 3 Q12059 mass spectrometry studies of complexes 11805837 - C 3 Q12059 mass spectrometry studies of complexes 11805826 - C 3 Q12059 mass spectrometry studies of complexes 11805837 - C 3 P14682 Q12059 interaction detection method 9545234 - X 2 Q12059 P32366 two hybrid 11283351 - X 2 Q12059 P51601 two hybrid 11283351 - X 2 Q12059 Q99344 two hybrid 10688190 - X 2 Q12059 Q99344 two hybrid 11283351 - X 2

PPI - HINT Gene A Gene B PMID Method Quality VMA6 ULA1 11283351,11283351,11283351 0018,0399,0398 HT CAB3 ULA1 14690591 0397 LC SSB2 ULA1 23332755 0401 LC FOL2 ULA1 11283351,11283351,11283351 0018,0399,0398 HT ULA1 UBA3 18719252,11283351,11283351,11283351,10688190,10688190 0018,0018,0399,0398,0397,0018 HT TDH2 ULA1 16554755,16554755 0676,0004 HT SSA1 ULA1 19536198,16429126 0676,0676 HT SSA2 ULA1 19536198 0676 HT PPH22 ULA1 11805837,11805837 0004,0007 HT NAB2 ULA1 19840948 0004 LC SSE1 ULA1 19536198 0676 HT SSB2 ULA1 23332755 0401 LC UBC12 ULA1 11805837,11805837 0004,0007 HT BUD7 ULA1 16554755 0363 HT ULA1 UBA3 9545234,11805826,16429126,16429126,11805826,11805826,11805826,17200106,16429126,20826334 0096,0007,0676,0363,0676,0363,0004,0004,0004,0004 LC,HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q12059 P23595 ULA1 PPH22 0.126 11805837 Q12059 P00358 ULA1 TDH2 0.236 16554755 Q12059 P10592 ULA1 SSA2 0.126 19536198 Q12059 P32589 ULA1 SSE1 0.126 19536198 Q12059 P36076 ULA1 CAB3 0.126 14690591 Q12059 P10080 ULA1 SBP1 0.126 23222640 Q12059 P10591 ULA1 SSA1 0.236 16429126,19536198 Q99344 Q12059 UBA3 ULA1 0.908 11805826,10688190,9545234,16429126,18719252,11283351,20826334 Q12059 P32366 ULA1 VMA6 0.236 11283351 Q12059 P32505 ULA1 NAB2 0.126 19840948 Q12059 P40150 ULA1 SSB2 0.126 23332755 Q12059 P51601 ULA1 FOL2 0.236 11283351 Q12059 P52491 ULA1 UBC12 0.236 11805837 Q12059 Q08754 ULA1 BUD7 0.126 16554755