PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus SSA2 ELC1 19536198 intact exp MDJ1 ELC1 10760578 biogrid exp SSA1 ELC1 19536198 intact exp RPO21 ELC1 23993092,19920177 biogrid exp PCL6 ELC1 10760578 biogrid exp ELC1 SWA2 19536198 intact exp ERJ5 ELC1 19536198 intact exp DSK2 ELC1 23993092 biogrid exp SSB1 ELC1 19536198 intact exp SNF4 ELC1 10760578 biogrid exp CBF1 ELC1 10760578 biogrid exp DEF1 ELC1 23993092 biogrid exp SIS1 ELC1 19536198 intact exp ELC1 YAP6 10760578 biogrid exp CIN5 ELC1 10760578 biogrid exp RAD7 ELC1 16429126,15226437,16675952,16554755,19920177,11805837, 23023127 biogrid,i2d,mint,intact,dip exp, pred ELA1 ELC1 23993092,10430890,10753924, 23023127 biogrid,intact,dip exp, pred CUL3 ELC1 19920177, 23023127 biogrid exp, pred ELC1 ELC1 10430890, 23023127 biogrid,dip exp, pred RAD16 ELC1 15226437,16675952,19920177, 23023127 biogrid exp, pred ELC1 HRT1 23023127 pred UBC1 ELC1 23023127 pred CDC34 ELC1 23023127 pred RAD23 ELC1 23023127 pred ELC1 TFB3 23023127 pred CDC4 ELC1 23023127 pred ELC1 TFB5 23023127 pred PRE2 ELC1 23023127 pred SHP1 ELC1 23023127 pred UBC5 ELC1 23023127 pred RPB9 ELC1 23023127 pred RAD6 ELC1 23023127 pred ABF1 ELC1 23023127 pred PRE1 ELC1 23023127 pred RSP5 ELC1 23023127 pred UBI4 ELC1 23023127 pred SKP1 ELC1 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q03071 - 11805837 - C 3 Q03071 - 10430890,11545595 - X 2 Q03071 - 10430890,11545595 - X 2 P0CG63 Q03071 biochemical 23583075 association X 2 Q03071 P12904 two hybrid 10760578 direct interaction X 2 Q03071 P12904 affinity chromatography technology 10760578 physical association X 2 Q03071 Q03071 biochemical 10430890 association X 2 Q03071 P04050 affinity chromatography technology 23993092 physical association X 2 Q03071 Q03935 two hybrid 10760578 direct interaction X 2 Q03071 P12904 pull down 10760578 direct interaction X 2 Q03071 P04050 enzymatic study 19920177 direct interaction X 2 P48510 Q03071 pull down 23993092 direct interaction X 2 P31244 Q03071 affinity chromatography technology 15226437 physical association X 2 P31244 Q03071 affinity chromatography technology 15226437 physical association X 2 P31244 Q03071 biochemical 16675952 association X 2 P31244 Q03071 affinity chromatography technology 19920177 physical association X 2 P53202 Q03071 affinity chromatography technology 19920177 physical association X 2 P06779 Q03071 affinity chromatography technology 15226437 physical association X 2 P06779 Q03071 affinity chromatography technology 11805837 physical association X 2 P06779 Q03071 affinity chromatography technology 16554755 physical association X 2 P06779 Q03071 affinity chromatography technology 16675952 physical association X 2 P06779 Q03071 biochemical 16675952 association X 2 P06779 Q03071 affinity chromatography technology 17200106 physical association X 2 P06779 Q03071 affinity chromatography technology 19920177 physical association X 2 P06779 Q03071 affinity chromatography technology 11805837 physical association X 2 P53861 Q03071 affinity chromatography technology 10753924 physical association X 2 P53861 Q03071 affinity chromatography technology 10753924 physical association X 2 P53861 Q03071 pull down 10430890 direct interaction X 2 P53861 Q03071 biochemical 10753924 association X 2 P53861 Q03071 affinity chromatography technology 23993092 physical association X 2 Q03071 P40337-3 x-ray crystallography 11545595 association X 2 Q03071 P40038 two hybrid 10760578 direct interaction X 2 Q03071 P40038 affinity chromatography technology 10760578 physical association X 2 Q03071 A0A024R7R0 pull down 23993092 direct interaction X 2 Q03071 C9JQV6 pull down 23993092 direct interaction X 2 Q03071 P17106 two hybrid 10760578 direct interaction X 2 Q03071 P40038 pull down 10760578 direct interaction X 2 Q03071 P40337-3 x-ray crystallography 10998253 association X 2 P35191 Q03071 two hybrid 10760578 direct interaction X 2 P40917 Q03071 two hybrid 10760578 direct interaction X 2 P40917 Q03071 pull down 10760578 direct interaction X 2 P35732 Q03071 affinity chromatography technology 23993092 physical association X 2 P35732 Q03071 pull down 23993092 direct interaction X 2 Q03071 anti tag coimmunoprecipitation 11805837 - C 3 Q03071 anti tag coimmunoprecipitation 11805837 - C 8 P06779 Q03071 pull down 11805837 physical association X 2 P06779 Q03071 anti tag coimmunoprecipitation 11805837 physical association X 2 P53861 Q03071 biochemical 10753924 direct interaction X 2 P53861 Q03071 nuclear magnetic resonance 10430890 direct interaction X 2 P53861 Q03071 cosedimentation in solution 10430890 direct interaction X 2 P53861 Q03071 coimmunoprecipitation 10753924 direct interaction X 2 P53861 Q03071 coimmunoprecipitation 10753924 direct interaction X 2 Q03071 Q03071 nuclear magnetic resonance 10430890 direct interaction Y 1 Q03071 Q03071 cosedimentation in solution 10430890 direct interaction Y 1 Q03071 anti tag coimmunoprecipitation 11805837 association C 3 P10592 Q03071 tandem affinity purification 19536198 association X 2 Q03071 Q06677 tandem affinity purification 19536198 association X 2 P06779 Q03071 inferred by author 16554755 association X 2 P06779 Q03071 tandem affinity purification 16554755 physical association X 2 P06779 Q03071 anti bait coimmunoprecipitation 16675952 physical association X 2 Q03071 tandem affinity purification 16429126 association C 5 P53861 Q03071 anti tag coimmunoprecipitation 10753924 physical association X 2 P53861 Q03071 chromatography technology 10753924 physical association X 2 P53861 Q03071 anti tag coimmunoprecipitation 10753924 physical association X 2 P53861 Q03071 chromatography technology 10753924 physical association X 2 P53861 Q03071 circular dichroism 10753924 direct interaction X 2 P53861 Q03071 nuclear magnetic resonance 10753924 direct interaction X 2 P11484 Q03071 tandem affinity purification 19536198 association X 2 Q03071 P25294 tandem affinity purification 19536198 association X 2 Q03071 P43613 tandem affinity purification 19536198 association X 2 P10591 Q03071 tandem affinity purification 19536198 association X 2 Q03071 mass spectrometry studies of complexes 11805837 - C 4

PPI - HINT Gene A Gene B PMID Method Quality RPO21 ELC1 19920177 0415 LC RAD7 ELC1 16675952,16675952,16675952 0401,0004,0006 LC SNF4 ELC1 10760578,10760578,10760578 0018,0004,0096 LC CBF1 ELC1 10760578 0018 LC RAD16 ELC1 16675952 0401 LC MDJ1 ELC1 10760578 0018 LC PCL6 ELC1 10760578,10760578,10760578 0018,0004,0096 LC CIN5 ELC1 10760578,10760578 0018,0096 LC ELA1 ELC1 10430890,10753924,10753924,10430890,10753924,10753924,10430890,10753924,10753924,10753924 0077,0077,0004,0096,0016,0091,0028,0401,0007,0019 LC ELC1 ELC1 10430890,10430890,10430890 0028,0077,0401 LC ELC1 YAP6 10760578 0018 LC RPO21 ELC1 23993092 0004 LC RAD7 ELC1 11805837,16675952,16675952,16554755,16429126,15226437,19920177,11805837,16554755,17200106,11805837,16675952,16554755 0004,0401,0004,0676,0676,0004,0004,0096,0363,0004,0007,0006,0004 HT,LC SSA1 ELC1 19536198 0676 HT SSA2 ELC1 19536198 0676 HT SSB1 ELC1 19536198 0676 HT SNF4 ELC1 10760578,10760578,10760578 0018,0004,0096 LC SIS1 ELC1 19536198 0676 HT RAD16 ELC1 16675952,15226437,19920177 0401,0004,0004 LC DEF1 ELC1 23993092,23993092 0096,0004 LC PCL6 ELC1 10760578,10760578,10760578 0018,0004,0096 LC CIN5 ELC1 10760578,10760578 0018,0096 LC ERJ5 ELC1 19536198 0676 HT DSK2 ELC1 23993092 0096 LC CUL3 ELC1 19920177 0004 LC ELA1 ELC1 10430890,23993092,10753924,10753924,10430890,10753924,10753924,10430890,10753924,10753924,10753924 0077,0004,0077,0004,0096,0016,0091,0028,0401,0007,0019 LC ELC1 ELC1 10430890,10430890,10430890 0028,0077,0401 LC ELC1 SWA2 19536198 0676 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q03071 P10591 ELC1 SSA1 0.126 19536198 Q03071 P12904 ELC1 SNF4 0.623 10760578 Q03071 P04050 ELC1 RPO21 0.454 19920177,23993092 Q03071 P40917 ELC1 CIN5 0.523 10760578 Q03071 P06779 ELC1 RAD7 0.772 19920177,16429126,16675952,15226437,16554755,11805837 Q03071 P40337 ELC1 VHL 0.523 11545595,10998253 Q03071 P40038 ELC1 PCL6 0.623 10760578 Q03071 P53861 ELC1 ELA1 0.953 10753924,10430890,23993092 Q03071 P31244 ELC1 RAD16 0.507 19920177,15226437 Q96RL1 Q03071 UIMC1 ELC1 0.309 23993092 Q03071 P35732 ELC1 DEF1 0.454 23993092 Q03071 P43613 ELC1 ERJ5 0.126 19536198 Q03071 P48510 ELC1 DSK2 0.309 23993092 Q03071 P10592 ELC1 SSA2 0.126 19536198 Q03071 P11484 ELC1 SSB1 0.126 19536198 Q03071 P17106 ELC1 CBF1 0.309 10760578 Q03071 P25294 ELC1 SIS1 0.126 19536198 Q03071 P35191 ELC1 MDJ1 0.309 10760578 Q03071 P53202 ELC1 CUL3 0.21 19920177 Q03071 Q03071 ELC1 ELC1 0.454 10430890 Q03935 Q03071 YAP6 ELC1 0.309 10760578 Q06677 Q03071 SWA2 ELC1 0.126 19536198 Q03071 P54252 ELC1 ATXN3 0.309 23993092