PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus SWE1 ATG21 i2d exp SSB1 ATG21 19536198 intact exp SSB2 ATG21 23332755 biogrid exp YPK1 ATG21 25279700 biogrid exp CMK1 ATG21 16319894 biogrid,i2d exp SSA1 ATG21 19536198 intact exp NAB2 ATG21 19840948 biogrid exp ECM10 ATG21 19536198 intact exp MEK1 ATG21 16319894 biogrid,i2d exp LSB6 ATG21 18719252 biogrid,intact exp PTK2 ATG21 16319894 biogrid,i2d exp PHO85 ATG21 16319894, 23023127 biogrid,i2d exp, pred CDC25 ATG21 19841731, 23023127 biogrid,mint,intact exp, pred ATG21 TVP15 18719252, 23023127 biogrid,intact exp, pred TPK1 ATG21 16319894, 23023127 biogrid,i2d exp, pred YCK1 ATG21 16319894, 23023127 biogrid exp, pred ATG1 ATG21 16319894, 23023127 biogrid,i2d exp, pred ATG21 ATG11 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P0CG63 Q02887 affinity chromatography technology 23749301 physical association X 2 Q02887 P24719 enzymatic study 16319894 direct interaction X 2 Q02887 Q03860 two hybrid 18719252 direct interaction X 2 Q02887 P42951 two hybrid 18719252 direct interaction X 2 Q02887 P04821 two hybrid 19841731 direct interaction X 2 Q02887 P12688 enzymatic study 25279700 direct interaction X 2 Q02887 P40150 biochemical 23332755 association X 2 Q02887 P53104 enzymatic study 16319894 direct interaction X 2 Q02887 P47116 enzymatic study 16319894 direct interaction X 2 Q02887 P06244 enzymatic study 16319894 direct interaction X 2 Q02887 P23291 enzymatic study 16319894 direct interaction X 2 Q02887 P17157 enzymatic study 16319894 direct interaction X 2 P27466 Q02887 enzymatic study 16319894 direct interaction X 2 Q02887 Q03860 two hybrid 18719252 physical association X 2 Q02887 P42951 two hybrid 18719252 physical association X 2 Q02887 P11484 tandem affinity purification 19536198 association X 2 Q02887 P04821 two hybrid pooling approach 19841731 physical association X 2 P10591 Q02887 tandem affinity purification 19536198 association X 2 Q02887 P39987 tandem affinity purification 19536198 association X 2

PPI - HINT Gene A Gene B PMID Method Quality CDC25 ATG21 19841731,19841731 0398,0018 HT TPK1 ATG21 16319894 0415 LC YPK1 ATG21 25279700 0415 LC PHO85 ATG21 16319894 0415 LC YCK1 ATG21 16319894 0415 LC MEK1 ATG21 16319894 0415 LC CMK1 ATG21 16319894 0415 LC SSB2 ATG21 23332755 0401 LC LSB6 ATG21 18719252 0018 HT PTK2 ATG21 16319894 0415 LC ATG1 ATG21 16319894 0415 LC ATG21 TVP15 18719252 0018 HT SSA1 ATG21 19536198 0676 HT SSB1 ATG21 19536198 0676 HT NAB2 ATG21 19840948 0004 LC ECM10 ATG21 19536198 0676 HT SSB2 ATG21 23332755 0401 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q02887 P53104 ATG21 ATG1 0.183 16319894 Q02887 P23291 ATG21 YCK1 0.183 16319894 Q02887 P24719 ATG21 MEK1 0.183 16319894 Q02887 P17157 ATG21 PHO85 0.183 16319894 Q02887 P10591 ATG21 SSA1 0.126 19536198 Q02887 P12688 ATG21 YPK1 0.309 25279700 Q02887 P06244 ATG21 TPK1 0.183 16319894 Q02887 P04821 ATG21 CDC25 0.286 19841731 Q03860 Q02887 TVP15 ATG21 0.332 18719252 Q02887 P32505 ATG21 NAB2 0.126 19840948 Q02887 P27466 ATG21 CMK1 0.183 16319894 Q02887 P40150 ATG21 SSB2 0.126 23332755 Q02887 P47116 ATG21 PTK2 0.183 16319894 Q02887 P42951 ATG21 LSB6 0.332 18719252 Q02887 P11484 ATG21 SSB1 0.126 19536198 Q02887 P39987 ATG21 ECM10 0.126 19536198