PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus VAM6 MEX67 25026036 biogrid exp ESA1 MEX67 i2d exp CYS4 MEX67 16429126 intact exp ENP1 MEX67 22956913 biogrid exp PAN3 MEX67 11283351 i2d,mint,intact,dip exp PMA1 MEX67 22244335 biogrid exp YCK1 MEX67 20489023 biogrid,mint,intact exp SRO9 MEX67 20494970 biogrid exp HPR1 MEX67 19401465,17056718,17475778 biogrid exp MLP1 MEX67 17922018,15692572,24152732 biogrid exp MRT4 MEX67 19797079 biogrid exp FBP1 MEX67 11283351 i2d,mint,intact,dip exp RPL25 MEX67 21852791,doi:10.1038/embor.2011.155 biogrid,mint,intact exp RPT6 MEX67 20494970 biogrid exp YVH1 MEX67 19797079 biogrid exp HSP26 MEX67 11283351 i2d,mint,intact,dip exp ARX1 MEX67 17803941,23907389,19797079,18046452,23142978,24371142,23185031,23045392,22956913 biogrid,intact exp SWD2 MEX67 22244335 biogrid exp SSB2 MEX67 23332755,19536198 biogrid,intact exp Uncharacterized protein YHR127W MEX67 17922018 biogrid exp RIO2 MEX67 22956913 biogrid exp UBI4 MEX67 19401465,17475778 biogrid exp PRO3 MEX67 11283351 biogrid,i2d,mint,intact,dip exp SDA1 MEX67 23142978 biogrid exp SSA1 MEX67 16429126 intact exp IMD3 MEX67 16429126 intact exp MET2 MEX67 11283351 i2d,mint,intact,dip exp PKR1 MEX67 11283351 i2d,mint,intact,dip exp ADE2 MEX67 11283351 i2d,mint,intact,dip exp BUD20 MEX67 23045392 biogrid,intact exp ACK1 MEX67 16429126 intact exp SKM1 MEX67 20489023 biogrid,mint,intact exp MLP2 MEX67 24500206,17922018,15692572,24152732 biogrid exp ESS1 MEX67 21179020 intact exp ALB1 MEX67 23045392 biogrid,intact exp SEH1 MEX67 17922018,18046452,16554755, 23023127 biogrid,intact exp, ortho, pred NIC96 MEX67 17922018, 23023127 biogrid exp, ortho, pred KAP95 MEX67 17922018, 23023127 biogrid exp, ortho, pred LSG1 MEX67 23142978,23907389,19797079,22956913, 23023127 biogrid exp, ortho, pred MEX67 MEX67 25220466,17922018, 23023127 biogrid,intact exp, ortho, pred SRP1 MEX67 17922018, 23023127 biogrid exp, ortho, pred GLE2 MEX67 17922018, 23023127 biogrid exp, ortho, pred DBP5 MEX67 17922018, 23023127 biogrid exp, ortho, pred NMD3 MEX67 17803941,23907389,18077551, 23023127 biogrid exp, pred NUP1 MEX67 19723816,17922018,12411502, 23023127 biogrid,intact exp, pred NUP85 MEX67 17922018,18046452,16554755, 23023127 biogrid,i2d,mint,intact exp, pred NAB2 MEX67 19840948,20810649,20823268, 23023127 biogrid exp, pred NUP82 MEX67 17922018, 23023127 biogrid exp, pred NUP116 MEX67 11104765,17875746,17922018,12411502,10684247,18046452,10952996, 23023127 biogrid,i2d,intact exp, pred NUP188 MEX67 17922018, 23023127 biogrid exp, pred NUP120 MEX67 15741174,16554755, 23023127 biogrid,intact exp, pred MIP6 MEX67 9214641, 23023127 biogrid,i2d,dip exp, pred SAC3 MEX67 17922018,12631707,12411502, 23023127 biogrid,intact exp, pred NUP170 MEX67 17922018, 23023127 biogrid exp, pred NUP159 MEX67 17922018,10952996, 23023127 biogrid exp, pred YRA1 MEX67 11675790,20810649,17922018,10722314,16554755,10786854,11390651, 23023127 biogrid,i2d,mint,intact,dip exp, pred NUP157 MEX67 17922018, 23023127 biogrid exp, pred ROM2 MEX67 16429126, 23023127 biogrid,intact exp, pred PAB1 MEX67 17922018,12543930,11805837, 23023127 biogrid,dip exp, pred NUP57 MEX67 17875746,17922018, 23023127 biogrid exp, pred STO1 MEX67 17922018, 23023127 biogrid exp, pred POM34 MEX67 17922018, 23023127 biogrid exp, pred SUS1 MEX67 20230609,18923079, 23023127 biogrid exp, pred NUP145 MEX67 18046452,16554755, 23023127 biogrid,i2d,intact exp, pred NSP1 MEX67 19401465,17922018,10952996, 23023127 biogrid exp, pred YRA2 MEX67 11390651, 23023127 biogrid,dip exp, pred CBC2 MEX67 24500206,22244335,20810649,17922018, 23023127 biogrid exp, pred NUP100 MEX67 11104765,11387327,12543930,18046405, 23023127 biogrid,i2d,intact,dip exp, pred NUP192 MEX67 17922018, 23023127 biogrid exp, pred GLE1 MEX67 18046405, 23023127 biogrid exp, pred NUP133 MEX67 17922018, 23023127 biogrid exp, pred NUP60 MEX67 17922018,12411502,15741174, 23023127 biogrid,intact exp, pred NUP84 MEX67 16429126,17922018,18046452,15741174,16554755, 23023127 biogrid,intact exp, pred NPL3 MEX67 17922018,14759366, 23023127 biogrid exp, pred MTR2 MEX67 20494970,20810649,17922018,12835756,9774696,18046452,10952996,25618852, 23023127 biogrid,i2d exp, pred ACC1 MEX67 ortho SEC61 MEX67 ortho RRP4 MEX67 ortho KOG1 MEX67 ortho POL1 MEX67 ortho OXA1 MEX67 ortho ERG20 MEX67 ortho VPS36 MEX67 ortho CKA2 MEX67 ortho GLN4 MEX67 ortho GPN2 MEX67 ortho TPK2 MEX67 ortho BNA5 MEX67 ortho CYB5 MEX67 ortho DBI56 MEX67 ortho CHC1 MEX67 ortho MAS1 MEX67 ortho ALG8 MEX67 ortho NOP7 MEX67 ortho AIP1 MEX67 ortho UTP22 MEX67 ortho CCT2 MEX67 ortho RET1 MEX67 ortho YEA4 MEX67 ortho DBP2 MEX67 ortho SCH9 MEX67 ortho SEC26 MEX67 ortho CCT7 MEX67 ortho NPL4 MEX67 ortho RKI1 MEX67 ortho BNA3 MEX67 ortho MTR10 MEX67 ortho VMA16 MEX67 ortho ERV29 MEX67 ortho RPT3 MEX67 ortho DIC1 MEX67 ortho ATG8 MEX67 ortho IDP1 MEX67 ortho PRP16 MEX67 ortho NTF2 MEX67 ortho CIR2 MEX67 ortho NOP1 MEX67 ortho DPH5 MEX67 ortho PNP1 MEX67 ortho MCM7 MEX67 ortho FAL1 MEX67 ortho RVB1 MEX67 ortho EFB1 MEX67 ortho RAD27 MEX67 ortho NPR2 MEX67 ortho RPF2 MEX67 ortho MSF1 MEX67 ortho YSH1 MEX67 ortho ARC19 MEX67 ortho AAT2 MEX67 ortho RPN3 MEX67 ortho GUK1 MEX67 ortho UBC1 MEX67 ortho RRD2 MEX67 ortho RIP1 MEX67 ortho ARP3 MEX67 ortho HEM12 MEX67 ortho FAD1 MEX67 ortho COP1 MEX67 ortho SUA7 MEX67 ortho VPS35 MEX67 ortho SFB3 MEX67 ortho FAP1 MEX67 ortho VPS15 MEX67 ortho IDH1 MEX67 ortho KAP123 MEX67 ortho CDC23 MEX67 ortho ERG12 MEX67 ortho MCD4 MEX67 ortho PRP8 MEX67 ortho PPX1 MEX67 ortho TOR2 MEX67 ortho RAT1 MEX67 ortho SPT16 MEX67 ortho NOC2 MEX67 ortho SAR1 MEX67 ortho SPE3 MEX67 ortho ERG26 MEX67 ortho RVB2 MEX67 ortho VPS21 MEX67 ortho ATP-dependent (S)-NAD(P)H-hydrate dehydratase MEX67 ortho ERG2 MEX67 ortho ALA1 MEX67 ortho RPL3 MEX67 ortho SPT5 MEX67 ortho RPN2 MEX67 ortho NOP56 MEX67 ortho GDB1 MEX67 ortho CBF5 MEX67 ortho SSL2 MEX67 ortho FRS1 MEX67 ortho MCM4 MEX67 ortho GCN20 MEX67 ortho RCL1 MEX67 ortho KGD1 MEX67 ortho ATP1 MEX67 ortho SLH1 MEX67 ortho KAR2 MEX67 ortho CIT2 MEX67 ortho ARB1 MEX67 ortho Eukaryotic translation initiation factor 2A, eIF-2A MEX67 ortho RRB1 MEX67 ortho CDC16 MEX67 ortho NAM7 MEX67 ortho HTS1 MEX67 ortho BMS1 MEX67 ortho DPH1 MEX67 ortho UBC9 MEX67 ortho PRP22 MEX67 ortho PPT1 MEX67 ortho CKB2 MEX67 ortho YSP3 MEX67 ortho RRP40 MEX67 ortho MCP2 MEX67 ortho ADE13 MEX67 ortho HSP60 MEX67 ortho FRA1 MEX67 ortho MEU1 MEX67 ortho KRR1 MEX67 ortho RPO21 MEX67 ortho YKU70 MEX67 ortho TYS1 MEX67 ortho SLY1 MEX67 ortho PRP43 MEX67 ortho RAD51 MEX67 ortho SSC1 MEX67 ortho UTP5 MEX67 ortho PRI1 MEX67 ortho RPN1 MEX67 ortho MRD1 MEX67 ortho SDH1 MEX67 ortho HMT1 MEX67 ortho VPS4 MEX67 ortho URA6 MEX67 ortho RPT5 MEX67 ortho UBP8 MEX67 ortho GUS1 MEX67 ortho RPS3 MEX67 ortho RPT1 MEX67 ortho LST8 MEX67 ortho ELP2 MEX67 ortho ALG1 MEX67 ortho PHO89 MEX67 ortho TPC1 MEX67 ortho TAZ1 MEX67 ortho UBP6 MEX67 ortho SSE1 MEX67 ortho RPA190 MEX67 ortho RPS5 MEX67 ortho CRM1 MEX67 23023127 ortho, pred RNA1 MEX67 23023127 ortho, pred SRM1 MEX67 23023127 ortho, pred UBX5 MEX67 23023127 pred GSP2 MEX67 23023127 pred MLC1 MEX67 23023127 pred NUP49 MEX67 23023127 pred CUE5 MEX67 23023127 pred UBI4 MEX67 23023127 pred DMA1 MEX67 23023127 pred YRB1 MEX67 23023127 pred CDC24 MEX67 23023127 pred RSP5 MEX67 23023127 pred CDC31 MEX67 23023127 pred NOG1 MEX67 23023127 pred GSP1 MEX67 23023127 pred BCP1 MEX67 23023127 pred SDO1 MEX67 23023127 pred RUP1 MEX67 23023127 pred EGD2 MEX67 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P34232 Q99257 - 9774696 - X 2 P34232 Q99257 - 9774696 - X 2 P34232 Q99257 - 12835756 - X 2 Q99257 - 15692572 - C 4 P21264 Q99257 - 11283351 - X 2 P36102 Q99257 - 11283351 - X 2 Q02630 Q99257 - 11104765 - X 2 P09201 Q99257 - 11283351 - X 2 P38760 Q99257 - 9214641 - X 2 P08465 Q99257 - 11283351 - X 2 Q03880 Q99257 - 11283351 - X 2 Q99257 - 15692572 - C 4 P32263 Q99257 - 11283351 - X 2 P46674 Q99257 - 12411502 - X 2 P46674 Q99257 - 12631707 - X 2 Q02629 Q99257 - 11104765 - X 2 Q99257 Q12159 - 10786854 - X 2 Q99257 P15992 - 11283351 - X 2 P34232 Q99257 affinity chromatography technology 9774696 physical association X 2 P34232 Q99257 affinity chromatography technology 10952996 physical association X 2 P34232 Q99257 pull down 9774696 direct interaction X 2 P34232 Q99257 pull down 20810649 direct interaction X 2 P34232 Q99257 x-ray crystallography 12835756 association X 2 P34232 Q99257 affinity chromatography technology 17922018 physical association X 2 P34232 Q99257 pull down 18046452 direct interaction X 2 P34232 Q99257 affinity chromatography technology 20494970 physical association X 2 P39705 Q99257 pull down 12411502 direct interaction X 2 P39705 Q99257 affinity chromatography technology 15741174 physical association X 2 P39705 Q99257 affinity chromatography technology 17922018 physical association X 2 Q08004 Q99257 affinity chromatography technology 23045392 physical association X 2 Q08004 Q99257 affinity chromatography technology 23045392 physical association X 2 P53011 Q99257 affinity chromatography technology 17922018 physical association X 2 P53011 Q99257 affinity chromatography technology 18046452 physical association X 2 P51862 Q99257 affinity chromatography technology 16429126 physical association X 2 Q08920 Q99257 affinity chromatography technology 24500206 physical association X 2 Q08920 Q99257 affinity chromatography technology 24500206 physical association X 2 Q08920 Q99257 affinity chromatography technology 17922018 physical association X 2 Q08920 Q99257 affinity chromatography technology 20810649 physical association X 2 Q08920 Q99257 affinity chromatography technology 22244335 physical association X 2 Q02630 Q99257 affinity chromatography technology 11104765 physical association X 2 Q02630 Q99257 affinity chromatography technology 10952996 physical association X 2 Q02630 Q99257 pull down 11104765 direct interaction X 2 Q02630 Q99257 two hybrid 11104765 direct interaction X 2 Q02630 Q99257 biochemical 10684247 association X 2 Q02630 Q99257 pull down 17875746 direct interaction X 2 Q02630 Q99257 affinity chromatography technology 17922018 physical association X 2 Q01560 Q99257 pull down 14759366 direct interaction X 2 Q01560 Q99257 affinity chromatography technology 17922018 physical association X 2 Q01939 Q99257 affinity chromatography technology 20494970 physical association X 2 P40150 Q99257 biochemical 23332755 association X 2 P40160 Q99257 affinity chromatography technology 22956913 physical association X 2 P38760 Q99257 two hybrid 9214641 direct interaction X 2 P04456 Q99257 affinity chromatography technology 21852791 physical association X 2 P25567 Q99257 affinity chromatography technology 20494970 physical association X 2 P35729 Q99257 affinity chromatography technology 15741174 physical association X 2 Q99257 P48837 pull down 17875746 direct interaction X 2 Q99257 P48837 affinity chromatography technology 17922018 physical association X 2 P49687 Q99257 pull down 18046452 direct interaction X 2 Q99257 P23291 affinity chromatography technology 20489023 physical association X 2 Q12315 Q99257 affinity chromatography technology 18046405 physical association X 2 P17629 Q99257 fluorescent resonance energy transfer 19401465 direct interaction X 2 P17629 Q99257 two hybrid 17056718 direct interaction X 2 P17629 Q99257 affinity chromatography technology 17056718 physical association X 2 P17629 Q99257 pull down 17056718 direct interaction X 2 P17629 Q99257 affinity chromatography technology 17475778 physical association X 2 P17629 Q99257 two hybrid 17475778 direct interaction X 2 P17629 Q99257 pull down 17475778 direct interaction X 2 P17629 Q99257 pull down 19401465 direct interaction X 2 P38181 Q99257 affinity chromatography technology 17922018 physical association X 2 P34160 Q99257 affinity chromatography technology 17922018 physical association X 2 P34160 Q99257 affinity chromatography technology 17922018 physical association X 2 P04147 Q99257 pull down 12543930 direct interaction X 2 P04147 Q99257 biochemical 12543930 association X 2 P04147 Q99257 affinity chromatography technology 17922018 physical association X 2 P52891 Q99257 affinity chromatography technology 16429126 physical association X 2 P52891 Q99257 affinity chromatography technology 15741174 physical association X 2 P52891 Q99257 affinity chromatography technology 17922018 physical association X 2 P52891 Q99257 affinity chromatography technology 18046452 physical association X 2 P40368 Q99257 affinity chromatography technology 17922018 physical association X 2 Q12445 Q99257 affinity chromatography technology 17922018 physical association X 2 P36036 Q99257 affinity chromatography technology 11390651 physical association X 2 Q02256 Q99257 affinity chromatography technology 19797079 physical association X 2 P32263 Q99257 two hybrid 11283351 direct interaction X 2 P0CG63 Q99257 affinity chromatography technology 20810649 physical association X 2 P0CG63 Q99257 fluorescent resonance energy transfer 19401465 direct interaction X 2 P0CG63 Q99257 pull down 17475778 direct interaction X 2 P47019 Q99257 affinity chromatography technology 23045392 physical association X 2 P38861 Q99257 affinity chromatography technology 18077551 physical association X 2 P38861 Q99257 affinity chromatography technology 17803941 physical association X 2 P20676 Q99257 pull down 12411502 direct interaction X 2 P20676 Q99257 affinity chromatography technology 17922018 physical association X 2 P20676 Q99257 pull down 19723816 direct interaction X 2 P20676 Q99257 affinity chromatography technology 19723816 physical association X 2 P38333 Q99257 affinity chromatography technology 22956913 physical association X 2 Q02455 Q99257 affinity chromatography technology 15692572 physical association X 2 Q02455 Q99257 affinity chromatography technology 17922018 physical association X 2 P46673 Q99257 affinity chromatography technology 16554755 physical association X 2 P46673 Q99257 affinity chromatography technology 17200106 physical association X 2 P46673 Q99257 affinity chromatography technology 17922018 physical association X 2 P46673 Q99257 pull down 18046452 direct interaction X 2 P20449 Q99257 affinity chromatography technology 17922018 physical association X 2 P33201 Q99257 affinity chromatography technology 19797079 physical association X 2 P35658 Q99257 two hybrid 10228171 direct interaction X 2 P53145 Q99257 affinity chromatography technology 23142978 physical association X 2 P53145 Q99257 affinity chromatography technology 22956913 physical association X 2 P53145 Q99257 affinity chromatography technology 19797079 physical association X 2 P36104 Q99257 affinity chromatography technology 22244335 physical association X 2 P36104 Q99257 two hybrid 22244335 direct interaction X 2 Q6WNK7 Q99257 affinity chromatography technology 18923079 physical association X 2 Q6WNK7 Q99257 affinity chromatography technology 20230609 physical association X 2 Q06142 Q99257 affinity chromatography technology 17922018 physical association X 2 P46674 Q99257 affinity chromatography technology 12631707 physical association X 2 P46674 Q99257 pull down 12411502 direct interaction X 2 P46674 Q99257 affinity chromatography technology 12411502 physical association X 2 P46674 Q99257 affinity chromatography technology 17922018 physical association X 2 P46674 Q99257 affinity chromatography technology 17922018 physical association X 2 P38833 Q99257 affinity chromatography technology 17922018 physical association X 2 P52593 Q99257 affinity chromatography technology 17922018 physical association X 2 Q02821 Q99257 affinity chromatography technology 17922018 physical association X 2 Q02629 Q99257 affinity chromatography technology 12543930 physical association X 2 Q02629 Q99257 affinity chromatography technology 11387327 physical association X 2 Q02629 Q99257 pull down 11104765 direct interaction X 2 Q02629 Q99257 affinity chromatography technology 18046405 physical association X 2 Q99257 P53313 affinity chromatography technology 23142978 physical association X 2 Q99257 Q03862 affinity chromatography technology 23142978 physical association X 2 Q99257 P14907 affinity chromatography technology 10952996 physical association X 2 Q99257 P40477 affinity chromatography technology 10952996 physical association X 2 Q99257 Q12159 affinity chromatography technology 11675790 physical association X 2 Q99257 Q12159 affinity chromatography technology 11390651 physical association X 2 Q99257 Q12159 pull down 10786854 direct interaction X 2 Q99257 Q12159 pull down 10722314 direct interaction X 2 Q99257 Q03862 affinity chromatography technology 22956913 physical association X 2 Q99257 Q03862 affinity chromatography technology 23185031 physical association X 2 Q99257 Q03862 affinity chromatography technology 23045392 physical association X 2 Q99257 P40457 affinity chromatography technology 15692572 physical association X 2 Q99257 P32505 pull down 20810649 direct interaction X 2 Q99257 Q12159 pull down 20810649 direct interaction X 2 Q99257 P14907 fluorescent resonance energy transfer 19401465 direct interaction X 2 Q99257 P40457 affinity chromatography technology 24500206 physical association X 2 Q99257 P40457 affinity chromatography technology 24500206 physical association X 2 Q99257 Q12159 affinity chromatography technology 16554755 physical association X 2 Q99257 Q12159 affinity chromatography technology 17922018 physical association X 2 Q99257 Q12159 affinity chromatography technology 17922018 physical association X 2 Q99257 Q99257 affinity chromatography technology 17922018 physical association X 2 Q99257 P40457 affinity chromatography technology 17922018 physical association X 2 Q99257 P40477 affinity chromatography technology 17922018 physical association X 2 Q99257 P40064 affinity chromatography technology 17922018 physical association X 2 Q99257 P36161 affinity chromatography technology 17922018 physical association X 2 Q99257 P14907 affinity chromatography technology 17922018 physical association X 2 Q99257 Q03862 pull down 18046452 direct interaction X 2 Q99257 P14907 pull down 19401465 direct interaction X 2 Q99257 P32505 affinity chromatography technology 19840948 physical association X 2 Q99257 Q03862 affinity chromatography technology 19797079 physical association X 2 Q99257 Q12469 affinity chromatography technology 20489023 physical association X 2 Q99257 P32505 affinity chromatography technology 20823268 physical association X 2 Q99257 P32505 affinity chromatography technology 20823268 physical association X 2 Q99257 P32505 affinity chromatography technology 20810649 physical association X 2 Q99257 P32505 two hybrid 20810649 direct interaction X 2 Q99257 Q03862 affinity chromatography technology 17803941 physical association X 2 P40066 Q99257 affinity chromatography technology 17922018 physical association X 2 P47054 Q99257 affinity chromatography technology 17922018 physical association X 2 P34077 Q99257 affinity chromatography technology 17922018 physical association X 2 P21264 Q99257 two hybrid pooling approach 11283351 physical association X 2 P36102 Q99257 two hybrid pooling approach 11283351 physical association X 2 P09201 Q99257 two hybrid pooling approach 11283351 physical association X 2 P38760 Q99257 two hybrid 9214641 physical association X 2 P08465 Q99257 two hybrid pooling approach 11283351 physical association X 2 Q03880 Q99257 two hybrid pooling approach 11283351 physical association X 2 P04147 Q99257 anti tag coimmunoprecipitation 11805837 physical association X 2 P36036 Q99257 affinity chromatography technology 11390651 physical association X 2 P32263 Q99257 two hybrid pooling approach 11283351 physical association X 2 Q02629 Q99257 affinity chromatography technology 11387327 physical association X 2 Q99257 P15992 two hybrid pooling approach 11283351 physical association X 2 Q99257 Q12159 affinity chromatography technology 11390651 physical association X 2 Q99257 tandem affinity purification 16429126 association C 3 Q99257 inferred by author 16429126 physical association C 12 Q99257 pull down 12411502 physical association C 3 Q99257 inferred by author 16429126 physical association C 16 Q99257 tandem affinity purification 16429126 association C 11 Q99257 affinity chromatography technology 12411502 association C 3 Q99257 tandem affinity purification 21179020 association C 24 Q99257 anti tag coimmunoprecipitation 20489023 association C 10 P21264 Q99257 two hybrid fragment pooling approach 11283351 physical association X 2 P36102 Q99257 two hybrid fragment pooling approach 11283351 physical association X 2 Q02630 Q99257 pull down 11104765 direct interaction X 2 Q02630 Q99257 anti tag coimmunoprecipitation 11104765 physical association X 2 Q02630 Q99257 two hybrid 11104765 physical association X 2 P09201 Q99257 two hybrid fragment pooling approach 11283351 physical association X 2 P40150 Q99257 tandem affinity purification 19536198 association X 2 P08465 Q99257 two hybrid fragment pooling approach 11283351 physical association X 2 P04456 Q99257 anti tag coimmunoprecipitation 21852791 physical association X 2 Q03880 Q99257 two hybrid fragment pooling approach 11283351 physical association X 2 Q99257 tandem affinity purification 18046452 association C 3 Q99257 tandem affinity purification 18046452 association C 3 Q99257 tandem affinity purification 18046452 association C 8 Q99257 anti tag coimmunoprecipitation 20489023 association C 5 Q99257 inferred by author 16554755 association C 6 Q99257 pull down 12411502 physical association C 3 Q99257 tandem affinity purification 16429126 association C 6 Q99257 pull down 12411502 physical association C 3 Q99257 pull down 12411502 physical association C 3 Q99257 pull down 18046452 association C 3 Q99257 tandem affinity purification 18046452 association C 3 P32263 Q99257 two hybrid fragment pooling approach 11283351 physical association X 2 P46673 Q99257 tandem affinity purification 16554755 physical association X 2 Q02629 Q99257 pull down 11104765 direct interaction X 2 Q99257 P15992 two hybrid fragment pooling approach 11283351 physical association X 2 Q99257 Q12159 tandem affinity purification 16554755 physical association X 2 P21264 Q99257 two hybrid 11283351 - X 2 P36102 Q99257 two hybrid 11283351 - X 2 Q02630 Q99257 coimmunoprecipitation 11104765 - X 2 Q02630 Q99257 pull down 11104765 - X 2 Q02630 Q99257 two hybrid 11104765 - X 2 P09201 Q99257 two hybrid 11283351 - X 2 P38760 Q99257 two hybrid 9214641 - X 2 P08465 Q99257 two hybrid 11283351 - X 2 Q03880 Q99257 two hybrid 11283351 - X 2 P32263 Q99257 two hybrid 11283351 - X 2 P46673 Q99257 interaction detection method 9214641 - X 2 Q02629 Q99257 pull down 11104765 - X 2 Q99257 P15992 two hybrid 11283351 - X 2

PPI - HINT Gene A Gene B PMID Method Quality PAB1 MEX67 12543930,12543930 0096,0401 LC MET2 MEX67 11283351,11283351,11283351 0018,0399,0398 HT FBP1 MEX67 11283351,11283351,11283351 0018,0399,0398 HT UBI4 MEX67 19401465 0055 LC NSP1 MEX67 19401465,19401465 0055,0096 LC HSP26 MEX67 11283351,11283351,11283351 0018,0399,0398 HT HPR1 MEX67 17056718,17475778,17056718,17475778,19401465,17056718,17475778,19401465,17056718 0004,0096,0096,0004,0055,0018,0018,0096,0006 LC ADE2 MEX67 11283351,11283351,11283351 0018,0399,0398 HT PRO3 MEX67 11283351,11283351,11283351 0018,0399,0398 HT NAB2 MEX67 20810649,20810649,20810649 0096,0018,0004 LC MTR2 MEX67 25618852,12835756,25618852 0096,0114,0114 LC PAN3 MEX67 11283351,11283351,11283351 0018,0399,0398 HT SWD2 MEX67 22244335,22244335 0004,0018 LC MIP6 MEX67 9214641 0018 LC SSB2 MEX67 23332755 0401 LC NUP116 MEX67 11104765,11104765,11104765,11104765,10684247,11104765 0007,0004,0018,0019,0401,0096 LC PKR1 MEX67 11283351,11283351,11283351 0018,0399,0398 HT THP2 MEX67 17056718 0006 LC PAB1 MEX67 17922018,12543930,11805837,12543930 0004,0096,0007,0401 LC,HT RPL25 MEX67 21852791,21852791 0004,0007 LC PMA1 MEX67 22244335 0004 LC UBI4 MEX67 17475778 0096 LC SSA1 MEX67 16429126 0676 HT NSP1 MEX67 10952996,17922018,19401465,19401465 0004,0004,0055,0096 LC HPR1 MEX67 17056718,17475778,17056718,17475778,19401465,17056718,17475778,19401465,17056718 0004,0096,0096,0004,0055,0018,0018,0096,0006 LC DBP5 MEX67 17922018 0004 LC NUP1 MEX67 19723816,12411502,17922018,19723816 0004,0096,0004,0096 LC ESS1 MEX67 21179020 0676 HT YCK1 MEX67 20489023,20489023 0007,0004 HT SRO9 MEX67 20494970 0004 LC NAB2 MEX67 19840948,20810649,20823268,20810649,20810649 0004,0096,0004,0018,0004 LC CYS4 MEX67 16429126 0363 HT MRT4 MEX67 19797079 0004 LC NIC96 MEX67 17922018 0004 LC STO1 MEX67 17922018 0004 LC MTR2 MEX67 20494970,25618852,9774696,17922018,20810649,10952996,18046452,25618852,9774696 0004,0096,0004,0004,0096,0004,0096,0114,0096 LC NUP120 MEX67 16554755,15741174 0363,0004 HT,LC YRA2 MEX67 11390651 0004 LC SWD2 MEX67 22244335,22244335 0004,0018 LC NUP133 MEX67 17922018 0004 LC NUP170 MEX67 17922018 0004 LC ENP1 MEX67 22956913 0004 LC P38833 MEX67 17922018 0004 LC NMD3 MEX67 23907389,17803941,18077551 0004,0004,0004 LC NUP60 MEX67 12411502,15741174,17922018 0096,0004,0004 LC NUP157 MEX67 17922018 0004 LC GLE2 MEX67 17922018 0004 LC SSB2 MEX67 19536198,23332755 0676,0401 HT,LC RIO2 MEX67 22956913 0004 LC NUP82 MEX67 17922018 0004 LC MLP2 MEX67 24500206,17922018,24152732,15692572 0004,0004,0004,0004 LC NUP159 MEX67 10952996,17922018 0004,0004 LC NUP85 MEX67 17922018,16554755,16554755,18046452,17200106,16554755 0004,0363,0676,0096,0004,0004 LC,HT SAC3 MEX67 17922018,12411502,12631707,12411502 0004,0096,0004,0004 LC ALB1 MEX67 23045392,23045392 0004,0676 LC NUP192 MEX67 17922018 0004 LC NUP57 MEX67 17875746,17922018 0096,0004 LC NUP145 MEX67 16554755,18046452 0363,0096 HT,LC IMD3 MEX67 16429126 0676 HT ROM2 MEX67 16429126,16429126 0676,0004 HT NUP188 MEX67 17922018 0004 LC NUP84 MEX67 18046452,16554755,15741174,16429126,17922018,18046452,16429126 0676,0363,0004,0676,0004,0004,0004 LC,HT SEH1 MEX67 18046452,17922018,18046452,16554755 0676,0004,0004,0363 LC,HT LSG1 MEX67 22956913,23142978,19797079,23907389 0004,0004,0004,0004 LC SDA1 MEX67 23142978 0004 LC NPL3 MEX67 14759366,17922018 0096,0004 LC RPT6 MEX67 20494970 0004 LC YVH1 MEX67 19797079 0004 LC MLP1 MEX67 17922018,24152732,15692572 0004,0004,0004 LC NUP100 MEX67 12543930,11104765,11387327,18046405 0004,0096,0004,0004 LC NUP116 MEX67 10952996,12411502,11104765,11104765,11104765,17922018,11104765,18046452,10684247,17875746,11104765 0004,0096,0007,0004,0018,0004,0019,0096,0401,0096,0096 LC SRP1 MEX67 17922018 0004 LC ARX1 MEX67 23142978,17803941,22956913,24371142,23185031,23045392,23045392,23907389,18046452,19797079 0004,0004,0004,0004,0004,0004,0676,0004,0096,0004 LC KAP95 MEX67 17922018 0004 LC ACK1 MEX67 16429126 0363 HT BUD20 MEX67 23045392,23045392 0004,0676 LC CBC2 MEX67 22244335,20810649,17922018,24500206,24476359 0004,0004,0004,0004,0004 LC YRA1 MEX67 10786854,10722314,17922018,20810649,11390651,11675790,10786854,16554755,16554755 0096,0096,0004,0096,0004,0004,0004,0004,0676 LC,HT GLE1 MEX67 18046405 0004 LC POM34 MEX67 17922018 0004 LC SKM1 MEX67 20489023,20489023 0007,0004 HT SUS1 MEX67 18923079,20230609 0004,0004 LC MEX67 MEX67 17922018 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q99257 P22696 MEX67 ESS1 0.126 21179020 Q99257 P23291 MEX67 YCK1 0.286 20489023 Q99257 P53313 MEX67 SDA1 0.126 23142978 Q99257 Q12315 MEX67 GLE1 0.126 18046405 Q99257 P08465 MEX67 MET2 0.21 11283351 Q99257 P04449 MEX67 RPL24A 0.126 27775710 Q99257 P52891 MEX67 NUP84 0.539 16554755,18046452,17922018,16429126 Q99257 Q01560 MEX67 NPL3 0.396 17922018,14759366 Q99257 Q08004 MEX67 BUD20 0.236 23045392 Q99257 P47019 MEX67 ALB1 0.236 23045392 Q99257 Q6WNK7 MEX67 SUS1 0.376 20230609,18923079 Q99257 Q02256 MEX67 YVH1 0.376 19797079,27775710 Q99257 P14907 MEX67 NSP1 0.583 17922018,19401465 Q99257 P38861 MEX67 NMD3 0.569 17803941,27775710,23907389,18077551 Q99257 P17629 MEX67 HPR1 0.82 19401465,17475778 Q99257 P34232 MEX67 MTR2 0.772 17922018,25618852,20810649,20494970 Q99257 P32505 MEX67 NAB2 0.74 20810649,20823268,19840948 Q99257 P53145 MEX67 LSG1 0.659 23142978,27775710,23907389,22956913,19797079 Q99257 Q03862 MEX67 ARX1 0.872 27775710,24371142,23907389,17803941,23045392,22956913,23185031,19797079,23142978 Q99257 P38333 MEX67 ENP1 0.21 22956913 Q99257 P32263 MEX67 PRO3 0.236 11283351 Q99257 P36102 MEX67 PAN3 0.21 11283351 Q99257 P36104 MEX67 SWD2 0.454 22244335 Q99257 P15992 MEX67 HSP26 0.236 11283351 Q99257 P36161 MEX67 NUP133 0.126 17922018 Q99257 P05030 MEX67 PMA1 0.21 22244335 Q99257 P04147 MEX67 PAB1 0.332 11805837,17922018,12543930 Q99257 P04456 MEX67 RPL25 0.376 21852791 Q99257 P10591 MEX67 SSA1 0.126 16429126 Q99257 P09201 MEX67 FBP1 0.236 11283351 Q99257 P0CG63 MEX67 UBI4 0.523 17475778,19401465 Q99257 P20676 MEX67 NUP1 0.583 17922018,19723816,12411502 Q99257 P20449 MEX67 DBP5 0.126 17922018 Q99257 P21264 MEX67 ADE2 0.236 11283351 Q99257 P25567 MEX67 SRO9 0.21 20494970 Q99257 P34077 MEX67 NIC96 0.126 17922018 Q99257 P34160 MEX67 STO1 0.236 17922018 Q99257 P36036 MEX67 YRA2 0.236 11390651 Q99257 P35658 MEX67 NUP214 0.309 10228171 Q99257 P35729 MEX67 NUP120 0.126 16554755 Q99257 Q99257 MEX67 MEX67 0.155 17922018 Q99257 P48837 MEX67 NUP57 0.396 17875746,17922018 Q99257 P38181 MEX67 NUP170 0.126 17922018 Q99257 P40064 MEX67 NUP157 0.126 17922018 Q99257 P39705 MEX67 NUP60 0.523 17922018,12411502,15741174 Q99257 P38760 MEX67 MIP6 0.033 9214641 Q99257 P38833 MEX67 P38833 0.126 17922018 Q99257 P47054 MEX67 NUP192 0.126 17922018 Q99257 P40368 MEX67 NUP82 0.126 17922018 Q99257 P40066 MEX67 GLE2 0.126 17922018 Q99257 P40150 MEX67 SSB2 0.126 19536198 Q99257 P46674 MEX67 SAC3 0.583 17922018,12411502 Q99257 P40457 MEX67 MLP2 0.396 17922018,24152732,24500206 Q99257 P40477 MEX67 NUP159 0.126 17922018 Q99257 Q02821 MEX67 SRP1 0.126 17922018 Q99257 P52593 MEX67 NUP188 0.126 17922018 Q99257 P49687 MEX67 NUP145 0.126 16554755 Q99257 P50095 MEX67 IMD3 0.126 16429126 Q99257 Q02630 MEX67 NUP116 0.523 18046452,17922018,17875746 Q99257 Q01939 MEX67 RPT6 0.21 20494970 Q99257 Q02455 MEX67 MLP1 0.236 24152732,17922018 Q99257 Q12469 MEX67 SKM1 0.332 20489023 Q99257 Q06142 MEX67 KAP95 0.126 17922018 Q99257 Q03880 MEX67 PKR1 0.21 11283351 Q99257 Q12445 MEX67 POM34 0.126 17922018 Q99257 Q08920 MEX67 CBC2 0.659 17922018,24476359,20810649,22244335,24500206 Q99257 Q12159 MEX67 YRA1 0.853 17922018,10722314,20810649,11390651,10786854,16554755,11675790 Q99257 P32582 MEX67 CYS4 0.126 16429126 Q99257 P33201 MEX67 MRT4 0.126 19797079 Q99257 P40160 MEX67 RIO2 0.21 22956913 Q99257 P46673 MEX67 NUP85 0.332 16554755,17922018 Q99257 P51862 MEX67 ROM2 0.126 16429126 Q99257 Q02629 MEX67 NUP100 0.436 12543930,11387327,11104765 Q99257 Q07622 MEX67 ACK1 0.126 16429126 Q99257 P53011 MEX67 SEH1 0.396 16554755,18046452,17922018