PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus SPC25 MDM36 17634282 biogrid exp SWE1 MDM36 i2d exp SSE1 MDM36 19536198 intact exp MDM36 ESA1 19303850 biogrid exp CCT6 MDM36 19536198 intact exp MDM36 PKH2 21460040 biogrid exp SSA1 MDM36 19536198 intact exp SPC19 MDM36 17634282 biogrid exp YCK1 MDM36 16319894 biogrid exp HSP82 MDM36 19536198 intact exp AIM26 MDM36 16554755 intact exp SSB1 MDM36 19536198 intact exp TOS3 MDM36 16319894 biogrid,i2d exp NUP57 MDM36 11283351 i2d,mint,intact,dip exp NKP2 MDM36 17634282 biogrid exp PFD1 MDM36 19536198 intact exp MDM36 GIN4 21460040 biogrid exp HRR25 MDM36 21460040 biogrid exp HEK2 MDM36 18805955 biogrid exp SPC24 MDM36 17634282 biogrid exp CMK1 MDM36 16319894 biogrid,i2d exp WHI3 MDM36 18667435 biogrid exp JNM1 MDM36 11283351, 23023127 biogrid,i2d,mint,intact,dip exp, pred SML1 MDM36 16554755, 23023127 biogrid,i2d,mint,intact exp, pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q06820 P48837 - 11283351 - X 2 Q06820 P36224 - 11283351 - X 2 Q06820 P43637 enzymatic study 16319894 direct interaction X 2 Q06820 Q03954 two hybrid 17634282 direct interaction X 2 Q12236 Q06820 pull down 21460040 direct interaction X 2 Q04477 Q06820 two hybrid 17634282 direct interaction X 2 Q08649 Q06820 enzymatic study 19303850 direct interaction X 2 Q06162 Q06820 two hybrid 17634282 direct interaction X 2 Q06820 P23291 enzymatic study 16319894 direct interaction X 2 Q06820 P36224 two hybrid 11283351 direct interaction X 2 Q06820 P40014 two hybrid 17634282 direct interaction X 2 Q06820 P29295 pull down 21460040 direct interaction X 2 P0CG63 Q06820 biochemical 23583075 association X 2 Q04964 Q06820 affinity chromatography technology 16554755 physical association X 2 Q12263 Q06820 pull down 21460040 direct interaction X 2 P27466 Q06820 enzymatic study 16319894 direct interaction X 2 Q06820 P36224 two hybrid pooling approach 11283351 physical association X 2 Q06820 P48837 two hybrid pooling approach 11283351 physical association X 2 P02829 Q06820 tandem affinity purification 19536198 association X 2 P39079 Q06820 tandem affinity purification 19536198 association X 2 P10591 Q06820 tandem affinity purification 19536198 association X 2 Q06820 inferred by author 16554755 association C 17 P32589 Q06820 tandem affinity purification 19536198 association X 2 P11484 Q06820 tandem affinity purification 19536198 association X 2 Q06820 P48837 two hybrid fragment pooling approach 11283351 physical association X 2 Q06820 P36224 two hybrid fragment pooling approach 11283351 physical association X 2 P46988 Q06820 tandem affinity purification 19536198 association X 2 Q04964 Q06820 tandem affinity purification 16554755 physical association X 2 Q06820 P36224 two hybrid 11283351 - X 2 Q06820 P48837 two hybrid 11283351 - X 2

PPI - HINT Gene A Gene B PMID Method Quality YCK1 MDM36 16319894 0415 LC CMK1 MDM36 16319894 0415 LC JNM1 MDM36 11283351,11283351,11283351 0018,0399,0398 HT SPC25 MDM36 17634282 0018 HT TOS3 MDM36 16319894 0415 LC NUP57 MDM36 11283351,11283351,11283351 0018,0399,0398 HT SPC19 MDM36 17634282 0018 HT SPC24 MDM36 17634282 0018 HT NKP2 MDM36 17634282 0018 HT MDM36 ESA1 19303850 0415 LC HSP82 MDM36 19536198 0676 HT SSA1 MDM36 19536198 0676 HT SSB1 MDM36 19536198 0676 HT HRR25 MDM36 21460040 0096 LC SSE1 MDM36 19536198 0676 HT AIM26 MDM36 16554755 0363 HT CCT6 MDM36 19536198 0676 HT PFD1 MDM36 19536198 0676 HT SML1 MDM36 16554755,16554755 0676,0004 HT MDM36 PKH2 21460040 0096 LC MDM36 GIN4 21460040 0096 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q06820 Q04477 MDM36 SPC24 0.183 17634282 Q06820 P23291 MDM36 YCK1 0.183 16319894 Q12236 Q06820 PKH2 MDM36 0.183 21460040 Q12263 Q06820 GIN4 MDM36 0.183 21460040 Q06820 P0CS90 MDM36 SSC1 0.126 25792736 Q06820 P02829 MDM36 HSP82 0.126 19536198 Q06820 Q04964 MDM36 SML1 0.236 16554755 Q06820 P29295 MDM36 HRR25 0.183 21460040 Q06820 P38199 MDM36 HEK2 0.126 18805955 Q06820 P36224 MDM36 JNM1 0.21 11283351 Q06820 P27466 MDM36 CMK1 0.183 16319894 Q06820 P32858 MDM36 AIM26 0.126 16554755 Q06820 P40014 MDM36 SPC25 0.183 17634282 Q06820 P34761 MDM36 WHI3 0.183 18667435 Q06820 P10591 MDM36 SSA1 0.126 19536198 Q06820 P11484 MDM36 SSB1 0.126 19536198 Q06820 P32589 MDM36 SSE1 0.126 19536198 Q06820 P39079 MDM36 CCT6 0.126 19536198 Q06820 P46988 MDM36 PFD1 0.126 19536198 Q06820 P48837 MDM36 NUP57 0.21 11283351 Q08649 Q06820 ESA1 MDM36 0.183 19303850