PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus SSA1 AOS1 19536198 intact exp TEF1, TEF2 AOS1 16429126 intact exp SRP1 AOS1 i2d exp RPS0A AOS1 16429126 intact exp PSA1 AOS1 16429126 intact exp RPL5 AOS1 16429126 intact exp RPB7 AOS1 11805826,16429126 biogrid,mint,intact,dip exp RPP0 AOS1 16429126 intact exp SSB2 AOS1 23332755 biogrid exp KAP114 AOS1 22562154,doi:10.1038/emboj.2012.102 biogrid,mint,intact exp AOS1 ASR1 16429126 intact exp ADH1 AOS1 11805826,16429126,21036361 biogrid,mint,intact,dip exp VMA2 AOS1 16429126 intact exp IMD3 AOS1 16429126 intact exp SBP1 AOS1 23222640 biogrid exp HSP60 AOS1 19536198 i2d,intact exp NAB2 AOS1 19840948 biogrid exp SSB1 AOS1 16429126,19536198 intact exp SSE1 AOS1 16429126 intact exp FAS1 AOS1 16429126 intact exp AOS1 CMR1 25817432 biogrid exp MGM101 AOS1 i2d exp KAP95 AOS1 i2d exp YEF3 AOS1 11805826,16429126 biogrid,mint,intact,dip exp GIS2 AOS1 21232131 biogrid exp SSA3 AOS1 19536198 intact exp SSA2 AOS1 16429126,19536198 intact exp FMC1 AOS1 11283351 i2d,mint,intact,dip exp GDS1 AOS1 i2d exp URA2 AOS1 16429126 intact exp UBC9 AOS1 21209884,15738391, 23023127 biogrid exp, ortho, pred AOS1 AOS1 11805826, 23023127 mint,intact exp, ortho, pred UBA2 AOS1 11805826,16429126,9312010,16554755,9341106, 23023127 biogrid,i2d,mint,intact,dip exp, ortho, pred PRE3 AOS1 11595789, 23023127 biogrid,i2d,intact,dip exp, ortho, pred AOS1 SMT3 9312010, 23023127 i2d,dip exp, pred GDI1 AOS1 11283351, 23023127 i2d,mint,intact,dip exp, pred PAN5 AOS1 11283351, 23023127 i2d,mint,intact,dip exp, pred RNA1 AOS1 ortho DYS1 AOS1 ortho CDC21 AOS1 ortho NPL4 AOS1 ortho MCM3 AOS1 ortho RLI1 AOS1 ortho ADE13 AOS1 ortho BUD32 AOS1 ortho KAE1 AOS1 ortho UBC12 AOS1 ortho AOS1 TRM10 ortho ALA1 AOS1 ortho CAB1 AOS1 ortho AOS1 ULA1 23023127 pred UBI4 AOS1 23023127 pred AOS1 UBA3 23023127 pred UBC1 AOS1 23023127 pred RSP5 AOS1 23023127 pred UBC4 AOS1 23023127 pred UBC5 AOS1 23023127 pred RUB1 AOS1 23023127 pred UBP6 AOS1 23023127 pred CDC34 AOS1 23023127 pred UBA1 AOS1 23023127 pred RAD6 AOS1 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q06624 P52488 - 9312010 - X 2 Q06624 P38787 - 11283351 - X 2 Q06624 - 11805826 - C 13 Q06624 - 11805826 - C 4 Q06624 P40491 - 11283351 - X 2 Q06624 P38624 - 11595789 - X 2 Q06624 P39958 - 11283351 - X 2 Q06624 P52488 pull down 9312010 direct interaction X 2 Q06624 P52488 biochemical 9312010 colocalization X 2 Q06624 P52488 pull down 9341106 direct interaction X 2 Q06624 P40150 biochemical 23332755 association X 2 Q06624 P52488 affinity chromatography technology 16554755 physical association X 2 Q06624 P52488 affinity chromatography technology 16429126 physical association X 2 Q06624 P16521 affinity chromatography technology 16429126 physical association X 2 Q06624 P52488 affinity chromatography technology 17200106 physical association X 2 Q06624 P52488 affinity chromatography technology 11805826 physical association X 2 Q06624 P16521 affinity chromatography technology 11805826 physical association X 2 P0CG63 Q06624 biochemical 23583075 association X 2 P0CG63 Q06624 affinity chromatography technology 23793018 physical association X 2 Q06624 P38624 two hybrid 11595789 direct interaction X 2 Q06624 Q12306 protein complementation assay 23403034 direct interaction X 2 Q06624 Q12306 affinity chromatography technology 15292183 physical association X 2 Q06624 Q12306 affinity chromatography technology 23935535 physical association X 2 Q06624 P50623 pull down 15738391 direct interaction X 2 Q06624 P34087 affinity chromatography technology 16429126 physical association X 2 Q06624 Q12306 affinity chromatography technology 15326169 physical association X 2 Q06624 Q12306 affinity chromatography technology 15166219 physical association X 2 Q06624 P00330 affinity chromatography technology 11805826 physical association X 2 Q06624 P34087 affinity chromatography technology 11805826 physical association X 2 Q06624 P50623 enzymatic study 21209884 direct interaction X 2 Q06624 Q12306 affinity chromatography technology 15542864 physical association X 2 Q06624 P53067 two hybrid 22562154 direct interaction X 2 Q06624 inferred by author 11805826 physical association C 19 Q06624 P38787 two hybrid pooling approach 11283351 physical association X 2 Q06624 P16521 tandem affinity purification 11805826 physical association X 2 Q06624 P52488 affinity chromatography technology 9341106 direct interaction X 2 Q06624 P52488 molecular sieving 20164921 direct interaction X 2 Q06624 P52488 tandem affinity purification 11805826 direct interaction X 2 Q06624 tandem affinity purification 11805826 - C 13 Q06624 tandem affinity purification 11805826 physical association C 4 Q06624 inferred by author 11805826 physical association C 4 Q06624 P39958 two hybrid pooling approach 11283351 physical association X 2 Q06624 P40491 two hybrid pooling approach 11283351 physical association X 2 Q06624 Q12306 biochemical 9312010 physical association X 2 Q06624 P00330 tandem affinity purification 11805826 physical association X 2 Q06624 P34087 tandem affinity purification 11805826 physical association X 2 Q06624 P38624 two hybrid 11595789 physical association X 2 Q06624 P38624 two hybrid 10688190 physical association X 2 Q06624 tandem affinity purification 16429126 association C 16 Q06624 inferred by author 16429126 physical association C 11 Q06624 inferred by author 16429126 physical association C 28 Q06624 tandem affinity purification 16429126 association C 14 Q06624 P38787 two hybrid fragment pooling approach 11283351 physical association X 2 Q06624 P52488 inferred by author 16554755 association X 2 Q06624 P52488 tandem affinity purification 16554755 physical association X 2 Q06624 P52488 tandem affinity purification 16554755 physical association X 2 Q06624 P52488 tandem affinity purification 16554755 physical association X 2 Q06624 P52488 tandem affinity purification 16554755 physical association X 2 Q06624 P52488 tandem affinity purification 16554755 physical association X 2 Q06624 P52488 tandem affinity purification 16554755 physical association X 2 Q06624 P52488 tandem affinity purification 16554755 physical association X 2 Q06624 P52488 tandem affinity purification 16554755 physical association X 2 Q06624 P52488 tandem affinity purification 16554755 physical association X 2 Q06624 P52488 tandem affinity purification 16554755 physical association X 2 Q06624 P52488 tandem affinity purification 16554755 physical association X 2 Q06624 P52488 tandem affinity purification 16554755 physical association X 2 Q06624 P52488 tandem affinity purification 16554755 physical association X 2 Q06624 P52488 tandem affinity purification 16554755 physical association X 2 Q06624 P52488 tandem affinity purification 16554755 physical association X 2 Q06624 P52488 tandem affinity purification 16554755 physical association X 2 Q06624 P52488 tandem affinity purification 16554755 physical association X 2 Q06624 P52488 tandem affinity purification 16554755 physical association X 2 Q06624 P52488 tandem affinity purification 16554755 physical association X 2 Q06624 P52488 tandem affinity purification 16554755 physical association X 2 Q06624 P19882 tandem affinity purification 19536198 association X 2 Q06624 P09435 tandem affinity purification 19536198 association X 2 Q06624 tandem affinity purification 11805826 association C 5 Q06624 tandem affinity purification 11805826 association C 5 Q06624 tandem affinity purification 11805826 association C 14 Q06624 P39958 two hybrid fragment pooling approach 11283351 physical association X 2 Q06624 P40491 two hybrid fragment pooling approach 11283351 physical association X 2 Q06624 P38624 two hybrid array 11595789 physical association X 2 Q06624 P10591 tandem affinity purification 19536198 association X 2 Q06624 P10592 tandem affinity purification 19536198 association X 2 Q06624 P11484 tandem affinity purification 19536198 association X 2 Q06624 P53067 two hybrid 22562154 physical association X 2 Q06624 mass spectrometry studies of complexes 11805826 - C 23 Q06624 P38787 two hybrid 11283351 - X 2 Q06624 P52488 interaction detection method 9312010 - X 2 Q06624 mass spectrometry studies of complexes 11805826 - C 5 Q06624 mass spectrometry studies of complexes 11805826 - C 5 Q06624 P40491 two hybrid 11283351 - X 2 Q06624 P39958 two hybrid 11283351 - X 2

PPI - HINT Gene A Gene B PMID Method Quality ADH1 AOS1 21036361 0401 LC PRE3 AOS1 11595789,11595789,10688190 0018,0397,0018 LC,HT PAN5 AOS1 11283351,11283351,11283351 0018,0399,0398 HT GDI1 AOS1 11283351,11283351,11283351 0018,0399,0398 HT SSB2 AOS1 23332755 0401 LC FMC1 AOS1 11283351,11283351,11283351 0018,0399,0398 HT UBC9 AOS1 21209884 0415 LC UBA2 AOS1 9312010,20164921,9312010 0401,0071,0096 LC KAP114 AOS1 22562154 0018 LC AOS1 SMT3 9312010,9312010 0401,0096 LC AOS1 CMR1 25817432 0090 LC ADH1 AOS1 11805826,11805826,16429126,11805826,21036361 0676,0007,0676,0004,0401 HT,LC TEF1|TEF2 AOS1 16429126 0676 HT RPP0 AOS1 16429126 0676 HT FAS1 AOS1 16429126 0676 HT URA2 AOS1 16429126 0676 HT SSA3 AOS1 19536198 0676 HT SSA1 AOS1 19536198 0676 HT SSA2 AOS1 19536198,16429126 0676,0676 HT SSB1 AOS1 19536198,16429126 0676,0676 HT VMA2 AOS1 16429126 0676 HT YEF3 AOS1 16429126,11805826,11805826,11805826,16429126,16429126 0676,0676,0004,0007,0004,0363 HT HSP60 AOS1 19536198 0676 HT RPL5 AOS1 16429126 0676 HT NAB2 AOS1 19840948 0004 LC SSE1 AOS1 16429126 0676 HT RPS0A AOS1 16429126 0676 HT RPB7 AOS1 11805826,16429126,11805826,16429126,11805826 0004,0004,0007,0676,0676 HT SSB2 AOS1 23332755 0401 LC PSA1 AOS1 16429126 0676 HT IMD3 AOS1 16429126 0676 HT UBC9 AOS1 15738391 0096 LC UBA2 AOS1 16554755,16554755,9312010,16429126,9341106,11805826,9341106,11805826,9312010,17200106,11805826,16429126,16554755 0363,0676,0401,0676,0096,0004,0004,0676,0096,0004,0007,0004,0004 HT,LC AOS1 AOS1 11805826,11805826 0676,0007 HT AOS1 ASR1 16429126 0363 HT AOS1 SMT3 15542864,15292183,9312010,15326169,9312010,15166219,9341106 0004,0004,0401,0004,0096,0004,0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q12221 Q06624 PUF2 AOS1 0.126 26668354 Q06624 P10080 AOS1 SBP1 0.126 23222640 Q06624 P00330 AOS1 ADH1 0.396 11805826,21036361,16429126 Q06624 P11484 AOS1 SSB1 0.236 16429126,19536198 Q06624 P10592 AOS1 SSA2 0.236 16429126,19536198 Q06624 P52488 AOS1 UBA2 0.884 11805826,16429126,9341106,20164921,9312010,16554755 Q06624 P32505 AOS1 NAB2 0.126 19840948 Q06624 P39958 AOS1 GDI1 0.236 11283351 Q06624 P40150 AOS1 SSB2 0.126 23332755 Q06624 P40491 AOS1 FMC1 0.236 11283351 Q12510 Q06624 Q12510 AOS1 0.183 25817432 Q06624 P16521 AOS1 YEF3 0.472 11805826,16429126 Q06624 P50623 AOS1 UBC9 0.523 15738391,21209884 Q06624 P19882 AOS1 HSP60 0.126 19536198 Q06624 P02994 AOS1 TEF2 0.126 16429126 Q06624 P05317 AOS1 RPP0 0.126 16429126 Q06624 P07149 AOS1 FAS1 0.126 16429126 Q06624 P07259 AOS1 URA2 0.126 16429126 Q06624 P09435 AOS1 SSA3 0.126 19536198 Q06624 P10591 AOS1 SSA1 0.126 19536198 Q06624 P16140 AOS1 VMA2 0.126 16429126 Q06624 P26321 AOS1 RPL5 0.126 16429126 Q06624 P32589 AOS1 SSE1 0.126 16429126 Q06624 P32905 AOS1 RPS0A 0.126 16429126 Q06624 P34087 AOS1 RPB7 0.49 11805826,16429126 Q06624 P38624 AOS1 PRE3 0.126 11595789,10688190 Q06624 P38787 AOS1 PAN5 0.21 11283351 Q06624 P41940 AOS1 PSA1 0.126 16429126 Q06624 P50095 AOS1 IMD3 0.126 16429126 Q06624 P53067 AOS1 KAP114 0.523 22562154 Q06624 Q06624 AOS1 AOS1 0.155 11805826 Q12306 Q06624 SMT3 AOS1 0.033 9312010 Q06834 Q06624 ASR1 AOS1 0.126 16429126 Q06624 P53849 AOS1 GIS2 0.126 21232131