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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046563
UUCD1 version UUC-HoS-01177
Ensembl Protein ID ENSP00000290810.3
UniProt Accession Q13564; A6NCK0; A6NFN4; A8MU28; B2R700; B3KUP9; ULA1_HUMAN
Genbank Protein ID AAC50477.1; AAP35030.1; BAG53511.1; BAH12735.1; BAG35647.1; AAC23784.1; CAB66732.1; EAW83042.1; AAH00480.1; AAH13301.1
Protein Name NEDD8-activating enzyme E1 regulatory subunit; Amyloid beta precursor protein-binding protein 1, 59 kDa; Amyloid protein-binding protein 1; Proto-oncogene protein 1
Genbank Nucleotide ID U50939; AY197612; AK097680; AK298159; AK312784; AC004638; AC044802; CH471092; BC000480; BC013301
Gene Name NAE1; APPBP1; HPP1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000159593.14 ENST00000562428.6 ENSP00000463546.1
ENSG00000159593.14 ENST00000359087.8 ENSP00000351990.4
ENSG00000159593.14 ENST00000290810.7 ENSP00000290810.3
ENSG00000159593.14 ENST00000566663.5 ENSP00000462937.2
ENSG00000159593.14 ENST00000379463.6 ENSP00000368776.2
ENSG00000159593.14 ENST00000567743.5 ENSP00000455562.1
ENSG00000159593.14 ENST00000563253.5 ENSP00000454471.1
ENSG00000159593.14 ENST00000563185.6 ENSP00000454506.2
ENSG00000159593.14 ENST00000569388.5 ENSP00000456847.1
ENSG00000159593.14 ENST00000565535.5 ENSP00000455967.1
ENSG00000159593.14 ENST00000569348.5 ENSP00000456564.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACmiRWalk
RepTarmiRNAMapSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDBSCOP
Disease-associated Information
GWASdbOMIM
Drug and target
DrugBankManually
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtBioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E1 E1_ThiF 12740388; 19509147
Classification
Family E-value Score Start End
E1 4.10e-134 449.5 13 525
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E1
   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnvea 92
           YDRQ+rlwG+++qe+l+sa+v+l++a+++G+E+lKnLvl G+gs+t++D+++v+ ++ +++F+++++++gk++Ae+a+e+l+eln+dv++++
   Q: 13   YDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGSFTIIDGNQVSGEDAGNNFFLQRSSIGKNRAEAAMEFLQELNSDVSGSF 104
           ******************************************************************************************** PP
   S: 93   heesiteleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiPfctlketp 180
           +ees+++l ++++ Ff++f+vVv+++ +++++++++++++n ++pl++++t+Gl+G++r+iik++++++s++d   +++++++Pf++l+e++
   Q: 105  VEESPENLLDNDPsFFCRFTVVVATQLPESTSLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDnalEDLRLDKPFPELREHF 196
           *******************************************************************************************9 PP
   S: 181  n.........aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselks......edeenfeeaieiavkafakttins.ikql 256
           +         +++++++w+v+++k+l+++++e++++ +++++eke+++d++++++ +      edeenfeeai+++++a+++t+i+s i+++
   Q: 197  QsydldhmekKDHSHTPWIVIIAKYLAQWYSETNGRIPKTYKEKEDFRDLIRQGILKnengapEDEENFEEAIKNVNTALNTTQIPSsIEDI 288
           9999999998***********************************************9********************************** PP
   S: 257  lksfecdivtkskspfwv.......................................................................... 274
           +++++c ++tk++++fw+                                                                          
   Q: 289  FNDDRCINITKQTPSFWIlaralkefvakegqgnlpvrgtipdmiadsgkyiklqnvyrekakkdaaavgnhvakllqsigqapesisekel 380
           ******************************************************************************************** PP
   S: 275  .sfcsnaealqvp...........ekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekddds..avdlvtaaanlraesl 347
             +csn++ l+v            ++++kde+++++++p     lyl+lra++rf+k++gr+pg++++++++d+  + +++t ++    +++
   Q: 381  kLLCSNSAFLRVVrcrslaeeyglDTINKDEIISSMDNPdneivLYLMLRAVDRFHKQQGRYPGVSNYQVEEDIgkLKSCLTGFL----QEY 468
           *99********7777777888888**************9***********************************999********....*** PP
   S: 348  giepkldddlikeiagniipaiattnavvgGlaaqEviKvvsgkfeplknfflfdae 404
           g++ +++dd+++e++++++++ +t++a++gG+aaqEviK+++++f+ ++n++++ ++
   Q: 469  GLSVMVKDDYVHEFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGM 525
           *****************************************************9776 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation.
 Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation.
Protein Sequence
(Fasta)
MAQLGKLLKE QKYDRQLRLW GDHGQEALES AHVCLINATA TGTEILKNLV LPGIGSFTII 60
DGNQVSGEDA GNNFFLQRSS IGKNRAEAAM EFLQELNSDV SGSFVEESPE NLLDNDPSFF 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046563|E1,E1_ThiF|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGCAGAGTCG GCTGCGTCAG CAGGCAATGG CCTTGGAGCA CCGGCCTGAG CTACCCAGGG 60
AGACGGTGGA TCTCCAGGAA ACCGCGAGTG CCTAGGAGCC CCTCCCCACC TTTTCCGGGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046563|E1,E1_ThiF|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0131--Cell cycle
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0472--Membrane
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
Pfam

PF00899--ThiF
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005886--C:plasma membrane
GO:0019781--F:NEDD8 activating enzyme activity
GO:0046982--F:protein heterodimerization activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0033314--P:mitotic DNA replication checkpoint
GO:0051402--P:neuron apoptotic process
GO:0045116--P:protein neddylation
GO:0042981--P:regulation of apoptotic process
GO:0043523--P:regulation of neuron apoptotic process
GO:0007165--P:signal transduction
KEGG hsa:8883
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000764 Aegilops tauschii 42.53 2.00e-125 442.00
IUUC-Aml-002333 Ailuropoda melanoleuca 97.20 0.00e+00 1083.00
IUUC-Atr-002644 Amborella trichopoda 41.27 1.00e-113 403.00
IUUC-Apl-003446 Anas platyrhynchos 83.82 0.00e+00 917.00
IUUC-Aca-004450 Anolis carolinensis 80.11 0.00e+00 915.00
IUUC-Aly-006187 Arabidopsis lyrata 40.46 2.00e-124 439.00
IUUC-Ath-007600 Arabidopsis thaliana 41.03 8.00e-126 444.00
IUUC-Ago-007900 Ashbya gossypii 27.07 7.00e-40 158.00
IUUC-Acl-008333 Aspergillus clavatus 34.87 4.00e-82 299.00
IUUC-Afl-008529 Aspergillus flavus 36.54 4.00e-87 315.00
IUUC-Afu-009071 Aspergillus fumigatus 33.87 2.00e-82 300.00
IUUC-Ani-009443 Aspergillus nidulans 34.05 5.00e-80 291.00
IUUC-Ang-009669 Aspergillus niger 33.69 3.00e-83 302.00
IUUC-Aor-009914 Aspergillus oryzae 35.87 7.00e-84 305.00
IUUC-Ate-010450 Aspergillus terreus 34.88 4.00e-85 308.00
IUUC-Ame-011183 Astyanax mexicanus 72.02 0.00e+00 830.00
IUUC-Bgr-012111 Blumeria graminis 33.33 4.00e-67 249.00
IUUC-Bta-012583 Bos taurus 97.75 0.00e+00 1090.00
IUUC-Bci-013892 Botrytis cinerea 33.39 9.00e-66 244.00
IUUC-Bdi-014592 Brachypodium distachyon 43.32 6.00e-128 451.00
IUUC-Bol-016399 Brassica oleracea 40.08 4.00e-123 434.00
IUUC-Bra-017506 Brassica rapa 39.05 1.00e-118 420.00
IUUC-Cel-018456 Caenorhabditis elegans 36.16 1.00e-94 340.00
IUUC-Cja-020007 Callithrix jacchus 97.95 0.00e+00 1092.00
IUUC-Cfa-020324 Canis familiaris 97.75 0.00e+00 1088.00
IUUC-Cpo-022248 Cavia porcellus 66.54 0.00e+00 643.00
IUUC-Csa-023149 Chlorocebus sabaeus 99.34 0.00e+00 936.00
IUUC-Cho-024537 Choloepus hoffmanni 85.47 0.00e+00 808.00
IUUC-Cin-025763 Ciona intestinalis 49.53 2.00e-156 545.00
IUUC-Csv-026113 Ciona savignyi 46.67 1.00e-146 513.00
IUUC-Cgl-026428 Colletotrichum gloeosporioides 31.64 2.00e-65 243.00
IUUC-Cne-026884 Cryptococcus neoformans 30.07 2.00e-72 267.00
IUUC-Cme-027210 Cyanidioschyzon merolae 27.11 3.00e-19 90.50
IUUC-Dre-028140 Danio rerio 73.35 0.00e+00 850.00
IUUC-Dno-030033 Dasypus novemcinctus 97.89 0.00e+00 966.00
IUUC-Dor-030513 Dipodomys ordii 68.69 3.00e-115 408.00
IUUC-Dse-031536 Dothistroma septosporum 35.47 7.00e-86 311.00
IUUC-Dme-031683 Drosophila melanogaster 44.47 2.00e-127 449.00
IUUC-Ete-032420 Echinops telfairi 83.14 0.00e+00 887.00
IUUC-Eca-033992 Equus caballus 97.98 0.00e+00 917.00
IUUC-Eeu-034713 Erinaceus europaeus 79.92 1.00e-117 417.00
IUUC-Fca-036548 Felis catus 96.63 0.00e+00 1078.00
IUUC-Fal-037600 Ficedula albicollis 80.65 0.00e+00 886.00
IUUC-Fox-038037 Fusarium oxysporum 33.94 2.00e-77 283.00
IUUC-Fso-038387 Fusarium solani 34.77 5.00e-79 288.00
IUUC-Gmo-038562 Gadus morhua 71.21 0.00e+00 823.00
IUUC-Ggr-040005 Gaeumannomyces graminis 34.48 4.00e-74 272.00
IUUC-Gga-041129 Gallus gallus 84.11 0.00e+00 937.00
IUUC-Gac-042558 Gasterosteus aculeatus 72.50 0.00e+00 833.00
IUUC-Gma-043610 Glycine max 41.44 6.00e-120 424.00
IUUC-Ggo-045611 Gorilla gorilla 99.07 0.00e+00 1103.00
IUUC-Hvu-047790 Hordeum vulgare 38.11 9.00e-77 280.00
IUUC-Itr-048066 Ictidomys tridecemlineatus 97.94 0.00e+00 1091.00
IUUC-Kpa-049309 Komagataella pastoris 35.55 2.00e-82 299.00
IUUC-Lch-050038 Latimeria chalumnae 76.42 0.00e+00 856.00
IUUC-Lpe-051535 Leersia perrieri 41.45 5.00e-111 394.00
IUUC-Loc-051917 Lepisosteus oculatus 69.37 0.00e+00 794.00
IUUC-Lma-053112 Leptosphaeria maculans 35.69 5.00e-87 315.00
IUUC-Laf-053690 Loxodonta africana 96.44 0.00e+00 1082.00
IUUC-Mcc-055117 Macaca mulatta 97.03 0.00e+00 1078.00
IUUC-Meu-056761 Macropus eugenii 77.18 0.00e+00 827.00
IUUC-Mor-057230 Magnaporthe oryzae 33.63 3.00e-78 285.00
IUUC-Mpo-057514 Magnaporthe poae 33.63 8.00e-72 264.00
IUUC-Mtr-058551 Medicago truncatula 40.74 7.00e-117 414.00
IUUC-Mla-059183 Melampsora laricipopulina 36.80 7.00e-96 344.00
IUUC-Mga-060144 Meleagris gallopavo 82.95 0.00e+00 915.00
IUUC-Mvi-060221 Microbotryum violaceum 35.81 3.00e-82 299.00
IUUC-Mmr-061325 Microcebus murinus 94.97 0.00e+00 1059.00
IUUC-Mdo-062532 Monodelphis domestica 91.74 0.00e+00 1030.00
IUUC-Mmu-063956 Mus musculus 97.00 0.00e+00 1083.00
IUUC-Mac-064521 Musa acuminata 40.75 4.00e-123 435.00
IUUC-Mpu-066716 Mustela putorius furo 96.81 0.00e+00 1021.00
IUUC-Mlu-067459 Myotis lucifugus 95.87 0.00e+00 1063.00
IUUC-Nfi-068245 Neosartorya fischeri 34.22 2.00e-82 300.00
IUUC-Ncr-068910 Neurospora crassa 33.88 6.00e-77 281.00
IUUC-Nle-070034 Nomascus leucogenys 96.38 0.00e+00 1050.00
IUUC-Opr-070552 Ochotona princeps 87.43 0.00e+00 886.00
IUUC-Ont-071426 Oreochromis niloticus 73.16 0.00e+00 851.00
IUUC-Oan-073389 Ornithorhynchus anatinus 83.60 0.00e+00 776.00
IUUC-Ocu-074911 Oryctolagus cuniculus 96.25 0.00e+00 1082.00
IUUC-Oba-075437 Oryza barthii 42.94 4.00e-118 418.00
IUUC-Obr-076684 Oryza brachyantha 42.97 2.00e-113 402.00
IUUC-Ogl-077170 Oryza glaberrima 42.94 4.00e-118 418.00
IUUC-Ogu-078844 Oryza glumaepatula 43.71 4.00e-111 395.00
IUUC-Oin-079105 Oryza indica 42.94 1.00e-117 416.00
IUUC-Olo-080943 Oryza longistaminata 40.44 5.00e-106 378.00
IUUC-Oni-082891 Oryza nivara 40.08 2.00e-111 396.00
IUUC-Opu-083457 Oryza punctata 42.94 1.00e-117 416.00
IUUC-Oru-084960 Oryza rufipogon 40.44 5.00e-106 378.00
IUUC-Osa-085358 Oryza sativa 43.13 4.00e-118 418.00
IUUC-Ola-086420 Oryzias latipes 71.05 7.00e-168 583.00
IUUC-Olu-087625 Ostreococcus lucimarinus 30.85 2.00e-60 227.00
IUUC-Oga-088810 Otolemur garnettii 96.07 0.00e+00 1077.00
IUUC-Oar-089196 Ovis aries 97.21 0.00e+00 1087.00
IUUC-Ptr-090617 Pan troglodytes 99.63 0.00e+00 1107.00
IUUC-Pan-092761 Papio anubis 99.06 0.00e+00 1100.00
IUUC-Psi-093191 Pelodiscus sinensis 86.65 0.00e+00 963.00
IUUC-Pma-094380 Petromyzon marinus 62.07 0.00e+00 663.00
IUUC-Pno-095084 Phaeosphaeria nodorum 32.79 3.00e-74 274.00
IUUC-Ppa-095875 Physcomitrella patens 40.04 4.00e-119 421.00
IUUC-Pfo-096467 Poecilia formosa 72.40 0.00e+00 833.00
IUUC-Pab-098255 Pongo abelii 98.65 0.00e+00 914.00
IUUC-Pop-099722 Populus trichocarpa 41.03 6.00e-124 437.00
IUUC-Pca-100807 Procavia capensis 78.87 3.00e-118 418.00
IUUC-Ppe-101280 Prunus persica 40.68 8.00e-123 434.00
IUUC-Pva-102333 Pteropus vampyrus 92.74 0.00e+00 1023.00
IUUC-Pgr-103401 Puccinia graminis 32.30 2.00e-81 296.00
IUUC-Ptt-103889 Puccinia triticina 27.67 1.00e-58 221.00
IUUC-Pte-104355 Pyrenophora teres 36.77 1.00e-90 327.00
IUUC-Pyt-104545 Pyrenophora triticirepentis 36.19 4.00e-91 328.00
IUUC-Rno-105810 Rattus norvegicus 96.44 0.00e+00 1078.00
IUUC-Sce-106397 Saccharomyces cerevisiae 26.02 4.00e-37 149.00
IUUC-Sha-106770 Sarcophilus harrisii 90.11 2.00e-154 537.00
IUUC-Sja-107926 Schizosaccharomyces japonicus 33.14 1.00e-77 283.00
IUUC-Spo-108276 Schizosaccharomyces pombe 34.83 1.00e-82 300.00
IUUC-Ssl-108387 Sclerotinia sclerotiorum 32.55 6.00e-68 251.00
IUUC-Smo-109296 Selaginella moellendorffii 42.42 7.00e-123 434.00
IUUC-Sit-110157 Setaria italica 44.40 1.00e-134 473.00
IUUC-Sly-111105 Solanum lycopersicum 40.19 2.00e-121 429.00
IUUC-Stu-112469 Solanum tuberosum 40.71 2.00e-123 436.00
IUUC-Sar-113083 Sorex araneus 73.26 0.00e+00 752.00
IUUC-Sbi-113813 Sorghum bicolor 44.40 1.00e-133 470.00
IUUC-Sre-115058 Sporisorium reilianum 38.89 4.00e-85 309.00
IUUC-Tgu-116772 Taeniopygia guttata 80.27 0.00e+00 885.00
IUUC-Tru-118686 Takifugu rubripes 71.46 0.00e+00 834.00
IUUC-Tsy-119111 Tarsius syrichta 89.05 5.00e-149 521.00
IUUC-Tni-120231 Tetraodon nigroviridis 66.23 0.00e+00 751.00
IUUC-Tca-121491 Theobroma cacao 40.72 3.00e-116 412.00
IUUC-Tre-122103 Trichoderma reesei 37.00 9.00e-84 304.00
IUUC-Tvi-122672 Trichoderma virens 36.88 8.00e-76 278.00
IUUC-Tae-125679 Triticum aestivum 43.13 1.00e-127 450.00
IUUC-Tur-126487 Triticum urartu 41.41 6.00e-121 427.00
IUUC-Tme-127097 Tuber melanosporum 38.73 5.00e-94 338.00
IUUC-Ttr-128465 Tursiops truncatus 90.13 0.00e+00 995.00
IUUC-Uma-129645 Ustilago maydis 33.83 1.00e-90 327.00
IUUC-Vda-129989 Verticillium dahliae 30.68 2.00e-56 213.00
IUUC-Vpa-130529 Vicugna pacos 92.74 0.00e+00 1030.00
IUUC-Vvi-131059 Vitis vinifera 41.63 2.00e-121 429.00
IUUC-Xtr-132002 Xenopus tropicalis 78.75 0.00e+00 906.00
IUUC-Xma-133930 Xiphophorus maculatus 72.81 0.00e+00 838.00
IUUC-Yli-134505 Yarrowia lipolytica 35.05 3.00e-86 312.00
IUUC-Zma-135895 Zea mays 44.66 6.00e-133 468.00
Created Date 25-Jun-2017

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