iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Sce-106165

UUCD1 version

UUC-SaC-00257

Ensembl Protein ID

YEL012W

UniProt Accession

P28263; D3DLN7; UBC8_YEAST

Genbank Protein ID

AAB64489.1; CAA82526.1; DAA07641.1

Protein Name

Ubiquitin-conjugating enzyme E2-24 kDa; E2 ubiquitin-conjugating enzyme 8; Glucose-induced degradation protein 3; Ubiquitin carrier protein; Ubiquitin-protein ligase

Genbank Nucleotide ID

M65083; Z29329; BK006939

Gene Name

UBC8; GID3; YEL012W

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
YEL012W	YEL012W	YEL012W

Annotation

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UBC	E2_UBC	21070970

Classification

Family	E-value	Score	Start	End
E2/UBC	3.40e-37	125.7	16	140

Active Site

Position(s)	Description	Evidence
85	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 13   ppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyen.GkvClsilkeeekWspalsvesvl.lsiqsllaep 112
            ++  ++++ ++  ++e++v++lGp+dtpYe+gv++l++e+p++YP+k+P++ f++kifhPn++ + G++Cl++++  ++Wsp +++ +++ + i  ll+ep
   Q: 16   LMSDHQVDLIND-SMQEFHVKFLGPKDTPYENGVWRLHVELPDNYPYKSPSIGFVNKIFHPNIDIAsGSICLDVIN--STWSPLYDLINIVeWMIPGLLKEP 114
           455567888899.6**************************************************999********9..************999********* PP
   S: 113  npesplneeaaellkknreeykkkvr 138
           n ++pln+eaa+l  ++++ y++k++
   Q: 115  NGSDPLNNEAATLQLRDKKLYEEKIK 140
           ************************98 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Catalyzes the covalent attachment of ubiquitin to other proteins. Capable, in vitro, to ubiquitinate histone H2A. Has a role in the negative regulation of gluconeogenesis. Required for proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase).

Protein Sequence
(Fasta)

MSSSKRRIET DVMKLLMSDH QVDLINDSMQ EFHVKFLGPK DTPYENGVWR LHVELPDNYP 60
YKSPSIGFVN KIFHPNIDIA SGSICLDVIN STWSPLYDLI NIVEWMIPGL LKEPNGSDPL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGGTATG TTTGATAAGA TATATACGTA TATTTATATA TCACTCTTCT GAGAAAGTAT 60
GCCATAGAAT GAGGATCACT AACAAAGAAA ATGTCAATGA ACTTCAAAGA TATCGTTTAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0045721--P:negative regulation of gluconeogenesis
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

sce:YEL012W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000745	Aegilops tauschii	60.67	2.00e-55	206.00
IUUC-Aml-001260	Ailuropoda melanoleuca	60.47	3.00e-44	168.00
IUUC-Atr-002681	Amborella trichopoda	60.67	2.00e-56	209.00
IUUC-Apl-003547	Anas platyrhynchos	61.06	1.00e-38	150.00
IUUC-Aca-005224	Anolis carolinensis	59.12	3.00e-38	149.00
IUUC-Aly-005836	Arabidopsis lyrata	62.59	6.00e-57	211.00
IUUC-Ath-007534	Arabidopsis thaliana	62.59	6.00e-57	211.00
IUUC-Ago-007727	Ashbya gossypii	87.18	9.00e-81	290.00
IUUC-Acl-008119	Aspergillus clavatus	65.19	1.00e-60	223.00
IUUC-Afl-008412	Aspergillus flavus	66.97	2.00e-43	166.00
IUUC-Afu-008925	Aspergillus fumigatus	61.68	6.00e-56	207.00
IUUC-Ani-009294	Aspergillus nidulans	62.67	1.00e-52	196.00
IUUC-Ang-009805	Aspergillus niger	68.00	3.00e-60	221.00
IUUC-Aor-010201	Aspergillus oryzae	57.89	4.00e-49	185.00
IUUC-Ate-010441	Aspergillus terreus	60.45	1.00e-45	173.00
IUUC-Ame-010807	Astyanax mexicanus	62.00	3.00e-36	141.00
IUUC-Bta-012802	Bos taurus	60.47	3.00e-44	168.00
IUUC-Bdi-014415	Brachypodium distachyon	61.33	4.00e-56	208.00
IUUC-Bol-016385	Brassica oleracea	62.59	1.00e-55	206.00
IUUC-Bra-018015	Brassica rapa	62.59	1.00e-55	206.00
IUUC-Cel-018412	Caenorhabditis elegans	55.10	1.00e-48	184.00
IUUC-Cja-019571	Callithrix jacchus	47.95	4.00e-33	132.00
IUUC-Cfa-020811	Canis familiaris	60.47	3.00e-44	168.00
IUUC-Cpo-021889	Cavia porcellus	54.62	2.00e-39	152.00
IUUC-Cre-022956	Chlamydomonas reinhardtii	62.67	9.00e-56	207.00
IUUC-Csa-023289	Chlorocebus sabaeus	60.47	3.00e-44	168.00
IUUC-Cgl-026627	Colletotrichum gloeosporioides	64.80	3.00e-50	188.00
IUUC-Cne-027006	Cryptococcus neoformans	62.69	5.00e-52	195.00
IUUC-Cme-027171	Cyanidioschyzon merolae	61.44	1.00e-57	214.00
IUUC-Dre-027450	Danio rerio	60.47	4.00e-44	168.00
IUUC-Dno-029838	Dasypus novemcinctus	60.47	3.00e-44	168.00
IUUC-Dor-031119	Dipodomys ordii	60.47	3.00e-44	168.00
IUUC-Dse-031243	Dothistroma septosporum	68.67	1.00e-62	230.00
IUUC-Dme-031807	Drosophila melanogaster	56.38	9.00e-50	187.00
IUUC-Ete-032437	Echinops telfairi	63.54	2.00e-35	139.00
IUUC-Eca-034123	Equus caballus	60.16	1.00e-41	160.00
IUUC-Fca-035502	Felis catus	60.47	3.00e-44	168.00
IUUC-Fal-037054	Ficedula albicollis	59.12	5.00e-39	151.00
IUUC-Fox-037912	Fusarium oxysporum	66.67	6.00e-39	150.00
IUUC-Fso-038148	Fusarium solani	59.73	8.00e-51	190.00
IUUC-Gmo-038858	Gadus morhua	58.82	3.00e-50	188.00
IUUC-Ggr-039749	Gaeumannomyces graminis	63.28	1.00e-47	180.00
IUUC-Gga-040942	Gallus gallus	60.47	3.00e-44	168.00
IUUC-Gac-042079	Gasterosteus aculeatus	57.52	2.00e-49	186.00
IUUC-Gma-042856	Glycine max	63.33	6.00e-58	214.00
IUUC-Hsa-046545	Homo sapiens	60.47	3.00e-44	168.00
IUUC-Hvu-047642	Hordeum vulgare	61.43	8.00e-53	197.00
IUUC-Itr-048474	Ictidomys tridecemlineatus	60.47	3.00e-44	168.00
IUUC-Kpa-049144	Komagataella pastoris	70.54	8.00e-54	200.00
IUUC-Lch-050589	Latimeria chalumnae	55.33	5.00e-39	151.00
IUUC-Lpe-051335	Leersia perrieri	62.00	9.00e-57	210.00
IUUC-Loc-052829	Lepisosteus oculatus	60.47	6.00e-44	167.00
IUUC-Lma-052971	Leptosphaeria maculans	48.47	7.00e-47	177.00
IUUC-Laf-053526	Loxodonta africana	60.63	4.00e-44	168.00
IUUC-Mcc-055611	Macaca mulatta	60.47	3.00e-44	168.00
IUUC-Mor-057278	Magnaporthe oryzae	65.85	3.00e-50	188.00
IUUC-Mpo-057484	Magnaporthe poae	64.22	1.00e-42	162.00
IUUC-Mtr-058579	Medicago truncatula	62.00	7.00e-58	214.00
IUUC-Mla-058926	Melampsora laricipopulina	69.59	1.00e-62	230.00
IUUC-Mga-059801	Meleagris gallopavo	60.47	3.00e-44	168.00
IUUC-Mvi-060244	Microbotryum violaceum	70.00	2.00e-64	236.00
IUUC-Mmr-061205	Microcebus murinus	60.47	3.00e-44	168.00
IUUC-Mmu-063974	Mus musculus	60.47	3.00e-44	168.00
IUUC-Mac-065395	Musa acuminata	62.00	2.00e-56	209.00
IUUC-Mpu-066759	Mustela putorius furo	60.47	3.00e-44	168.00
IUUC-Mlu-067674	Myotis lucifugus	56.92	9.00e-39	150.00
IUUC-Nfi-068618	Neosartorya fischeri	65.93	2.00e-52	196.00
IUUC-Ncr-068712	Neurospora crassa	63.11	7.00e-48	180.00
IUUC-Nle-069926	Nomascus leucogenys	60.47	3.00e-44	168.00
IUUC-Opr-070598	Ochotona princeps	60.47	3.00e-44	168.00
IUUC-Ont-071893	Oreochromis niloticus	60.40	5.00e-50	188.00
IUUC-Oan-073273	Ornithorhynchus anatinus	61.06	8.00e-39	150.00
IUUC-Ocu-074357	Oryctolagus cuniculus	60.47	7.00e-44	167.00
IUUC-Oba-075055	Oryza barthii	62.00	9.00e-57	210.00
IUUC-Obr-076538	Oryza brachyantha	62.67	3.00e-57	212.00
IUUC-Ogl-077784	Oryza glaberrima	62.00	9.00e-57	210.00
IUUC-Ogu-078045	Oryza glumaepatula	62.00	9.00e-57	210.00
IUUC-Oin-079163	Oryza indica	62.00	9.00e-57	210.00
IUUC-Olo-080847	Oryza longistaminata	56.55	7.00e-48	181.00
IUUC-Ome-081586	Oryza meridionalis	57.41	3.00e-54	202.00
IUUC-Oni-082913	Oryza nivara	62.00	9.00e-57	210.00
IUUC-Opu-083651	Oryza punctata	62.00	9.00e-57	210.00
IUUC-Oru-084980	Oryza rufipogon	62.00	9.00e-57	210.00
IUUC-Osa-085334	Oryza sativa	62.14	3.00e-53	198.00
IUUC-Ola-087423	Oryzias latipes	58.82	3.00e-50	189.00
IUUC-Oga-088412	Otolemur garnettii	60.47	3.00e-44	168.00
IUUC-Oar-090282	Ovis aries	58.68	2.00e-39	152.00
IUUC-Ptr-090470	Pan troglodytes	60.47	3.00e-44	168.00
IUUC-Pan-092552	Papio anubis	60.47	3.00e-44	168.00
IUUC-Psi-093516	Pelodiscus sinensis	57.60	7.00e-40	154.00
IUUC-Pno-094800	Phaeosphaeria nodorum	56.03	1.00e-43	166.00
IUUC-Ppa-095962	Physcomitrella patens	61.33	1.00e-57	213.00
IUUC-Pfo-097374	Poecilia formosa	60.47	3.00e-44	169.00
IUUC-Pab-098112	Pongo abelii	60.47	3.00e-44	168.00
IUUC-Pop-098987	Populus trichocarpa	64.67	8.00e-58	214.00
IUUC-Pca-100436	Procavia capensis	46.04	4.00e-30	121.00
IUUC-Ppe-101420	Prunus persica	63.33	6.00e-59	217.00
IUUC-Pva-102776	Pteropus vampyrus	60.47	2.00e-43	166.00
IUUC-Pgr-103325	Puccinia graminis	67.65	2.00e-56	209.00
IUUC-Ptt-104010	Puccinia triticina	65.41	3.00e-51	192.00
IUUC-Pte-104024	Pyrenophora teres	60.95	6.00e-59	218.00
IUUC-Pyt-104715	Pyrenophora triticirepentis	66.17	6.00e-54	201.00
IUUC-Rno-105699	Rattus norvegicus	58.17	9.00e-44	167.00
IUUC-Sha-106524	Sarcophilus harrisii	61.06	9.00e-39	150.00
IUUC-Sja-107813	Schizosaccharomyces japonicus	64.43	2.00e-57	213.00
IUUC-Spo-108105	Schizosaccharomyces pombe	66.00	3.00e-60	221.00
IUUC-Ssl-108543	Sclerotinia sclerotiorum	60.13	3.00e-51	192.00
IUUC-Smo-109023	Selaginella moellendorffii	63.40	2.00e-58	216.00
IUUC-Sit-109856	Setaria italica	61.33	2.00e-56	209.00
IUUC-Sly-111921	Solanum lycopersicum	64.00	3.00e-58	215.00
IUUC-Stu-112525	Solanum tuberosum	63.33	5.00e-58	214.00
IUUC-Sbi-114111	Sorghum bicolor	61.33	2.00e-56	209.00
IUUC-Sre-115027	Sporisorium reilianum	66.67	2.00e-62	229.00
IUUC-Ssc-116221	Sus scrofa	61.02	2.00e-40	155.00
IUUC-Tgu-116965	Taeniopygia guttata	61.06	1.00e-38	150.00
IUUC-Tru-117574	Takifugu rubripes	58.55	4.00e-44	168.00
IUUC-Tni-120422	Tetraodon nigroviridis	58.55	7.00e-44	167.00
IUUC-Tca-121070	Theobroma cacao	63.33	3.00e-58	215.00
IUUC-Tre-122110	Trichoderma reesei	63.91	3.00e-50	188.00
IUUC-Tvi-122592	Trichoderma virens	57.72	1.00e-48	183.00
IUUC-Tae-124413	Triticum aestivum	60.67	1.00e-55	206.00
IUUC-Tur-126414	Triticum urartu	60.67	3.00e-55	205.00
IUUC-Tme-127020	Tuber melanosporum	57.04	8.00e-40	153.00
IUUC-Tbe-128053	Tupaia belangeri	44.25	1.00e-21	93.60
IUUC-Ttr-128734	Tursiops truncatus	60.47	3.00e-44	168.00
IUUC-Uma-129334	Ustilago maydis	66.67	2.00e-62	229.00
IUUC-Vda-129953	Verticillium dahliae	62.11	2.00e-57	213.00
IUUC-Vpa-130729	Vicugna pacos	61.06	1.00e-38	150.00
IUUC-Vvi-131633	Vitis vinifera	64.00	7.00e-59	217.00
IUUC-Xtr-132368	Xenopus tropicalis	60.47	3.00e-44	168.00
IUUC-Xma-133864	Xiphophorus maculatus	60.47	3.00e-44	169.00
IUUC-Yli-134339	Yarrowia lipolytica	65.99	8.00e-61	224.00
IUUC-Zma-135728	Zea mays	61.43	2.00e-53	199.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence