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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046118
UUCD1 version UUC-HoS-00357
Ensembl Protein ID ENSP00000259605.6
UniProt Accession Q9H0F5; A6PVP9; B1AM81; B1AM82; B3KSG4; E7EVL3; Q7LB33; Q8N0Y0; Q9H748; RNF38_HUMAN
Genbank Protein ID AAM73697.1; CAB66751.3; BAB15050.1; BAG52726.1; CAO03553.1; CAO03553.1; CAO03540.1; CAO03540.1; CAO03541.1; CAO03541.1; CAO03554.1; CAO03554.1; EAW58305.1; AAH33786.2
Protein Name E3 ubiquitin-protein ligase RNF38; RING finger protein 38; RING-type E3 ubiquitin transferase RNF38
Genbank Nucleotide ID AF394047; AL136817; AK024996; AK093480; AL161792; AL354935; AL354935; AL161792; AL354935; AL161792; AL161792; AL354935; CH471071; BC033786
Gene Name RNF38
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000137075.17 ENST00000259605.10 ENSP00000259605.6
ENSG00000137075.17 ENST00000353739.8 ENSP00000335239.5
ENSG00000137075.17 ENST00000377877.4 ENSP00000367109.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPA
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 12874135; 23973461
Classification
Family E-value Score Start End
E3 activity/RING/RING 3.60e-08 35.4 463 504
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdg..plvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C +C++df+    ++vlpC+H fha+C+ kw       + + +CP+Cr
   Q: 463  CVVCMCDFESRqlLRVLPCNHEFHAKCVDKW------LKANRTCPICR 504
           ********4434599****************......**********8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Acts as an E3 ubiquitin-protein ligase able to ubiquitinate p53/TP53 which promotes its relocalization to discrete foci associated with PML nuclear bodies. Exhibits preference for UBE2D2 as a E2 enzyme.
 Acts as an E3 ubiquitin-protein ligase able to ubiquitinate p53/TP53 which promotes its relocalization to discrete foci associated with PML nuclear bodies. Exhibits preference for UBE2D2 as a E2 enzyme.
Protein Sequence
(Fasta)
MACKISPGAN SASLPGHPNK VICERVRLQS LFPLLPSDQN TTVQEDAHFK AFFQSEDSPS 60
PKRQRLSHSV FDYTSASPAP SPPMRPWEMT SNRQPPSVRP SQHHFSGERC NTPARNRRSP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046118|E3,RING|Homo sapiens
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Nucleotide Sequence
(Fasta)
GCGGCCGCCG CGGTCGCTGC CGCCGCCGCC TCAGCAGCCG CCGCCGCCGC GCACTTTCAG 60
CCTCAGTCGT CGTCTCCCAG GCCGGGCCCC GCCGAGCTTG GGCCCCCGCG CCGCCCGCGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046118|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF13639--zf-RING_2
SMART

SM00184--RING
Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0036126--C:sperm flagellum
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0008584--P:male gonad development
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016567--P:protein ubiquitination
KEGG hsa:152006
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001752 Ailuropoda melanoleuca 99.22 0.00e+00 831.00
IUUC-Atr-003122 Amborella trichopoda 45.95 4.00e-15 76.60
IUUC-Apl-003246 Anas platyrhynchos 90.85 0.00e+00 728.00
IUUC-Aca-005355 Anolis carolinensis 96.32 0.00e+00 697.00
IUUC-Bta-012401 Bos taurus 98.61 0.00e+00 694.00
IUUC-Bdi-014369 Brachypodium distachyon 37.36 5.00e-16 78.60
IUUC-Cja-018848 Callithrix jacchus 99.42 0.00e+00 877.00
IUUC-Cfa-020501 Canis familiaris 99.54 0.00e+00 693.00
IUUC-Cpo-021722 Cavia porcellus 98.05 0.00e+00 821.00
IUUC-Csa-024088 Chlorocebus sabaeus 100.00 0.00e+00 704.00
IUUC-Cho-024540 Choloepus hoffmanni 82.03 0.00e+00 647.00
IUUC-Cin-025552 Ciona intestinalis 65.98 5.00e-36 143.00
IUUC-Dre-028201 Danio rerio 69.82 1.00e-133 470.00
IUUC-Dno-029482 Dasypus novemcinctus 98.62 0.00e+00 819.00
IUUC-Dor-030261 Dipodomys ordii 88.26 0.00e+00 781.00
IUUC-Dse-031302 Dothistroma septosporum 47.73 7.00e-11 62.80
IUUC-Dme-032187 Drosophila melanogaster 64.23 3.00e-43 171.00
IUUC-Ete-032580 Echinops telfairi 90.41 0.00e+00 747.00
IUUC-Eca-033264 Equus caballus 98.84 0.00e+00 707.00
IUUC-Eeu-035181 Erinaceus europaeus 91.19 0.00e+00 754.00
IUUC-Fca-036484 Felis catus 99.02 0.00e+00 827.00
IUUC-Fal-037568 Ficedula albicollis 95.81 0.00e+00 720.00
IUUC-Gga-040685 Gallus gallus 94.65 0.00e+00 672.00
IUUC-Ggo-044571 Gorilla gorilla 100.00 0.00e+00 851.00
IUUC-Hvu-047245 Hordeum vulgare 45.33 3.00e-15 76.30
IUUC-Itr-048953 Ictidomys tridecemlineatus 99.35 0.00e+00 736.00
IUUC-Lch-050401 Latimeria chalumnae 92.41 0.00e+00 739.00
IUUC-Lpe-051226 Leersia perrieri 44.74 2.00e-15 77.40
IUUC-Loc-052875 Lepisosteus oculatus 85.93 4.00e-161 560.00
IUUC-Lma-052952 Leptosphaeria maculans 33.04 4.00e-11 63.20
IUUC-Laf-054381 Loxodonta africana 99.35 0.00e+00 731.00
IUUC-Mcc-055576 Macaca mulatta 100.00 0.00e+00 851.00
IUUC-Meu-056433 Macropus eugenii 91.38 6.00e-142 497.00
IUUC-Mtr-058188 Medicago truncatula 38.10 2.00e-14 73.20
IUUC-Mga-059597 Meleagris gallopavo 92.41 0.00e+00 677.00
IUUC-Mmr-061247 Microcebus murinus 99.61 0.00e+00 838.00
IUUC-Mdo-061822 Monodelphis domestica 97.69 0.00e+00 716.00
IUUC-Mmu-064200 Mus musculus 98.05 0.00e+00 731.00
IUUC-Mac-065545 Musa acuminata 39.18 3.00e-16 79.00
IUUC-Mpu-066571 Mustela putorius furo 99.41 0.00e+00 827.00
IUUC-Mlu-067948 Myotis lucifugus 98.63 0.00e+00 853.00
IUUC-Nle-069466 Nomascus leucogenys 99.61 0.00e+00 839.00
IUUC-Opr-071151 Ochotona princeps 98.80 2.00e-110 392.00
IUUC-Ont-072424 Oreochromis niloticus 66.02 3.00e-130 458.00
IUUC-Oan-073236 Ornithorhynchus anatinus 83.48 0.00e+00 631.00
IUUC-Ocu-073866 Oryctolagus cuniculus 99.22 0.00e+00 882.00
IUUC-Oba-075267 Oryza barthii 44.00 1.00e-14 74.30
IUUC-Obr-076920 Oryza brachyantha 37.08 3.00e-15 75.50
IUUC-Ogl-077938 Oryza glaberrima 38.46 3.00e-15 75.50
IUUC-Ogu-078754 Oryza glumaepatula 44.00 1.00e-14 74.30
IUUC-Oin-080031 Oryza indica 38.46 4.00e-15 75.50
IUUC-Ome-081863 Oryza meridionalis 44.00 1.00e-14 74.30
IUUC-Oni-082943 Oryza nivara 44.00 1.00e-14 74.30
IUUC-Opu-083391 Oryza punctata 37.08 3.00e-15 75.90
IUUC-Oru-084675 Oryza rufipogon 44.00 1.00e-14 74.30
IUUC-Osa-085452 Oryza sativa 38.46 4.00e-15 75.50
IUUC-Oga-087997 Otolemur garnettii 99.61 0.00e+00 842.00
IUUC-Oar-090272 Ovis aries 98.44 0.00e+00 830.00
IUUC-Ptr-091566 Pan troglodytes 99.81 0.00e+00 849.00
IUUC-Pan-091884 Papio anubis 99.80 0.00e+00 843.00
IUUC-Psi-093539 Pelodiscus sinensis 97.22 0.00e+00 714.00
IUUC-Pab-098694 Pongo abelii 100.00 0.00e+00 704.00
IUUC-Pop-098962 Populus trichocarpa 41.49 1.00e-16 79.70
IUUC-Pva-103055 Pteropus vampyrus 98.99 0.00e+00 790.00
IUUC-Rno-105006 Rattus norvegicus 97.69 0.00e+00 715.00
IUUC-Sit-109831 Setaria italica 38.46 7.00e-16 78.20
IUUC-Sly-111171 Solanum lycopersicum 36.05 4.00e-13 68.20
IUUC-Stu-112327 Solanum tuberosum 47.95 2.00e-15 76.60
IUUC-Sar-112966 Sorex araneus 96.87 0.00e+00 819.00
IUUC-Sre-114942 Sporisorium reilianum 29.85 7.00e-12 66.60
IUUC-Ssc-115502 Sus scrofa 99.41 0.00e+00 830.00
IUUC-Tgu-117480 Taeniopygia guttata 92.64 0.00e+00 702.00
IUUC-Tsy-118844 Tarsius syrichta 95.15 0.00e+00 788.00
IUUC-Tca-121858 Theobroma cacao 41.11 2.00e-16 80.10
IUUC-Tae-123101 Triticum aestivum 38.46 6.00e-16 78.60
IUUC-Tur-126249 Triticum urartu 36.26 3.00e-15 75.10
IUUC-Tbe-127237 Tupaia belangeri 87.96 0.00e+00 746.00
IUUC-Ttr-129073 Tursiops truncatus 98.79 0.00e+00 788.00
IUUC-Uma-129479 Ustilago maydis 29.85 1.00e-11 65.50
IUUC-Vpa-130240 Vicugna pacos 99.38 2.00e-148 519.00
IUUC-Vvi-131462 Vitis vinifera 38.89 5.00e-17 81.60
IUUC-Xtr-131963 Xenopus tropicalis 93.75 0.00e+00 755.00
Created Date 25-Jun-2017

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