iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	HINT
Post-translational Modifications (PTMs)
UniProt
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD	WD_repeat	21282611

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.80e-28	97.2	336	366

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf..sd.tllvsGsdDgtikvWD 29
           H ++ +c+++  +d +l+++Gs D+t++++D
   Q: 336  HDADLHCVDWnpHDdNLILTGSADNTVRLFD 366
           9999*******9445**************** PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of the flowering autonomous pathway which positively regulates flowering by promoting transcriptional repression of the flowering repressor FLC. May promote histone deacetylation at the FLC locus leading to the formation of repressive chromatin structures. Also negatively regulates cold-responsive genes.

Protein Sequence
(Fasta)

MESDEAAAVS PQATTPSGGT GASGPKKRGR KPKTKEDSQT PSSQQQSDVK MKESGKKTQQ 60
SPSVDEKYSQ WKGLVPILYD WLANHNLVWP SLSCRWGPQL EQATYKNRQR LYLSEQTDGS 120

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Nucleotide Sequence
(Fasta)

GTTTTTCAGG TTTTGAAGTT TAGATTCAGT CGGATATTTG AAAATTTCAG GTTCGAATTT 60
AGATTGGGAT TTTTGGATTG GGATTTTTGG ATCGGGTTCA GATCGGTTTT TTCGGATTCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0287--Flowering
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat

Interpro

IPR022052--Histone-bd_RBBP4_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12265--CAF1C_H4-bd
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0046872--F:metal ion binding
GO:0030154--P:cell differentiation
GO:0016569--P:covalent chromatin modification
GO:0006281--P:DNA repair
GO:0009908--P:flower development
GO:0006355--P:regulation of transcription, DNA-templated
GO:0010224--P:response to UV-B
GO:0006351--P:transcription, DNA-templated

KEGG

ath:AT2G19520

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000914	Aegilops tauschii	74.83	0.00e+00	647.00
IUUC-Atr-003045	Amborella trichopoda	79.87	0.00e+00	740.00
IUUC-Aly-006131	Arabidopsis lyrata	98.22	0.00e+00	954.00
IUUC-Bdi-014938	Brachypodium distachyon	76.84	0.00e+00	732.00
IUUC-Bol-015960	Brassica oleracea	90.62	0.00e+00	939.00
IUUC-Bra-017112	Brassica rapa	92.18	0.00e+00	924.00
IUUC-Gma-044151	Glycine max	81.75	0.00e+00	840.00
IUUC-Hvu-047149	Hordeum vulgare	74.13	1.00e-53	201.00
IUUC-Lpe-051595	Leersia perrieri	69.51	6.00e-179	619.00
IUUC-Mtr-057993	Medicago truncatula	86.58	0.00e+00	822.00
IUUC-Mac-065523	Musa acuminata	80.80	0.00e+00	634.00
IUUC-Oba-075959	Oryza barthii	67.80	8.00e-179	619.00
IUUC-Obr-076021	Oryza brachyantha	75.16	0.00e+00	702.00
IUUC-Ogl-077211	Oryza glaberrima	74.30	0.00e+00	697.00
IUUC-Ogu-078314	Oryza glumaepatula	63.97	3.00e-163	567.00
IUUC-Oin-079269	Oryza indica	75.76	0.00e+00	704.00
IUUC-Olo-080631	Oryza longistaminata	65.02	1.00e-178	618.00
IUUC-Oni-082416	Oryza nivara	69.72	0.00e+00	643.00
IUUC-Opu-083571	Oryza punctata	65.14	1.00e-168	585.00
IUUC-Oru-084902	Oryza rufipogon	69.08	0.00e+00	628.00
IUUC-Osa-085579	Oryza sativa	75.76	0.00e+00	704.00
IUUC-Olu-087795	Ostreococcus lucimarinus	39.38	8.00e-86	310.00
IUUC-Ppa-095350	Physcomitrella patens	63.53	3.00e-177	613.00
IUUC-Pop-099098	Populus trichocarpa	84.93	0.00e+00	808.00
IUUC-Ppe-101724	Prunus persica	85.05	0.00e+00	797.00
IUUC-Sit-110597	Setaria italica	77.90	0.00e+00	718.00
IUUC-Sly-111411	Solanum lycopersicum	77.97	0.00e+00	730.00
IUUC-Stu-112285	Solanum tuberosum	79.60	9.00e-168	582.00
IUUC-Sbi-114341	Sorghum bicolor	76.81	0.00e+00	709.00
IUUC-Tca-121523	Theobroma cacao	87.31	0.00e+00	825.00
IUUC-Tae-125672	Triticum aestivum	74.95	0.00e+00	713.00
IUUC-Tur-126763	Triticum urartu	74.60	0.00e+00	640.00
IUUC-Vvi-131642	Vitis vinifera	80.40	0.00e+00	740.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence