iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Sce-106304

UUCD1 version

UUC-SaC-00273

Ensembl Protein ID

YBR058C

UniProt Accession

P38237; D6VQ57; UBP14_YEAST

Genbank Protein ID

CAA85001.1; CAA86402.1; DAA07177.1

Protein Name

Ubiquitin carboxyl-terminal hydrolase 14; Deubiquitinating enzyme 14; Glucose-induced degradation protein 6; Ubiquitin thioesterase 14; Ubiquitin-specific-processing protease 14

Genbank Nucleotide ID

Z35927; Z46260; BK006936

Gene Name

UBP14; GID6; YBR058C; YBR0515

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
YBR058C	YBR058C	YBR058C

Annotation

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	9305625
UBD/ZnF/ZnF_UBP	ZnF_UBP	9305625

Classification

Family	E-value	Score	Start	End
DUB/USP	1.00e-61	207.4	323	780
UBD/ZnF/ZnF_UBP	1.50e-25	87.6	190	261
UBD/Alpha-Helix/UBA	1.10e-15	55.7	591	626

Active Site

Position(s)	Description	Evidence
332	Nucleophile
737	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsn..ipelrelllekkkeklneenpkepkgellkslqklfeelw...kskkkavsprellkalkkeaeefsgyeqqDaqEfla 97
           +Gl NlgN+CY+NSv+Q+L+n  +p+   ++l    +k++ +    p+++l +++ kl++++    +   + ++p++++k++++ ++efs+++qqDa Efl+
   Q: 323  CGLINLGNSCYLNSVIQSLVNggVPNWSLDFLG---SKFPLDV-VYPDNNLKCQWIKLLNAMKcepELYPNGIKPTTFKKCIGQNHQEFSSNRQQDAMEFLT 420
           7*******************9999****99999...5555443.57899*************777777777******************************* PP
   S: 98   flldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkkeslqdcLesftkeee 199
           flld l++++                         +  +++    +dl ++ ++++++c+ c++v+ ++ep   +++p+++++e   +++ + ++++++ ++
   Q: 421  FLLDLLDKKF------------------------FSSSSSGIPNPNDLVRFMMEDRLQCNICGKVKYSYEPTEAIQIPLEENDEP--QDMLERIKAYFEGQT 496
           **********........................46778899999***********************************99965..8************** PP
   S: 200  legenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefp......leLdlspfcts............................ 267
           +e    ++c +ck+k++a+kk ++k+lP++Lil+  R+  + +++ + k ++++++p      ++Ld+s+++++                            
   Q: 497  IE----FKCANCKEKVTANKKPGFKSLPQTLILNPIRI--RLQNWIPVKTSNELSLPglidrdDMLDVSSYLSQgfdpqtenllpdedenrssftpnqcsis 592
           *9....********************************..7788*************99999667*********9999999999999999999999999999 PP
   S: 268  ...................................................................................................... 267
                                                                                                                 
   Q: 593  qliemgftqnasvralfntgnqdaesamnwlfqhmddpdlndpfvpppnvpkkdkrevdevsltsmlsmglnpnlcrkalilnngdvnrsvewvfnnmdddg 694
           999999998888888888888888888888888888888888888888887777777777777777777777777777777777777777777777777766 PP
   S: 268  .......peekqke.............kkkYeLiavvvHsG.slssGHYvayvkn...ekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
                  p     +              k Y L+av++H+G s++sGHYv+++++   +k kW+l++D+k  + +  e  +   +++Y++fY+r
   Q: 695  tfpepevP-----NeeqqqkkdlgystAKPYALTAVICHKGnSVHSGHYVVFIRKlvaDKWKWVLYNDEKLVAADSIEDMK---KNGYIYFYTR 780
           66666662.....04444467899999****************************8888999*********9997655555...7*******98 PP

UBD/ZnF/ZnF_UBP

   S: 1    kkcsvcdktenlWlcLtcgsvgCGRyveg.....HalkHye.etqhpl.....vlslstlsvycYacddyvh 61
           ++cs+cd t+nlWlcL+cg++gCGR++ g     Hal+Hy+ +++hpl     +ls+st+++ycYacdd+++
   Q: 190  NQCSSCDLTQNLWLCLHCGNIGCGREQIGidghsHALDHYRsNNNHPLaiklgSLSSSTYDLYCYACDDETR 261
           58**************************************8799*************************975 PP

UBD/Alpha-Helix/UBA

   S: 7    leqlveMGFdreealqaLraa.nnnleaAveyLldg 41
           + ql+eMGF++++ ++aL ++ n ++e A+++L+ +
   Q: 591  ISQLIEMGFTQNASVRALFNTgNQDAESAMNWLFQH 626
           89*******************************976 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Has a role in the negative regulation of gluconeogenesis. Required for proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase). Accelerates proteasomal breakdown of ubiquitinated proteins as it disassembles free ubiquitin chains that would compete with ubiquitinated proteins to bind to the proteasome.

Protein Sequence
(Fasta)

MAEAVLENVN VPAVVSKDEC IYCFESPYNE PLALNASPKH SLNICLNCFQ ATCNRHVPLH 60
IRVTEYACDT IHSNYLTIAK VEKPKQENVE ENNNNKKIKL QVIETSEDDT HNTIWSLQRF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCAGAAG CAGTACTAGA AAACGTTAAC GTTCCTGCAG TCGTTTCAAA AGATGAGTGT 60
ATTTATTGCT TTGAATCCCC TTATAATGAA CCATTGGCCC TCAATGCATC ACCTAAACAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR033864--UBA2_scUBP14-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0045721--P:negative regulation of gluconeogenesis
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016579--P:protein deubiquitination

KEGG

sce:YBR058C

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	29.80	1.00e-64	239.00
IUUC-Aml-002104	Ailuropoda melanoleuca	28.33	8.00e-74	269.00
IUUC-Atr-002580	Amborella trichopoda	31.63	2.00e-42	165.00
IUUC-Apl-003774	Anas platyrhynchos	28.74	2.00e-73	268.00
IUUC-Aca-005368	Anolis carolinensis	29.24	6.00e-80	290.00
IUUC-Aly-005727	Arabidopsis lyrata	31.34	1.00e-66	245.00
IUUC-Ath-006974	Arabidopsis thaliana	31.49	5.00e-66	243.00
IUUC-Ago-007890	Ashbya gossypii	49.75	0.00e+00	750.00
IUUC-Acl-008057	Aspergillus clavatus	34.39	2.00e-114	404.00
IUUC-Afl-008547	Aspergillus flavus	35.47	9.00e-111	392.00
IUUC-Afu-008805	Aspergillus fumigatus	35.37	3.00e-94	337.00
IUUC-Ani-009441	Aspergillus nidulans	34.55	7.00e-86	309.00
IUUC-Ang-009720	Aspergillus niger	33.70	5.00e-115	406.00
IUUC-Aor-010111	Aspergillus oryzae	32.88	6.00e-115	406.00
IUUC-Ate-010531	Aspergillus terreus	32.17	8.00e-101	359.00
IUUC-Ame-011470	Astyanax mexicanus	25.05	3.00e-58	218.00
IUUC-Bgr-012183	Blumeria graminis	32.44	4.00e-108	383.00
IUUC-Bta-013179	Bos taurus	28.40	1.00e-74	272.00
IUUC-Bci-013858	Botrytis cinerea	34.44	3.00e-118	417.00
IUUC-Bdi-014904	Brachypodium distachyon	28.99	5.00e-63	233.00
IUUC-Bol-015296	Brassica oleracea	30.05	2.00e-64	238.00
IUUC-Bra-017619	Brassica rapa	30.92	1.00e-64	239.00
IUUC-Cel-018625	Caenorhabditis elegans	27.62	4.00e-61	227.00
IUUC-Cja-019063	Callithrix jacchus	27.82	3.00e-73	268.00
IUUC-Cfa-020976	Canis familiaris	28.65	2.00e-75	275.00
IUUC-Cpo-022265	Cavia porcellus	28.51	1.00e-74	272.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	34.46	3.00e-35	140.00
IUUC-Csa-024177	Chlorocebus sabaeus	27.70	8.00e-63	233.00
IUUC-Cho-024702	Choloepus hoffmanni	26.87	1.00e-33	136.00
IUUC-Cin-025411	Ciona intestinalis	27.09	6.00e-59	220.00
IUUC-Csv-026347	Ciona savignyi	27.32	6.00e-55	207.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	33.54	5.00e-108	383.00
IUUC-Cne-026831	Cryptococcus neoformans	32.97	6.00e-99	353.00
IUUC-Cme-027335	Cyanidioschyzon merolae	26.22	2.00e-33	136.00
IUUC-Dre-027982	Danio rerio	25.84	1.00e-56	213.00
IUUC-Dno-029034	Dasypus novemcinctus	27.86	4.00e-75	274.00
IUUC-Dor-030130	Dipodomys ordii	27.75	4.00e-26	111.00
IUUC-Dse-031467	Dothistroma septosporum	30.46	1.00e-101	362.00
IUUC-Dme-032075	Drosophila melanogaster	28.11	7.00e-66	243.00
IUUC-Ete-032865	Echinops telfairi	26.08	5.00e-59	220.00
IUUC-Eca-034059	Equus caballus	28.14	2.00e-72	265.00
IUUC-Eeu-035304	Erinaceus europaeus	30.28	1.00e-68	252.00
IUUC-Fca-035515	Felis catus	28.40	2.00e-74	271.00
IUUC-Fal-037271	Ficedula albicollis	29.52	1.00e-72	266.00
IUUC-Fox-037745	Fusarium oxysporum	33.67	1.00e-114	405.00
IUUC-Fso-038158	Fusarium solani	34.39	2.00e-117	414.00
IUUC-Gmo-039071	Gadus morhua	27.53	4.00e-60	224.00
IUUC-Ggr-040098	Gaeumannomyces graminis	32.05	2.00e-97	348.00
IUUC-Gga-040635	Gallus gallus	28.24	3.00e-77	281.00
IUUC-Gac-042528	Gasterosteus aculeatus	26.53	6.00e-63	233.00
IUUC-Gma-043614	Glycine max	30.17	2.00e-60	224.00
IUUC-Ggo-044602	Gorilla gorilla	28.12	4.00e-73	267.00
IUUC-Hsa-045959	Homo sapiens	28.12	4.00e-73	267.00
IUUC-Hvu-047563	Hordeum vulgare	32.66	1.00e-68	252.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	28.06	1.00e-74	273.00
IUUC-Kpa-049156	Komagataella pastoris	37.68	6.00e-132	462.00
IUUC-Lch-049648	Latimeria chalumnae	27.58	1.00e-72	266.00
IUUC-Lpe-051523	Leersia perrieri	27.70	3.00e-63	234.00
IUUC-Loc-052072	Lepisosteus oculatus	25.99	3.00e-61	228.00
IUUC-Lma-053216	Leptosphaeria maculans	32.23	2.00e-104	373.00
IUUC-Laf-054327	Loxodonta africana	28.09	1.00e-74	272.00
IUUC-Mcc-055443	Macaca mulatta	28.06	3.00e-72	264.00
IUUC-Meu-056298	Macropus eugenii	27.91	6.00e-40	157.00
IUUC-Mor-057106	Magnaporthe oryzae	33.95	2.00e-110	391.00
IUUC-Mpo-057589	Magnaporthe poae	31.84	4.00e-98	350.00
IUUC-Mtr-058680	Medicago truncatula	30.49	2.00e-65	241.00
IUUC-Mla-058903	Melampsora laricipopulina	29.24	1.00e-84	305.00
IUUC-Mga-059669	Meleagris gallopavo	28.51	6.00e-73	266.00
IUUC-Mvi-060476	Microbotryum violaceum	31.78	7.00e-94	336.00
IUUC-Mmr-060575	Microcebus murinus	27.98	9.00e-74	269.00
IUUC-Mdo-062183	Monodelphis domestica	28.15	1.00e-73	269.00
IUUC-Mmu-063592	Mus musculus	27.82	5.00e-75	273.00
IUUC-Mac-065634	Musa acuminata	28.61	7.00e-35	140.00
IUUC-Mpu-066082	Mustela putorius furo	28.54	7.00e-74	270.00
IUUC-Mlu-067345	Myotis lucifugus	28.17	3.00e-75	274.00
IUUC-Nfi-068558	Neosartorya fischeri	36.06	2.00e-112	397.00
IUUC-Ncr-068960	Neurospora crassa	33.78	2.00e-103	368.00
IUUC-Nle-070173	Nomascus leucogenys	28.38	7.00e-74	270.00
IUUC-Opr-070556	Ochotona princeps	28.56	2.00e-73	268.00
IUUC-Ont-071502	Oreochromis niloticus	27.40	1.00e-62	233.00
IUUC-Oan-072959	Ornithorhynchus anatinus	27.23	1.00e-19	87.80
IUUC-Ocu-074861	Oryctolagus cuniculus	28.23	2.00e-74	272.00
IUUC-Oba-075109	Oryza barthii	28.37	8.00e-68	249.00
IUUC-Obr-076292	Oryza brachyantha	29.04	2.00e-62	232.00
IUUC-Ogl-077065	Oryza glaberrima	29.42	3.00e-72	264.00
IUUC-Ogu-078776	Oryza glumaepatula	28.30	5.00e-70	257.00
IUUC-Oin-080048	Oryza indica	29.14	2.00e-69	255.00
IUUC-Olo-080711	Oryza longistaminata	29.36	4.00e-65	240.00
IUUC-Ome-081506	Oryza meridionalis	30.21	7.00e-67	246.00
IUUC-Oni-082320	Oryza nivara	30.33	5.00e-67	247.00
IUUC-Opu-083801	Oryza punctata	28.61	2.00e-62	231.00
IUUC-Oru-085139	Oryza rufipogon	30.19	2.00e-66	245.00
IUUC-Osa-085713	Oryza sativa	29.42	2.00e-72	265.00
IUUC-Ola-086951	Oryzias latipes	25.84	1.00e-56	213.00
IUUC-Olu-087822	Ostreococcus lucimarinus	26.75	2.00e-58	218.00
IUUC-Oga-088625	Otolemur garnettii	28.06	4.00e-72	264.00
IUUC-Oar-089995	Ovis aries	28.22	6.00e-74	270.00
IUUC-Ptr-090640	Pan troglodytes	28.82	2.00e-75	275.00
IUUC-Pan-091974	Papio anubis	27.96	1.00e-72	266.00
IUUC-Psi-093957	Pelodiscus sinensis	27.91	5.00e-78	283.00
IUUC-Pma-094242	Petromyzon marinus	27.00	7.00e-29	119.00
IUUC-Pno-094835	Phaeosphaeria nodorum	33.12	9.00e-89	319.00
IUUC-Ppa-095901	Physcomitrella patens	29.50	1.00e-65	242.00
IUUC-Pfo-097148	Poecilia formosa	26.59	6.00e-63	233.00
IUUC-Pab-098068	Pongo abelii	29.10	9.00e-57	213.00
IUUC-Pop-098943	Populus trichocarpa	30.76	4.00e-59	221.00
IUUC-Pca-100738	Procavia capensis	28.91	4.00e-53	201.00
IUUC-Ppe-101315	Prunus persica	30.12	2.00e-63	235.00
IUUC-Pva-102154	Pteropus vampyrus	28.28	8.00e-72	263.00
IUUC-Pgr-103343	Puccinia graminis	29.17	4.00e-69	253.00
IUUC-Ptt-103928	Puccinia triticina	26.28	3.00e-67	247.00
IUUC-Pte-104306	Pyrenophora teres	32.49	5.00e-93	333.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	32.65	8.00e-97	346.00
IUUC-Rno-105801	Rattus norvegicus	27.83	8.00e-74	270.00
IUUC-Sha-107635	Sarcophilus harrisii	28.52	4.00e-74	270.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	31.71	2.00e-96	345.00
IUUC-Spo-108144	Schizosaccharomyces pombe	32.65	3.00e-100	357.00
IUUC-Smo-108848	Selaginella moellendorffii	30.94	6.00e-66	243.00
IUUC-Sit-110728	Setaria italica	28.35	1.00e-69	255.00
IUUC-Sly-111523	Solanum lycopersicum	30.06	2.00e-64	238.00
IUUC-Stu-112122	Solanum tuberosum	35.63	4.00e-10	57.00
IUUC-Sar-113733	Sorex araneus	28.48	1.00e-26	112.00
IUUC-Sbi-114419	Sorghum bicolor	28.17	2.00e-66	245.00
IUUC-Sre-115225	Sporisorium reilianum	29.20	7.00e-86	309.00
IUUC-Ssc-115686	Sus scrofa	28.09	3.00e-73	267.00
IUUC-Tgu-117346	Taeniopygia guttata	28.14	3.00e-74	271.00
IUUC-Tru-118350	Takifugu rubripes	26.02	2.00e-60	225.00
IUUC-Tsy-119278	Tarsius syrichta	25.13	6.00e-48	183.00
IUUC-Tni-120658	Tetraodon nigroviridis	26.76	8.00e-59	219.00
IUUC-Tca-121585	Theobroma cacao	29.68	2.00e-56	212.00
IUUC-Tre-122043	Trichoderma reesei	33.50	2.00e-107	381.00
IUUC-Tvi-122303	Trichoderma virens	33.58	1.00e-110	391.00
IUUC-Tae-123798	Triticum aestivum	29.68	2.00e-70	258.00
IUUC-Tur-126732	Triticum urartu	28.18	2.00e-66	244.00
IUUC-Tme-126909	Tuber melanosporum	34.67	2.00e-117	414.00
IUUC-Tbe-127261	Tupaia belangeri	28.37	6.00e-36	144.00
IUUC-Ttr-129119	Tursiops truncatus	28.19	5.00e-36	144.00
IUUC-Uma-129599	Ustilago maydis	29.71	6.00e-93	333.00
IUUC-Vda-129688	Verticillium dahliae	32.84	2.00e-110	391.00
IUUC-Vpa-130170	Vicugna pacos	22.59	1.00e-36	146.00
IUUC-Vvi-131116	Vitis vinifera	30.43	4.00e-57	214.00
IUUC-Xtr-131953	Xenopus tropicalis	29.51	1.00e-64	239.00
IUUC-Xma-133837	Xiphophorus maculatus	26.57	3.00e-63	234.00
IUUC-Yli-134510	Yarrowia lipolytica	34.33	2.00e-107	381.00
IUUC-Zma-135786	Zea mays	29.46	1.00e-58	219.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence