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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Ath-006855
UUCD1 version UUC-ArT-00270
Ensembl Protein ID AT5G58230.1
UniProt Accession O22467; MSI1_ARATH
Genbank Protein ID AAB70242.1; BAA96914.1; AED97021.1; AAL24356.1; AAM47965.1
Protein Name Histone-binding protein MSI1; CAF-1 p48 homolog; Chromatin assembly factor 1 subunit MSI1; Protein MULTICOPY SUPPRESSOR OF IRA 1; Protein medicis; WD-40 repeat-containing protein MSI1
Genbank Nucleotide ID AF016846; AB019228; CP002688; AY059874; AY114646
Gene Name MSI1; At5g58230; MCK7.10
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
AT5G58230 AT5G58230.1 AT5G58230.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
Protein-protein Interaction
iRefIndexPINAHINTMentha
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.90e-29 101.3 272 305
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf...sdtllvsGsdDgtikvWDlrt 32
           H+ +v+claf   +++ +++Gs D+t+k++Dlr+
   Q: 272  HSMEVNCLAFnpfNEWVVATGSTDKTVKLFDLRK 305
           8889*******977799**************986 PP
   
Organism Arabidopsis thaliana
Functional Description
(View)

Functional Description


     Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair, and the fertilization independent seed (FIS) complex, a polycomb group protein complex which is required to maintain the transcriptionally repressive state of homeotic genes throughout development. Required for several aspects of plant development including normal leaf expansion, correct development of flowers, normal endosperm development, repression of parthenogenetic seed development and repression of floral homeotic genes in leaf tissue. Also required for the recruitment of chromosomal DNA into heterochromatic chromocenters. Also involved in regulation of imprinted genes. Acts together with RBR1 to repress the expression of MET1 during female gametogenesis. This in turn activates expression of the imprinted genes FIS2 and FWA.
 Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair, and the fertilization independent seed (FIS) complex, a polycomb group protein complex which is required to maintain the transcriptionally repressive state of homeotic genes throughout development. Required for several aspects of plant development including normal leaf expansion, correct development of flowers, normal endosperm development, repression of parthenogenetic seed development and repression of floral homeotic genes in leaf tissue. Also required for the recruitment of chromosomal DNA into heterochromatic chromocenters. Also involved in regulation of imprinted genes. Acts together with RBR1 to repress the expression of MET1 during female gametogenesis. This in turn activates expression of the imprinted genes FIS2 and FWA.
Protein Sequence
(Fasta)
MGKDEEEMRG EIEERLINEE YKIWKKNTPF LYDLVITHAL EWPSLTVEWL PDREEPSGKD 60
YSVQKMILGT HTSESEPNYL MLAQVQLPLD DTESEARQYD DDRSEFGGFG CATGKVQIIQ 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Ath-006855|E3,WD_repeat|Arabidopsis thaliana
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATTCAGAAAC AGAAGCGAGA AGTTTCTTAC AATTTGTAAA GAGATCTGTT TTAGGGTTTT 60
GCCTTGTTCT TGTGGCGGGA ATAACAAAGA CATCGCCGAT ATGGGGAAAG ACGAAGAGGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Ath-006855|E3,WD_repeat|Arabidopsis thaliana
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0235--DNA replication
KW-0287--Flowering
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR022052--Histone-bd_RBBP4_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12265--CAF1C_H4-bd
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0009507--C:chloroplast
GO:0005677--C:chromatin silencing complex
GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0005634--C:nucleus
GO:0043234--C:protein complex
GO:0008283--P:cell proliferation
GO:0016569--P:covalent chromatin modification
GO:0006260--P:DNA replication
GO:0009793--P:embryo development ending in seed dormancy
GO:0009908--P:flower development
GO:0031507--P:heterochromatin assembly
GO:0070828--P:heterochromatin organization
GO:0048366--P:leaf development
GO:0007275--P:multicellular organism development
GO:0009555--P:pollen development
GO:0045787--P:positive regulation of cell cycle
GO:0009909--P:regulation of flower development
GO:0006349--P:regulation of gene expression by genetic imprinting
GO:2000653--P:regulation of genetic imprinting
GO:0006355--P:regulation of transcription, DNA-templated
GO:0010214--P:seed coat development
GO:0048316--P:seed development
GO:0006351--P:transcription, DNA-templated
GO:0010026--P:trichome differentiation
KEGG ath:AT5G58230
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000757 Aegilops tauschii 78.97 0.00e+00 668.00
IUUC-Aml-001256 Ailuropoda melanoleuca 67.25 2.00e-163 567.00
IUUC-Atr-003075 Amborella trichopoda 86.56 0.00e+00 768.00
IUUC-Apl-003952 Anas platyrhynchos 68.25 2.00e-166 577.00
IUUC-Aca-004508 Anolis carolinensis 68.25 3.00e-166 577.00
IUUC-Aly-006342 Arabidopsis lyrata 98.83 0.00e+00 850.00
IUUC-Ago-007892 Ashbya gossypii 35.64 1.00e-68 252.00
IUUC-Acl-008163 Aspergillus clavatus 48.53 7.00e-114 403.00
IUUC-Afl-008645 Aspergillus flavus 48.55 9.00e-114 402.00
IUUC-Afu-009091 Aspergillus fumigatus 48.28 1.00e-111 395.00
IUUC-Ani-009478 Aspergillus nidulans 45.45 9.00e-96 343.00
IUUC-Ang-009707 Aspergillus niger 48.28 2.00e-110 392.00
IUUC-Aor-010028 Aspergillus oryzae 48.55 9.00e-114 402.00
IUUC-Ate-010416 Aspergillus terreus 48.77 6.00e-115 406.00
IUUC-Ame-010598 Astyanax mexicanus 67.75 3.00e-164 570.00
IUUC-Bgr-012001 Blumeria graminis 44.42 3.00e-97 348.00
IUUC-Bta-012851 Bos taurus 68.25 2.00e-166 577.00
IUUC-Bci-013815 Botrytis cinerea 47.38 2.00e-113 401.00
IUUC-Bdi-014926 Brachypodium distachyon 87.56 0.00e+00 766.00
IUUC-Bol-015856 Brassica oleracea 94.16 0.00e+00 823.00
IUUC-Bra-016725 Brassica rapa 84.27 0.00e+00 758.00
IUUC-Cel-018587 Caenorhabditis elegans 60.85 4.00e-146 510.00
IUUC-Cja-019884 Callithrix jacchus 68.25 2.00e-166 577.00
IUUC-Cfa-020343 Canis familiaris 68.25 2.00e-166 577.00
IUUC-Cpo-021591 Cavia porcellus 68.25 2.00e-166 577.00
IUUC-Cre-022563 Chlamydomonas reinhardtii 69.08 4.00e-173 600.00
IUUC-Csa-023738 Chlorocebus sabaeus 67.50 3.00e-164 570.00
IUUC-Cho-024506 Choloepus hoffmanni 68.00 7.00e-165 572.00
IUUC-Cin-025589 Ciona intestinalis 65.70 1.00e-164 572.00
IUUC-Csv-026216 Ciona savignyi 64.73 3.00e-163 566.00
IUUC-Cgl-026564 Colletotrichum gloeosporioides 45.17 2.00e-106 378.00
IUUC-Cne-026792 Cryptococcus neoformans 50.38 7.00e-124 436.00
IUUC-Cme-027307 Cyanidioschyzon merolae 49.88 2.00e-121 428.00
IUUC-Dre-028742 Danio rerio 67.50 7.00e-164 569.00
IUUC-Dno-029114 Dasypus novemcinctus 68.25 2.00e-166 577.00
IUUC-Dor-030733 Dipodomys ordii 58.25 9.00e-134 469.00
IUUC-Dse-031282 Dothistroma septosporum 44.30 2.00e-96 345.00
IUUC-Dme-032126 Drosophila melanogaster 66.50 1.00e-163 568.00
IUUC-Ete-032731 Echinops telfairi 68.25 2.00e-166 577.00
IUUC-Eca-034138 Equus caballus 67.25 3.00e-163 567.00
IUUC-Eeu-034644 Erinaceus europaeus 62.78 1.00e-80 293.00
IUUC-Fca-036202 Felis catus 68.25 2.00e-166 577.00
IUUC-Fal-037084 Ficedula albicollis 68.25 2.00e-166 577.00
IUUC-Fox-037974 Fusarium oxysporum 46.84 4.00e-112 397.00
IUUC-Fso-038246 Fusarium solani 45.88 2.00e-101 362.00
IUUC-Gmo-038593 Gadus morhua 67.08 2.00e-164 571.00
IUUC-Ggr-039741 Gaeumannomyces graminis 47.70 2.00e-107 381.00
IUUC-Gga-040396 Gallus gallus 68.25 2.00e-166 577.00
IUUC-Gac-041389 Gasterosteus aculeatus 66.91 3.00e-164 570.00
IUUC-Gma-042791 Glycine max 90.22 0.00e+00 781.00
IUUC-Ggo-045422 Gorilla gorilla 62.38 3.00e-145 507.00
IUUC-Hsa-045683 Homo sapiens 68.25 2.00e-166 577.00
IUUC-Hvu-047457 Hordeum vulgare 88.94 1.00e-106 377.00
IUUC-Itr-047950 Ictidomys tridecemlineatus 68.25 2.00e-166 577.00
IUUC-Kpa-049119 Komagataella pastoris 36.98 4.00e-73 268.00
IUUC-Lch-050545 Latimeria chalumnae 67.57 6.00e-167 579.00
IUUC-Lpe-051337 Leersia perrieri 87.29 0.00e+00 763.00
IUUC-Loc-052473 Lepisosteus oculatus 67.75 4.00e-165 573.00
IUUC-Lma-053275 Leptosphaeria maculans 42.86 7.00e-66 243.00
IUUC-Laf-054114 Loxodonta africana 68.25 2.00e-166 577.00
IUUC-Mcc-055648 Macaca mulatta 68.25 2.00e-166 577.00
IUUC-Meu-056490 Macropus eugenii 68.25 2.00e-166 577.00
IUUC-Mor-056947 Magnaporthe oryzae 47.60 3.00e-106 377.00
IUUC-Mpo-057602 Magnaporthe poae 47.84 5.00e-108 384.00
IUUC-Mtr-057853 Medicago truncatula 89.39 0.00e+00 762.00
IUUC-Mla-058884 Melampsora laricipopulina 52.16 9.00e-123 432.00
IUUC-Mga-059452 Meleagris gallopavo 68.25 2.00e-166 578.00
IUUC-Mvi-060450 Microbotryum violaceum 53.87 4.00e-126 444.00
IUUC-Mmr-061008 Microcebus murinus 67.50 8.00e-164 569.00
IUUC-Mdo-062817 Monodelphis domestica 68.50 2.00e-166 578.00
IUUC-Mmu-063282 Mus musculus 68.25 2.00e-166 577.00
IUUC-Mac-065480 Musa acuminata 88.44 0.00e+00 771.00
IUUC-Mpu-066529 Mustela putorius furo 67.75 4.00e-165 573.00
IUUC-Mlu-068072 Myotis lucifugus 68.25 2.00e-166 577.00
IUUC-Nfi-068374 Neosartorya fischeri 48.28 1.00e-109 389.00
IUUC-Ncr-068794 Neurospora crassa 45.72 1.00e-107 382.00
IUUC-Nle-069577 Nomascus leucogenys 68.25 2.00e-166 577.00
IUUC-Opr-070245 Ochotona princeps 56.00 8.00e-126 442.00
IUUC-Ont-071809 Oreochromis niloticus 67.75 3.00e-164 570.00
IUUC-Oan-073579 Ornithorhynchus anatinus 68.25 7.00e-166 575.00
IUUC-Ocu-074778 Oryctolagus cuniculus 67.50 3.00e-164 570.00
IUUC-Oba-075719 Oryza barthii 75.78 0.00e+00 652.00
IUUC-Obr-076859 Oryza brachyantha 87.07 0.00e+00 757.00
IUUC-Ogl-077920 Oryza glaberrima 87.29 0.00e+00 761.00
IUUC-Ogu-078048 Oryza glumaepatula 75.78 0.00e+00 650.00
IUUC-Oin-079960 Oryza indica 72.88 1.00e-176 611.00
IUUC-Olo-080553 Oryza longistaminata 72.64 0.00e+00 637.00
IUUC-Ome-081835 Oryza meridionalis 87.29 0.00e+00 765.00
IUUC-Oni-082494 Oryza nivara 75.54 0.00e+00 646.00
IUUC-Opu-083913 Oryza punctata 83.62 0.00e+00 716.00
IUUC-Oru-084666 Oryza rufipogon 87.29 0.00e+00 761.00
IUUC-Osa-085884 Oryza sativa 87.29 0.00e+00 761.00
IUUC-Ola-086664 Oryzias latipes 67.75 3.00e-164 570.00
IUUC-Olu-087579 Ostreococcus lucimarinus 67.94 2.00e-160 557.00
IUUC-Oga-088364 Otolemur garnettii 64.76 8.00e-153 532.00
IUUC-Oar-089652 Ovis aries 68.25 2.00e-166 577.00
IUUC-Ptr-091598 Pan troglodytes 67.50 5.00e-164 569.00
IUUC-Pan-092412 Papio anubis 67.50 3.00e-164 570.00
IUUC-Psi-093300 Pelodiscus sinensis 66.75 2.00e-153 534.00
IUUC-Pma-094307 Petromyzon marinus 66.58 1.00e-165 575.00
IUUC-Pno-095153 Phaeosphaeria nodorum 45.59 2.00e-100 358.00
IUUC-Ppa-095800 Physcomitrella patens 76.30 0.00e+00 669.00
IUUC-Pfo-097240 Poecilia formosa 66.18 3.00e-163 567.00
IUUC-Pab-097697 Pongo abelii 68.25 2.00e-166 577.00
IUUC-Pop-099709 Populus trichocarpa 90.09 0.00e+00 790.00
IUUC-Pca-100642 Procavia capensis 60.36 1.00e-139 489.00
IUUC-Ppe-101212 Prunus persica 92.42 0.00e+00 800.00
IUUC-Pva-102253 Pteropus vampyrus 68.25 2.00e-166 577.00
IUUC-Pgr-103441 Puccinia graminis 50.13 1.00e-116 412.00
IUUC-Pte-104332 Pyrenophora teres 44.97 3.00e-101 361.00
IUUC-Pyt-104516 Pyrenophora triticirepentis 44.97 3.00e-101 361.00
IUUC-Rno-105678 Rattus norvegicus 68.25 2.00e-166 577.00
IUUC-Sce-106364 Saccharomyces cerevisiae 35.20 4.00e-66 244.00
IUUC-Sha-107575 Sarcophilus harrisii 68.50 2.00e-166 577.00
IUUC-Sja-108001 Schizosaccharomyces japonicus 48.50 2.00e-107 381.00
IUUC-Spo-108145 Schizosaccharomyces pombe 48.15 1.00e-107 382.00
IUUC-Smo-109159 Selaginella moellendorffii 76.46 0.00e+00 671.00
IUUC-Sit-110144 Setaria italica 87.10 0.00e+00 729.00
IUUC-Sly-111680 Solanum lycopersicum 91.02 0.00e+00 798.00
IUUC-Stu-111931 Solanum tuberosum 92.44 0.00e+00 786.00
IUUC-Sar-113236 Sorex araneus 61.25 1.00e-140 491.00
IUUC-Sbi-114637 Sorghum bicolor 86.62 0.00e+00 755.00
IUUC-Sre-114980 Sporisorium reilianum 52.72 4.00e-131 460.00
IUUC-Ssc-116352 Sus scrofa 67.25 1.00e-163 568.00
IUUC-Tgu-116925 Taeniopygia guttata 68.00 5.00e-166 576.00
IUUC-Tru-117549 Takifugu rubripes 67.41 9.00e-162 562.00
IUUC-Tsy-118854 Tarsius syrichta 67.50 9.00e-164 569.00
IUUC-Tni-120398 Tetraodon nigroviridis 67.66 5.00e-164 570.00
IUUC-Tca-121841 Theobroma cacao 91.98 0.00e+00 803.00
IUUC-Tre-122190 Trichoderma reesei 47.09 1.00e-103 369.00
IUUC-Tvi-122304 Trichoderma virens 46.84 3.00e-111 394.00
IUUC-Tae-124648 Triticum aestivum 86.59 0.00e+00 733.00
IUUC-Tur-126850 Triticum urartu 84.26 2.00e-166 577.00
IUUC-Tme-126949 Tuber melanosporum 50.37 9.00e-118 416.00
IUUC-Tbe-128010 Tupaia belangeri 60.50 2.00e-139 488.00
IUUC-Ttr-128558 Tursiops truncatus 61.50 3.00e-143 500.00
IUUC-Uma-129424 Ustilago maydis 52.72 2.00e-133 468.00
IUUC-Vda-129873 Verticillium dahliae 46.42 2.00e-110 392.00
IUUC-Vpa-130079 Vicugna pacos 67.75 1.00e-164 571.00
IUUC-Vvi-131585 Vitis vinifera 92.22 0.00e+00 804.00
IUUC-Xtr-132005 Xenopus tropicalis 67.57 1.00e-165 575.00
IUUC-Xma-133066 Xiphophorus maculatus 67.75 3.00e-164 570.00
IUUC-Yli-134334 Yarrowia lipolytica 36.60 5.00e-78 284.00
IUUC-Zma-135873 Zea mays 86.62 0.00e+00 729.00
Created Date 25-Jun-2017

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