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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Sce-106400
UUCD1 version UUC-SaC-00066
Ensembl Protein ID YOR080W
UniProt Accession Q08496; D6W2E3; O00034; Q7LGN4; DIA2_YEAST
Genbank Protein ID CAA94565.1; CAA99273.1; CAA99275.1; DAA10859.2
Protein Name Protein DIA2; Digs into agar protein 2
Genbank Nucleotide ID Z70678; Z74988; Z74989; BK006948
Gene Name DIA2; YOR080W; YOR29-31
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YOR080W YOR080W YOR080W
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Post-translational Modifications (PTMs)
dbPAFdbPTMUniProtBioGRID
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box F-box 20219119; 19858292
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/SCF/F-box 0.014 13.9 204 241
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/SCF/F-box
   S: 100  aglldrlpeeilveilklldkeellraarvcrrwq.el 136
           ++l+ +lp eil  i+++ +++el+++++vc++w+ ++
   Q: 204  TDLVGNLPIEILPIIFQRFTTKELVTLSLVCNKWRdKI 241
           566789****************************9655 PP
   
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     F-box protein component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity). The SCF(DIA2) complex is specifically involved in the pheromone induced degradation of phosphorylated TEC1. The SCF(DIA2) complex binds to DNA replication origins. Involved in DNA replication, genome stability, and the control of cell cycle, probably through its association to replication origins to facilitate the ubiquitination of another origin-binding protein. Required for invasive growth and growth under alkaline conditions.
 F-box protein component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity). The SCF(DIA2) complex is specifically involved in the pheromone induced degradation of phosphorylated TEC1. The SCF(DIA2) complex binds to DNA replication origins. Involved in DNA replication, genome stability, and the control of cell cycle, probably through its association to replication origins to facilitate the ubiquitination of another origin-binding protein. Required for invasive growth and growth under alkaline conditions.
Protein Sequence
(Fasta)
MSSPGNSGVA IDSTVLKAIE LGTRLFKSGE YLQAKRIFTN ALRVCDSYSQ EQIMRIRNAY 60
QLDTARPDNK RLYHPRYIKI LDNICACYEK LNDLKSCLDV SQRLLKLEPG NIKCYIRCTR 120
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Protein Fasta Sequence


>IUUC-Sce-106400|E3,F-box|Saccharomyces cerevisiae
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Nucleotide Sequence
(Fasta)
ATGTCTTCCC CAGGGAATTC AGGCGTGGCT ATAGATTCTA CCGTTCTGAA AGCAATTGAA 60
TTAGGAACGA GGCTTTTTAA ATCTGGAGAA TATTTGCAAG CGAAAAGGAT ATTCACAAAT 120
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Nucleotide Fasta Sequence


>IUUC-Sce-106400|E3,F-box|Saccharomyces cerevisiae
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Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0433--Leucine-rich repeat
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0802--TPR repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR001810--F-box_dom
IPR032675--L_dom-like
IPR001611--Leu-rich_rpt
IPR006553--Leu-rich_rpt_Cys-con_subtyp
IPR013026--TPR-contain_dom
IPR011990--TPR-like_helical_dom
PROSITE

PS50181--FBOX
PS51450--LRR
PS50293--TPR_REGION
Pfam

PF00646--F-box
SMART

SM00256--FBOX
SM00367--LRR_CC
Gene Ontology

GO:0000781--C:chromosome, telomeric region
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0003688--F:DNA replication origin binding
GO:0007049--P:cell cycle
GO:0030466--P:chromatin silencing at silent mating-type cassette
GO:0006348--P:chromatin silencing at telomere
GO:0001403--P:invasive growth in response to glucose limitation
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0006275--P:regulation of DNA replication
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
KEGG sce:YOR080W
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ago-007793 Ashbya gossypii 26.41 7.00e-46 176.00
IUUC-Ang-009799 Aspergillus niger 20.76 1.00e-04 39.30
IUUC-Bgr-012086 Blumeria graminis 29.13 2.00e-04 38.50
IUUC-Bci-013665 Botrytis cinerea 33.33 9.00e-06 43.10
IUUC-Cel-018357 Caenorhabditis elegans 23.91 1.60e+00 29.60
IUUC-Ete-032991 Echinops telfairi 30.34 6.00e-03 34.70
IUUC-Kpa-049108 Komagataella pastoris 22.73 2.00e-18 85.90
IUUC-Mor-057081 Magnaporthe oryzae 20.86 2.00e-03 35.80
IUUC-Mla-058833 Melampsora laricipopulina 44.19 2.00e-03 35.40
IUUC-Mvi-060308 Microbotryum violaceum 27.69 9.00e-05 39.70
IUUC-Pno-095042 Phaeosphaeria nodorum 19.18 1.00e-05 42.40
IUUC-Pgr-103647 Puccinia graminis 29.41 2.00e-06 42.70
IUUC-Ssl-108627 Sclerotinia sclerotiorum 24.84 9.00e-07 46.20
IUUC-Tni-120506 Tetraodon nigroviridis 27.05 4.00e-06 42.70
Created Date 25-Jun-2017

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