iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
CPLM	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBA	UBA	11528422; 22847417
ULD/UDP/UBQ/UBQ_PIM	UBQ_PIM	10807547

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UBA	5.70e-10	39.4	540	577
ULD/UDP/UBQ/UBQ_PIM	4.30e-25	87.8	28	101

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGF.dreealqaLraannnleaAveyLl 39
           ++++leql +MGF +re++lqaL a++++++aA+e+Ll
   Q: 540  FQQQLEQLSAMGFlNREANLQALIATGGDINAAIERLL 577
           799**********************************9 PP

ULD/UDP/UBQ/UBQ_PIM

   S: 1    mkltvktlkgkefelevseddtveelKekiakesgvppeqqkLIyaGkiLkDdttLselgikdgsvvhlvvkksk 75
           mk+tvkt+k+ke e+ v e+++v+++Ke+i+k+++ +++q+ LI+aGkiLkD++tLs++gi+dg +vhlv+k+++
   Q: 28   MKVTVKTPKEKE-EFAVPENSSVQQFKEEISKRFKSHIDQLVLIFAGKILKDQDTLSQHGIHDGLTVHLVIKTQN 101
           99**********.***********************************************************987 PP

Organism

Rattus norvegicus

Functional Description
(View)

Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome. Plays a role in the ERAD pathway via its interaction with ER-localized proteins UBXN4, VCP and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome. Plays a role in unfolded protein response (UPR) by attenuating the induction of UPR-inducible genes, DDTI3/CHOP, HSPA5 and PDIA2 during ER stress. Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion. Negatively regulates the TICAM1/TRIF-dependent toll-like receptor signaling pathway by decreasing the abundance of TICAM1 via the autophagic pathway. Plays a key role in the regulation of the levels of PSEN1 by targeting its accumulation to aggresomes which may then be removed from cells by autophagocytosis. Promotes the ubiquitination and lysosomal degradation of ORAI1, consequently downregulating the ORAI1-mediated Ca2+ mobilization (By similarity). Suppresses the maturation and proteasomal degradation of amyloid beta A4 protein (A4) by stimulating the lysine 63 (K63)-linked polyubiquitination. Delays the maturation of A4 by sequestering it in the Golgi apparatus and preventing its transport to the cell surface for subsequent processing (PubMed:22847417). Promotes the surface expression of GABA-A receptors (PubMed:11528422).

Protein Sequence
(Fasta)

MAESAESGGP PGAQDSAADS GPAEPKIMKV TVKTPKEKEE FAVPENSSVQ QFKEEISKRF 60
KSHIDQLVLI FAGKILKDQD TLSQHGIHDG LTVHLVIKTQ NRPQDNSAQQ TNTTGNSVTS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACGAGCGTG GGGGAGGTGC GGGAGGAGGA AGCGGCGGCG ACGCGGAGAG TCCCCGCGTC 60
CACACGGCAG CCGATCGCCC ACCGGGGCCT GCACCCGCAG CCCGCGTCTA CGCACCGTCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0072--Autophagy
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0903--Direct protein sequencing
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0539--Nucleus
KW-0647--Proteasome
KW-1185--Reference proteome
KW-0832--Ubl conjugation

Interpro

IPR006636--STI1_HS-bd
IPR015940--UBA
IPR009060--UBA-like
IPR015496--Ubiquilin
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS50030--UBA
PS50053--UBIQUITIN_2

Pfam

PF00627--UBA
PF00240--ubiquitin

SMART

SM00727--STI1
SM00165--UBA
SM00213--UBQ

Gene Ontology

GO:0016235--C:aggresome
GO:0005776--C:autophagosome
GO:0005737--C:cytoplasm
GO:0031410--C:cytoplasmic vesicle
GO:0005783--C:endoplasmic reticulum
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0000502--C:proteasome complex
GO:0031593--F:polyubiquitin binding
GO:0019904--F:protein domain specific binding
GO:0035973--P:aggrephagy
GO:0071456--P:cellular response to hypoxia
GO:1901340--P:negative regulation of store-operated calcium channel activity
GO:1903071--P:positive regulation of ER-associated ubiquitin-dependent protein catabolic process
GO:0031398--P:positive regulation of protein ubiquitination
GO:1902175--P:regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:0031396--P:regulation of protein ubiquitination
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG

rno:114590

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000864	Aegilops tauschii	50.35	7.00e-38	152.00
IUUC-Aml-001461	Ailuropoda melanoleuca	83.08	0.00e+00	773.00
IUUC-Atr-002470	Amborella trichopoda	39.19	4.00e-44	172.00
IUUC-Apl-003241	Anas platyrhynchos	78.73	0.00e+00	699.00
IUUC-Aca-004511	Anolis carolinensis	77.62	0.00e+00	715.00
IUUC-Aly-005736	Arabidopsis lyrata	37.22	4.00e-53	202.00
IUUC-Ath-007271	Arabidopsis thaliana	40.26	4.00e-47	182.00
IUUC-Ago-007963	Ashbya gossypii	37.68	2.00e-08	53.50
IUUC-Bta-013048	Bos taurus	84.58	0.00e+00	793.00
IUUC-Bdi-014506	Brachypodium distachyon	36.01	1.00e-53	204.00
IUUC-Bol-015452	Brassica oleracea	35.56	2.00e-48	186.00
IUUC-Bra-016907	Brassica rapa	34.92	4.00e-50	192.00
IUUC-Cel-018631	Caenorhabditis elegans	38.22	8.00e-68	251.00
IUUC-Cja-019976	Callithrix jacchus	88.01	0.00e+00	808.00
IUUC-Cfa-020092	Canis familiaris	87.46	0.00e+00	797.00
IUUC-Cpo-022388	Cavia porcellus	87.28	0.00e+00	785.00
IUUC-Csa-024087	Chlorocebus sabaeus	87.50	0.00e+00	800.00
IUUC-Cho-024834	Choloepus hoffmanni	87.82	0.00e+00	805.00
IUUC-Cin-025136	Ciona intestinalis	51.47	4.00e-111	395.00
IUUC-Csv-026009	Ciona savignyi	48.34	7.00e-114	404.00
IUUC-Cne-026833	Cryptococcus neoformans	27.95	5.00e-12	65.50
IUUC-Cme-027155	Cyanidioschyzon merolae	58.82	2.00e-34	140.00
IUUC-Dno-028970	Dasypus novemcinctus	73.51	0.00e+00	635.00
IUUC-Dor-030519	Dipodomys ordii	86.58	0.00e+00	769.00
IUUC-Dse-031421	Dothistroma septosporum	28.14	9.00e-13	68.20
IUUC-Dme-032013	Drosophila melanogaster	46.35	1.00e-113	403.00
IUUC-Ete-032273	Echinops telfairi	85.71	0.00e+00	774.00
IUUC-Eca-033667	Equus caballus	85.28	0.00e+00	805.00
IUUC-Fca-036179	Felis catus	84.79	0.00e+00	762.00
IUUC-Fal-037642	Ficedula albicollis	78.63	0.00e+00	760.00
IUUC-Gmo-039317	Gadus morhua	59.69	4.00e-158	551.00
IUUC-Gga-041264	Gallus gallus	79.12	0.00e+00	803.00
IUUC-Gma-042681	Glycine max	34.82	2.00e-45	176.00
IUUC-Ggo-044969	Gorilla gorilla	88.17	0.00e+00	788.00
IUUC-Hsa-046669	Homo sapiens	87.81	0.00e+00	813.00
IUUC-Itr-048337	Ictidomys tridecemlineatus	88.81	0.00e+00	660.00
IUUC-Lch-050192	Latimeria chalumnae	80.18	8.00e-174	603.00
IUUC-Lpe-050974	Leersia perrieri	39.58	6.00e-38	152.00
IUUC-Loc-052846	Lepisosteus oculatus	80.00	2.00e-166	578.00
IUUC-Lma-053152	Leptosphaeria maculans	26.69	7.00e-09	55.50
IUUC-Laf-054278	Loxodonta africana	87.86	0.00e+00	769.00
IUUC-Mcc-055680	Macaca mulatta	87.81	0.00e+00	813.00
IUUC-Meu-056414	Macropus eugenii	77.61	7.00e-156	543.00
IUUC-Mtr-058674	Medicago truncatula	38.64	1.00e-44	174.00
IUUC-Mga-059894	Meleagris gallopavo	83.06	0.00e+00	632.00
IUUC-Mmr-061094	Microcebus murinus	87.81	0.00e+00	793.00
IUUC-Mdo-062728	Monodelphis domestica	81.06	0.00e+00	762.00
IUUC-Mmu-064088	Mus musculus	96.39	0.00e+00	922.00
IUUC-Mac-065458	Musa acuminata	34.85	2.00e-46	180.00
IUUC-Mpu-066282	Mustela putorius furo	85.87	0.00e+00	780.00
IUUC-Mlu-068158	Myotis lucifugus	84.41	0.00e+00	768.00
IUUC-Nle-069321	Nomascus leucogenys	87.81	0.00e+00	813.00
IUUC-Opr-071098	Ochotona princeps	80.55	9.00e-176	609.00
IUUC-Oan-072808	Ornithorhynchus anatinus	84.24	0.00e+00	629.00
IUUC-Ocu-074301	Oryctolagus cuniculus	80.14	0.00e+00	764.00
IUUC-Oba-074973	Oryza barthii	39.93	1.00e-44	174.00
IUUC-Obr-076444	Oryza brachyantha	49.70	2.00e-32	134.00
IUUC-Ogl-077319	Oryza glaberrima	35.32	8.00e-47	181.00
IUUC-Ogu-078074	Oryza glumaepatula	33.51	7.00e-53	201.00
IUUC-Oin-079142	Oryza indica	40.59	3.00e-45	176.00
IUUC-Olo-080565	Oryza longistaminata	36.45	6.00e-50	191.00
IUUC-Ome-081155	Oryza meridionalis	50.88	3.00e-34	139.00
IUUC-Oni-082272	Oryza nivara	40.59	3.00e-45	176.00
IUUC-Opu-083241	Oryza punctata	35.73	6.00e-53	202.00
IUUC-Oru-085257	Oryza rufipogon	40.59	3.00e-45	176.00
IUUC-Osa-086257	Oryza sativa	35.32	9.00e-47	181.00
IUUC-Olu-087597	Ostreococcus lucimarinus	29.71	1.00e-25	110.00
IUUC-Oga-088495	Otolemur garnettii	87.46	0.00e+00	775.00
IUUC-Oar-089711	Ovis aries	83.95	0.00e+00	768.00
IUUC-Ptr-091439	Pan troglodytes	87.46	0.00e+00	807.00
IUUC-Pan-092641	Papio anubis	87.81	0.00e+00	813.00
IUUC-Psi-093518	Pelodiscus sinensis	82.58	0.00e+00	706.00
IUUC-Pno-094908	Phaeosphaeria nodorum	25.00	2.00e-08	53.10
IUUC-Ppa-095193	Physcomitrella patens	53.60	6.00e-36	145.00
IUUC-Pab-098699	Pongo abelii	86.38	0.00e+00	808.00
IUUC-Pop-099214	Populus trichocarpa	35.29	2.00e-49	190.00
IUUC-Pca-100497	Procavia capensis	74.08	2.00e-126	446.00
IUUC-Ppe-101901	Prunus persica	37.05	7.00e-57	214.00
IUUC-Pva-102513	Pteropus vampyrus	86.42	2.00e-126	446.00
IUUC-Sce-106332	Saccharomyces cerevisiae	31.51	4.00e-17	82.00
IUUC-Sha-106881	Sarcophilus harrisii	77.24	0.00e+00	678.00
IUUC-Spo-108223	Schizosaccharomyces pombe	27.19	3.00e-09	55.80
IUUC-Smo-108910	Selaginella moellendorffii	37.84	2.00e-41	163.00
IUUC-Sit-110766	Setaria italica	38.24	6.00e-37	148.00
IUUC-Sly-111731	Solanum lycopersicum	30.65	1.00e-48	187.00
IUUC-Stu-112263	Solanum tuberosum	34.48	2.00e-47	183.00
IUUC-Sar-113648	Sorex araneus	79.46	6.00e-171	593.00
IUUC-Sbi-114273	Sorghum bicolor	51.09	2.00e-37	150.00
IUUC-Ssc-115820	Sus scrofa	87.10	0.00e+00	798.00
IUUC-Tgu-116845	Taeniopygia guttata	75.94	0.00e+00	684.00
IUUC-Tsy-119008	Tarsius syrichta	76.77	4.00e-154	538.00
IUUC-Tni-119780	Tetraodon nigroviridis	63.80	1.00e-170	593.00
IUUC-Tca-121610	Theobroma cacao	35.45	5.00e-48	185.00
IUUC-Tae-125801	Triticum aestivum	50.35	8.00e-38	151.00
IUUC-Tur-126783	Triticum urartu	55.22	8.00e-39	155.00
IUUC-Tme-127116	Tuber melanosporum	25.91	2.00e-09	57.40
IUUC-Tbe-127379	Tupaia belangeri	76.55	0.00e+00	645.00
IUUC-Ttr-128630	Tursiops truncatus	83.70	0.00e+00	807.00
IUUC-Uma-129639	Ustilago maydis	34.78	7.00e-09	55.10
IUUC-Vvi-131518	Vitis vinifera	50.94	3.00e-09	56.60
IUUC-Xtr-132595	Xenopus tropicalis	77.28	0.00e+00	696.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence