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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Rno-106085
UUCD1 version UUC-RaN-00932
Ensembl Protein ID ENSRNOP00000049754.3
UniProt Accession Q6YDN7; CDC26_RAT
Genbank Protein ID AAO18338.1; AAH86343.1
Protein Name Anaphase-promoting complex subunit CDC26; Cell division cycle protein 26 homolog; Protein BWK-2
Genbank Nucleotide ID AY156922; BC086343
Gene Name Cdc26
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000029785.4 ENSRNOT00000040894.4 ENSRNOP00000049754.3
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNATRANSFACRAID2
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusUniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 adaptor/Cullin RING/APC_C/APC_C 89.41 1.00e-37 151.00 IUUC-Hsa-046899
E3 adaptor/Cullin RING/APC_C/APC_C 33.33 1.90e-01 28.50 IUUC-Sce-106324
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex (By similarity).
 Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex (By similarity).
Protein Sequence
(Fasta)
MLRRKPTRLE LKLDDIEEFE NIRKDLEARK KQKEDVEGVG TSDGEGAAGL SSDPKSREQM 60
INDRIGYKPQ LKTNNRTSQF GNFEF 85
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Protein Fasta Sequence


>IUUC-Rno-106085|E3,APC_C|Rattus norvegicus
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Nucleotide Sequence
(Fasta)
CGGGCTGCGT AGCAATGGAG TCAAGGTGGG AGTTGAGGTT CTGGGAAGCT TCAGAGGCCT 60
GAAAAGAGGT AAGTTTGCGA ATCGCAAGTC TAATCTGGAA CAAACCAAGG GTCTCTGCTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-106085|E3,APC_C|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0498--Mitosis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR018860--APC_suCDC26
Pfam

PF10471--ANAPC_CDC26
Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:0070979--P:protein K11-linked ubiquitination
GO:0030071--P:regulation of mitotic metaphase/anaphase transition
KEGG rno:366381
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001456 Ailuropoda melanoleuca 87.06 2.00e-38 149.00
IUUC-Atr-002458 Amborella trichopoda 37.14 6.00e-04 35.00
IUUC-Aca-004376 Anolis carolinensis 78.82 4.00e-34 135.00
IUUC-Ago-007754 Ashbya gossypii 47.62 4.20e-01 26.60
IUUC-Acl-008116 Aspergillus clavatus 52.17 9.80e-02 27.70
IUUC-Ani-009376 Aspergillus nidulans 46.67 3.50e-01 25.80
IUUC-Ame-011022 Astyanax mexicanus 59.77 5.00e-22 95.10
IUUC-Bta-012581 Bos taurus 89.41 4.00e-39 151.00
IUUC-Bci-013595 Botrytis cinerea 47.62 1.60e+00 25.40
IUUC-Cja-019622 Callithrix jacchus 85.88 7.00e-38 147.00
IUUC-Cfa-021044 Canis familiaris 87.06 2.00e-38 149.00
IUUC-Cpo-022441 Cavia porcellus 85.88 3.00e-33 132.00
IUUC-Csa-024091 Chlorocebus sabaeus 88.24 3.00e-31 125.00
IUUC-Cho-025001 Choloepus hoffmanni 81.03 2.00e-21 93.20
IUUC-Csv-025958 Ciona savignyi 29.67 6.00e-07 45.10
IUUC-Dre-027369 Danio rerio 61.36 5.00e-26 108.00
IUUC-Dno-029137 Dasypus novemcinctus 85.88 6.00e-38 147.00
IUUC-Dor-030181 Dipodomys ordii 88.24 4.00e-39 152.00
IUUC-Ete-032555 Echinops telfairi 85.88 4.00e-37 145.00
IUUC-Eca-033227 Equus caballus 88.24 2.00e-31 126.00
IUUC-Eeu-034615 Erinaceus europaeus 84.21 2.00e-23 100.00
IUUC-Fca-035838 Felis catus 85.88 1.00e-37 147.00
IUUC-Fal-036994 Ficedula albicollis 86.21 2.00e-09 53.10
IUUC-Gga-040675 Gallus gallus 64.71 5.00e-22 95.10
IUUC-Ggo-044779 Gorilla gorilla 84.48 5.00e-16 75.50
IUUC-Hsa-046899 Homo sapiens 89.41 1.00e-31 127.00
IUUC-Itr-048643 Ictidomys tridecemlineatus 87.06 2.00e-33 132.00
IUUC-Lch-049544 Latimeria chalumnae 64.71 1.00e-28 117.00
IUUC-Loc-052390 Lepisosteus oculatus 59.09 3.00e-21 92.80
IUUC-Laf-053681 Loxodonta africana 89.41 8.00e-32 127.00
IUUC-Mcc-054912 Macaca mulatta 88.24 3.00e-31 125.00
IUUC-Meu-056222 Macropus eugenii 74.14 1.00e-20 90.50
IUUC-Mor-057242 Magnaporthe oryzae 34.38 1.40e-01 29.30
IUUC-Mmr-061790 Microcebus murinus 87.06 8.00e-39 150.00
IUUC-Mmu-064350 Mus musculus 97.65 3.00e-44 169.00
IUUC-Mlu-067848 Myotis lucifugus 87.06 2.00e-33 133.00
IUUC-Nle-069077 Nomascus leucogenys 87.06 1.00e-30 124.00
IUUC-Opr-071004 Ochotona princeps 85.88 3.00e-33 132.00
IUUC-Ont-071525 Oreochromis niloticus 46.39 2.00e-15 73.60
IUUC-Oan-073200 Ornithorhynchus anatinus 85.88 1.00e-37 147.00
IUUC-Ocu-074476 Oryctolagus cuniculus 87.06 6.00e-39 151.00
IUUC-Oba-075520 Oryza barthii 61.90 3.70e-02 29.30
IUUC-Obr-076249 Oryza brachyantha 61.90 1.90e-01 29.30
IUUC-Ogu-078445 Oryza glumaepatula 61.90 3.70e-02 29.30
IUUC-Ola-087554 Oryzias latipes 48.39 1.00e-17 80.90
IUUC-Oga-088195 Otolemur garnettii 88.24 7.00e-30 121.00
IUUC-Oar-089399 Ovis aries 88.24 2.00e-38 149.00
IUUC-Ptr-090822 Pan troglodytes 89.41 1.00e-31 127.00
IUUC-Pan-092857 Papio anubis 88.24 3.00e-31 125.00
IUUC-Ppa-095794 Physcomitrella patens 75.00 4.00e-03 32.30
IUUC-Pfo-097147 Poecilia formosa 47.87 3.00e-14 69.30
IUUC-Pab-098774 Pongo abelii 89.41 1.00e-31 127.00
IUUC-Pca-100745 Procavia capensis 88.24 7.00e-31 124.00
IUUC-Pva-102647 Pteropus vampyrus 89.41 2.00e-34 136.00
IUUC-Pte-104296 Pyrenophora teres 54.17 8.10e-02 28.10
IUUC-Pyt-104747 Pyrenophora triticirepentis 54.17 6.40e-02 28.50
IUUC-Sce-106324 Saccharomyces cerevisiae 33.33 1.10e-01 28.50
IUUC-Sha-107235 Sarcophilus harrisii 83.53 7.00e-37 144.00
IUUC-Spo-108195 Schizosaccharomyces pombe 28.21 3.80e-01 25.80
IUUC-Ssl-108598 Sclerotinia sclerotiorum 47.62 1.70e+00 25.00
IUUC-Sar-113299 Sorex araneus 84.48 3.00e-16 76.30
IUUC-Ssc-115650 Sus scrofa 78.82 9.00e-28 114.00
IUUC-Tgu-117309 Taeniopygia guttata 58.14 1.00e-21 93.60
IUUC-Tsy-119267 Tarsius syrichta 89.41 8.00e-32 127.00
IUUC-Tni-120675 Tetraodon nigroviridis 48.24 6.00e-17 78.20
IUUC-Tvi-122490 Trichoderma virens 47.62 3.30e-01 26.90
IUUC-Ttr-129250 Tursiops truncatus 85.88 2.00e-32 129.00
IUUC-Vpa-130562 Vicugna pacos 88.24 5.00e-39 151.00
Created Date 25-Jun-2017

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