iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box	F-box	21323640; 14747994

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/SCF/F-box	0.025	13.1	49	91

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/SCF/F-box

   S: 103  ldrlpeeilveilklldkeellraarvcrrwqelasqkalwktv 146
           l++lp+e+++e++++l++++ l++ +v +r++++a  k l++++
   Q: 49   LTKLPDELMQEVFSHLPQPDRLQLCLVNKRLNKIAT-KLLYRRI 91
           579*****************************9999.7777765 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity).

Protein Sequence
(Fasta)

MPFQDYFQKK KAAFINRNNK SNADASALRD INDININFAA KSKNYVFPLT KLPDELMQEV 60
FSHLPQPDRL QLCLVNKRLN KIATKLLYRR IYLNDSNVVK SDFMHLAINW TLLNLPSSLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCCATTTC AAGATTATTT TCAGAAGAAA AAAGCAGCGT TCATTAACAG AAACAATAAA 60
AGTAACGCAG ATGCTTCAGC GCTACGAGAT ATTAACGATA TTAACATAAA TTTCGCCGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR001810--F-box_dom
IPR032675--L_dom-like

PROSITE

PS50181--FBOX

Pfam

PF12937--F-box-like

SMART

SM00256--FBOX

Gene Ontology

GO:0019005--C:SCF ubiquitin ligase complex
GO:0030674--F:protein binding, bridging
GO:0016567--P:protein ubiquitination
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

KEGG

sce:YJL149W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000724	Aegilops tauschii	32.53	1.00e-04	40.00
IUUC-Aly-006075	Arabidopsis lyrata	41.30	2.00e-03	35.00
IUUC-Ago-007792	Ashbya gossypii	56.03	0.00e+00	629.00
IUUC-Afu-009024	Aspergillus fumigatus	26.83	1.00e-03	35.80
IUUC-Ate-010378	Aspergillus terreus	40.91	2.00e-03	35.40
IUUC-Bci-013585	Botrytis cinerea	37.21	6.00e-04	37.70
IUUC-Bdi-014437	Brachypodium distachyon	48.15	3.00e-03	34.70
IUUC-Bol-015238	Brassica oleracea	34.62	7.00e-03	33.90
IUUC-Bra-016832	Brassica rapa	34.85	2.00e-03	34.30
IUUC-Cel-018163	Caenorhabditis elegans	32.84	3.00e-04	37.70
IUUC-Cho-024460	Choloepus hoffmanni	54.55	8.00e-02	30.00
IUUC-Cgl-026420	Colletotrichum gloeosporioides	38.00	9.00e-05	39.70
IUUC-Ete-033103	Echinops telfairi	59.09	2.20e-02	32.00
IUUC-Fso-038105	Fusarium solani	27.47	1.30e-01	29.30
IUUC-Gma-043760	Glycine max	25.81	1.20e-02	32.30
IUUC-Hvu-047066	Hordeum vulgare	40.00	1.20e-02	32.30
IUUC-Lpe-051267	Leersia perrieri	41.94	8.00e-03	34.70
IUUC-Lma-053093	Leptosphaeria maculans	42.86	7.00e-04	37.00
IUUC-Mor-057192	Magnaporthe oryzae	37.78	1.00e-03	36.20
IUUC-Mla-058821	Melampsora laricipopulina	31.65	1.40e-01	29.30
IUUC-Mac-065172	Musa acuminata	38.64	2.00e-03	35.00
IUUC-Ncr-068943	Neurospora crassa	33.33	3.00e-03	35.80
IUUC-Oba-075694	Oryza barthii	37.21	5.30e-02	32.30
IUUC-Obr-076092	Oryza brachyantha	30.49	7.00e-03	33.10
IUUC-Ogu-079027	Oryza glumaepatula	25.00	4.70e-02	31.60
IUUC-Oin-079365	Oryza indica	41.46	8.00e-03	32.70
IUUC-Olo-080514	Oryza longistaminata	29.63	3.00e-03	35.40
IUUC-Ome-081133	Oryza meridionalis	29.79	1.20e-01	31.20
IUUC-Oni-082701	Oryza nivara	25.00	5.10e-02	31.20
IUUC-Opu-083869	Oryza punctata	46.67	1.30e-02	33.90
IUUC-Oru-085106	Oryza rufipogon	44.74	1.50e-01	31.60
IUUC-Osa-085649	Oryza sativa	41.46	9.00e-03	32.70
IUUC-Pno-094816	Phaeosphaeria nodorum	44.00	4.00e-06	41.60
IUUC-Ppa-095844	Physcomitrella patens	31.03	6.00e-03	33.10
IUUC-Ppe-101815	Prunus persica	35.00	9.30e-02	28.10
IUUC-Smo-108868	Selaginella moellendorffii	25.77	1.00e-03	33.90
IUUC-Sit-110045	Setaria italica	35.00	5.00e-03	33.50
IUUC-Sly-111140	Solanum lycopersicum	26.67	8.00e-03	32.70
IUUC-Stu-112851	Solanum tuberosum	30.85	5.00e-03	33.50
IUUC-Sbi-114177	Sorghum bicolor	34.00	3.00e-03	33.10
IUUC-Sre-115004	Sporisorium reilianum	29.51	9.00e-02	30.00
IUUC-Tre-122073	Trichoderma reesei	31.34	6.00e-04	38.10
IUUC-Tvi-122364	Trichoderma virens	29.03	2.00e-03	36.60
IUUC-Tae-125133	Triticum aestivum	43.59	2.00e-04	37.70
IUUC-Tur-126449	Triticum urartu	34.33	3.00e-03	35.00
IUUC-Vda-129824	Verticillium dahliae	26.04	2.00e-04	38.10
IUUC-Vvi-131350	Vitis vinifera	37.04	1.90e-01	29.60

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence