iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	3.70e-35	120.7	46	179

Active Site

Position(s)	Description	Evidence
130	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 1    Rlkkelkelekdppegisakpvde.sdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltk..ifhPnvyenGkvClsilkeeekWspa 95
           Rl+kel++l k+pp+g+++++++  ++l ew++ i G e+t Yeg+ F+l ++f+++YPf++P+v+f+ +    hP+vy+nG++Clsil+  e+Wspa
   Q: 46   RLHKELMSLIKEPPPGVTIDTESVqQNLSEWKINIKGFEGTLYEGEDFQLLFKFNNKYPFDSPEVTFIGTniPVHPHVYSNGHICLSILT--EDWSPA 141
           99****************998875147*****************************************98889****************9..****** PP
   S: 96   lsvesvllsiqsll..aepnpesplneeaaellkknre 131
           lsv+sv+lsi s+l  ++ + + p n+  +++++kn++
   Q: 142  LSVQSVCLSIASMLssCREKKRPPDNTIYVKTCNKNPK 179
           **************444455666777777788888876 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MMKLFKKPKD KIPKSEILTE PKEPKTPPVS KCGKPLQLDN SRWERRLHKE LMSLIKEPPP 60
GVTIDTESVQ QNLSEWKINI KGFEGTLYEG EDFQLLFKFN NKYPFDSPEV TFIGTNIPVH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACACATCTAA AAAAAACACA TCCATTCTAG GGACCACAAC AACTTTTCTA AACTGTCGTC 60
AGTATAACTT GTCAACCCAA ATTGGATTGA CAAATTTTTA AAACAATTAT TGTACTCCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000608--UBQ-conjugat_E2
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination

KEGG

dme:Dmel_CG7220

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000363	Aegilops tauschii	42.18	1.00e-29	122.00
IUUC-Aml-002375	Ailuropoda melanoleuca	57.95	1.00e-64	238.00
IUUC-Apl-003950	Anas platyrhynchos	72.73	2.00e-64	236.00
IUUC-Aly-006450	Arabidopsis lyrata	50.34	1.00e-37	147.00
IUUC-Ath-007383	Arabidopsis thaliana	50.34	1.00e-31	127.00
IUUC-Acl-008034	Aspergillus clavatus	38.16	2.00e-26	110.00
IUUC-Afl-008476	Aspergillus flavus	39.74	9.00e-30	121.00
IUUC-Afu-008827	Aspergillus fumigatus	39.74	1.00e-28	117.00
IUUC-Ani-009244	Aspergillus nidulans	34.75	4.00e-21	92.80
IUUC-Ang-009545	Aspergillus niger	41.45	4.00e-28	116.00
IUUC-Aor-009924	Aspergillus oryzae	40.14	3.00e-27	112.00
IUUC-Ate-010478	Aspergillus terreus	32.96	3.00e-23	100.00
IUUC-Ame-011757	Astyanax mexicanus	71.92	4.00e-66	242.00
IUUC-Bgr-012004	Blumeria graminis	41.06	9.00e-28	115.00
IUUC-Bta-013365	Bos taurus	72.60	5.00e-66	242.00
IUUC-Bci-013609	Botrytis cinerea	38.56	2.00e-27	114.00
IUUC-Bdi-014005	Brachypodium distachyon	51.02	7.00e-39	152.00
IUUC-Bol-016083	Brassica oleracea	50.34	2.00e-37	147.00
IUUC-Bra-017578	Brassica rapa	50.00	1.00e-31	127.00
IUUC-Cel-018273	Caenorhabditis elegans	64.38	3.00e-56	209.00
IUUC-Cja-018997	Callithrix jacchus	71.72	4.00e-64	235.00
IUUC-Cfa-020790	Canis familiaris	72.60	4.00e-66	243.00
IUUC-Cpo-021615	Cavia porcellus	73.24	5.00e-64	235.00
IUUC-Cre-022615	Chlamydomonas reinhardtii	37.91	2.00e-27	113.00
IUUC-Csa-024236	Chlorocebus sabaeus	72.60	5.00e-66	242.00
IUUC-Cho-024448	Choloepus hoffmanni	65.22	2.00e-50	190.00
IUUC-Cin-025579	Ciona intestinalis	60.54	2.00e-54	203.00
IUUC-Cgl-026554	Colletotrichum gloeosporioides	40.40	5.00e-29	119.00
IUUC-Cne-026943	Cryptococcus neoformans	50.00	1.00e-19	87.80
IUUC-Cme-027157	Cyanidioschyzon merolae	52.63	6.00e-42	162.00
IUUC-Dre-027411	Danio rerio	71.92	4.00e-66	242.00
IUUC-Dno-029321	Dasypus novemcinctus	72.60	5.00e-66	242.00
IUUC-Dor-030985	Dipodomys ordii	80.36	1.00e-54	202.00
IUUC-Dse-031193	Dothistroma septosporum	38.56	1.00e-27	114.00
IUUC-Ete-032344	Echinops telfairi	73.10	1.00e-65	240.00
IUUC-Eca-033939	Equus caballus	73.24	4.00e-64	235.00
IUUC-Eeu-034593	Erinaceus europaeus	73.10	1.00e-65	240.00
IUUC-Fca-035457	Felis catus	72.73	3.00e-64	236.00
IUUC-Fal-037512	Ficedula albicollis	75.78	2.00e-59	219.00
IUUC-Fox-038001	Fusarium oxysporum	40.52	1.00e-26	111.00
IUUC-Fso-038237	Fusarium solani	41.18	1.00e-26	111.00
IUUC-Gmo-039574	Gadus morhua	72.60	3.00e-66	243.00
IUUC-Ggr-040091	Gaeumannomyces graminis	37.75	5.00e-27	112.00
IUUC-Gga-040125	Gallus gallus	72.60	4.00e-66	242.00
IUUC-Gac-041300	Gasterosteus aculeatus	69.80	1.00e-64	237.00
IUUC-Gma-043703	Glycine max	48.98	4.00e-31	126.00
IUUC-Ggo-044461	Gorilla gorilla	73.10	1.00e-65	241.00
IUUC-Hsa-046710	Homo sapiens	72.60	7.00e-66	241.00
IUUC-Itr-048816	Ictidomys tridecemlineatus	72.60	7.00e-66	241.00
IUUC-Kpa-049405	Komagataella pastoris	41.78	4.00e-32	129.00
IUUC-Lch-050426	Latimeria chalumnae	71.72	2.00e-64	237.00
IUUC-Lpe-051342	Leersia perrieri	50.34	6.00e-39	152.00
IUUC-Loc-052247	Lepisosteus oculatus	71.62	1.00e-65	240.00
IUUC-Lma-053151	Leptosphaeria maculans	38.41	2.00e-26	111.00
IUUC-Laf-053849	Loxodonta africana	73.24	4.00e-64	235.00
IUUC-Mcc-055520	Macaca mulatta	73.10	1.00e-65	241.00
IUUC-Mor-057224	Magnaporthe oryzae	38.41	2.00e-28	117.00
IUUC-Mpo-057368	Magnaporthe poae	37.75	5.00e-27	112.00
IUUC-Mtr-058312	Medicago truncatula	49.66	2.00e-31	127.00
IUUC-Mla-059112	Melampsora laricipopulina	47.50	2.00e-30	123.00
IUUC-Mga-059919	Meleagris gallopavo	73.10	1.00e-65	240.00
IUUC-Mvi-060408	Microbotryum violaceum	47.68	1.00e-37	148.00
IUUC-Mmr-061136	Microcebus murinus	72.73	8.00e-65	238.00
IUUC-Mdo-062768	Monodelphis domestica	72.60	4.00e-66	242.00
IUUC-Mmu-063097	Mus musculus	71.92	2.00e-65	240.00
IUUC-Mac-064973	Musa acuminata	49.66	1.00e-37	148.00
IUUC-Mpu-066887	Mustela putorius furo	72.73	3.00e-64	236.00
IUUC-Mlu-067762	Myotis lucifugus	72.60	2.00e-65	240.00
IUUC-Nfi-068242	Neosartorya fischeri	38.82	7.00e-27	112.00
IUUC-Ncr-068788	Neurospora crassa	39.07	1.00e-28	118.00
IUUC-Nle-070082	Nomascus leucogenys	72.60	5.00e-66	242.00
IUUC-Ont-072026	Oreochromis niloticus	72.60	2.00e-66	243.00
IUUC-Oan-073013	Ornithorhynchus anatinus	75.00	1.00e-58	217.00
IUUC-Ocu-074009	Oryctolagus cuniculus	72.73	2.00e-64	236.00
IUUC-Oba-075133	Oryza barthii	50.34	9.00e-39	151.00
IUUC-Obr-076142	Oryza brachyantha	48.98	1.00e-37	147.00
IUUC-Ogl-077944	Oryza glaberrima	50.34	9.00e-39	151.00
IUUC-Ogu-078744	Oryza glumaepatula	50.34	9.00e-39	151.00
IUUC-Oin-079726	Oryza indica	50.34	9.00e-39	151.00
IUUC-Olo-080356	Oryza longistaminata	50.34	9.00e-39	151.00
IUUC-Ome-081601	Oryza meridionalis	50.34	9.00e-39	151.00
IUUC-Oni-082217	Oryza nivara	50.34	9.00e-39	151.00
IUUC-Opu-083614	Oryza punctata	49.66	2.00e-38	150.00
IUUC-Oru-085028	Oryza rufipogon	50.34	9.00e-39	151.00
IUUC-Osa-085386	Oryza sativa	50.34	9.00e-39	151.00
IUUC-Ola-086845	Oryzias latipes	64.71	1.00e-39	153.00
IUUC-Oga-087990	Otolemur garnettii	72.60	7.00e-66	241.00
IUUC-Oar-090149	Ovis aries	72.73	2.00e-64	236.00
IUUC-Ptr-090701	Pan troglodytes	73.10	2.00e-65	240.00
IUUC-Pan-092007	Papio anubis	73.10	1.00e-65	241.00
IUUC-Psi-093380	Pelodiscus sinensis	72.11	5.00e-66	241.00
IUUC-Pma-094682	Petromyzon marinus	73.83	4.00e-67	245.00
IUUC-Ppa-095456	Physcomitrella patens	49.66	6.00e-31	126.00
IUUC-Pfo-097000	Poecilia formosa	72.60	6.00e-66	241.00
IUUC-Pab-098188	Pongo abelii	72.60	5.00e-66	242.00
IUUC-Pop-099724	Populus trichocarpa	48.98	5.00e-30	122.00
IUUC-Pca-100346	Procavia capensis	73.57	4.00e-63	232.00
IUUC-Ppe-101296	Prunus persica	50.34	2.00e-31	127.00
IUUC-Pva-102207	Pteropus vampyrus	81.25	1.00e-54	203.00
IUUC-Pgr-103668	Puccinia graminis	42.07	7.00e-32	129.00
IUUC-Pte-104294	Pyrenophora teres	37.96	5.00e-23	99.00
IUUC-Pyt-104534	Pyrenophora triticirepentis	37.96	1.00e-23	101.00
IUUC-Rno-105466	Rattus norvegicus	73.10	1.00e-65	240.00
IUUC-Sha-106707	Sarcophilus harrisii	73.43	1.00e-64	238.00
IUUC-Smo-109161	Selaginella moellendorffii	51.72	2.00e-39	154.00
IUUC-Sit-110080	Setaria italica	50.34	2.00e-39	153.00
IUUC-Sly-111213	Solanum lycopersicum	51.02	4.00e-32	129.00
IUUC-Stu-112148	Solanum tuberosum	51.02	1.00e-31	128.00
IUUC-Sar-113531	Sorex araneus	73.10	1.00e-65	240.00
IUUC-Sbi-114650	Sorghum bicolor	50.34	3.00e-39	153.00
IUUC-Sre-114974	Sporisorium reilianum	46.00	4.00e-36	142.00
IUUC-Ssc-115770	Sus scrofa	71.14	4.00e-66	242.00
IUUC-Tgu-117316	Taeniopygia guttata	73.10	1.00e-65	240.00
IUUC-Tru-117640	Takifugu rubripes	71.92	9.00e-65	238.00
IUUC-Tsy-119222	Tarsius syrichta	72.73	2.00e-64	236.00
IUUC-Tni-120737	Tetraodon nigroviridis	71.92	9.00e-66	241.00
IUUC-Tca-121226	Theobroma cacao	49.66	8.00e-31	125.00
IUUC-Tre-121998	Trichoderma reesei	41.18	1.00e-21	94.70
IUUC-Tvi-122565	Trichoderma virens	39.87	1.00e-25	107.00
IUUC-Tae-125253	Triticum aestivum	51.02	2.00e-39	154.00
IUUC-Tur-126577	Triticum urartu	51.85	2.00e-37	146.00
IUUC-Tme-127110	Tuber melanosporum	38.82	2.00e-27	113.00
IUUC-Tbe-127701	Tupaia belangeri	73.10	2.00e-65	240.00
IUUC-Ttr-128279	Tursiops truncatus	67.13	6.00e-57	211.00
IUUC-Uma-129371	Ustilago maydis	45.33	1.00e-35	140.00
IUUC-Vda-129698	Verticillium dahliae	37.75	1.00e-27	114.00
IUUC-Vpa-130053	Vicugna pacos	73.13	9.00e-58	214.00
IUUC-Vvi-131675	Vitis vinifera	49.66	1.00e-31	127.00
IUUC-Xtr-132804	Xenopus tropicalis	50.69	2.00e-42	163.00
IUUC-Xma-133451	Xiphophorus maculatus	72.60	6.00e-66	241.00
IUUC-Yli-134332	Yarrowia lipolytica	43.42	6.00e-29	119.00
IUUC-Zma-135814	Zea mays	50.34	4.00e-39	152.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence