iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
CPLM	dbPAF	dbPTM	UniProt
BioGRID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.60e-25	85.9	254	288
UBD/Beta-Prp	2.00e-57	193.1	57	366

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 4    dsvtclaf.sdtllvsGsdDgtikvWDlrtgvllk 37
           +++++l++ ++  +++ + D ti+vWD++t ++++
   Q: 254  GGIFALSWlDSQKFATVGADATIRVWDVTTSKCVQ 288
           679*****75499********************97 PP

UBD/Beta-Prp

   S: 3    ktlkghhksvitcvkf..spdksllatgsrdgtikvwdvttgkllrslsgheae........vtavkfspdgkilvtgseD.rtikvw.dlstgkcvhtlk 91
           +++ gh +sv+t vkf  ++++++l +g ++g+++vw +t  k   s++ + +         +++++++ +g  l  ++e  ++  v+ + ++g  +  ++
   Q: 57   VQFTGHGSSVVTTVKFspIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSefqvlagpISDISWDFEGRRLCVVGEGrDNFGVFiSWDSGNSLGEVS 157
           578899**********9999********************9999555544444445555555999999999998877777778999999999999999999 PP
   S: 92   ghedsvlslsfspsg.dklvsGshdrtirvwdletgqclee..tlsghdgvvncvvvhpdg.nllvsGslDrtvrlWdlktgkllrtltgghtdsvysls. 187
           gh++++ ++++ +s+  +  + ++d  +  ++ +  + + +  t  ++ ++v+ v+++pd+   +++ + Dr++  +d k+g+ l+  +  ++++v+  + 
   Q: 158  GHSQRINACHLKQSRpMRSMTVGDDGSVVFYQGPPFKFSASdrTHHKQGSFVRDVEFSPDSgEFVITVGSDRKISCFDGKSGEFLKYIED-DQEPVQGGIf 257
           999999999999988777777788999999988888888766777888889999999999999999999999999999999999999965.6666555552 PP
   S: 188  ...fdsngkelvsgsldgtvklwdlqtgecvrtlnght.....dnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisvavlsfgdnvl 280
              + + ++ +++++ d t+++wd+ t++cv++++  +     ++v +v++   + r++s s Dg+++++ l ++++lkt+++hn+ +++ +v     n l
   Q: 258  alsWLD-SQKFATVGADATIRVWDVTTSKCVQKWTLDKqqlgnQQVGVVATG--NGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTV-----NPL 350
           222555.589999999999999999999997777766644544677777666..999999999999999999999999999999999999999.....999 PP
   S: 281  vlgsedskvniwklkk 296
           ++gs d++++ w+ ++
   Q: 351  ISGSYDGRIMEWSSSS 366
           9999999999988655 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Involved in the depolymerization of actin filaments. Enhances the filament disassembly activity of cofilin and restricts cofilin localization to cortical actin patches.

Protein Sequence
(Fasta)

MSSISLKEII PPQPSTQRNF TTHLSYDPTT NAIAYPCGKS AFVRCLDDGD SKVPPVVQFT 60
GHGSSVVTTV KFSPIKGSQY LCSGDESGKV IVWGWTFDKE SNSVEVNVKS EFQVLAGPIS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCATCTA TCTCTTTGAA GGAAATTATA CCACCTCAGC CTTCGACACA GCGTAACTTT 60
ACTACGCATT TATCGTATGA CCCTACAACC AACGCAATTG CTTACCCATG TGGAAAATCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0009--Actin-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0030479--C:actin cortical patch
GO:0005884--C:actin filament
GO:0042643--C:actomyosin, actin portion
GO:0003779--F:actin binding
GO:0051015--F:actin filament binding
GO:0030042--P:actin filament depolymerization
GO:0051016--P:barbed-end actin filament capping
GO:0032466--P:negative regulation of cytokinesis
GO:0030836--P:positive regulation of actin filament depolymerization
GO:0006970--P:response to osmotic stress

KEGG

sce:YMR092C

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000457	Aegilops tauschii	30.02	8.00e-51	192.00
IUUC-Aml-002368	Ailuropoda melanoleuca	29.46	1.00e-68	251.00
IUUC-Atr-003160	Amborella trichopoda	31.72	6.00e-71	259.00
IUUC-Apl-004012	Anas platyrhynchos	27.66	8.00e-64	236.00
IUUC-Aca-004707	Anolis carolinensis	29.13	4.00e-69	253.00
IUUC-Aly-006423	Arabidopsis lyrata	30.62	2.00e-70	258.00
IUUC-Ath-006829	Arabidopsis thaliana	31.97	4.00e-72	263.00
IUUC-Ago-007920	Ashbya gossypii	52.02	0.00e+00	676.00
IUUC-Acl-008262	Aspergillus clavatus	36.22	2.00e-91	328.00
IUUC-Afl-008471	Aspergillus flavus	29.11	3.00e-62	231.00
IUUC-Afu-008989	Aspergillus fumigatus	35.02	3.00e-83	300.00
IUUC-Ani-009167	Aspergillus nidulans	35.89	1.00e-93	335.00
IUUC-Ang-009595	Aspergillus niger	35.36	8.00e-81	292.00
IUUC-Aor-009908	Aspergillus oryzae	35.29	4.00e-84	303.00
IUUC-Ate-010580	Aspergillus terreus	34.64	7.00e-88	317.00
IUUC-Ame-011269	Astyanax mexicanus	36.32	9.00e-33	132.00
IUUC-Bgr-011996	Blumeria graminis	34.32	5.00e-92	330.00
IUUC-Bta-013278	Bos taurus	29.53	1.00e-71	261.00
IUUC-Bci-013925	Botrytis cinerea	37.33	4.00e-104	370.00
IUUC-Bdi-014659	Brachypodium distachyon	28.57	2.00e-58	218.00
IUUC-Bol-016043	Brassica oleracea	30.95	1.00e-70	258.00
IUUC-Bra-017719	Brassica rapa	31.01	2.00e-70	257.00
IUUC-Cel-018241	Caenorhabditis elegans	31.28	5.00e-68	249.00
IUUC-Cja-019952	Callithrix jacchus	28.44	4.00e-63	233.00
IUUC-Cfa-020225	Canis familiaris	29.69	2.00e-69	254.00
IUUC-Cpo-021900	Cavia porcellus	29.22	7.00e-67	246.00
IUUC-Csa-023028	Chlorocebus sabaeus	28.28	3.00e-63	234.00
IUUC-Cho-025030	Choloepus hoffmanni	35.86	1.00e-37	149.00
IUUC-Cin-025152	Ciona intestinalis	33.59	3.00e-37	146.00
IUUC-Csv-025986	Ciona savignyi	25.57	2.00e-33	134.00
IUUC-Cgl-026597	Colletotrichum gloeosporioides	37.79	7.00e-106	375.00
IUUC-Cne-026814	Cryptococcus neoformans	29.98	9.00e-71	259.00
IUUC-Dre-027498	Danio rerio	37.56	8.00e-33	130.00
IUUC-Dno-029383	Dasypus novemcinctus	29.38	4.00e-64	237.00
IUUC-Dor-030633	Dipodomys ordii	29.45	7.00e-63	233.00
IUUC-Dse-031526	Dothistroma septosporum	37.67	1.00e-101	362.00
IUUC-Dme-031597	Drosophila melanogaster	30.68	2.00e-70	257.00
IUUC-Ete-032780	Echinops telfairi	27.99	1.00e-61	228.00
IUUC-Eca-034306	Equus caballus	28.55	3.00e-63	234.00
IUUC-Eeu-034531	Erinaceus europaeus	44.04	8.00e-25	106.00
IUUC-Fca-036301	Felis catus	29.42	5.00e-70	256.00
IUUC-Fal-037361	Ficedula albicollis	28.46	1.00e-69	255.00
IUUC-Fox-037924	Fusarium oxysporum	36.63	3.00e-97	347.00
IUUC-Fso-038199	Fusarium solani	36.19	2.00e-98	351.00
IUUC-Gmo-039238	Gadus morhua	27.49	1.00e-62	231.00
IUUC-Ggr-039830	Gaeumannomyces graminis	36.42	4.00e-90	323.00
IUUC-Gga-040235	Gallus gallus	28.44	5.00e-68	249.00
IUUC-Gac-042363	Gasterosteus aculeatus	28.90	2.00e-65	241.00
IUUC-Gma-044189	Glycine max	32.72	9.00e-72	262.00
IUUC-Ggo-044632	Gorilla gorilla	27.46	4.00e-59	220.00
IUUC-Hsa-045792	Homo sapiens	28.75	2.00e-65	241.00
IUUC-Hvu-047517	Hordeum vulgare	29.78	6.00e-65	239.00
IUUC-Itr-048076	Ictidomys tridecemlineatus	29.24	6.00e-68	249.00
IUUC-Kpa-049183	Komagataella pastoris	40.39	2.00e-110	390.00
IUUC-Lch-050428	Latimeria chalumnae	27.80	6.00e-69	253.00
IUUC-Lpe-051306	Leersia perrieri	30.28	3.00e-68	251.00
IUUC-Loc-052096	Lepisosteus oculatus	27.36	7.00e-56	209.00
IUUC-Lma-053313	Leptosphaeria maculans	36.83	1.00e-96	347.00
IUUC-Laf-054060	Loxodonta africana	28.24	3.00e-64	237.00
IUUC-Mcc-055619	Macaca mulatta	27.57	2.00e-59	221.00
IUUC-Meu-056689	Macropus eugenii	32.37	4.00e-35	140.00
IUUC-Mor-056940	Magnaporthe oryzae	41.06	1.00e-74	272.00
IUUC-Mpo-057557	Magnaporthe poae	29.42	5.00e-53	200.00
IUUC-Mtr-058478	Medicago truncatula	32.45	2.00e-73	268.00
IUUC-Mla-059103	Melampsora laricipopulina	30.81	2.00e-65	241.00
IUUC-Mga-060150	Meleagris gallopavo	28.28	2.00e-67	248.00
IUUC-Mvi-060448	Microbotryum violaceum	35.53	2.00e-82	298.00
IUUC-Mmr-061226	Microcebus murinus	28.57	8.00e-64	236.00
IUUC-Mdo-062674	Monodelphis domestica	29.22	4.00e-68	250.00
IUUC-Mmu-064170	Mus musculus	28.12	5.00e-67	246.00
IUUC-Mac-065124	Musa acuminata	31.03	5.00e-72	263.00
IUUC-Mpu-066001	Mustela putorius furo	28.05	3.00e-62	230.00
IUUC-Mlu-067253	Myotis lucifugus	29.51	6.00e-68	249.00
IUUC-Nfi-068550	Neosartorya fischeri	35.26	4.00e-93	333.00
IUUC-Ncr-068948	Neurospora crassa	36.38	1.00e-99	354.00
IUUC-Nle-070115	Nomascus leucogenys	28.96	4.00e-58	217.00
IUUC-Opr-070254	Ochotona princeps	27.90	3.00e-59	221.00
IUUC-Ont-071666	Oreochromis niloticus	29.42	3.00e-63	234.00
IUUC-Oan-073292	Ornithorhynchus anatinus	43.07	1.00e-29	120.00
IUUC-Ocu-074824	Oryctolagus cuniculus	27.80	3.00e-58	217.00
IUUC-Oba-075010	Oryza barthii	30.28	3.00e-68	251.00
IUUC-Obr-076364	Oryza brachyantha	30.64	1.00e-68	252.00
IUUC-Ogl-077019	Oryza glaberrima	30.28	3.00e-68	251.00
IUUC-Ogu-078496	Oryza glumaepatula	30.28	3.00e-68	251.00
IUUC-Oin-080116	Oryza indica	30.28	6.00e-68	249.00
IUUC-Olo-080290	Oryza longistaminata	30.14	6.00e-68	249.00
IUUC-Ome-081969	Oryza meridionalis	30.14	4.00e-68	250.00
IUUC-Oni-082075	Oryza nivara	29.83	3.00e-67	247.00
IUUC-Opu-083959	Oryza punctata	30.20	5.00e-68	250.00
IUUC-Oru-084711	Oryza rufipogon	30.28	3.00e-68	251.00
IUUC-Osa-085958	Oryza sativa	30.28	6.00e-68	249.00
IUUC-Ola-086968	Oryzias latipes	28.86	1.00e-66	245.00
IUUC-Oga-089108	Otolemur garnettii	29.61	4.00e-69	253.00
IUUC-Oar-089986	Ovis aries	29.20	9.00e-65	239.00
IUUC-Ptr-091281	Pan troglodytes	28.68	3.00e-65	241.00
IUUC-Pan-092585	Papio anubis	28.28	2.00e-63	234.00
IUUC-Psi-093811	Pelodiscus sinensis	28.98	9.00e-71	259.00
IUUC-Pma-094396	Petromyzon marinus	27.98	1.00e-68	251.00
IUUC-Pno-095086	Phaeosphaeria nodorum	35.75	5.00e-98	349.00
IUUC-Ppa-095876	Physcomitrella patens	29.59	6.00e-66	243.00
IUUC-Pfo-096973	Poecilia formosa	29.31	1.00e-68	251.00
IUUC-Pab-098391	Pongo abelii	27.97	1.00e-62	231.00
IUUC-Pop-098850	Populus trichocarpa	30.66	2.00e-67	248.00
IUUC-Pca-100257	Procavia capensis	45.68	1.00e-16	79.30
IUUC-Ppe-101578	Prunus persica	30.93	7.00e-66	243.00
IUUC-Pva-102872	Pteropus vampyrus	28.39	3.00e-65	241.00
IUUC-Pgr-103593	Puccinia graminis	29.84	4.00e-70	256.00
IUUC-Pte-104365	Pyrenophora teres	35.88	6.00e-96	342.00
IUUC-Pyt-104689	Pyrenophora triticirepentis	36.45	6.00e-99	352.00
IUUC-Rno-105737	Rattus norvegicus	29.15	2.00e-69	254.00
IUUC-Sha-107084	Sarcophilus harrisii	29.91	4.00e-59	220.00
IUUC-Sja-107688	Schizosaccharomyces japonicus	35.31	1.00e-94	338.00
IUUC-Spo-108309	Schizosaccharomyces pombe	32.45	2.00e-80	291.00
IUUC-Ssl-108408	Sclerotinia sclerotiorum	37.01	2.00e-101	360.00
IUUC-Smo-109255	Selaginella moellendorffii	30.27	1.00e-66	245.00
IUUC-Sit-109962	Setaria italica	30.91	2.00e-70	258.00
IUUC-Sly-110897	Solanum lycopersicum	30.71	2.00e-65	241.00
IUUC-Stu-111971	Solanum tuberosum	30.88	6.00e-67	246.00
IUUC-Sar-113415	Sorex araneus	34.43	3.00e-12	64.70
IUUC-Sbi-114857	Sorghum bicolor	30.64	1.00e-68	252.00
IUUC-Sre-114900	Sporisorium reilianum	32.44	2.00e-81	294.00
IUUC-Tgu-117256	Taeniopygia guttata	28.28	1.00e-68	251.00
IUUC-Tru-117871	Takifugu rubripes	28.01	2.00e-67	248.00
IUUC-Tsy-119172	Tarsius syrichta	37.92	7.00e-41	159.00
IUUC-Tni-120339	Tetraodon nigroviridis	27.76	3.00e-69	253.00
IUUC-Tca-121563	Theobroma cacao	34.01	7.00e-76	276.00
IUUC-Tre-122076	Trichoderma reesei	35.67	1.00e-91	328.00
IUUC-Tvi-122528	Trichoderma virens	36.19	4.00e-99	353.00
IUUC-Tae-123530	Triticum aestivum	30.25	9.00e-65	239.00
IUUC-Tur-126845	Triticum urartu	29.57	2.00e-50	191.00
IUUC-Tme-127217	Tuber melanosporum	36.85	2.00e-107	380.00
IUUC-Tbe-127526	Tupaia belangeri	27.57	1.00e-60	225.00
IUUC-Ttr-128898	Tursiops truncatus	27.43	2.00e-59	221.00
IUUC-Uma-129631	Ustilago maydis	33.07	1.00e-88	318.00
IUUC-Vda-129732	Verticillium dahliae	35.38	3.00e-90	323.00
IUUC-Vvi-131217	Vitis vinifera	30.61	7.00e-70	256.00
IUUC-Xtr-132860	Xenopus tropicalis	26.01	4.00e-52	197.00
IUUC-Xma-133830	Xiphophorus maculatus	29.62	5.00e-70	256.00
IUUC-Yli-134335	Yarrowia lipolytica	38.17	9.00e-104	368.00
IUUC-Zma-135907	Zea mays	30.79	1.00e-69	255.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence