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Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Mmu-064295
Ensembl Protein ID ENSMUSP00000105049.1
UniProt Accession P23204; PPARA_MOUSE
Genbank Protein ID CAA40856.1; CAA53042.1; CAA53042.1; CAA53042.1; CAA53042.1; CAA53042.1; CAA53042.1; AAH16892.1; CAA61754.1
Protein Name Peroxisome proliferator-activated receptor alpha; Nuclear receptor subfamily 1 group C member 1
Genbank Nucleotide ID X57638; X75289; X75290; X75291; X75292; X75293; X75294; BC016892; X89577
Gene Name Ppara; Nr1c1; Ppar
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000022383.13 ENSMUST00000109422.7 ENSMUSP00000105049.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
mUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 92.31 0.00e+00 840.00 IUUC-Hsa-046893
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description



     Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.
Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.
Protein Sequence
(Fasta)
MVDTESPICP LSPLEADDLE SPLSEEFLQE MGNIQEISQS IGEESSGSFG FADYQYLGSC 60
PGSEGSVITD TLSPASSPSS VSCPVIPAST DESPGSALNI ECRICGDKAS GYHYGVHACE 120
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Protein Fasta Sequence



>IUUC-Mmu-064295|E3,RING|Mus musculus
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Nucleotide Sequence
(Fasta)
TTTCTCATCC TGGGACTCTA AAGATCAGAT TCCGCCTGTC CGTCCACCTC CCCACGAACT 60
CCCGGGACTC GGGGAACAAG CTGTGCGATC TAGACCAGCT CAACGAGGGC ACCCGGAGGA 120
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Nucleotide Fasta Sequence



>IUUC-Mmu-064295|E3,RING|Mus musculus
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Sequence Source Ensembl
Keyword

KW-0010--Activator
KW-0090--Biological rhythms
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0446--Lipid-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0675--Receptor
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003074--1Cnucl_rcpt
IPR003076--1Cnucl_rcpt_A
IPR000536--Nucl_hrmn_rcpt_lig-bd
IPR001723--Nuclear_hrmn_rcpt
IPR001628--Znf_hrmn_rcpt
IPR013088--Znf_NHR/GATA

PROSITE

PS00031--NUCLEAR_REC_DBD_1
PS51030--NUCLEAR_REC_DBD_2

Pfam

PF00104--Hormone_recep
PF00105--zf-C4

PRINTS

PR01288--PROXISOMEPAR
PR01289--PROXISOMPAAR
PR00398--STRDHORMONER
PR00047--STROIDFINGER

SMART

SM00430--HOLI
SM00399--ZnF_C4

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0008144--F:drug binding
GO:0008289--F:lipid binding
GO:0046982--F:protein heterodimerization activity
GO:0004872--F:receptor activity
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001103--F:RNA polymerase II repressing transcription factor binding
GO:0004879--F:RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
GO:0043565--F:sequence-specific DNA binding
GO:0003707--F:steroid hormone receptor activity
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0008134--F:transcription factor binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001190--F:transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0001078--F:transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0008270--F:zinc ion binding
GO:0035095--P:behavioral response to nicotine
GO:0032922--P:circadian regulation of gene expression
GO:0007623--P:circadian rhythm
GO:0070166--P:enamel mineralization
GO:0008544--P:epidermis development
GO:0006631--P:fatty acid metabolic process
GO:0006006--P:glucose metabolic process
GO:0007507--P:heart development
GO:0006629--P:lipid metabolic process
GO:0042157--P:lipoprotein metabolic process
GO:0032099--P:negative regulation of appetite
GO:0045776--P:negative regulation of blood pressure
GO:0010887--P:negative regulation of cholesterol storage
GO:0050728--P:negative regulation of inflammatory response
GO:1903038--P:negative regulation of leukocyte cell-cell adhesion
GO:0010745--P:negative regulation of macrophage derived foam cell differentiation
GO:1901215--P:negative regulation of neuron death
GO:1902894--P:negative regulation of pri-miRNA transcription from RNA polymerase II promoter
GO:0032091--P:negative regulation of protein binding
GO:0010871--P:negative regulation of receptor biosynthetic process
GO:0010891--P:negative regulation of sequestering of triglyceride
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:2000678--P:negative regulation of transcription regulatory region DNA binding
GO:0046321--P:positive regulation of fatty acid oxidation
GO:0045722--P:positive regulation of gluconeogenesis
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0072366--P:regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter
GO:0042752--P:regulation of circadian rhythm
GO:0019217--P:regulation of fatty acid metabolic process
GO:0010468--P:regulation of gene expression
GO:0072363--P:regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter
GO:0072369--P:regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter
GO:0006355--P:regulation of transcription, DNA-templated
GO:0001666--P:response to hypoxia
GO:0032868--P:response to insulin
GO:0042060--P:wound healing

KEGG mmu:19013
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002222 Ailuropoda melanoleuca 89.57 0.00e+00 862.00
IUUC-Apl-003330 Anas platyrhynchos 84.32 0.00e+00 798.00
IUUC-Aca-004598 Anolis carolinensis 81.84 0.00e+00 791.00
IUUC-Acl-008339 Aspergillus clavatus 48.48 7.00e-02 30.40
IUUC-Ame-011508 Astyanax mexicanus 71.28 0.00e+00 659.00
IUUC-Bta-012621 Bos taurus 91.24 0.00e+00 865.00
IUUC-Cja-019688 Callithrix jacchus 91.24 0.00e+00 866.00
IUUC-Cfa-020859 Canis familiaris 90.17 0.00e+00 867.00
IUUC-Cpo-021607 Cavia porcellus 87.61 0.00e+00 826.00
IUUC-Csa-023313 Chlorocebus sabaeus 91.67 0.00e+00 872.00
IUUC-Cho-024741 Choloepus hoffmanni 80.77 0.00e+00 731.00
IUUC-Cgl-026615 Colletotrichum gloeosporioides 30.51 1.40e+00 25.80
IUUC-Dre-027446 Danio rerio 70.28 0.00e+00 648.00
IUUC-Dno-029173 Dasypus novemcinctus 89.74 0.00e+00 822.00
IUUC-Dor-030581 Dipodomys ordii 91.86 0.00e+00 817.00
IUUC-Dme-031794 Drosophila melanogaster 35.41 9.00e-55 209.00
IUUC-Ete-032330 Echinops telfairi 87.18 0.00e+00 829.00
IUUC-Eca-033712 Equus caballus 90.81 0.00e+00 853.00
IUUC-Fca-036555 Felis catus 90.64 0.00e+00 865.00
IUUC-Fal-036677 Ficedula albicollis 83.97 0.00e+00 793.00
IUUC-Gmo-039240 Gadus morhua 78.93 0.00e+00 626.00
IUUC-Gga-040473 Gallus gallus 84.62 0.00e+00 800.00
IUUC-Gac-041872 Gasterosteus aculeatus 69.77 0.00e+00 668.00
IUUC-Ggo-045226 Gorilla gorilla 92.31 0.00e+00 879.00
IUUC-Hsa-046893 Homo sapiens 92.31 0.00e+00 879.00
IUUC-Itr-048952 Ictidomys tridecemlineatus 92.31 0.00e+00 870.00
IUUC-Lch-050116 Latimeria chalumnae 75.64 0.00e+00 716.00
IUUC-Loc-052131 Lepisosteus oculatus 80.37 0.00e+00 647.00
IUUC-Laf-054323 Loxodonta africana 91.03 0.00e+00 867.00
IUUC-Mcc-054841 Macaca mulatta 91.88 0.00e+00 872.00
IUUC-Meu-056833 Macropus eugenii 79.49 0.00e+00 726.00
IUUC-Mga-059995 Meleagris gallopavo 75.85 0.00e+00 704.00
IUUC-Mdo-061954 Monodelphis domestica 84.52 0.00e+00 735.00
IUUC-Mpu-066216 Mustela putorius furo 90.60 0.00e+00 866.00
IUUC-Nle-069970 Nomascus leucogenys 92.09 0.00e+00 877.00
IUUC-Ont-071594 Oreochromis niloticus 70.40 0.00e+00 655.00
IUUC-Oan-073501 Ornithorhynchus anatinus 87.01 0.00e+00 712.00
IUUC-Ocu-074634 Oryctolagus cuniculus 84.10 0.00e+00 832.00
IUUC-Oni-082926 Oryza nivara 29.41 1.30e-02 30.80
IUUC-Ola-086585 Oryzias latipes 76.72 2.00e-178 618.00
IUUC-Oga-088738 Otolemur garnettii 91.88 0.00e+00 860.00
IUUC-Oar-090453 Ovis aries 90.81 0.00e+00 862.00
IUUC-Ptr-091518 Pan troglodytes 92.09 0.00e+00 873.00
IUUC-Pan-092006 Papio anubis 92.09 0.00e+00 874.00
IUUC-Psi-093352 Pelodiscus sinensis 82.84 0.00e+00 791.00
IUUC-Pfo-096060 Poecilia formosa 70.40 0.00e+00 652.00
IUUC-Pab-098602 Pongo abelii 86.71 0.00e+00 786.00
IUUC-Pva-102175 Pteropus vampyrus 85.26 0.00e+00 807.00
IUUC-Rno-105283 Rattus norvegicus 98.08 0.00e+00 877.00
IUUC-Sce-106436 Saccharomyces cerevisiae 29.03 9.00e-03 32.00
IUUC-Sha-106560 Sarcophilus harrisii 88.25 0.00e+00 816.00
IUUC-Smo-109075 Selaginella moellendorffii 30.61 2.20e-01 28.90
IUUC-Ssc-115266 Sus scrofa 91.03 0.00e+00 875.00
IUUC-Tgu-116778 Taeniopygia guttata 83.55 0.00e+00 791.00
IUUC-Tru-118436 Takifugu rubripes 69.56 0.00e+00 655.00
IUUC-Tsy-119642 Tarsius syrichta 93.07 2.00e-128 452.00
IUUC-Tni-119859 Tetraodon nigroviridis 69.56 0.00e+00 649.00
IUUC-Tvi-122624 Trichoderma virens 29.09 4.70e-01 27.30
IUUC-Tbe-127464 Tupaia belangeri 89.74 0.00e+00 868.00
IUUC-Ttr-129307 Tursiops truncatus 87.21 0.00e+00 810.00
Created Date 25-Jun-2017

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