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Basic Information Integrated Annotations

Tag Content
UUCD2 ID IUUC-Spo-108280
UUCD1 version UUC-ScP-00064
Ensembl Protein ID SPAC17G6.12.1:pep
UniProt Accession O13790; Q9USB3; Q9UUL3; CUL1_SCHPO
Genbank Protein ID BAA32428.2; CAB16223.1; BAA87201.1
Protein Name Cullin-1; Cell division control 53 homolog
Genbank Nucleotide ID AB016896; CU329670; AB027897
Gene Name cul1; pcu1; SPAC17G6.12
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
SPAC17G6.12 SPAC17G6.12.1 SPAC17G6.12.1:pep
Annotation
mRNA Expression
GEO
Protein-protein Interaction
iRefIndexHINTMentha
Post-translational Modifications (PTMs)
dbPTM
Protein Expression/Proteomics
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/Cullin 2.70e-165 549.6 28 668
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/Cullin

   S: 3    reavkkilrq..esv.kkeyeelytavynlclsk................vgaklYkklkevleefikqvkkkveesedeq.lLktynreWe 74
    +++v++i ++ e + ++y+elyta++n+c +g+ lY++l +lee++++++k+ ++++++ L++y ++W+
   Q: 28 KTGVSQIFERldEGMtITKYMELYTAIHNYCADAsktitvdnfndqtanvLGEALYNNLVLYLEEYLARLRKECISQTNHEeQLAAYAKYWT 119
    566666655322667789**************9999**********************************999988888877********** PP
   S: 75 kfreqlkvlrkifayldrtyvkk.....skkvsevrkLaldlwrkeivedikkrllelllklieaeRkgeavdrrllsgvveslveLslnk. 160
    +f++++ ++++f yl+r++vk ++ v+++++L l +w+++++++i+++ll+ ll + ++R e d ++++ v s +Ls +k
   Q: 120 RFTTSARFINHLFGYLNRYWVKLknrftETLVYDIYTLCLVSWHHHVFSHIRDSLLQNLLYMFTKKRLYEPTDMKYVEVCVDSITSLSFDKt 211
    *********************98566666666************************************************************ PP
   S: 161 ......laiykesFEakfleatqefykaesaeflqenevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesllaelval 246
    l+ yk+ FE +f e t++fy++es+e+l+++++++Ylkk+e rl eeee ++ yl+est+++Lle e +lia+h e l++++ +
   Q: 212 dmtkpnLSSYKTFFETNFIENTKNFYAKESSEYLASHSITDYLKKAEIRLAEEEELVRLYLHESTLKPLLEATEDVLIAQHEEVLHNDFARM 303
    ******************************************************************************************** PP
   S: 247 lrdkktedlsrmykLlsrvlngleellkeleshikeqgkaalt......aeekekdpkkyVerllelknklqklvseaFnndakFlkaldka 332
    l+++ ed+ rmy+L+sr +ngl++l++++e+++k g aa++ e++ dpk+y e ll+ ++ ++lv++aF+ d+ F+k+ld a
   Q: 304 LDQNCSEDIIRMYRLMSRTPNGLQPLRQTFEEFVKRSGFAAVAkivpqvGGEADVDPKEYMEMLLSTYKASKELVNTAFHGDTDFTKSLDTA 395
    *****************************************99777766677888************************************* PP
   S: 333 fetfvnknsvlka..akspEllAryiDqlLrksskglteeeleaqldkvllvfkyisekdvFekyYkkhLakRLlsgksasseaEesviekL 422
    f++ vn+n v ++ ++spEllA+y D+ Lrks+k+++ ++e+ l +++++f+y+++kdvF+++Y+k+LakRL++g+s s++aE s+++kL
   Q: 396 FRELVNRNVVCQRssSRSPELLAKYADSILRKSNKNVDIDDVEDCLSSIIIIFRYVEDKDVFQNFYTKLLAKRLVNGTSNSQDAESSMLSKL 487
    ********99998889**************************************************************************** PP
   S: 423 keecgaeftskLerMfqdlkvSedlnrqFkeekenteesesvelsvlvLsagaWptasetekvsLPaelektiekfeefYlekhsgRkLqWq 514
    ke+cg+e+tskL+rMfqd+++S++++++F + ++ ++++s lvL +++Wp +++ ++++LP+el ++e f+++Y + h+gRkL+W+
   Q: 488 KEVCGFEYTSKLQRMFQDISLSQEITEAFW--QLPQSRAGNIDFSALVLGTSFWPLSPNNVNFHLPEELVPLYEGFQNYYYSCHNGRKLSWL 577
    ******************************..7778889*********************9******************************* PP
   S: 515 htlgraelkaelkkg...kyelqVstfQmavLLafnnsekvsveelkkatelpeeeLrrtlqsLvsskkqvlkkepeskeieeedlfsvNqe 603
    +l+++e+ka ++ + +y +qVst+Qm vLL++n+++++++eel+k+t+l+++ L+ +l+ +++ k vl ++ k + ++++++N++
   Q: 578 FHLSKGEIKARINPQtnvTYVFQVSTYQMGVLLLYNHRDSYTYEELAKITGLSTDFLTGILNIFLKAK--VLLLGDNDKLGDPNSTYKINEN 667
    ************9888899***********************************************98..7766666666678999999999 PP
   S: 604 f 604
    f
   Q: 668 F 668
    8 PP
   

Organism Schizosaccharomyces pombe
Functional Description
(View)

Functional Description



     Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(pop1-pop2) is required for the maintenance of ploidy and directs ubiquitination of cig2.
Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(pop1-pop2) is required for the maintenance of ploidy and directs ubiquitination of cig2.
Protein Sequence
(Fasta)
MTTLNTNDKD LPIVKKYDSL NGTWDFLKTG VSQIFERLDE GMTITKYMEL YTAIHNYCAD 60
ASKTITVDNF NDQTANVLGE ALYNNLVLYL EEYLARLRKE CISQTNHEEQ LAAYAKYWTR 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Spo-108280|E3,Cullin|Schizosaccharomyces pombe
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AAATATATTT TACTTGTTAT ACATTTATAA CCATTTTGGT TAATGACTAC TTTGAATACC 60
AACGATAAAG ACCTCCCGAT TGTTAAAAAA TATGATTCAT TGAATGGAAC GTATGTTACA 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Spo-108280|E3,Cullin|Schizosaccharomyces pombe
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-1185--Reference proteome
KW-0832--Ubl conjugation

Interpro

IPR016157--Cullin_CS
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR016159--Cullin_repeat-like_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS01256--CULLIN_1
PS50069--CULLIN_2

Pfam

PF00888--Cullin
PF10557--Cullin_Nedd8

SMART

SM00182--CULLIN
SM00884--Cullin_Nedd8

Gene Ontology

GO:0005829--C:cytosol
GO:0043224--C:nuclear SCF ubiquitin ligase complex
GO:0019005--C:SCF ubiquitin ligase complex
GO:0031625--F:ubiquitin protein ligase binding
GO:0007049--P:cell cycle
GO:0051301--P:cell division
GO:1903467--P:negative regulation of mitotic DNA replication initiation
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

KEGG spo:SPAC17G6.12
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002277 Ailuropoda melanoleuca 41.32 4.00e-162 563.00
IUUC-Apl-003503 Anas platyrhynchos 38.81 2.00e-121 427.00
IUUC-Aca-005030 Anolis carolinensis 35.91 6.00e-110 389.00
IUUC-Ago-007977 Ashbya gossypii 32.35 3.00e-120 424.00
IUUC-Acl-008190 Aspergillus clavatus 46.27 0.00e+00 657.00
IUUC-Afl-008542 Aspergillus flavus 46.71 2.00e-152 530.00
IUUC-Afu-009007 Aspergillus fumigatus 48.02 0.00e+00 627.00
IUUC-Ani-009290 Aspergillus nidulans 46.28 0.00e+00 678.00
IUUC-Ang-009600 Aspergillus niger 47.77 0.00e+00 633.00
IUUC-Aor-009978 Aspergillus oryzae 48.35 4.00e-172 596.00
IUUC-Ate-010584 Aspergillus terreus 46.60 0.00e+00 667.00
IUUC-Ame-011861 Astyanax mexicanus 41.53 1.00e-160 558.00
IUUC-Bgr-012209 Blumeria graminis 45.66 0.00e+00 634.00
IUUC-Bta-012878 Bos taurus 41.37 3.00e-162 563.00
IUUC-Bci-013941 Botrytis cinerea 47.98 0.00e+00 720.00
IUUC-Cel-018294 Caenorhabditis elegans 33.59 6.00e-127 446.00
IUUC-Cja-018965 Callithrix jacchus 41.29 4.00e-157 546.00
IUUC-Cfa-020671 Canis familiaris 41.37 3.00e-162 563.00
IUUC-Cpo-021762 Cavia porcellus 41.91 2.00e-162 564.00
IUUC-Csa-023873 Chlorocebus sabaeus 41.91 2.00e-162 563.00
IUUC-Cin-025547 Ciona intestinalis 40.28 4.00e-152 529.00
IUUC-Csv-026083 Ciona savignyi 40.43 2.00e-159 554.00
IUUC-Cgl-026452 Colletotrichum gloeosporioides 44.69 0.00e+00 659.00
IUUC-Cne-026919 Cryptococcus neoformans 41.05 7.00e-165 572.00
IUUC-Dre-027875 Danio rerio 41.50 6.00e-162 562.00
IUUC-Dno-028931 Dasypus novemcinctus 41.70 1.00e-161 561.00
IUUC-Dor-030846 Dipodomys ordii 47.32 1.00e-124 438.00
IUUC-Dse-031472 Dothistroma septosporum 46.77 0.00e+00 657.00
IUUC-Dme-031793 Drosophila melanogaster 39.79 1.00e-152 531.00
IUUC-Ete-033112 Echinops telfairi 42.07 1.00e-66 245.00
IUUC-Eca-034309 Equus caballus 41.37 3.00e-162 563.00
IUUC-Fca-036330 Felis catus 40.28 6.00e-154 535.00
IUUC-Fal-036899 Ficedula albicollis 39.29 6.00e-129 452.00
IUUC-Fox-037705 Fusarium oxysporum 42.62 3.00e-179 619.00
IUUC-Fso-038367 Fusarium solani 44.21 0.00e+00 646.00
IUUC-Gmo-038708 Gadus morhua 41.75 3.00e-160 556.00
IUUC-Ggr-039917 Gaeumannomyces graminis 43.99 0.00e+00 642.00
IUUC-Gga-041038 Gallus gallus 41.50 1.00e-162 565.00
IUUC-Gac-041820 Gasterosteus aculeatus 41.35 7.00e-170 588.00
IUUC-Ggo-045154 Gorilla gorilla 38.49 4.00e-105 373.00
IUUC-Hsa-046034 Homo sapiens 41.91 2.00e-162 563.00
IUUC-Itr-048285 Ictidomys tridecemlineatus 41.50 1.00e-162 565.00
IUUC-Kpa-049231 Komagataella pastoris 35.11 8.00e-133 465.00
IUUC-Lch-049673 Latimeria chalumnae 40.99 2.00e-161 560.00
IUUC-Loc-052490 Lepisosteus oculatus 41.70 1.00e-159 554.00
IUUC-Lma-053191 Leptosphaeria maculans 47.03 0.00e+00 662.00
IUUC-Laf-054582 Loxodonta africana 41.37 3.00e-162 563.00
IUUC-Mcc-055162 Macaca mulatta 41.40 6.00e-158 549.00
IUUC-Meu-055904 Macropus eugenii 43.52 1.00e-64 239.00
IUUC-Mor-057035 Magnaporthe oryzae 44.56 0.00e+00 625.00
IUUC-Mpo-057555 Magnaporthe poae 44.59 0.00e+00 646.00
IUUC-Mla-059021 Melampsora laricipopulina 44.72 5.00e-176 609.00
IUUC-Mga-060078 Meleagris gallopavo 41.50 1.00e-162 565.00
IUUC-Mvi-060519 Microbotryum violaceum 43.68 1.00e-174 605.00
IUUC-Mmr-061312 Microcebus murinus 41.91 2.00e-162 563.00
IUUC-Mdo-062867 Monodelphis domestica 41.37 1.00e-161 561.00
IUUC-Mmu-063336 Mus musculus 41.50 1.00e-162 565.00
IUUC-Mpu-066400 Mustela putorius furo 39.14 2.00e-128 451.00
IUUC-Mlu-067800 Myotis lucifugus 41.06 6.00e-162 562.00
IUUC-Nfi-068384 Neosartorya fischeri 46.00 0.00e+00 639.00
IUUC-Ncr-068965 Neurospora crassa 45.80 0.00e+00 634.00
IUUC-Nle-069729 Nomascus leucogenys 41.91 2.00e-162 563.00
IUUC-Opr-071197 Ochotona princeps 30.35 7.00e-82 296.00
IUUC-Ont-071729 Oreochromis niloticus 41.13 3.00e-162 563.00
IUUC-Oan-073309 Ornithorhynchus anatinus 41.50 1.00e-162 565.00
IUUC-Ocu-074661 Oryctolagus cuniculus 40.99 2.00e-161 560.00
IUUC-Ola-087422 Oryzias latipes 41.53 5.00e-164 569.00
IUUC-Oga-088130 Otolemur garnettii 41.91 2.00e-162 563.00
IUUC-Oar-089510 Ovis aries 40.26 6.00e-151 526.00
IUUC-Ptr-090665 Pan troglodytes 41.91 2.00e-162 563.00
IUUC-Pan-092218 Papio anubis 41.91 2.00e-162 563.00
IUUC-Psi-093175 Pelodiscus sinensis 41.50 1.00e-162 564.00
IUUC-Pma-094502 Petromyzon marinus 41.66 5.00e-160 556.00
IUUC-Pno-095067 Phaeosphaeria nodorum 46.42 0.00e+00 688.00
IUUC-Pfo-096705 Poecilia formosa 41.13 5.00e-170 589.00
IUUC-Pab-097578 Pongo abelii 41.91 2.00e-162 563.00
IUUC-Pca-100242 Procavia capensis 42.36 1.00e-109 388.00
IUUC-Pva-102155 Pteropus vampyrus 35.83 3.00e-125 440.00
IUUC-Pgr-103297 Puccinia graminis 40.46 2.00e-168 583.00
IUUC-Ptt-103706 Puccinia triticina 41.93 1.00e-90 326.00
IUUC-Pte-104257 Pyrenophora teres 47.66 0.00e+00 696.00
IUUC-Pyt-104795 Pyrenophora triticirepentis 47.53 0.00e+00 694.00
IUUC-Rno-105939 Rattus norvegicus 41.50 1.00e-162 565.00
IUUC-Sce-106293 Saccharomyces cerevisiae 32.31 2.00e-121 427.00
IUUC-Sha-106949 Sarcophilus harrisii 41.50 1.00e-162 565.00
IUUC-Sja-107737 Schizosaccharomyces japonicus 61.21 0.00e+00 937.00
IUUC-Sar-113138 Sorex araneus 33.04 2.00e-104 371.00
IUUC-Sre-114984 Sporisorium reilianum 42.59 4.00e-172 596.00
IUUC-Ssc-115829 Sus scrofa 41.09 2.00e-157 547.00
IUUC-Tgu-116950 Taeniopygia guttata 41.50 1.00e-162 565.00
IUUC-Tru-118558 Takifugu rubripes 41.41 6.00e-167 578.00
IUUC-Tsy-119621 Tarsius syrichta 35.47 7.00e-87 313.00
IUUC-Tni-120460 Tetraodon nigroviridis 41.41 9.00e-169 585.00
IUUC-Tre-122223 Trichoderma reesei 45.85 0.00e+00 634.00
IUUC-Tvi-122539 Trichoderma virens 43.21 9.00e-174 601.00
IUUC-Tme-126926 Tuber melanosporum 49.15 0.00e+00 716.00
IUUC-Tbe-127369 Tupaia belangeri 48.01 1.00e-81 295.00
IUUC-Ttr-129022 Tursiops truncatus 41.41 6.00e-125 439.00
IUUC-Uma-129341 Ustilago maydis 43.02 5.00e-166 575.00
IUUC-Vda-129857 Verticillium dahliae 45.12 7.00e-176 608.00
IUUC-Vpa-130166 Vicugna pacos 36.04 6.00e-109 386.00
IUUC-Xtr-131818 Xenopus tropicalis 41.42 3.00e-161 560.00
IUUC-Xma-134206 Xiphophorus maculatus 41.67 4.00e-163 566.00
IUUC-Yli-134486 Yarrowia lipolytica 38.78 2.00e-144 504.00
Created Date 25-Jun-2017

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