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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Cel-018398
UUCD1 version UUC-CaE-00671
Ensembl Protein ID F39B2.2.1
UniProt Accession O45495; UB2V1_CAEEL
Genbank Protein ID CAB07383.1
Protein Name Ubiquitin-conjugating enzyme E2 variant 1
Genbank Nucleotide ID BX284601
Gene Name uev-1; F39B2.2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00006730 F39B2.2.1 F39B2.2.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNAmiRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E2/UEV E2_UEV 15530417
Classification
Family E-value Score Start End
E2/UBC 3.80e-20 72.4 9 127
E2/UEV 1.30e-61 206.9 1 139
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E2/UBC
   S: 1    Rlkkelkelekdpp.egisakpvdesd..ltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyen.GkvClsilkeeekWspal 96
           Rl +el+e +k +   +is +++d+sd  lt+w + i+Gp++tpYe ++++l+i++  +YP +PP+v+f+tk+    v+++ G +    l++ ++Ws  +
   Q: 9    RLLEELEEGQKGKGdGNISWGLEDDSDmtLTRWTASIIGPPRTPYESRIYNLQIQCGGNYPREPPTVRFTTKVHMVGVNQSnGVIDKRNLTTLRNWSNSY 108
           5666666665544425788999999997789*****************************************999999988799998888889******* PP
   S: 97   svesvllsiqsll..aepn 113
            +++vl +i + +  a+ n
   Q: 109  MIKTVLEDIRKNMmmAKEN 127
           *********9876333333 PP
   

   E2/UEV
   S: 8    kvvvprnfrlleeleegekglgdgtvsygldDgddilllsltgtIigpertayegrIyqlklfvgkkYPekPPtvrfsskinmaevndsnGvvdpralpv 107
           +v vprnfrlleeleeg+kg gdg++s+gl+D++d++l+++t++Iigp+rt ye+rIy+l++++g +YP++PPtvrf++k++m +vn+snGv+d+r+l++
   Q: 1    MVDVPRNFRLLEELEEGQKGKGDGNISWGLEDDSDMTLTRWTASIIGPPRTPYESRIYNLQIQCGGNYPREPPTVRFTTKVHMVGVNQSNGVIDKRNLTT 100
           589************************************************************************************************* PP
   S: 108  LanWkreysievvlvqlkk.ellskenrklqqPpeGnlf 145
           L+nW+++y+i++vl++++k ++++ken klqqP+eG++f
   Q: 101  LRNWSNSYMIKTVLEDIRKnMMMAKENLKLQQPAEGAMF 139
           *****************997899*************997 PP
   
Organism Caenorhabditis elegans
Functional Description
(View)

Functional Description


     Involved in protein ubiquitination, but has no ubiquitin ligase activity on its own (PubMed:15530417). The uev-1-ubc-13 heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63 (PubMed:15530417, PubMed:24595290). Involved in sorting Lys-63-linked polyubiquinated maternal membrane proteins for degradation by targeting to multivesicular bodies (PubMed:24595290). Required for glr-1-containing glutamate receptor trafficking in neurons (PubMed:21179194). May have a role in synaptic transmission at motorneurons (PubMed:21179194). May be involved in the ubiquitination and growth of intracellular polyglutamine protein aggregates (PubMed:17663792, PubMed:22494772).
 Involved in protein ubiquitination, but has no ubiquitin ligase activity on its own (PubMed:15530417). The uev-1-ubc-13 heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63 (PubMed:15530417, PubMed:24595290). Involved in sorting Lys-63-linked polyubiquinated maternal membrane proteins for degradation by targeting to multivesicular bodies (PubMed:24595290). Required for glr-1-containing glutamate receptor trafficking in neurons (PubMed:21179194). May have a role in synaptic transmission at motorneurons (PubMed:21179194). May be involved in the ubiquitination and growth of intracellular polyglutamine protein aggregates (PubMed:17663792, PubMed:22494772).
Protein Sequence
(Fasta)
MVDVPRNFRL LEELEEGQKG KGDGNISWGL EDDSDMTLTR WTASIIGPPR TPYESRIYNL 60
QIQCGGNYPR EPPTVRFTTK VHMVGVNQSN GVIDKRNLTT LRNWSNSYMI KTVLEDIRKN 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Cel-018398|E2,E2/UEV;E2,E2/UBC|Caenorhabditis elegans
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGTTCCAGCA ACTTGGGCAC TTTCAAAATG GGTAAGTTCG CTTTCTAAAT TCAAAAATGA 60
TTATTTTCGC ATATTTTTCT CTTTTCCAGT CGATGTACCA CGCAATTTCC GTCTGCTGGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cel-018398|E2,E2/UEV;E2,E2/UBC|Caenorhabditis elegans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR000608--UBQ-conjugat_E2
IPR016135--UBQ-conjugating_enzyme/RWD
PROSITE

PS50127--UBIQUITIN_CONJUGAT_2
Pfam

PF00179--UQ_con
Gene Ontology

GO:0005829--C:cytosol
GO:0030425--C:dendrite
GO:0043005--C:neuron projection
GO:0005634--C:nucleus
GO:0043204--C:perikaryon
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0006301--P:postreplication repair
GO:0070534--P:protein K63-linked ubiquitination
GO:0090325--P:regulation of locomotion involved in locomotory behavior
GO:2000008--P:regulation of protein localization to cell surface
KEGG cel:CELE_F39B2.2
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000910 Aegilops tauschii 46.32 4.00e-32 128.00
IUUC-Aml-001242 Ailuropoda melanoleuca 66.67 3.00e-47 181.00
IUUC-Atr-003005 Amborella trichopoda 44.93 3.00e-31 125.00
IUUC-Apl-003600 Anas platyrhynchos 66.67 1.00e-47 180.00
IUUC-Aca-004448 Anolis carolinensis 64.75 9.00e-48 181.00
IUUC-Aly-006356 Arabidopsis lyrata 49.63 3.00e-33 132.00
IUUC-Ath-007588 Arabidopsis thaliana 47.41 2.00e-32 129.00
IUUC-Ago-007810 Ashbya gossypii 44.60 4.00e-28 115.00
IUUC-Acl-008375 Aspergillus clavatus 44.93 5.00e-27 112.00
IUUC-Afl-008598 Aspergillus flavus 42.65 2.00e-25 106.00
IUUC-Afu-008838 Aspergillus fumigatus 44.85 3.00e-27 112.00
IUUC-Ani-009325 Aspergillus nidulans 44.12 1.00e-26 110.00
IUUC-Ang-009631 Aspergillus niger 43.38 5.00e-26 108.00
IUUC-Aor-010051 Aspergillus oryzae 42.65 2.00e-25 106.00
IUUC-Ate-010471 Aspergillus terreus 37.50 9.00e-21 90.90
IUUC-Ame-010710 Astyanax mexicanus 62.32 2.00e-50 189.00
IUUC-Bgr-012010 Blumeria graminis 46.32 2.00e-28 116.00
IUUC-Bta-013403 Bos taurus 66.67 1.00e-47 180.00
IUUC-Bci-013649 Botrytis cinerea 44.60 3.00e-26 109.00
IUUC-Bdi-014826 Brachypodium distachyon 47.10 9.00e-32 127.00
IUUC-Bol-015323 Brassica oleracea 48.55 1.00e-32 130.00
IUUC-Bra-016758 Brassica rapa 49.26 2.00e-33 133.00
IUUC-Cja-019316 Callithrix jacchus 66.67 1.00e-47 180.00
IUUC-Cfa-021118 Canis familiaris 66.67 9.00e-48 181.00
IUUC-Cpo-021317 Cavia porcellus 63.77 1.00e-51 193.00
IUUC-Cre-022629 Chlamydomonas reinhardtii 44.93 4.00e-32 129.00
IUUC-Csa-024275 Chlorocebus sabaeus 66.67 4.00e-47 180.00
IUUC-Cho-025024 Choloepus hoffmanni 51.69 9.00e-26 106.00
IUUC-Cin-025219 Ciona intestinalis 43.52 5.00e-22 94.70
IUUC-Cgl-026596 Colletotrichum gloeosporioides 45.59 5.00e-28 115.00
IUUC-Cne-026817 Cryptococcus neoformans 42.45 5.00e-33 132.00
IUUC-Cme-027257 Cyanidioschyzon merolae 48.55 2.00e-23 100.00
IUUC-Dre-028062 Danio rerio 64.49 2.00e-51 192.00
IUUC-Dno-029762 Dasypus novemcinctus 66.67 1.00e-47 180.00
IUUC-Dor-030185 Dipodomys ordii 85.71 8.00e-21 92.00
IUUC-Dse-031272 Dothistroma septosporum 47.79 2.00e-27 112.00
IUUC-Dme-031635 Drosophila melanogaster 63.77 3.00e-49 185.00
IUUC-Ete-033017 Echinops telfairi 63.77 5.00e-45 173.00
IUUC-Eca-034422 Equus caballus 66.67 1.00e-47 180.00
IUUC-Eeu-035327 Erinaceus europaeus 66.67 2.00e-47 181.00
IUUC-Fca-035746 Felis catus 63.77 1.00e-51 193.00
IUUC-Fal-037350 Ficedula albicollis 66.67 9.00e-48 181.00
IUUC-Fox-037803 Fusarium oxysporum 42.65 8.00e-27 111.00
IUUC-Fso-038147 Fusarium solani 43.38 1.00e-26 110.00
IUUC-Gmo-039237 Gadus morhua 61.15 1.00e-49 186.00
IUUC-Ggr-039839 Gaeumannomyces graminis 41.18 2.00e-24 103.00
IUUC-Gga-040746 Gallus gallus 65.94 3.00e-47 179.00
IUUC-Gac-041936 Gasterosteus aculeatus 60.14 5.00e-39 151.00
IUUC-Gma-043467 Glycine max 48.89 6.00e-32 128.00
IUUC-Ggo-044696 Gorilla gorilla 63.77 8.00e-52 194.00
IUUC-Hsa-045659 Homo sapiens 66.67 1.00e-47 180.00
IUUC-Hvu-047368 Hordeum vulgare 45.93 1.00e-31 127.00
IUUC-Itr-048139 Ictidomys tridecemlineatus 66.67 1.00e-47 180.00
IUUC-Kpa-049337 Komagataella pastoris 43.88 8.00e-27 111.00
IUUC-Lch-050494 Latimeria chalumnae 63.04 1.00e-50 190.00
IUUC-Lpe-050874 Leersia perrieri 48.15 8.00e-33 131.00
IUUC-Loc-052012 Lepisosteus oculatus 64.49 2.00e-51 192.00
IUUC-Lma-053194 Leptosphaeria maculans 43.38 3.00e-26 109.00
IUUC-Laf-054176 Loxodonta africana 66.67 1.00e-47 180.00
IUUC-Mcc-055788 Macaca mulatta 66.67 4.00e-47 180.00
IUUC-Meu-056842 Macropus eugenii 50.56 3.00e-17 81.60
IUUC-Mor-056915 Magnaporthe oryzae 30.46 7.00e-17 78.60
IUUC-Mpo-057437 Magnaporthe poae 41.18 1.00e-24 103.00
IUUC-Mtr-058655 Medicago truncatula 47.76 1.00e-30 124.00
IUUC-Mla-058919 Melampsora laricipopulina 49.26 1.00e-28 117.00
IUUC-Mga-059210 Meleagris gallopavo 64.75 2.00e-47 179.00
IUUC-Mvi-060260 Microbotryum violaceum 46.04 9.00e-30 120.00
IUUC-Mmr-061751 Microcebus murinus 62.32 5.00e-50 188.00
IUUC-Mdo-062503 Monodelphis domestica 65.22 2.00e-47 179.00
IUUC-Mmu-063294 Mus musculus 63.04 6.00e-52 194.00
IUUC-Mac-065351 Musa acuminata 48.53 3.00e-32 129.00
IUUC-Mpu-065775 Mustela putorius furo 66.67 1.00e-47 180.00
IUUC-Mlu-067702 Myotis lucifugus 63.77 1.00e-51 193.00
IUUC-Nfi-068400 Neosartorya fischeri 39.58 3.00e-22 95.50
IUUC-Ncr-068946 Neurospora crassa 40.52 2.00e-32 130.00
IUUC-Nle-069245 Nomascus leucogenys 66.67 1.00e-47 180.00
IUUC-Opr-070859 Ochotona princeps 65.65 1.00e-44 172.00
IUUC-Ont-072098 Oreochromis niloticus 63.77 2.00e-42 163.00
IUUC-Oan-073215 Ornithorhynchus anatinus 62.86 4.00e-44 168.00
IUUC-Ocu-074447 Oryctolagus cuniculus 65.94 2.00e-47 179.00
IUUC-Oba-075005 Oryza barthii 45.93 1.00e-31 127.00
IUUC-Obr-076238 Oryza brachyantha 47.41 9.00e-33 130.00
IUUC-Ogl-077309 Oryza glaberrima 47.83 2.00e-33 132.00
IUUC-Ogu-078374 Oryza glumaepatula 45.93 1.00e-31 127.00
IUUC-Oin-079314 Oryza indica 47.83 2.00e-33 132.00
IUUC-Olo-080528 Oryza longistaminata 45.71 4.00e-30 122.00
IUUC-Ome-081761 Oryza meridionalis 45.93 1.00e-31 127.00
IUUC-Oni-082956 Oryza nivara 47.83 2.00e-33 132.00
IUUC-Opu-083148 Oryza punctata 45.93 1.00e-31 127.00
IUUC-Oru-084710 Oryza rufipogon 47.83 2.00e-33 132.00
IUUC-Osa-085558 Oryza sativa 47.83 2.00e-33 132.00
IUUC-Ola-087529 Oryzias latipes 64.49 5.00e-43 165.00
IUUC-Olu-087815 Ostreococcus lucimarinus 35.65 3.00e-16 76.30
IUUC-Oga-087972 Otolemur garnettii 66.67 1.00e-47 180.00
IUUC-Oar-090166 Ovis aries 66.67 2.00e-47 181.00
IUUC-Ptr-090866 Pan troglodytes 66.67 1.00e-47 180.00
IUUC-Pan-091955 Papio anubis 63.77 8.00e-52 194.00
IUUC-Psi-093138 Pelodiscus sinensis 65.22 2.00e-47 179.00
IUUC-Pma-094142 Petromyzon marinus 75.56 7.00e-17 77.00
IUUC-Pno-095070 Phaeosphaeria nodorum 43.38 8.00e-26 107.00
IUUC-Ppa-095557 Physcomitrella patens 45.65 4.00e-31 125.00
IUUC-Pfo-096483 Poecilia formosa 63.77 2.00e-42 162.00
IUUC-Pab-098403 Pongo abelii 66.67 2.00e-47 181.00
IUUC-Pop-099176 Populus trichocarpa 45.65 2.00e-31 126.00
IUUC-Pca-100723 Procavia capensis 66.67 2.00e-47 181.00
IUUC-Ppe-101725 Prunus persica 49.63 2.00e-32 130.00
IUUC-Pva-102989 Pteropus vampyrus 63.77 8.00e-52 194.00
IUUC-Pgr-103617 Puccinia graminis 48.53 2.00e-27 112.00
IUUC-Ptt-104008 Puccinia triticina 37.68 5.00e-13 65.50
IUUC-Pte-104176 Pyrenophora teres 43.38 1.00e-26 110.00
IUUC-Pyt-104517 Pyrenophora triticirepentis 43.38 1.00e-26 110.00
IUUC-Rno-105839 Rattus norvegicus 63.77 4.00e-52 195.00
IUUC-Sce-106349 Saccharomyces cerevisiae 48.20 3.00e-29 119.00
IUUC-Sha-107363 Sarcophilus harrisii 66.67 8.00e-48 181.00
IUUC-Sja-107722 Schizosaccharomyces japonicus 43.88 3.00e-26 109.00
IUUC-Spo-108027 Schizosaccharomyces pombe 44.60 2.00e-27 112.00
IUUC-Ssl-108493 Sclerotinia sclerotiorum 45.59 6.00e-26 108.00
IUUC-Smo-109272 Selaginella moellendorffii 43.38 1.00e-33 134.00
IUUC-Sit-110196 Setaria italica 46.67 8.00e-32 127.00
IUUC-Sly-110942 Solanum lycopersicum 45.65 4.00e-31 125.00
IUUC-Stu-111991 Solanum tuberosum 46.38 2.00e-31 127.00
IUUC-Sar-113197 Sorex araneus 75.82 7.00e-38 149.00
IUUC-Sbi-114412 Sorghum bicolor 46.67 7.00e-32 128.00
IUUC-Sre-114909 Sporisorium reilianum 50.36 2.00e-30 123.00
IUUC-Ssc-115939 Sus scrofa 66.67 1.00e-47 180.00
IUUC-Tgu-117289 Taeniopygia guttata 66.67 1.00e-47 181.00
IUUC-Tru-118526 Takifugu rubripes 63.04 2.00e-36 143.00
IUUC-Tsy-119103 Tarsius syrichta 75.82 2.00e-37 147.00
IUUC-Tni-120169 Tetraodon nigroviridis 65.22 7.00e-39 151.00
IUUC-Tca-121025 Theobroma cacao 49.63 8.00e-33 132.00
IUUC-Tre-121971 Trichoderma reesei 43.48 1.00e-27 114.00
IUUC-Tvi-122622 Trichoderma virens 44.85 2.00e-27 113.00
IUUC-Tae-123220 Triticum aestivum 45.93 1.00e-31 127.00
IUUC-Tur-126236 Triticum urartu 46.32 3.00e-32 129.00
IUUC-Tme-127171 Tuber melanosporum 43.17 4.00e-26 108.00
IUUC-Tbe-128105 Tupaia belangeri 63.77 1.00e-50 192.00
IUUC-Ttr-128790 Tursiops truncatus 66.67 2.00e-47 181.00
IUUC-Uma-129419 Ustilago maydis 50.36 7.00e-30 121.00
IUUC-Vda-129776 Verticillium dahliae 44.93 9.00e-26 107.00
IUUC-Vpa-130575 Vicugna pacos 66.67 3.00e-47 181.00
IUUC-Vvi-130831 Vitis vinifera 48.15 5.00e-32 128.00
IUUC-Xtr-132359 Xenopus tropicalis 64.49 2.00e-46 176.00
IUUC-Xma-133222 Xiphophorus maculatus 63.77 3.00e-42 162.00
IUUC-Yli-134591 Yarrowia lipolytica 44.12 2.00e-23 99.00
IUUC-Zma-135558 Zea mays 46.67 8.00e-32 127.00
Created Date 25-Jun-2017

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