iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	1.00e-47	161.7	8	142

Active Site

Position(s)	Description	Evidence
88	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkeeekWspalsves 100
           R+ ke+++l +dp++gisa+p+++ +   ++v+i Gp+d+p++ggvFkle+ +pe+YP+ +Pkv+f+tki+hPn+++ G++Cl+ilk  +kWspal++++
   Q: 8    RIIKETQRLLADPVPGISANPDES-NARYFHVMIAGPDDSPFAGGVFKLELFLPEEYPMAAPKVRFMTKIYHPNIDKLGRICLDILK--DKWSPALQIRT 104
           899*********************.9************************************************************9..*********** PP
   S: 101  vllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           vllsiq+ll+ pnpe+pl +++ae++k+n++e  k+++
   Q: 105  VLLSIQALLSAPNPEDPLATDVAEQWKTNEAEAIKTAK 142
           *****************************998777765 PP

Organism

Caenorhabditis elegans

Functional Description
(View)

Involved in protein ubiquitination, but has no ubiquitin ligase activity on its own (PubMed:15530417). The uev-1-ubc-13 heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains (PubMed:15530417, PubMed:24595290). Involved in sorting Lys-63-linked polyubiquinated maternal membrane proteins for degradation by targeting to multivesicular bodies (PubMed:24595290). May be involved in the ubiquitination and growth of intracellular polyglutamine protein aggregates (PubMed:17663792, PubMed:22494772). May have a role in AMPA-type glutamate receptor trafficking in neurons (PubMed:21179194).

Protein Sequence
(Fasta)

MAGQLPRRII KETQRLLADP VPGISANPDE SNARYFHVMI AGPDDSPFAG GVFKLELFLP 60
EEYPMAAPKV RFMTKIYHPN IDKLGRICLD ILKDKWSPAL QIRTVLLSIQ ALLSAPNPED 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AATGGCCGGG CAACTTCCGC GTCGAATCAT CAAAGAGACA CAACGACTTC TCGCGGATCC 60
GGTTCCCGGA ATATCGGCAA ATCCAGACGA GAGCAACGCC AGATACTTCC ATGTCATGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0031371--C:ubiquitin conjugating enzyme complex
GO:0016874--F:ligase activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0006301--P:postreplication repair
GO:0070534--P:protein K63-linked ubiquitination
GO:0016567--P:protein ubiquitination
GO:2000008--P:regulation of protein localization to cell surface

KEGG

cel:CELE_Y54G2A.31

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000100	Aegilops tauschii	79.73	8.00e-69	250.00
IUUC-Aml-001889	Ailuropoda melanoleuca	85.92	3.00e-71	259.00
IUUC-Atr-002818	Amborella trichopoda	80.41	8.00e-70	254.00
IUUC-Apl-003469	Anas platyrhynchos	86.62	2.00e-72	262.00
IUUC-Aca-005051	Anolis carolinensis	88.59	3.00e-75	272.00
IUUC-Aly-006258	Arabidopsis lyrata	79.19	8.00e-70	254.00
IUUC-Ath-007639	Arabidopsis thaliana	79.19	2.00e-69	253.00
IUUC-Ago-007837	Ashbya gossypii	76.23	3.00e-53	199.00
IUUC-Acl-008263	Aspergillus clavatus	70.34	1.00e-61	226.00
IUUC-Afl-008733	Aspergillus flavus	69.66	3.00e-61	225.00
IUUC-Afu-008946	Aspergillus fumigatus	70.34	1.00e-61	226.00
IUUC-Ani-009482	Aspergillus nidulans	71.81	2.00e-63	233.00
IUUC-Ang-009678	Aspergillus niger	71.03	1.00e-61	226.00
IUUC-Aor-010025	Aspergillus oryzae	69.66	3.00e-61	225.00
IUUC-Ate-010254	Aspergillus terreus	70.34	9.00e-61	224.00
IUUC-Ame-010742	Astyanax mexicanus	87.92	6.00e-75	271.00
IUUC-Bgr-012156	Blumeria graminis	64.19	4.00e-53	198.00
IUUC-Bta-012636	Bos taurus	88.59	3.00e-75	272.00
IUUC-Bci-013761	Botrytis cinerea	70.07	7.00e-61	224.00
IUUC-Bdi-014796	Brachypodium distachyon	79.19	8.00e-70	254.00
IUUC-Bol-016613	Brassica oleracea	79.19	7.00e-70	254.00
IUUC-Bra-016938	Brassica rapa	79.19	7.00e-70	254.00
IUUC-Cja-019108	Callithrix jacchus	88.59	3.00e-75	272.00
IUUC-Cfa-020561	Canis familiaris	87.92	1.00e-74	270.00
IUUC-Cpo-022280	Cavia porcellus	84.46	6.00e-72	261.00
IUUC-Cre-022978	Chlamydomonas reinhardtii	79.33	7.00e-69	251.00
IUUC-Csa-023860	Chlorocebus sabaeus	81.21	6.00e-68	248.00
IUUC-Cho-024459	Choloepus hoffmanni	88.59	3.00e-75	272.00
IUUC-Cin-025278	Ciona intestinalis	77.40	1.00e-65	240.00
IUUC-Csv-025952	Ciona savignyi	71.03	1.00e-57	213.00
IUUC-Cgl-026752	Colletotrichum gloeosporioides	71.72	6.00e-62	228.00
IUUC-Cne-026809	Cryptococcus neoformans	74.63	1.00e-57	213.00
IUUC-Cme-027100	Cyanidioschyzon merolae	67.33	2.00e-60	223.00
IUUC-Dre-027814	Danio rerio	87.92	6.00e-75	271.00
IUUC-Dno-030059	Dasypus novemcinctus	86.58	2.00e-73	266.00
IUUC-Dor-030269	Dipodomys ordii	90.70	7.00e-68	247.00
IUUC-Dse-031505	Dothistroma septosporum	68.00	2.00e-61	226.00
IUUC-Dme-032097	Drosophila melanogaster	80.27	3.00e-71	258.00
IUUC-Ete-032369	Echinops telfairi	88.59	3.00e-75	272.00
IUUC-Eca-033230	Equus caballus	88.59	3.00e-75	272.00
IUUC-Fca-036161	Felis catus	86.21	2.00e-72	262.00
IUUC-Fal-036781	Ficedula albicollis	85.23	1.00e-72	263.00
IUUC-Fox-037840	Fusarium oxysporum	71.23	1.00e-61	226.00
IUUC-Fso-038118	Fusarium solani	71.92	3.00e-62	229.00
IUUC-Gmo-039561	Gadus morhua	84.67	2.00e-73	266.00
IUUC-Ggr-039807	Gaeumannomyces graminis	71.72	3.00e-62	228.00
IUUC-Gga-041024	Gallus gallus	88.59	3.00e-75	272.00
IUUC-Gac-042450	Gasterosteus aculeatus	85.23	1.00e-72	263.00
IUUC-Gma-043982	Glycine max	79.19	8.00e-70	254.00
IUUC-Ggo-044660	Gorilla gorilla	87.92	1.00e-74	270.00
IUUC-Hsa-045881	Homo sapiens	88.59	3.00e-75	272.00
IUUC-Hvu-047346	Hordeum vulgare	79.19	9.00e-70	253.00
IUUC-Itr-048778	Ictidomys tridecemlineatus	87.50	1.00e-68	250.00
IUUC-Kpa-049285	Komagataella pastoris	70.75	3.00e-62	229.00
IUUC-Lch-050548	Latimeria chalumnae	85.61	4.00e-70	255.00
IUUC-Lpe-051394	Leersia perrieri	79.19	2.00e-69	252.00
IUUC-Loc-052205	Lepisosteus oculatus	87.92	6.00e-75	271.00
IUUC-Lma-053056	Leptosphaeria maculans	71.23	8.00e-62	227.00
IUUC-Laf-053540	Loxodonta africana	88.41	8.00e-71	257.00
IUUC-Mcc-054863	Macaca mulatta	88.59	3.00e-75	272.00
IUUC-Meu-056482	Macropus eugenii	88.41	8.00e-71	257.00
IUUC-Mor-057014	Magnaporthe oryzae	71.72	9.00e-62	227.00
IUUC-Mpo-057586	Magnaporthe poae	71.72	4.00e-62	228.00
IUUC-Mtr-058552	Medicago truncatula	71.17	9.00e-66	241.00
IUUC-Mla-058920	Melampsora laricipopulina	70.86	6.00e-63	231.00
IUUC-Mga-059649	Meleagris gallopavo	84.93	8.00e-72	260.00
IUUC-Mvi-060483	Microbotryum violaceum	75.51	1.00e-65	240.00
IUUC-Mmr-061167	Microcebus murinus	88.59	3.00e-75	272.00
IUUC-Mdo-062701	Monodelphis domestica	88.59	3.00e-75	272.00
IUUC-Mmu-064070	Mus musculus	88.59	3.00e-75	272.00
IUUC-Mac-064742	Musa acuminata	79.87	4.00e-70	255.00
IUUC-Mpu-066401	Mustela putorius furo	88.59	3.00e-75	272.00
IUUC-Mlu-067229	Myotis lucifugus	87.41	3.00e-72	262.00
IUUC-Nfi-068526	Neosartorya fischeri	70.34	2.00e-61	226.00
IUUC-Ncr-068643	Neurospora crassa	71.03	1.00e-61	226.00
IUUC-Nle-070146	Nomascus leucogenys	88.59	3.00e-75	272.00
IUUC-Opr-070232	Ochotona princeps	69.80	1.00e-53	200.00
IUUC-Ont-072369	Oreochromis niloticus	87.25	2.00e-74	269.00
IUUC-Oan-073174	Ornithorhynchus anatinus	86.81	2.00e-72	262.00
IUUC-Ocu-074712	Oryctolagus cuniculus	88.59	3.00e-75	272.00
IUUC-Oba-075408	Oryza barthii	79.19	2.00e-69	252.00
IUUC-Obr-076881	Oryza brachyantha	79.19	2.00e-69	252.00
IUUC-Ogl-077242	Oryza glaberrima	79.19	2.00e-69	252.00
IUUC-Ogu-078465	Oryza glumaepatula	79.19	2.00e-69	252.00
IUUC-Oin-080035	Oryza indica	79.29	3.00e-65	238.00
IUUC-Olo-080555	Oryza longistaminata	79.19	2.00e-69	252.00
IUUC-Ome-081653	Oryza meridionalis	79.19	2.00e-69	252.00
IUUC-Oni-082400	Oryza nivara	79.19	2.00e-69	252.00
IUUC-Opu-083130	Oryza punctata	81.16	2.00e-65	240.00
IUUC-Oru-084649	Oryza rufipogon	79.19	2.00e-69	252.00
IUUC-Osa-085629	Oryza sativa	79.19	2.00e-69	252.00
IUUC-Ola-087083	Oryzias latipes	87.92	2.00e-74	269.00
IUUC-Olu-087886	Ostreococcus lucimarinus	63.76	7.00e-57	211.00
IUUC-Oga-088983	Otolemur garnettii	84.83	2.00e-71	259.00
IUUC-Oar-090440	Ovis aries	87.92	1.00e-74	270.00
IUUC-Ptr-090572	Pan troglodytes	88.59	3.00e-75	272.00
IUUC-Pan-092503	Papio anubis	86.58	1.00e-73	266.00
IUUC-Psi-093419	Pelodiscus sinensis	87.88	3.00e-67	245.00
IUUC-Pma-094136	Petromyzon marinus	80.85	6.00e-41	157.00
IUUC-Pno-094838	Phaeosphaeria nodorum	70.20	7.00e-62	228.00
IUUC-Ppa-096014	Physcomitrella patens	79.73	8.00e-70	254.00
IUUC-Pfo-096074	Poecilia formosa	87.92	9.00e-75	270.00
IUUC-Pab-097778	Pongo abelii	88.59	3.00e-75	272.00
IUUC-Pop-099707	Populus trichocarpa	79.19	1.00e-69	253.00
IUUC-Pca-100334	Procavia capensis	75.17	4.00e-63	231.00
IUUC-Ppe-101149	Prunus persica	79.19	8.00e-70	254.00
IUUC-Pva-102979	Pteropus vampyrus	88.59	3.00e-75	272.00
IUUC-Pgr-103654	Puccinia graminis	70.67	4.00e-62	228.00
IUUC-Ptt-103752	Puccinia triticina	69.66	4.00e-59	218.00
IUUC-Pte-104137	Pyrenophora teres	70.55	2.00e-61	226.00
IUUC-Pyt-104513	Pyrenophora triticirepentis	70.55	2.00e-61	226.00
IUUC-Rno-105927	Rattus norvegicus	87.92	5.00e-75	271.00
IUUC-Sce-106178	Saccharomyces cerevisiae	66.89	7.00e-59	218.00
IUUC-Sha-107493	Sarcophilus harrisii	88.59	3.00e-75	272.00
IUUC-Sja-107878	Schizosaccharomyces japonicus	65.99	4.00e-55	205.00
IUUC-Spo-108062	Schizosaccharomyces pombe	65.52	6.00e-54	201.00
IUUC-Ssl-108395	Sclerotinia sclerotiorum	70.07	1.00e-60	223.00
IUUC-Smo-109587	Selaginella moellendorffii	74.50	3.00e-63	232.00
IUUC-Sit-110151	Setaria italica	79.19	2.00e-69	253.00
IUUC-Sly-111322	Solanum lycopersicum	79.19	7.00e-70	254.00
IUUC-Stu-112254	Solanum tuberosum	78.52	2.00e-69	253.00
IUUC-Sar-113464	Sorex araneus	88.41	8.00e-71	257.00
IUUC-Sbi-114864	Sorghum bicolor	79.87	2.00e-69	253.00
IUUC-Sre-114927	Sporisorium reilianum	77.40	3.00e-66	242.00
IUUC-Ssc-116096	Sus scrofa	88.59	3.00e-75	272.00
IUUC-Tgu-117266	Taeniopygia guttata	88.41	8.00e-71	257.00
IUUC-Tru-117903	Takifugu rubripes	85.91	1.00e-73	266.00
IUUC-Tsy-118952	Tarsius syrichta	88.41	8.00e-71	257.00
IUUC-Tni-120038	Tetraodon nigroviridis	85.91	1.00e-73	266.00
IUUC-Tca-121752	Theobroma cacao	77.18	3.00e-66	243.00
IUUC-Tre-121979	Trichoderma reesei	71.23	7.00e-62	227.00
IUUC-Tvi-122515	Trichoderma virens	70.75	1.00e-61	226.00
IUUC-Tae-124984	Triticum aestivum	79.19	6.00e-70	254.00
IUUC-Tur-126865	Triticum urartu	80.58	4.00e-65	238.00
IUUC-Tme-127129	Tuber melanosporum	70.75	2.00e-62	229.00
IUUC-Tbe-127846	Tupaia belangeri	88.41	8.00e-71	257.00
IUUC-Ttr-128808	Tursiops truncatus	86.21	6.00e-72	261.00
IUUC-Uma-129548	Ustilago maydis	75.51	2.00e-65	239.00
IUUC-Vda-129810	Verticillium dahliae	69.59	6.00e-62	228.00
IUUC-Vpa-130221	Vicugna pacos	82.14	3.00e-62	228.00
IUUC-Vvi-131158	Vitis vinifera	80.58	3.00e-65	239.00
IUUC-Xtr-132366	Xenopus tropicalis	86.09	5.00e-73	264.00
IUUC-Xma-132986	Xiphophorus maculatus	87.25	3.00e-74	268.00
IUUC-Yli-134605	Yarrowia lipolytica	70.75	2.00e-61	226.00
IUUC-Zma-135587	Zea mays	75.48	4.00e-67	245.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence