iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.50e-25	86.7	296	333
E3 adaptor/Cullin RING/APC_C/CDC20	3.70e-145	482.9	160	464
UBD/Beta-Prp	8.80e-44	149.9	294	461

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
           gH  +v++l++ +d  +l+sG++D+ ++vW+ ++ +++
   Q: 296  GHRQEVCGLKWsPDnQYLASGGNDNRLYVWNQHSVNPV 333
           8***********888****************7766665 PP

E3 adaptor/Cullin RING/APC_C/CDC20

   S: 1    pekvldapelrddfylnLldWssknvlavaLgssvylwsaktgdvskladl.eekdlvtsvswieegtllavGtkkgeveiyDveekkkvrtltghsa 97
           p+kvldapel+ddfylnL+dWss+nvlav+Lgs+vylwsa+t++v++l+dl  + ++vtsvsw e+g+ +avGt++g v+++Dv+++k++ +l+ghsa
   Q: 160  PFKVLDAPELQDDFYLNLVDWSSQNVLAVGLGSCVYLWSACTSQVTRLCDLsPDANTVTSVSWNERGNTVAVGTHHGYVTVWDVAANKQINKLNGHSA 257
           689************************************************77899****************************************** PP
   S: 98   rvgaLsWnaevlssGsrdgeilhrdvrvkelkl.stlqahaqevCGlkwnedaklLasGGnDnsvsvwdasssePlkkfkehkaavkaiawsPwqksl 194
           rvgaL+Wn+++lssGsrd+ i +rd r+++l+  ++l++h+qevCGlkw+ d+++LasGGnDn + vw+++s +P+++++eh aavkaiawsP++++l
   Q: 258  RVGALAWNSDILSSGSRDRWIIQRDTRTPQLQSeRRLAGHRQEVCGLKWSPDNQYLASGGNDNRLYVWNQHSVNPVQSYTEHMAAVKAIAWSPHHHGL 355
           *********************************999************************************************************** PP
   S: 195  LasGGGtaDrcikfwntltgalleeidtgsqvcsllwskkskelvsthGfaenkitlwkypslskvaelkgheaRvlslalspdgeaivtaagDetlr 292
           LasGGGtaDrci+fwntltg+ ++++dtgsqvc+l+wsk+s+elvsthG+++n+i +wkypsl++va+l+gh++Rvl+lalspdgeaivt+agDetlr
   Q: 356  LASGGGTADRCIRFWNTLTGQPMQCVDTGSQVCNLAWSKHSSELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLALSPDGEAIVTGAGDETLR 453
           ************************************************************************************************** PP
   S: 293  fwklfdkkkak 303
           fw++f+k +++
   Q: 454  FWNVFSKARSQ 464
           ******98875 PP

UBD/Beta-Prp

   S: 90   lkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdg.nllvsG..slDrtvrlWdlktgkllrtltgghtdsvy 184
           l gh ++v+ l++sp++++l+sG++d+ + vw+ ++   ++   ++h+++v  ++++p    ll+sG  ++Dr++r+W+  tg+ ++       ++v 
   Q: 294  LAGHRQEVCGLKWSPDNQYLASGGNDNRLYVWNQHSVNPVQ-SYTEHMAAVKAIAWSPHHhGLLASGggTADRCIRFWNTLTGQPMQCVD--TGSQVC 388
           55777777777777777777777777777777777777777.777777777777777777777777522467777777777777777773..356777 PP
   S: 185  slsfdsngkelvs..gsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgd 255
            l++++ + elvs  g   +++ +w + + + v +l+gh+  v+ +++sp++e +v+g+ D+++r+W++ s+ 
   Q: 389  NLAWSKHSSELVSthGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLALSPDGEAIVTGAGDETLRFWNVFSKA 461
           7777777777776455667777777777777777777777777777777777777777777777777665544 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MFSPEYEKRI LKHYSPVARN LFNNFESSTT PTSLDRFIPC RAYNNWQTNF ASINKSNDNS 60
PQTSKKQRDC GETARDSLAY SCLLKNELLG SAIDDVKTAG EERNENAYTP AAKRSLFKYQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AACTTTTTTT GTTGTAATGA AGGAAGCAGC ACGGGCAGTA GACCAACTCG AAATCGCGCA 60
TTGCCAACAC GTAACGTACC AGCCCGTGTA ATAACAGAAG AAACCCCGAG CCGCAACAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR024977--Apc4_WD40_dom
IPR033010--Cdc20/Fizzy
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0030424--C:axon
GO:0005814--C:centriole
GO:0005813--C:centrosome
GO:0005737--C:cytoplasm
GO:0005819--C:spindle
GO:0061630--F:ubiquitin protein ligase activity
GO:0097027--F:ubiquitin-protein transferase activator activity
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0001745--P:compound eye morphogenesis
GO:0007455--P:eye-antennal disc morphogenesis
GO:0010001--P:glial cell differentiation
GO:0008347--P:glial cell migration
GO:0031536--P:positive regulation of exit from mitosis
GO:1904668--P:positive regulation of ubiquitin protein ligase activity
GO:0030163--P:protein catabolic process
GO:0007088--P:regulation of mitotic nuclear division
GO:0019233--P:sensory perception of pain

KEGG

dme:Dmel_CG3000

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000670	Aegilops tauschii	61.73	2.00e-115	409.00
IUUC-Aml-002003	Ailuropoda melanoleuca	68.42	0.00e+00	662.00
IUUC-Atr-002753	Amborella trichopoda	56.26	1.00e-130	459.00
IUUC-Apl-003212	Anas platyrhynchos	70.12	0.00e+00	690.00
IUUC-Aly-005442	Arabidopsis lyrata	53.47	2.00e-138	484.00
IUUC-Ath-006938	Arabidopsis thaliana	55.98	1.00e-137	481.00
IUUC-Ago-007784	Ashbya gossypii	50.29	1.00e-97	349.00
IUUC-Acl-008269	Aspergillus clavatus	47.42	3.00e-129	454.00
IUUC-Afl-008432	Aspergillus flavus	48.28	2.00e-129	455.00
IUUC-Afu-008829	Aspergillus fumigatus	48.35	1.00e-129	456.00
IUUC-Ani-009471	Aspergillus nidulans	47.27	3.00e-130	457.00
IUUC-Ang-009711	Aspergillus niger	47.25	7.00e-127	446.00
IUUC-Aor-010118	Aspergillus oryzae	48.28	2.00e-129	455.00
IUUC-Ate-010534	Aspergillus terreus	46.88	2.00e-128	452.00
IUUC-Ame-011011	Astyanax mexicanus	74.83	0.00e+00	645.00
IUUC-Bgr-012013	Blumeria graminis	49.59	2.00e-128	452.00
IUUC-Bta-012586	Bos taurus	69.51	0.00e+00	686.00
IUUC-Bci-013807	Botrytis cinerea	49.90	1.00e-123	436.00
IUUC-Bdi-014981	Brachypodium distachyon	68.15	4.00e-128	450.00
IUUC-Bol-016301	Brassica oleracea	56.14	1.00e-137	482.00
IUUC-Bra-017453	Brassica rapa	56.14	8.00e-138	482.00
IUUC-Cel-018472	Caenorhabditis elegans	64.17	3.00e-143	501.00
IUUC-Cja-019929	Callithrix jacchus	69.29	0.00e+00	682.00
IUUC-Cfa-020977	Canis familiaris	69.49	0.00e+00	683.00
IUUC-Cpo-021537	Cavia porcellus	69.72	0.00e+00	687.00
IUUC-Csa-023389	Chlorocebus sabaeus	69.51	0.00e+00	686.00
IUUC-Cin-025327	Ciona intestinalis	65.65	2.00e-169	587.00
IUUC-Csv-025921	Ciona savignyi	66.60	2.00e-176	611.00
IUUC-Cgl-026631	Colletotrichum gloeosporioides	49.69	8.00e-130	456.00
IUUC-Cne-026933	Cryptococcus neoformans	62.10	4.00e-126	444.00
IUUC-Cme-027143	Cyanidioschyzon merolae	62.71	3.00e-115	409.00
IUUC-Dre-027470	Danio rerio	74.44	0.00e+00	645.00
IUUC-Dno-029629	Dasypus novemcinctus	64.30	1.00e-162	565.00
IUUC-Dor-030187	Dipodomys ordii	72.85	0.00e+00	633.00
IUUC-Dse-031502	Dothistroma septosporum	48.36	1.00e-120	426.00
IUUC-Ete-032562	Echinops telfairi	62.40	3.00e-168	583.00
IUUC-Eca-034210	Equus caballus	69.72	0.00e+00	687.00
IUUC-Fca-035839	Felis catus	68.99	0.00e+00	664.00
IUUC-Fal-036895	Ficedula albicollis	70.33	0.00e+00	692.00
IUUC-Fox-037814	Fusarium oxysporum	60.83	3.00e-120	423.00
IUUC-Fso-038420	Fusarium solani	48.71	6.00e-129	453.00
IUUC-Gmo-039544	Gadus morhua	74.61	0.00e+00	654.00
IUUC-Ggr-039774	Gaeumannomyces graminis	50.70	1.00e-131	462.00
IUUC-Gga-041025	Gallus gallus	69.92	0.00e+00	688.00
IUUC-Gac-041596	Gasterosteus aculeatus	74.28	0.00e+00	653.00
IUUC-Gma-042657	Glycine max	55.65	6.00e-136	476.00
IUUC-Ggo-045599	Gorilla gorilla	69.09	0.00e+00	652.00
IUUC-Hsa-046695	Homo sapiens	69.09	0.00e+00	681.00
IUUC-Hvu-047486	Hordeum vulgare	64.29	2.00e-105	374.00
IUUC-Itr-048192	Ictidomys tridecemlineatus	69.92	0.00e+00	691.00
IUUC-Kpa-049239	Komagataella pastoris	56.08	1.00e-123	436.00
IUUC-Lch-049827	Latimeria chalumnae	69.72	0.00e+00	659.00
IUUC-Lpe-051568	Leersia perrieri	50.56	3.00e-113	401.00
IUUC-Loc-052856	Lepisosteus oculatus	70.45	0.00e+00	661.00
IUUC-Mcc-055601	Macaca mulatta	69.51	0.00e+00	686.00
IUUC-Meu-056276	Macropus eugenii	58.33	3.00e-143	500.00
IUUC-Mor-057113	Magnaporthe oryzae	49.79	2.00e-130	458.00
IUUC-Mpo-057599	Magnaporthe poae	49.90	8.00e-131	459.00
IUUC-Mtr-057689	Medicago truncatula	54.76	8.00e-135	473.00
IUUC-Mla-059048	Melampsora laricipopulina	48.88	5.00e-115	407.00
IUUC-Mga-060097	Meleagris gallopavo	65.13	1.00e-179	621.00
IUUC-Mvi-060465	Microbotryum violaceum	50.83	1.00e-131	462.00
IUUC-Mmr-061151	Microcebus murinus	62.42	2.00e-164	571.00
IUUC-Mdo-063062	Monodelphis domestica	69.72	0.00e+00	688.00
IUUC-Mmu-063731	Mus musculus	69.51	0.00e+00	684.00
IUUC-Mac-064942	Musa acuminata	55.71	1.00e-131	462.00
IUUC-Mpu-066173	Mustela putorius furo	69.51	0.00e+00	686.00
IUUC-Mlu-068030	Myotis lucifugus	69.29	0.00e+00	682.00
IUUC-Nfi-068536	Neosartorya fischeri	48.14	6.00e-130	456.00
IUUC-Ncr-068734	Neurospora crassa	51.24	1.00e-132	466.00
IUUC-Nle-070163	Nomascus leucogenys	69.51	0.00e+00	687.00
IUUC-Opr-070974	Ochotona princeps	79.11	6.00e-136	475.00
IUUC-Ont-072507	Oreochromis niloticus	68.95	0.00e+00	684.00
IUUC-Oan-073634	Ornithorhynchus anatinus	83.28	7.00e-150	521.00
IUUC-Oba-075417	Oryza barthii	62.54	8.00e-111	393.00
IUUC-Obr-076123	Oryza brachyantha	71.48	8.00e-127	446.00
IUUC-Ogl-077294	Oryza glaberrima	71.80	2.00e-126	444.00
IUUC-Ogu-077996	Oryza glumaepatula	71.48	5.00e-125	440.00
IUUC-Oin-080172	Oryza indica	71.80	4.00e-126	443.00
IUUC-Olo-081068	Oryza longistaminata	71.80	5.00e-126	443.00
IUUC-Ome-081250	Oryza meridionalis	71.80	3.00e-126	444.00
IUUC-Oni-083048	Oryza nivara	71.80	2.00e-126	444.00
IUUC-Opu-083333	Oryza punctata	71.80	3.00e-126	444.00
IUUC-Oru-085001	Oryza rufipogon	71.80	2.00e-126	444.00
IUUC-Osa-086243	Oryza sativa	71.80	2.00e-126	444.00
IUUC-Ola-087094	Oryzias latipes	73.79	2.00e-179	620.00
IUUC-Oga-088911	Otolemur garnettii	69.72	0.00e+00	687.00
IUUC-Oar-089508	Ovis aries	69.51	0.00e+00	686.00
IUUC-Ptr-090967	Pan troglodytes	53.94	2.00e-107	381.00
IUUC-Pan-092147	Papio anubis	69.09	0.00e+00	681.00
IUUC-Psi-093702	Pelodiscus sinensis	69.84	0.00e+00	684.00
IUUC-Pma-094581	Petromyzon marinus	72.37	0.00e+00	629.00
IUUC-Pno-095139	Phaeosphaeria nodorum	58.33	7.00e-111	393.00
IUUC-Ppa-095366	Physcomitrella patens	57.08	3.00e-140	491.00
IUUC-Pfo-096309	Poecilia formosa	74.50	0.00e+00	656.00
IUUC-Pab-098762	Pongo abelii	55.56	1.00e-139	488.00
IUUC-Pop-098924	Populus trichocarpa	56.92	1.00e-136	478.00
IUUC-Pca-100565	Procavia capensis	71.08	0.00e+00	645.00
IUUC-Ppe-101924	Prunus persica	55.33	1.00e-132	465.00
IUUC-Pva-102602	Pteropus vampyrus	67.81	0.00e+00	655.00
IUUC-Pgr-103466	Puccinia graminis	48.71	2.00e-110	392.00
IUUC-Ptt-103888	Puccinia triticina	53.57	2.00e-100	358.00
IUUC-Pte-104097	Pyrenophora teres	48.21	2.00e-127	448.00
IUUC-Pyt-104445	Pyrenophora triticirepentis	44.05	3.00e-109	388.00
IUUC-Rno-105028	Rattus norvegicus	69.51	0.00e+00	684.00
IUUC-Sce-106240	Saccharomyces cerevisiae	39.08	5.00e-97	347.00
IUUC-Sha-106538	Sarcophilus harrisii	60.04	8.00e-159	552.00
IUUC-Sja-107900	Schizosaccharomyces japonicus	48.74	5.00e-114	403.00
IUUC-Spo-108056	Schizosaccharomyces pombe	48.02	3.00e-112	397.00
IUUC-Ssl-108391	Sclerotinia sclerotiorum	50.10	2.00e-124	438.00
IUUC-Smo-109041	Selaginella moellendorffii	59.19	4.00e-144	503.00
IUUC-Sit-110550	Setaria italica	52.92	3.00e-128	451.00
IUUC-Sly-111446	Solanum lycopersicum	55.43	2.00e-130	457.00
IUUC-Stu-112491	Solanum tuberosum	55.43	3.00e-130	457.00
IUUC-Sar-112962	Sorex araneus	65.27	2.00e-97	347.00
IUUC-Sbi-114386	Sorghum bicolor	53.51	2.00e-125	441.00
IUUC-Sre-115222	Sporisorium reilianum	55.53	2.00e-123	435.00
IUUC-Ssc-116171	Sus scrofa	69.51	0.00e+00	686.00
IUUC-Tgu-116878	Taeniopygia guttata	60.08	2.00e-164	571.00
IUUC-Tru-118222	Takifugu rubripes	73.57	0.00e+00	647.00
IUUC-Tni-119863	Tetraodon nigroviridis	74.06	0.00e+00	647.00
IUUC-Tca-121599	Theobroma cacao	55.38	1.00e-131	462.00
IUUC-Tre-122249	Trichoderma reesei	50.31	4.00e-129	454.00
IUUC-Tvi-122675	Trichoderma virens	49.49	8.00e-129	452.00
IUUC-Tae-123028	Triticum aestivum	53.78	1.00e-126	445.00
IUUC-Tur-126545	Triticum urartu	58.39	1.00e-102	365.00
IUUC-Tme-127151	Tuber melanosporum	53.35	8.00e-143	499.00
IUUC-Tbe-128056	Tupaia belangeri	75.40	7.00e-138	482.00
IUUC-Ttr-129055	Tursiops truncatus	68.89	0.00e+00	676.00
IUUC-Uma-129555	Ustilago maydis	56.03	1.00e-124	439.00
IUUC-Vda-130027	Verticillium dahliae	50.10	9.00e-131	459.00
IUUC-Vvi-131749	Vitis vinifera	55.41	9.00e-134	469.00
IUUC-Xtr-132808	Xenopus tropicalis	69.73	0.00e+00	671.00
IUUC-Xma-133183	Xiphophorus maculatus	74.50	0.00e+00	656.00
IUUC-Yli-134584	Yarrowia lipolytica	59.14	1.00e-127	449.00
IUUC-Zma-135640	Zea mays	53.74	8.00e-126	442.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence