iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046957

UUCD1 version

UUC-HoS-00105

Ensembl Protein ID

ENSP00000454207.1

UniProt Accession

Q13114; B7Z8C4; Q12990; Q13076; Q13947; Q6AZX1; Q9UNL1; TRAF3_HUMAN

Genbank Protein ID

AAA56753.1; AAA65732.1; AAA68195.1; AAC50112.1; CAD62311.1; BAH13910.1; AAH75087.1; AAH75086.1; AAD29276.1

Protein Name

TNF receptor-associated factor 3; CAP-1; CD40 receptor-associated factor 1; CD40-binding protein; LMP1-associated protein 1; RING-type E3 ubiquitin transferase TRAF3

Genbank Nucleotide ID

U15637; U19260; L38509; U21092; BX247977; AK303172; AL117209; BC075086; AF110908

Gene Name

TRAF3; CAP1; CRAF1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000131323.14	ENST00000560371.5	ENSP00000454207.1
ENSG00000131323.14	ENST00000539721.5	ENSP00000445998.1
ENSG00000131323.14	ENST00000351691.9	ENSP00000332468.5
ENSG00000131323.14	ENST00000558700.5	ENSP00000453031.1
ENSG00000131323.14	ENST00000559734.1	ENSP00000453032.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	miRecords	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWASdb	GWAS Central	OMIM
Drug and target
KPID
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	15084608; 12944909; 25847972

Organism

Homo sapiens

Functional Description
(View)

Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14.

Protein Sequence
(Fasta)

MESSKKMDSP GALQTNPPLK LHTDRSAGTP VFVPEQGGYK EKFVKTVEDK YKCEKCHLVL 60
CSPKQTECGH RFCESCMAAL LSSSSPKCTA CQESIVKDKV FKDNCCKREI LALQIYCRNE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGAGGGAGCG CGGCGCGGCC GCCGCGTGCG CGAGCCGGGG TTGCAGCCCA GCCGGGACTT 60
TCCAGCCGGC GGCAGCCGCG GCGGCCGCCG GCTCTTCCCC GCCCCCCGCC ATGGGGCAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-0967--Endosome
KW-0391--Immunity
KW-0479--Metal-binding
KW-0496--Mitochondrion
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002083--MATH/TRAF_dom
IPR012227--TNF_rcpt--assoc_TRAF
IPR008974--TRAF-like
IPR027128--TRAF3
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR001293--Znf_TRAF

PROSITE

PS50144--MATH
PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS50145--ZF_TRAF

Pfam

PF02176--zf-TRAF

SMART

SM00061--MATH

Gene Ontology

GO:0035631--C:CD40 receptor complex
GO:0009898--C:cytoplasmic side of plasma membrane
GO:0005829--C:cytosol
GO:0005768--C:endosome
GO:0005739--C:mitochondrion
GO:0019903--F:protein phosphatase binding
GO:0004871--F:signal transducer activity
GO:0031996--F:thioesterase binding
GO:0005164--F:tumor necrosis factor receptor binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0045087--P:innate immune response
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0032480--P:negative regulation of type I interferon production
GO:0016579--P:protein deubiquitination
GO:0042981--P:regulation of apoptotic process
GO:0001817--P:regulation of cytokine production
GO:0050688--P:regulation of defense response to virus
GO:0032648--P:regulation of interferon-beta production
GO:0030162--P:regulation of proteolysis
GO:0007165--P:signal transduction
GO:0008063--P:Toll signaling pathway
GO:0002224--P:toll-like receptor signaling pathway
GO:0035666--P:TRIF-dependent toll-like receptor signaling pathway
GO:0033209--P:tumor necrosis factor-mediated signaling pathway

KEGG

hsa:7187

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002362	Ailuropoda melanoleuca	95.95	0.00e+00	1138.00
IUUC-Apl-004189	Anas platyrhynchos	88.20	0.00e+00	1058.00
IUUC-Aca-004540	Anolis carolinensis	85.04	0.00e+00	1023.00
IUUC-Ate-010296	Aspergillus terreus	26.70	4.00e-18	86.30
IUUC-Ame-010645	Astyanax mexicanus	57.96	0.00e+00	650.00
IUUC-Bta-013140	Bos taurus	94.72	0.00e+00	1126.00
IUUC-Cja-019436	Callithrix jacchus	98.59	0.00e+00	1169.00
IUUC-Cfa-021072	Canis familiaris	96.13	0.00e+00	1143.00
IUUC-Cpo-022472	Cavia porcellus	95.42	0.00e+00	1130.00
IUUC-Csa-024217	Chlorocebus sabaeus	98.94	0.00e+00	1170.00
IUUC-Cho-025066	Choloepus hoffmanni	83.06	0.00e+00	836.00
IUUC-Cin-025234	Ciona intestinalis	29.57	4.00e-54	206.00
IUUC-Csv-026078	Ciona savignyi	68.54	8.00e-80	289.00
IUUC-Dre-028208	Danio rerio	55.23	5.00e-177	614.00
IUUC-Dno-028868	Dasypus novemcinctus	94.37	0.00e+00	1127.00
IUUC-Dor-031056	Dipodomys ordii	97.53	0.00e+00	989.00
IUUC-Ete-033005	Echinops telfairi	81.84	0.00e+00	786.00
IUUC-Eca-033717	Equus caballus	96.83	0.00e+00	1151.00
IUUC-Eeu-035172	Erinaceus europaeus	84.13	0.00e+00	632.00
IUUC-Fca-035688	Felis catus	95.78	0.00e+00	1135.00
IUUC-Fal-037176	Ficedula albicollis	88.20	0.00e+00	1058.00
IUUC-Gmo-038931	Gadus morhua	55.68	1.00e-168	586.00
IUUC-Gac-042019	Gasterosteus aculeatus	56.94	6.00e-178	617.00
IUUC-Ggo-044424	Gorilla gorilla	99.65	0.00e+00	1178.00
IUUC-Itr-048352	Ictidomys tridecemlineatus	95.95	0.00e+00	1131.00
IUUC-Lch-050680	Latimeria chalumnae	68.31	0.00e+00	832.00
IUUC-Loc-052093	Lepisosteus oculatus	56.92	0.00e+00	687.00
IUUC-Laf-054573	Loxodonta africana	87.32	0.00e+00	1019.00
IUUC-Mcc-055049	Macaca mulatta	98.59	0.00e+00	1164.00
IUUC-Mga-059244	Meleagris gallopavo	87.50	0.00e+00	1053.00
IUUC-Mmr-061469	Microcebus murinus	97.18	0.00e+00	1150.00
IUUC-Mdo-063049	Monodelphis domestica	91.90	0.00e+00	1095.00
IUUC-Mmu-063763	Mus musculus	96.13	0.00e+00	1136.00
IUUC-Mpu-065956	Mustela putorius furo	94.02	0.00e+00	1088.00
IUUC-Mlu-067482	Myotis lucifugus	94.72	0.00e+00	1124.00
IUUC-Nle-069941	Nomascus leucogenys	99.12	0.00e+00	1172.00
IUUC-Opr-071027	Ochotona princeps	81.51	0.00e+00	908.00
IUUC-Ont-071914	Oreochromis niloticus	58.10	0.00e+00	658.00
IUUC-Oan-072802	Ornithorhynchus anatinus	91.02	0.00e+00	1083.00
IUUC-Ocu-074075	Oryctolagus cuniculus	96.65	0.00e+00	1142.00
IUUC-Oga-088149	Otolemur garnettii	96.83	0.00e+00	1151.00
IUUC-Oar-089922	Ovis aries	90.73	0.00e+00	1069.00
IUUC-Ptr-091412	Pan troglodytes	99.82	0.00e+00	1181.00
IUUC-Pan-092789	Papio anubis	98.94	0.00e+00	1170.00
IUUC-Psi-093603	Pelodiscus sinensis	85.17	0.00e+00	1027.00
IUUC-Pma-094463	Petromyzon marinus	48.85	6.00e-140	490.00
IUUC-Pfo-096518	Poecilia formosa	55.61	0.00e+00	642.00
IUUC-Pab-097664	Pongo abelii	99.65	0.00e+00	1178.00
IUUC-Pca-100821	Procavia capensis	85.80	0.00e+00	855.00
IUUC-Pva-103201	Pteropus vampyrus	83.45	0.00e+00	975.00
IUUC-Rno-105505	Rattus norvegicus	95.07	0.00e+00	1126.00
IUUC-Sha-107416	Sarcophilus harrisii	92.25	0.00e+00	1095.00
IUUC-Sar-113438	Sorex araneus	93.55	5.00e-100	357.00
IUUC-Ssc-115351	Sus scrofa	95.42	0.00e+00	1129.00
IUUC-Tgu-116608	Taeniopygia guttata	90.16	0.00e+00	1052.00
IUUC-Tru-117964	Takifugu rubripes	57.54	2.00e-180	625.00
IUUC-Tni-120211	Tetraodon nigroviridis	56.54	0.00e+00	636.00
IUUC-Tur-126245	Triticum urartu	24.60	1.00e-06	47.80
IUUC-Tbe-127700	Tupaia belangeri	79.06	3.00e-142	498.00
IUUC-Ttr-128450	Tursiops truncatus	90.00	4.00e-172	596.00
IUUC-Vda-129938	Verticillium dahliae	25.59	8.00e-21	95.50
IUUC-Vpa-130074	Vicugna pacos	97.72	0.00e+00	892.00
IUUC-Xtr-132563	Xenopus tropicalis	78.35	0.00e+00	952.00
IUUC-Xma-133628	Xiphophorus maculatus	55.61	0.00e+00	642.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence