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Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Spo-108063
UUCD1 version UUC-ScP-00021
Ensembl Protein ID SPAC4D7.03.1:pep
UniProt Accession O14170; POP2_SCHPO
Genbank Protein ID AAB95480.1; AAC39496.1; CAB11275.1
Protein Name WD repeat-containing protein pop2; Proteolysis factor sud1
Genbank Nucleotide ID AF038867; AF064515; CU329670
Gene Name pop2; sud1; SPAC4D7.03
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
SPAC4D7.03 SPAC4D7.03.1 SPAC4D7.03.1:pep
Annotation
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
iRefIndexHINTMentha
Protein Expression/Proteomics
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD WD_repeat 10589835; 18256526; 9990507; 14970237
E3 adaptor/Cullin RING/SCF/F-box F-box 10589835; 18256526; 9990507; 14970237
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 4.60e-48 157.2 505 541
E3 adaptor/Cullin RING/SCF/F-box 0.045 11.9 236 283
UBD/Beta-Prp 1.90e-103 343.8 354 627
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclafsdtllvsGsdDgtikvWDlrtgvllk 37
    gHtdsv+ ++ +++lvsGs+D +i++W+++tg +l
   Q: 505 GHTDSVRTISGYGDILVSGSYDSSIRIWRVSTGECLY 541
    8*********6248********************985 PP
   


   E3 adaptor/Cullin RING/SCF/F-box

   S: 100  aglldrlpeeilveilklldkeellraarvcrrwqelas.qkalwktv 146
    +++l++lp i+++il +ld ++ l++++v+ +w+++ + ++++wk++
   Q: 236 KDILSNLPFSIVQSILLNLDIHSFLSCRLVSPTWNRILDvHTSYWKHM 283
    677899*****************************7666589999876 PP
   


   UBD/Beta-Prp

   S: 13   itcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvls...... 99
    it++ +k+ ++t+s +gti+++++ tg l ++l+gh+++v+avk++++ +lv+gs D+t++vw++++ kc+h+++gh + +++
   Q: 354 ITSLLL--HKDRIITTSGSGTIQIHNAITGVLEARLEGHKEGVWAVKIHEN--TLVSGSIDKTVRVWNIEKAKCTHIFRGHISIIRCleilvp 442
    566666..7888999999*********************************..8*************************************** PP
   S: 100 .......lsfsp.sgdklvsGshdrtirvwdletgqclee...................tlsghdgvvncvvvhpdgnllvsGslDrtvrlWd 165
    +++ + ++ ++vsGs+d t+rvw+l++++ tl gh+++v++++ + ++lvsGs+D+ +r+W+
   Q: 443 srlirhgVEIVEpDQPYIVSGSRDHTLRVWKLPKNTDPPYlpdntnsidrweknpyfvhTLIGHTDSVRTISGYG--DILVSGSYDSSIRIWR 533
    *******99888788********************99888889***************************99999..**************** PP
   S: 166 lktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllk 258
    ++tg++l++l+g h ++ys+ ++++++ ++sgs+d+++++wdl+tg+c + l+gh+++v+ ++++ ++rl+sgs+D +iriWdl +g++l
   Q: 534 VSTGECLYHLRG-HSLRIYSVLYEPERNICISGSMDKSIRVWDLSTGTCKYVLEGHDAFVTLLNVF--QNRLISGSADSTIRIWDLNTGKPLM 623
    ***********9.*****************************************************..**********************998 PP
   S: 259 tlql 262
    +l
   Q: 624 VLPS 627
    7765 PP
   

Organism Schizosaccharomyces pombe
Functional Description
(View)

Functional Description



     Involved in maintenance of ploidy through proteasome dependent degradation of CDK inhibitor rum1 and S-phase initiator cdc18. Functions as a recognition factor for rum1 and cdc18, which are subsequently ubiquitinated and targeted to the 26S proteasome for degradation. Together with pop1, required for cig2 instability during G2 and M phase and cig2 degradation in exponentially growing cells.
Involved in maintenance of ploidy through proteasome dependent degradation of CDK inhibitor rum1 and S-phase initiator cdc18. Functions as a recognition factor for rum1 and cdc18, which are subsequently ubiquitinated and targeted to the 26S proteasome for degradation. Together with pop1, required for cig2 instability during G2 and M phase and cig2 degradation in exponentially growing cells.
Protein Sequence
(Fasta)
MSLSRCPTDN SSSRINSSVP LINSSSPATP PESFDPQVFP SSLIHGDNLL PQDDQIASDP 60
RSESNSCNGN TSSSLPCTDS YQYPLKHSCT PSFLRKFNES IENVSYKCLD HSPPDSVPGD 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Spo-108063|E3,WD_repeat;E3,F-box;UBD,Beta-Prp|Schizosaccharomyces pombe
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACAAAGATTC TGTATGGTAT GAACAACGCA TATTGAGCTT CTGTTATTTT TTCAATTAAA 60
AGATTACTTA TAAAAAAACC TTTCCATTAT TCATTTTCTC TTTATGCCCG CACTTTTTAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Spo-108063|E3,WD_repeat;E3,F-box;UBD,Beta-Prp|Schizosaccharomyces pombe
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR023302--Pept_S9A_N
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00646--F-box
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005635--C:nuclear envelope
GO:0019005--C:SCF ubiquitin ligase complex
GO:0030674--F:protein binding, bridging
GO:1903467--P:negative regulation of mitotic DNA replication initiation
GO:0070647--P:protein modification by small protein conjugation or removal
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG spo:SPAC4D7.03
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ago-007888 Ashbya gossypii 35.79 8.00e-88 316.00
IUUC-Acl-008250 Aspergillus clavatus 47.41 5.00e-109 387.00
IUUC-Afl-008413 Aspergillus flavus 48.02 2.00e-108 385.00
IUUC-Afu-009106 Aspergillus fumigatus 47.49 3.00e-108 384.00
IUUC-Ani-009352 Aspergillus nidulans 47.67 1.00e-111 395.00
IUUC-Ang-009529 Aspergillus niger 40.07 6.00e-121 426.00
IUUC-Aor-010182 Aspergillus oryzae 47.93 1.00e-110 392.00
IUUC-Ate-010332 Aspergillus terreus 47.93 2.00e-110 392.00
IUUC-Bgr-011997 Blumeria graminis 46.37 2.00e-103 368.00
IUUC-Bci-013601 Botrytis cinerea 46.94 5.00e-111 393.00
IUUC-Cel-018495 Caenorhabditis elegans 30.21 1.00e-56 212.00
IUUC-Cho-025026 Choloepus hoffmanni 35.27 4.00e-49 187.00
IUUC-Csv-026312 Ciona savignyi 28.76 5.00e-60 223.00
IUUC-Cgl-026707 Colletotrichum gloeosporioides 47.17 3.00e-112 398.00
IUUC-Dse-031358 Dothistroma septosporum 46.11 2.00e-107 382.00
IUUC-Dme-031702 Drosophila melanogaster 28.97 3.00e-62 232.00
IUUC-Fox-037701 Fusarium oxysporum 47.93 3.00e-111 394.00
IUUC-Fso-038362 Fusarium solani 47.93 6.00e-111 393.00
IUUC-Gmo-039478 Gadus morhua 34.88 3.00e-53 201.00
IUUC-Ggr-040085 Gaeumannomyces graminis 47.15 6.00e-108 383.00
IUUC-Kpa-049097 Komagataella pastoris 38.55 3.00e-102 363.00
IUUC-Lma-053123 Leptosphaeria maculans 43.98 8.00e-109 386.00
IUUC-Mor-057133 Magnaporthe oryzae 47.41 6.00e-110 390.00
IUUC-Mpo-057542 Magnaporthe poae 45.50 9.00e-108 382.00
IUUC-Mvi-060490 Microbotryum violaceum 43.19 4.00e-88 318.00
IUUC-Nfi-068570 Neosartorya fischeri 47.49 3.00e-108 384.00
IUUC-Ncr-068778 Neurospora crassa 46.37 1.00e-108 386.00
IUUC-Oga-088884 Otolemur garnettii 35.00 4.00e-55 206.00
IUUC-Pno-095026 Phaeosphaeria nodorum 46.49 6.00e-106 376.00
IUUC-Ptt-103698 Puccinia triticina 41.10 2.00e-64 238.00
IUUC-Pte-104253 Pyrenophora teres 47.15 1.00e-108 386.00
IUUC-Pyt-104635 Pyrenophora triticirepentis 47.15 1.00e-108 385.00
IUUC-Sce-106314 Saccharomyces cerevisiae 35.28 6.00e-86 310.00
IUUC-Sja-107764 Schizosaccharomyces japonicus 45.37 6.00e-164 568.00
IUUC-Sre-114901 Sporisorium reilianum 35.14 1.00e-51 196.00
IUUC-Tre-121989 Trichoderma reesei 48.45 6.00e-106 376.00
IUUC-Tvi-122620 Trichoderma virens 47.93 9.00e-105 372.00
IUUC-Tme-127195 Tuber melanosporum 46.93 7.00e-102 363.00
IUUC-Uma-129449 Ustilago maydis 34.12 2.00e-50 192.00
IUUC-Vda-129936 Verticillium dahliae 47.93 1.00e-110 392.00
IUUC-Yli-134479 Yarrowia lipolytica 38.56 2.00e-112 397.00
Created Date 25-Jun-2017

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