iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Spo-108109

UUCD1 version

UUC-ScP-00077

Ensembl Protein ID

SPAC3A11.08.1:pep

UniProt Accession

O14122; Q9USB6; CUL4_SCHPO

Genbank Protein ID

CAB16383.1; BAA32520.1; BAA87197.1

Protein Name

Cullin-4

Genbank Nucleotide ID

CU329670; AB017029; AB027893

Gene Name

pcu4; cul4; SPAC3A11.08

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPAC3A11.08	SPAC3A11.08.1	SPAC3A11.08.1:pep

Annotation

mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	HINT	Mentha
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/Cullin	3.60e-114	380.8	36	635

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/Cullin

   S: 5    avkkilrqesvkkeyeelytavynlclskvgaklYkklkevleefikqvkkkvee.......sedeqlLktynreWekfreqlkvlrkifay 89
           a++ ++    +k+ y+ely++v+nl  ++ + + ++ l++ + + i+ +k + e+       ++d +   +++ +W+k+ e ++++++if y
   Q: 36   ALQVVMAGLGLKTGYQELYSGVENLTRADQASRCFNILQHHMSSGIQLLKDSAESfiqlegtETDTNACTVVVGCWNKWLERVEIVQNIFYY 127
           55566666667999***************99999999999999988777655443221111144556899999******************* PP
   S: 90   ldrtyvkkskkvsevrkLaldlwrkeived..ikkrllelllklieaeRkgeavdrrllsgvveslveLslnklaiykesFEakfleatqef 179
           +d+t+ + + +  ++++L+l l+r++++    i+   l++ll+  e++ + +  d+ +l++++ +l     ++ ++y + F   +l + ++f
   Q: 128  MDKTFLSHHPDYPTIEELSLSLFREKLMAVknIQIPFLNSLLQSFENLHSSKSTDHAYLQDAMLML-----HRTEMYSSVFVPMYLVMLSRF 214
           *************************9965445******************************9994.....4569***************** PP
   S: 180  ykaesaeflqenevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesllaelvallrdkktedlsrmykLlsrvlnglee 271
           y +es++ +qe  ++eYl+++ ++l+ e+  ++++  ++ ++++ e+v+++li++hl++l++++ + +++      +++y Ll+  ++ +e 
   Q: 215  YDTESSQKIQELPLEEYLEYAMSSLEREDAYVEKFDIVRDKKSIRETVQRCLITSHLDTLTKGISQFIEKRDAHSCKLLYALLQ-FNHETEY 305
           **********************************************************************************96.68899** PP
   S: 272  llkeleshikeqgkaaltaeekekdpkkyVerllelknklqklvseaFnndakFlkaldkafetfvnknsvlkaakspEllAryiDqlLrks 363
           l++ ++  + + g +++ +e k+++    V++ll++++ lq +v+e+F +d++   a++kafetf+n ++  ++   + l+A+yiD lLr +
   Q: 306  LIQPWSDCLVDVGFKLVNDESKDDT---LVQELLSFHKFLQVVVDESFLHDETLSYAMRKAFETFINGAKGSQREAPARLIAKYIDYLLRVG 394
           **********************999...*****************************************888888788************** PP
   S: 364  skglteeeleaqldkvllvfkyisekdvFekyYkkhLakRLlsgksasseaEesviekLkeecgaeftskLerMfqdlkvSedlnrqFkeek 455
            +   ++ l++   ++l +f+yi++kd+Fe+yYk ++akRLl++ksas + E  ++  Lk+ cg +ft+ Le+Mf+d+++S++ +  F+  +
   Q: 395  EQASGGKPLKEVFSEILDLFRYIASKDIFEAYYKLDIAKRLLLNKSASAQNELMLLDMLKKTCGSQFTHSLEGMFRDVNISKEFTSSFR--H 484
           *****************************************************************************************..6 PP
   S: 456  enteesesvelsvlvLsagaWptasetekvsLPaelektiekfeefYlekhsgRkLqWqhtlgraelkaelkkgkyelqVstfQmavLLafn 547
           +++  + + +l+v+vLs+ +Wp ++e + + LP ++++ ++ fe+fYl+k+ g+k++W+ +lg++ +ka +  g++el +s fQ++vLL+fn
   Q: 485  SKAAHNLHRDLYVNVLSQAYWPSYPESH-IRLPDDMQQDLDCFEKFYLSKQVGKKISWYASLGHCIVKARFPLGNKELSISLFQACVLLQFN 575
           6677899*****************9965.*************************************************************** PP
   S: 548  ns...ekvsveelkkatelpeeeLrrtlqsLvsskkqvlkkepeskeieeedlfsvNqef 604
           n    e +s+++lkk+tel++ +L+rtlqsL + + + l + p+sk+ + +++f+vN++f
   Q: 576  NClggEGISYQDLKKSTELSDIDLTRTLQSLSCARIRPLVMVPKSKKPSPDTMFYVNEKF 635
           *9999******************************99999******************99 PP

Organism

Schizosaccharomyces pombe

Functional Description
(View)

Required, indirectly, for activation of ribonucleotide reductase through the degradation of the protein spd1, thereby supplying deoxyribonucleotides for DNA replication and repair. Also has a role as a scaffold for assembling ubiquitin ligases. Component of the rik1-associated E3 ubiquitin ligase complex that shows ubiquitin ligase activity and is required for histone H3K9 methylation. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting swi6/HP1 to methylated histones which leads to transcriptional silencing within centromeric heterochromatin, telomeric regions and at the silent mating-type loci.

Protein Sequence
(Fasta)

MPPEAKRIVV KGFDPRKSRQ RQETYYVTMI DRLNMALQVV MAGLGLKTGY QELYSGVENL 60
TRADQASRCF NILQHHMSSG IQLLKDSAES FIQLEGTETD TNACTVVVGC WNKWLERVEI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACACAAAAAA ATAGCTTGAA AGTGAAATAG GAACTTCGTA CCTTGTCTAT ATGTGCTGCT 60
CTAAACCGAC TTTTCTGAAC GTCACTACTT GAGCACAAAA TTGGTTTTTG CAGGTGAAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation

Interpro

IPR016157--Cullin_CS
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR016159--Cullin_repeat-like_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS01256--CULLIN_1
PS50069--CULLIN_2

Pfam

PF00888--Cullin
PF10557--Cullin_Nedd8

SMART

SM00182--CULLIN
SM00884--Cullin_Nedd8

Gene Ontology

GO:0000781--C:chromosome, telomeric region
GO:0043494--C:CLRC ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0031618--C:nuclear pericentric heterochromatin
GO:0005634--C:nucleus
GO:0031625--F:ubiquitin protein ligase binding
GO:0034613--P:cellular protein localization
GO:0030702--P:chromatin silencing at centromere
GO:0030466--P:chromatin silencing at silent mating-type cassette
GO:0006348--P:chromatin silencing at telomere
GO:0031048--P:chromatin silencing by small RNA
GO:0016569--P:covalent chromatin modification
GO:0031507--P:heterochromatin assembly
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0051446--P:positive regulation of meiotic cell cycle
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051570--P:regulation of histone H3-K9 methylation
GO:0006351--P:transcription, DNA-templated
GO:0006283--P:transcription-coupled nucleotide-excision repair

KEGG

spo:SPAC3A11.08

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000285	Aegilops tauschii	34.91	5.00e-109	386.00
IUUC-Aml-002062	Ailuropoda melanoleuca	33.87	4.00e-116	410.00
IUUC-Atr-002727	Amborella trichopoda	32.31	3.00e-105	374.00
IUUC-Apl-004157	Anas platyrhynchos	33.60	1.00e-115	408.00
IUUC-Aca-004430	Anolis carolinensis	33.60	7.00e-116	409.00
IUUC-Aly-006547	Arabidopsis lyrata	32.93	4.00e-109	387.00
IUUC-Ath-006748	Arabidopsis thaliana	33.43	8.00e-107	379.00
IUUC-Acl-008359	Aspergillus clavatus	33.76	3.00e-110	390.00
IUUC-Afl-008567	Aspergillus flavus	34.08	1.00e-117	415.00
IUUC-Afu-008833	Aspergillus fumigatus	34.36	1.00e-115	408.00
IUUC-Ani-009373	Aspergillus nidulans	35.61	7.00e-122	429.00
IUUC-Ang-009622	Aspergillus niger	35.19	1.00e-118	419.00
IUUC-Aor-010241	Aspergillus oryzae	33.83	8.00e-116	409.00
IUUC-Ate-010251	Aspergillus terreus	34.47	2.00e-122	431.00
IUUC-Ame-011580	Astyanax mexicanus	34.00	5.00e-118	416.00
IUUC-Bgr-012219	Blumeria graminis	33.20	1.00e-102	365.00
IUUC-Bta-013244	Bos taurus	33.60	2.00e-115	408.00
IUUC-Bci-013744	Botrytis cinerea	33.51	5.00e-105	373.00
IUUC-Bdi-014223	Brachypodium distachyon	34.91	5.00e-109	386.00
IUUC-Bol-016544	Brassica oleracea	32.35	5.00e-111	393.00
IUUC-Bra-017794	Brassica rapa	32.62	9.00e-113	399.00
IUUC-Cel-018369	Caenorhabditis elegans	27.26	1.00e-59	222.00
IUUC-Cja-019180	Callithrix jacchus	33.87	6.00e-117	413.00
IUUC-Cfa-021189	Canis familiaris	33.87	2.00e-116	411.00
IUUC-Cpo-021928	Cavia porcellus	33.87	9.00e-117	412.00
IUUC-Cre-022739	Chlamydomonas reinhardtii	31.32	6.00e-78	283.00
IUUC-Csa-023831	Chlorocebus sabaeus	33.87	1.00e-116	412.00
IUUC-Cho-024899	Choloepus hoffmanni	36.59	1.00e-89	322.00
IUUC-Cin-025727	Ciona intestinalis	35.27	2.00e-96	344.00
IUUC-Csv-026117	Ciona savignyi	30.28	2.00e-94	338.00
IUUC-Cgl-026761	Colletotrichum gloeosporioides	31.35	2.00e-103	368.00
IUUC-Cne-027026	Cryptococcus neoformans	34.10	2.00e-58	218.00
IUUC-Dre-027916	Danio rerio	33.51	5.00e-116	410.00
IUUC-Dno-029483	Dasypus novemcinctus	32.28	2.00e-103	368.00
IUUC-Dor-030698	Dipodomys ordii	32.12	5.00e-102	363.00
IUUC-Dse-031159	Dothistroma septosporum	30.53	1.00e-96	345.00
IUUC-Dme-031652	Drosophila melanogaster	32.71	1.00e-102	365.00
IUUC-Ete-032775	Echinops telfairi	30.00	2.00e-90	324.00
IUUC-Eca-033952	Equus caballus	33.73	3.00e-115	407.00
IUUC-Eeu-034767	Erinaceus europaeus	35.82	6.00e-111	393.00
IUUC-Fca-036211	Felis catus	33.78	1.00e-113	402.00
IUUC-Fal-037248	Ficedula albicollis	33.74	2.00e-116	411.00
IUUC-Fox-037854	Fusarium oxysporum	31.93	1.00e-100	358.00
IUUC-Fso-038138	Fusarium solani	31.78	4.00e-102	363.00
IUUC-Gmo-038754	Gadus morhua	33.78	3.00e-115	407.00
IUUC-Ggr-040003	Gaeumannomyces graminis	33.65	9.00e-94	336.00
IUUC-Gga-041002	Gallus gallus	33.74	2.00e-116	411.00
IUUC-Gac-041555	Gasterosteus aculeatus	33.78	9.00e-115	405.00
IUUC-Gma-042875	Glycine max	32.54	1.00e-110	392.00
IUUC-Ggo-045468	Gorilla gorilla	33.95	3.00e-112	397.00
IUUC-Hsa-046848	Homo sapiens	33.87	1.00e-116	412.00
IUUC-Itr-048365	Ictidomys tridecemlineatus	33.87	5.00e-116	410.00
IUUC-Lch-049858	Latimeria chalumnae	33.74	3.00e-117	414.00
IUUC-Lpe-051446	Leersia perrieri	35.06	2.00e-110	391.00
IUUC-Loc-052415	Lepisosteus oculatus	33.69	1.00e-115	409.00
IUUC-Lma-053080	Leptosphaeria maculans	32.18	7.00e-109	386.00
IUUC-Laf-053701	Loxodonta africana	33.47	2.00e-114	405.00
IUUC-Mcc-055538	Macaca mulatta	33.65	2.00e-114	404.00
IUUC-Mor-057102	Magnaporthe oryzae	32.69	1.00e-109	389.00
IUUC-Mpo-057342	Magnaporthe poae	35.47	3.00e-99	353.00
IUUC-Mtr-058660	Medicago truncatula	34.01	4.00e-110	390.00
IUUC-Mla-058936	Melampsora laricipopulina	32.12	8.00e-76	276.00
IUUC-Mga-059754	Meleagris gallopavo	33.60	2.00e-115	408.00
IUUC-Mvi-060455	Microbotryum violaceum	32.11	2.00e-86	311.00
IUUC-Mmr-060870	Microcebus murinus	33.56	2.00e-114	404.00
IUUC-Mdo-062015	Monodelphis domestica	33.65	2.00e-114	404.00
IUUC-Mmu-063751	Mus musculus	33.74	9.00e-117	412.00
IUUC-Mac-064443	Musa acuminata	36.01	1.00e-115	408.00
IUUC-Mpu-065903	Mustela putorius furo	33.87	2.00e-116	411.00
IUUC-Mlu-068213	Myotis lucifugus	33.87	4.00e-117	413.00
IUUC-Nfi-068363	Neosartorya fischeri	34.12	8.00e-118	416.00
IUUC-Ncr-068950	Neurospora crassa	32.46	6.00e-101	360.00
IUUC-Nle-069480	Nomascus leucogenys	33.87	1.00e-116	412.00
IUUC-Ont-071562	Oreochromis niloticus	32.52	5.00e-106	376.00
IUUC-Oan-073607	Ornithorhynchus anatinus	34.01	2.00e-117	414.00
IUUC-Ocu-074446	Oryctolagus cuniculus	34.09	9.00e-117	412.00
IUUC-Oba-075198	Oryza barthii	35.06	6.00e-110	389.00
IUUC-Obr-076095	Oryza brachyantha	35.22	1.00e-110	391.00
IUUC-Ogl-077032	Oryza glaberrima	35.06	8.00e-110	389.00
IUUC-Ogu-078051	Oryza glumaepatula	35.06	6.00e-110	389.00
IUUC-Oin-079399	Oryza indica	36.35	5.00e-106	376.00
IUUC-Olo-080988	Oryza longistaminata	34.95	1.00e-109	388.00
IUUC-Ome-081600	Oryza meridionalis	35.10	4.00e-110	390.00
IUUC-Oni-082623	Oryza nivara	35.10	3.00e-110	390.00
IUUC-Opu-083762	Oryza punctata	35.06	5.00e-110	390.00
IUUC-Oru-084499	Oryza rufipogon	35.06	6.00e-110	389.00
IUUC-Ola-087157	Oryzias latipes	34.18	1.00e-114	405.00
IUUC-Olu-087650	Ostreococcus lucimarinus	32.58	2.00e-93	334.00
IUUC-Oga-088416	Otolemur garnettii	33.38	1.00e-113	402.00
IUUC-Oar-090230	Ovis aries	33.60	2.00e-115	408.00
IUUC-Ptr-091153	Pan troglodytes	33.87	8.00e-117	412.00
IUUC-Pan-091729	Papio anubis	33.87	1.00e-116	412.00
IUUC-Psi-093773	Pelodiscus sinensis	33.38	2.00e-115	407.00
IUUC-Pma-094678	Petromyzon marinus	32.89	1.00e-87	315.00
IUUC-Pno-094946	Phaeosphaeria nodorum	32.89	2.00e-95	341.00
IUUC-Ppa-095688	Physcomitrella patens	33.65	9.00e-114	402.00
IUUC-Pfo-096828	Poecilia formosa	33.33	8.00e-116	409.00
IUUC-Pab-097622	Pongo abelii	32.56	1.00e-106	379.00
IUUC-Pca-100391	Procavia capensis	39.84	3.00e-80	290.00
IUUC-Ppe-101142	Prunus persica	35.22	1.00e-107	382.00
IUUC-Pva-102995	Pteropus vampyrus	38.55	9.00e-96	342.00
IUUC-Pgr-103334	Puccinia graminis	31.65	1.00e-71	262.00
IUUC-Ptt-103903	Puccinia triticina	35.56	7.00e-69	253.00
IUUC-Pte-104167	Pyrenophora teres	32.86	3.00e-107	380.00
IUUC-Pyt-104736	Pyrenophora triticirepentis	32.47	5.00e-107	380.00
IUUC-Rno-106119	Rattus norvegicus	34.09	1.00e-116	412.00
IUUC-Sha-106958	Sarcophilus harrisii	34.36	1.00e-117	415.00
IUUC-Sja-107940	Schizosaccharomyces japonicus	48.23	0.00e+00	705.00
IUUC-Ssl-108537	Sclerotinia sclerotiorum	32.86	2.00e-103	367.00
IUUC-Smo-108872	Selaginella moellendorffii	32.93	2.00e-116	410.00
IUUC-Sit-110626	Setaria italica	34.56	5.00e-108	383.00
IUUC-Sly-111497	Solanum lycopersicum	35.53	2.00e-114	404.00
IUUC-Sar-113581	Sorex araneus	33.33	3.00e-83	300.00
IUUC-Sbi-113931	Sorghum bicolor	35.02	3.00e-109	387.00
IUUC-Sre-114943	Sporisorium reilianum	30.34	9.00e-84	302.00
IUUC-Ssc-116133	Sus scrofa	31.84	1.00e-102	365.00
IUUC-Tgu-116462	Taeniopygia guttata	33.24	3.00e-114	404.00
IUUC-Tru-118299	Takifugu rubripes	33.47	3.00e-116	410.00
IUUC-Tsy-119517	Tarsius syrichta	41.53	2.00e-78	285.00
IUUC-Tni-120811	Tetraodon nigroviridis	32.89	4.00e-110	390.00
IUUC-Tca-121626	Theobroma cacao	33.72	5.00e-112	396.00
IUUC-Tre-121907	Trichoderma reesei	33.94	2.00e-109	387.00
IUUC-Tvi-122568	Trichoderma virens	32.61	3.00e-106	377.00
IUUC-Tae-123442	Triticum aestivum	34.91	4.00e-109	387.00
IUUC-Tur-126032	Triticum urartu	34.91	6.00e-109	386.00
IUUC-Tme-127162	Tuber melanosporum	35.46	8.00e-118	416.00
IUUC-Tbe-127658	Tupaia belangeri	32.98	2.00e-109	388.00
IUUC-Ttr-128326	Tursiops truncatus	30.77	2.00e-87	314.00
IUUC-Uma-129531	Ustilago maydis	32.14	2.00e-74	271.00
IUUC-Vda-129701	Verticillium dahliae	31.99	3.00e-106	377.00
IUUC-Vpa-130217	Vicugna pacos	29.82	1.00e-92	332.00
IUUC-Vvi-131133	Vitis vinifera	35.53	2.00e-112	398.00
IUUC-Xtr-132724	Xenopus tropicalis	33.91	9.00e-115	405.00
IUUC-Xma-134149	Xiphophorus maculatus	33.60	1.00e-116	412.00
IUUC-Yli-134592	Yarrowia lipolytica	27.06	3.00e-57	214.00
IUUC-Zma-135529	Zea mays	35.02	2.00e-109	387.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence