iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
CPLM	dbPAF	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/CUE	CUE	23665229

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/CUE	7.30e-11	40.3	67	106

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 3    etaleqLkeiFPnldysviqvvLeantgsleaavnnLLegs 43
           ++++e++++++Pnl++++i+  L +ntgs+e++v++ L+g 
   Q: 67   TQMVETVQNLAPNLHPEQIRYSL-ENTGSVEETVERYLRGD 106
           89*********************.**************985 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Component of the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Recruits the soluble ubiquitin-conjugating enzyme UBC7 to the cytoplasmic face of the endoplasmic reticulum membrane where it functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Targets the E2 conjugating enzyme UBC7 to the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains, and to the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M). Has also a role in cold adaptation, perhaps through effects on sterol biosynthesis.

Protein Sequence
(Fasta)

MEDSRLLITL ILVFGVIFLK KFFQSNQHPS AQRLSATGVN AHGRPQGSTQ NALRRTGRVN 60
GGHPVTTQMV ETVQNLAPNL HPEQIRYSLE NTGSVEETVE RYLRGDEFSF PPGFEPSRAP 120

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Nucleotide Sequence
(Fasta)

ATGGAGGATT CGAGATTGCT TATCACTTTG ATTCTTGTGT TTGGAGTTAT ATTTCTGAAA 60
AAATTCTTCC AAAGTAATCA GCATCCCTCA GCACAACGCT TATCCGCTAC AGGTGTAAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway

Interpro

IPR003892--CUE

PROSITE

PS51140--CUE

Pfam

PF02845--CUE

SMART

SM00546--CUE

Gene Ontology

GO:0000837--C:Doa10p ubiquitin ligase complex
GO:0000839--C:Hrd1p ubiquitin ligase ERAD-L complex
GO:0030176--C:integral component of endoplasmic reticulum membrane
GO:0043130--F:ubiquitin binding
GO:0097027--F:ubiquitin-protein transferase activator activity
GO:0097051--P:establishment of protein localization to endoplasmic reticulum membrane
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG

sce:YMR264W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ago-007976	Ashbya gossypii	42.86	9.00e-32	127.00
IUUC-Afl-008749	Aspergillus flavus	36.73	1.80e-02	30.00
IUUC-Afu-008970	Aspergillus fumigatus	32.00	6.00e-04	35.40
IUUC-Ang-009733	Aspergillus niger	38.78	2.00e-03	33.50
IUUC-Aor-010075	Aspergillus oryzae	36.73	1.80e-02	30.00
IUUC-Ate-010445	Aspergillus terreus	35.00	3.00e-03	32.70
IUUC-Cfa-020302	Canis familiaris	32.65	5.40e-02	30.80
IUUC-Cin-025544	Ciona intestinalis	40.00	7.00e-01	26.90
IUUC-Cgl-026461	Colletotrichum gloeosporioides	35.00	1.90e-01	28.50
IUUC-Dse-031559	Dothistroma septosporum	38.00	9.00e-03	31.20
IUUC-Eeu-035111	Erinaceus europaeus	31.37	5.50e-02	26.90
IUUC-Gma-043432	Glycine max	35.00	4.20e-02	29.60
IUUC-Mcc-055313	Macaca mulatta	27.27	9.00e-03	30.80
IUUC-Mvi-060273	Microbotryum violaceum	40.38	3.00e-04	36.60
IUUC-Mlu-067957	Myotis lucifugus	46.15	5.90e-01	28.10
IUUC-Nfi-068461	Neosartorya fischeri	32.00	4.00e-04	35.80
IUUC-Ocu-074450	Oryctolagus cuniculus	37.50	1.30e-01	27.30
IUUC-Olu-087605	Ostreococcus lucimarinus	29.63	1.20e-01	27.70
IUUC-Spo-108323	Schizosaccharomyces pombe	35.19	3.00e-05	40.00
IUUC-Sit-110173	Setaria italica	27.87	1.70e-01	29.30
IUUC-Sre-115215	Sporisorium reilianum	43.14	1.00e-05	41.20
IUUC-Tca-121253	Theobroma cacao	34.55	3.40e-02	30.00
IUUC-Uma-129431	Ustilago maydis	38.16	5.00e-07	45.80

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence