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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045800
Ensembl Protein ID ENSP00000417078.1
UniProt Accession Q9H2U1; B2RB00; Q70JU3; Q8IYE5; Q9P240; DHX36_HUMAN
Genbank Protein ID AAG36783.1; CAE11802.1; CAE11803.1; BAG37047.1; EAW78761.1; AAH36035.1; BAA96012.1
Protein Name ATP-dependent RNA helicase DHX36; DEAH box protein 36; G4-resolvase 1; MLE-like protein 1; RNA helicase associated with AU-rich element ARE
Genbank Nucleotide ID AF217190; AJ577133; AJ577134; AK314435; AC018452; BC036035; AB040921
Gene Name DHX36; DDX36; KIAA1488; MLEL1; RHAU
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000174953.13 ENST00000496811.5 ENSP00000417078.1
ENSG00000174953.13 ENST00000308361.10 ENSP00000309296.6
ENSG00000174953.13 ENST00000329463.9 ENSP00000330113.5
ENSG00000174953.13 ENST00000479934.5 ENSP00000418756.1
ENSG00000174953.13 ENST00000469977.1 ENSP00000419761.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircRNADbCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDB
Disease-associated Variation
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosSNPPhosphositePlus
dbPTMHPRDPhospho.ELMUniProt
PHOSIDABioGRIDmUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/Alpha-Helix/UBA 33.29 7.00e-107 383.00 IUUC-Spo-108229
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Proposed to have a global role in regulating mRNA expression including transcriptional regulation and mRNA stability. Binds with high affinity to and resolves tetramolecular RNA and DNA quadruplex structures. Unwinds intramolecular quadruplexes derived from the ZIC1 and the MYC promoters. Binds to quadruplex structures in the promoters of YY1 and ALPL genes and regulates their expression. Binds to telomerase RNA template component (TERC) 5'-end (nucleotides 1-43) and unwinds an internal quadruplex formation in TERC 5'-end to promote P1 helix formation; the P1 helix acts as a template boundary ensuring accurate reverse transcription and is disrupted by quadruplex formation. May be involved in regulation of telomere length. Plays a role in degradation and deadenylation of mRNAs containing in their 3'-UTR the consensus ARE sequence element. May function in sex development and spermatogenesis. May play a role in ossification.
 Proposed to have a global role in regulating mRNA expression including transcriptional regulation and mRNA stability. Binds with high affinity to and resolves tetramolecular RNA and DNA quadruplex structures. Unwinds intramolecular quadruplexes derived from the ZIC1 and the MYC promoters. Binds to quadruplex structures in the promoters of YY1 and ALPL genes and regulates their expression. Binds to telomerase RNA template component (TERC) 5'-end (nucleotides 1-43) and unwinds an internal quadruplex formation in TERC 5'-end to promote P1 helix formation; the P1 helix acts as a template boundary ensuring accurate reverse transcription and is disrupted by quadruplex formation. May be involved in regulation of telomere length. Plays a role in degradation and deadenylation of mRNAs containing in their 3'-UTR the consensus ARE sequence element. May function in sex development and spermatogenesis. May play a role in ossification.
Protein Sequence
(Fasta)
MSYDYHQNWG RDGGPRSSGG GYGGGPAGGH GGNRGSGGGG GGGGGGRGGR GRHPGHLKGR 60
EIGMWYAKKQ GQKNKEAERQ ERAVVHMDER REEQIVQLLN SVQAKNDKES EAQISWFAPE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045800|UBD,UBA|Homo sapiens
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Nucleotide Sequence
(Fasta)
AAGTGGGCGC ACAGTGGCTT CCGGGCCCGG ACGCCATTTC CAGCGGTTGC TGGTTCTGAC 60
GGGTTGTAGT CTGCCAGGAC AATGAGTTAT GACTACCATC AGAACTGGGG CCGTGATGGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045800|UBD,UBA|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0158--Chromosome
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0238--DNA-binding
KW-0347--Helicase
KW-0378--Hydrolase
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0694--RNA-binding
KW-0779--Telomere
KW-0804--Transcription
KW-0805--Transcription regulation
Interpro

IPR011545--DEAD/DEAH_box_helicase_dom
IPR002464--DNA/RNA_helicase_DEAH_CS
IPR011709--DUF1605
IPR007502--Helicase-assoc_dom
IPR014001--Helicase_ATP-bd
IPR001650--Helicase_C
IPR027417--P-loop_NTPase
PROSITE

PS00690--DEAH_ATP_HELICASE
PS51192--HELICASE_ATP_BIND_1
PS51194--HELICASE_CTER
Pfam

PF00270--DEAD
PF04408--HA2
PF00271--Helicase_C
PF07717--OB_NTP_bind
SMART

SM00487--DEXDc
SM00847--HA2
SM00490--HELICc
Gene Ontology

GO:0000781--C:chromosome, telomeric region
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0004004--F:ATP-dependent RNA helicase activity
GO:0001047--F:core promoter binding
GO:0008094--F:DNA-dependent ATPase activity
GO:0003725--F:double-stranded RNA binding
GO:0051880--F:G-quadruplex DNA binding
GO:0002151--F:G-quadruplex RNA binding
GO:0042826--F:histone deacetylase binding
GO:0003723--F:RNA binding
GO:0070034--F:telomerase RNA binding
GO:0044212--F:transcription regulatory region DNA binding
GO:0001503--P:ossification
GO:0032206--P:positive regulation of telomere maintenance
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0032481--P:positive regulation of type I interferon production
GO:0043330--P:response to exogenous dsRNA
GO:0009615--P:response to virus
GO:0006396--P:RNA processing
GO:0010501--P:RNA secondary structure unwinding
GO:0090669--P:telomerase RNA stabilization
GO:0006351--P:transcription, DNA-templated
KEGG hsa:170506
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001779 Ailuropoda melanoleuca 94.85 0.00e+00 1813.00
IUUC-Apl-003596 Anas platyrhynchos 41.20 2.00e-179 624.00
IUUC-Ago-007773 Ashbya gossypii 35.80 9.00e-99 355.00
IUUC-Acl-008083 Aspergillus clavatus 35.01 5.00e-115 409.00
IUUC-Afl-008510 Aspergillus flavus 34.09 7.00e-124 439.00
IUUC-Afu-008922 Aspergillus fumigatus 34.75 4.00e-118 419.00
IUUC-Ani-009411 Aspergillus nidulans 35.59 5.00e-109 389.00
IUUC-Ang-009730 Aspergillus niger 33.98 1.00e-111 398.00
IUUC-Aor-010172 Aspergillus oryzae 33.97 1.00e-123 438.00
IUUC-Ate-010493 Aspergillus terreus 34.47 2.00e-112 400.00
IUUC-Ame-011169 Astyanax mexicanus 41.50 4.00e-179 622.00
IUUC-Bgr-011983 Blumeria graminis 35.81 2.00e-115 411.00
IUUC-Bta-013378 Bos taurus 92.19 0.00e+00 1777.00
IUUC-Bci-013754 Botrytis cinerea 36.06 1.00e-107 385.00
IUUC-Bol-016139 Brassica oleracea 45.43 3.00e-179 622.00
IUUC-Bra-016816 Brassica rapa 45.56 1.00e-179 624.00
IUUC-Cja-019540 Callithrix jacchus 97.27 0.00e+00 1858.00
IUUC-Cfa-020791 Canis familiaris 94.54 0.00e+00 1843.00
IUUC-Csa-024273 Chlorocebus sabaeus 98.63 0.00e+00 1874.00
IUUC-Cho-024970 Choloepus hoffmanni 88.13 0.00e+00 1623.00
IUUC-Cin-025138 Ciona intestinalis 56.57 2.00e-110 392.00
IUUC-Cgl-026747 Colletotrichum gloeosporioides 35.40 6.00e-74 273.00
IUUC-Cne-026991 Cryptococcus neoformans 37.25 4.00e-128 453.00
IUUC-Dre-028088 Danio rerio 42.81 0.00e+00 646.00
IUUC-Dno-029278 Dasypus novemcinctus 43.38 0.00e+00 631.00
IUUC-Dor-030468 Dipodomys ordii 90.82 0.00e+00 1694.00
IUUC-Dse-031349 Dothistroma septosporum 35.13 6.00e-119 422.00
IUUC-Dme-031899 Drosophila melanogaster 43.10 2.00e-173 603.00
IUUC-Eca-033631 Equus caballus 93.85 0.00e+00 1741.00
IUUC-Eeu-035300 Erinaceus europaeus 90.40 0.00e+00 1707.00
IUUC-Fca-036139 Felis catus 95.06 0.00e+00 1822.00
IUUC-Fal-036635 Ficedula albicollis 42.22 1.00e-179 624.00
IUUC-Fox-037919 Fusarium oxysporum 35.16 1.00e-119 425.00
IUUC-Fso-038325 Fusarium solani 34.54 2.00e-122 434.00
IUUC-Gmo-038845 Gadus morhua 41.16 9.00e-167 581.00
IUUC-Ggr-039898 Gaeumannomyces graminis 36.88 9.00e-67 249.00
IUUC-Gga-040352 Gallus gallus 81.84 0.00e+00 1583.00
IUUC-Itr-047998 Ictidomys tridecemlineatus 95.91 0.00e+00 1838.00
IUUC-Kpa-049373 Komagataella pastoris 27.51 1.00e-75 278.00
IUUC-Lch-050113 Latimeria chalumnae 75.44 0.00e+00 1440.00
IUUC-Lma-053050 Leptosphaeria maculans 33.94 5.00e-116 413.00
IUUC-Mcc-055887 Macaca mulatta 99.11 0.00e+00 1882.00
IUUC-Mor-057213 Magnaporthe oryzae 34.37 8.00e-108 385.00
IUUC-Mga-059508 Meleagris gallopavo 84.72 0.00e+00 1483.00
IUUC-Mvi-060345 Microbotryum violaceum 37.31 3.00e-130 460.00
IUUC-Mmr-061784 Microcebus murinus 95.73 0.00e+00 1838.00
IUUC-Mdo-062130 Monodelphis domestica 41.90 2.00e-172 600.00
IUUC-Mmu-064388 Mus musculus 41.29 5.00e-179 622.00
IUUC-Mpu-066129 Mustela putorius furo 94.85 0.00e+00 1818.00
IUUC-Mlu-068060 Myotis lucifugus 42.40 2.00e-179 624.00
IUUC-Nfi-068341 Neosartorya fischeri 34.44 4.00e-111 396.00
IUUC-Ncr-068804 Neurospora crassa 35.07 5.00e-111 396.00
IUUC-Nle-069904 Nomascus leucogenys 99.05 0.00e+00 1884.00
IUUC-Oan-072940 Ornithorhynchus anatinus 86.63 0.00e+00 1632.00
IUUC-Ocu-074808 Oryctolagus cuniculus 95.69 0.00e+00 1835.00
IUUC-Ola-087195 Oryzias latipes 67.73 0.00e+00 1268.00
IUUC-Olu-087596 Ostreococcus lucimarinus 40.93 2.00e-166 579.00
IUUC-Oga-088185 Otolemur garnettii 92.10 0.00e+00 1786.00
IUUC-Oar-089378 Ovis aries 91.99 0.00e+00 1800.00
IUUC-Ptr-091400 Pan troglodytes 99.60 0.00e+00 1885.00
IUUC-Pan-092750 Papio anubis 99.21 0.00e+00 1885.00
IUUC-Psi-093597 Pelodiscus sinensis 42.43 8.00e-179 621.00
IUUC-Pno-094951 Phaeosphaeria nodorum 32.45 3.00e-100 360.00
IUUC-Pfo-097056 Poecilia formosa 74.10 0.00e+00 1246.00
IUUC-Pab-098729 Pongo abelii 41.77 3.00e-171 596.00
IUUC-Ppe-102067 Prunus persica 45.16 0.00e+00 652.00
IUUC-Pva-102886 Pteropus vampyrus 88.73 0.00e+00 1352.00
IUUC-Pgr-103316 Puccinia graminis 31.58 2.00e-88 321.00
IUUC-Ptt-103877 Puccinia triticina 30.47 6.00e-78 286.00
IUUC-Pte-104049 Pyrenophora teres 34.94 1.00e-114 408.00
IUUC-Pyt-104735 Pyrenophora triticirepentis 35.44 7.00e-115 409.00
IUUC-Rno-106032 Rattus norvegicus 41.51 1.00e-179 624.00
IUUC-Sce-106450 Saccharomyces cerevisiae 29.84 1.00e-93 338.00
IUUC-Sha-106606 Sarcophilus harrisii 86.00 0.00e+00 1660.00
IUUC-Sja-107784 Schizosaccharomyces japonicus 30.83 2.00e-98 354.00
IUUC-Spo-108229 Schizosaccharomyces pombe 32.81 4.00e-107 383.00
IUUC-Ssl-108517 Sclerotinia sclerotiorum 23.40 1.60e+00 28.50
IUUC-Smo-109377 Selaginella moellendorffii 47.24 0.00e+00 656.00
IUUC-Sre-115121 Sporisorium reilianum 35.30 5.00e-116 413.00
IUUC-Tgu-117294 Taeniopygia guttata 80.39 0.00e+00 1513.00
IUUC-Tru-118378 Takifugu rubripes 44.86 0.00e+00 630.00
IUUC-Tsy-119563 Tarsius syrichta 91.77 0.00e+00 1798.00
IUUC-Tni-120568 Tetraodon nigroviridis 68.20 0.00e+00 1250.00
IUUC-Tca-121301 Theobroma cacao 43.98 0.00e+00 634.00
IUUC-Tre-122120 Trichoderma reesei 34.68 1.00e-116 415.00
IUUC-Tvi-122632 Trichoderma virens 34.84 1.00e-114 408.00
IUUC-Tme-127179 Tuber melanosporum 28.05 4.00e-44 174.00
IUUC-Tbe-127844 Tupaia belangeri 89.90 0.00e+00 1737.00
IUUC-Ttr-128592 Tursiops truncatus 94.12 0.00e+00 1805.00
IUUC-Uma-129440 Ustilago maydis 34.50 2.00e-117 417.00
IUUC-Vda-129765 Verticillium dahliae 33.41 1.00e-116 415.00
IUUC-Vpa-130460 Vicugna pacos 89.82 0.00e+00 1756.00
IUUC-Vvi-131000 Vitis vinifera 45.74 0.00e+00 647.00
IUUC-Xtr-132421 Xenopus tropicalis 74.53 0.00e+00 1431.00
IUUC-Xma-134305 Xiphophorus maculatus 69.03 0.00e+00 1281.00
IUUC-Yli-134558 Yarrowia lipolytica 32.64 5.00e-102 366.00
Created Date 25-Jun-2017

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