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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Spo-108270
UUCD1 version UUC-ScP-00122
Ensembl Protein ID SPCC613.12c.1:pep
UniProt Accession O74910; RAF1_SCHPO
Genbank Protein ID CAA21064.1
Protein Name Rik1-associated factor 1; Cryptic loci regulator 8; De-localization of swi6 protein 1
Genbank Nucleotide ID CU329672
Gene Name raf1; clr8; cmc1; dos1; SPCC613.12c
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
SPCC613.12c SPCC613.12c.1 SPCC613.12c.1:pep
Annotation
mRNA Expression
GEO
Protein-protein Interaction
iRefIndexMentha
Protein 3D Structure
PDBMMDB
Protein Expression/Proteomics
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 4.00e-13 47.2 550 576
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 7    tclaf.sd.tllvsGsdDgtikvWDlr 31
           +  ++ +  +l+v+G+ Dg +kvWDlr
   Q: 550  NMAQWqPKgNLFVTGGSDGIVKVWDLR 576
           5567997779***************86 PP
   
Organism Schizosaccharomyces pombe
Functional Description
(View)

Functional Description


     Component of the rik1-associated E3 ubiquitin ligase complex that shows ubiquitin ligase activity and is required for histone H3K9 methylation. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting swi6/HP1 to methylated histones which leads to transcriptional silencing within centromeric heterochromatin, telomeric regions and at the silent mating-type loci. Has a role in both mitotic and meiotic chromosome segregation.
 Component of the rik1-associated E3 ubiquitin ligase complex that shows ubiquitin ligase activity and is required for histone H3K9 methylation. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting swi6/HP1 to methylated histones which leads to transcriptional silencing within centromeric heterochromatin, telomeric regions and at the silent mating-type loci. Has a role in both mitotic and meiotic chromosome segregation.
Protein Sequence
(Fasta)
MTNSSPRVKR RTDTQYLHSV SSKLPKVDFD TNNEEFFEEE FEIYDPFYRA ELPCPKPSLS 60
ISKHSIAKVP SNVNKRLELQ LLLTSGTFLP NSRPYLSERV RKHTHLLSNS ITGDDKPSLI 120
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Protein Fasta Sequence


>IUUC-Spo-108270|E3,WD_repeat|Schizosaccharomyces pombe
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Nucleotide Sequence
(Fasta)
TTTGGACTTA GTAAATTCTT TATATCAATC AGTGCCTTAA ACTCACTCAG CAACCCATAA 60
CTTCTGTTAA ACTAGTGAAC TTGCACACTG AAGGATTAAA AGTAAAAAGC CCAATAATTT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Spo-108270|E3,WD_repeat|Schizosaccharomyces pombe
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0034507--C:chromosome, centromeric outer repeat region
GO:0000781--C:chromosome, telomeric region
GO:0043494--C:CLRC ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0031934--C:mating-type region heterochromatin
GO:0031618--C:nuclear pericentric heterochromatin
GO:0005634--C:nucleus
GO:0034613--P:cellular protein localization
GO:0030702--P:chromatin silencing at centromere
GO:1990141--P:chromatin silencing at centromere outer repeat region
GO:0030466--P:chromatin silencing at silent mating-type cassette
GO:0006348--P:chromatin silencing at telomere
GO:0031048--P:chromatin silencing by small RNA
GO:0016569--P:covalent chromatin modification
GO:0035391--P:maintenance of chromatin silencing at silent mating-type cassette
GO:0045132--P:meiotic chromosome segregation
GO:0045141--P:meiotic telomere clustering
GO:0051572--P:negative regulation of histone H3-K4 methylation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0051574--P:positive regulation of histone H3-K9 methylation
GO:0031494--P:regulation of mating type switching
GO:0006351--P:transcription, DNA-templated
KEGG spo:SPCC613.12c
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000846 Aegilops tauschii 23.30 5.00e-09 54.30
IUUC-Atr-002668 Amborella trichopoda 24.44 8.00e-09 53.90
IUUC-Acl-008065 Aspergillus clavatus 29.76 1.00e-17 82.00
IUUC-Afl-008436 Aspergillus flavus 25.00 4.00e-22 98.60
IUUC-Afu-009043 Aspergillus fumigatus 27.63 2.00e-24 106.00
IUUC-Ani-009382 Aspergillus nidulans 27.35 9.00e-28 117.00
IUUC-Ang-009753 Aspergillus niger 28.95 2.00e-25 109.00
IUUC-Aor-010020 Aspergillus oryzae 25.12 4.00e-22 98.60
IUUC-Ate-010564 Aspergillus terreus 27.58 1.00e-29 123.00
IUUC-Bci-013668 Botrytis cinerea 23.39 7.00e-15 74.70
IUUC-Cgl-026459 Colletotrichum gloeosporioides 25.73 2.00e-21 96.30
IUUC-Dse-031276 Dothistroma septosporum 21.01 2.00e-16 79.00
IUUC-Fox-037886 Fusarium oxysporum 23.30 1.00e-23 103.00
IUUC-Fso-038210 Fusarium solani 22.48 8.00e-23 100.00
IUUC-Ggr-039952 Gaeumannomyces graminis 22.52 4.00e-18 85.50
IUUC-Lma-053206 Leptosphaeria maculans 27.15 3.00e-24 106.00
IUUC-Mor-057085 Magnaporthe oryzae 24.41 2.00e-17 83.20
IUUC-Mpo-057324 Magnaporthe poae 23.58 5.00e-19 88.20
IUUC-Mac-064887 Musa acuminata 24.02 2.00e-09 54.70
IUUC-Nfi-068408 Neosartorya fischeri 26.26 3.00e-23 101.00
IUUC-Obr-076372 Oryza brachyantha 24.22 9.00e-09 53.50
IUUC-Ogl-076950 Oryza glaberrima 24.84 2.00e-10 59.30
IUUC-Opu-083211 Oryza punctata 24.53 7.00e-10 57.40
IUUC-Osa-085998 Oryza sativa 24.53 9.00e-10 57.00
IUUC-Pno-095108 Phaeosphaeria nodorum 25.78 3.00e-28 119.00
IUUC-Pte-104227 Pyrenophora teres 27.96 8.00e-31 127.00
IUUC-Pyt-104536 Pyrenophora triticirepentis 27.74 1.00e-31 130.00
IUUC-Sja-107870 Schizosaccharomyces japonicus 46.42 3.00e-156 543.00
IUUC-Ssl-108569 Sclerotinia sclerotiorum 23.83 1.00e-16 80.90
IUUC-Sit-110580 Setaria italica 23.84 1.00e-07 50.10
IUUC-Sbi-114718 Sorghum bicolor 22.51 3.00e-10 58.90
IUUC-Tre-122228 Trichoderma reesei 23.94 5.00e-19 88.20
IUUC-Tvi-122460 Trichoderma virens 32.12 4.00e-16 78.60
IUUC-Tae-125757 Triticum aestivum 29.20 9.00e-08 50.80
IUUC-Tur-126661 Triticum urartu 29.20 6.00e-08 50.80
IUUC-Vda-129672 Verticillium dahliae 22.44 6.00e-20 91.30
IUUC-Zma-135703 Zea mays 22.88 3.00e-10 58.90
Created Date 25-Jun-2017

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