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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046319
Ensembl Protein ID ENSP00000455106.1
UniProt Accession Q14137; Q969Z6; Q96IS8; Q96Q25; Q9BSA7; Q9BVM0; BOP1_HUMAN
Genbank Protein ID BAB70666.1; AAH01086.2; AAH05160.2; AAH07274.1; AAH13787.1; AAH13980.1; AAH17674.1; BAA09473.1
Protein Name Ribosome biogenesis protein BOP1; Block of proliferation 1 protein
Genbank Nucleotide ID AB060694; AC145291; BC005160; BC007274; BC013787; BC013980; BC017674; D50914
Gene Name BOP1; KIAA0124
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000261236.6 ENST00000569669.5 ENSP00000455106.1
ENSG00000261236.6 ENST00000569403.1 ENSP00000456082.1
Annotation
Cancer Mutation
CGAPIntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOTCGAICGCTHPA
HPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
TRANSFACRepTarmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosSNPPhosphositePlus
dbPTMHPRDPhospho.ELMUniProt
PHOSIDAmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 2.00e-14 54.8 411 450
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllks 38
           gH+d v+cl+  ++   lvsGsdDg++++W++ t +++++
   Q: 411  GHSDLVRCLSVsPGgQWLVSGSDDGSLRLWEVATARCVRT 450
           8**********988899********************985 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
 Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
Protein Sequence
(Fasta)
MAGSRGAGRT AAPSVRPEKR RSEPELEPEP EPEPPLLCTS PLSHSTGSDS GVSDSEESVF 60
SGLEDSGSDS SEDDDEGDEE GEDGALDDEG HSGIKKTTEE QVQASTPCPR TEMASARIGD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046319|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGCGGGTT CGCGGGGTGC GGGGCGCACG GCGGCGCCGA GCGTGCGGCC GGAGAAGCGG 60
CGGTCTGAGC CCGAACTGGA GCCTGAGCCC GAGCCGGAGG TGACTGTGGC GATGCGGGGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046319|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0690--Ribosome biogenesis
KW-0698--rRNA processing
KW-0853--WD repeat
Interpro

IPR028598--BOP1/Erb1
IPR012953--BOP1_N_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF08145--BOP1NT
PF00400--WD40
SMART

SM01035--BOP1NT
SM00320--WD40
Gene Ontology

GO:0030529--C:intracellular ribonucleoprotein complex
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0070545--C:PeBoW complex
GO:0030687--C:preribosome, large subunit precursor
GO:0043021--F:ribonucleoprotein complex binding
GO:0003723--F:RNA binding
GO:0008283--P:cell proliferation
GO:0000448--P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000463--P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0051726--P:regulation of cell cycle
GO:0042254--P:ribosome biogenesis
GO:0006364--P:rRNA processing
KEGG hsa:23246
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001158 Aegilops tauschii 41.16 2.00e-123 436.00
IUUC-Aml-001507 Ailuropoda melanoleuca 86.19 0.00e+00 1095.00
IUUC-Atr-003141 Amborella trichopoda 41.72 1.00e-87 317.00
IUUC-Apl-003545 Anas platyrhynchos 67.88 0.00e+00 810.00
IUUC-Aly-005649 Arabidopsis lyrata 43.74 5.00e-153 535.00
IUUC-Ath-007625 Arabidopsis thaliana 43.74 2.00e-150 526.00
IUUC-Ago-007958 Ashbya gossypii 42.90 1.00e-159 557.00
IUUC-Acl-008344 Aspergillus clavatus 44.02 2.00e-144 506.00
IUUC-Afl-008616 Aspergillus flavus 43.43 6.00e-148 518.00
IUUC-Afu-009083 Aspergillus fumigatus 44.95 1.00e-142 500.00
IUUC-Ani-009365 Aspergillus nidulans 43.58 3.00e-146 512.00
IUUC-Ang-009796 Aspergillus niger 43.88 2.00e-142 499.00
IUUC-Aor-010015 Aspergillus oryzae 43.43 6.00e-148 518.00
IUUC-Ate-010537 Aspergillus terreus 44.10 1.00e-149 523.00
IUUC-Ame-011767 Astyanax mexicanus 69.92 4.00e-113 400.00
IUUC-Bgr-012286 Blumeria graminis 43.15 1.00e-150 527.00
IUUC-Bta-013569 Bos taurus 90.35 0.00e+00 1128.00
IUUC-Bci-013820 Botrytis cinerea 42.39 2.00e-143 503.00
IUUC-Bdi-014895 Brachypodium distachyon 45.91 3.00e-155 542.00
IUUC-Bol-016099 Brassica oleracea 43.92 2.00e-153 536.00
IUUC-Bra-017174 Brassica rapa 43.76 2.00e-153 537.00
IUUC-Cel-018201 Caenorhabditis elegans 46.39 3.00e-156 545.00
IUUC-Cja-019009 Callithrix jacchus 80.41 0.00e+00 1019.00
IUUC-Cfa-020173 Canis familiaris 84.82 0.00e+00 1070.00
IUUC-Cpo-021796 Cavia porcellus 89.53 0.00e+00 1122.00
IUUC-Cre-022650 Chlamydomonas reinhardtii 48.28 6.00e-157 547.00
IUUC-Csa-023440 Chlorocebus sabaeus 96.51 0.00e+00 1288.00
IUUC-Cin-025782 Ciona intestinalis 55.06 0.00e+00 744.00
IUUC-Csv-026352 Ciona savignyi 55.33 0.00e+00 741.00
IUUC-Cgl-026393 Colletotrichum gloeosporioides 39.25 1.00e-117 417.00
IUUC-Cne-027004 Cryptococcus neoformans 44.38 2.00e-169 589.00
IUUC-Cme-027242 Cyanidioschyzon merolae 39.68 4.00e-123 435.00
IUUC-Dre-028658 Danio rerio 74.04 0.00e+00 1000.00
IUUC-Dno-028883 Dasypus novemcinctus 84.34 0.00e+00 1137.00
IUUC-Dor-031031 Dipodomys ordii 88.99 0.00e+00 1170.00
IUUC-Dse-031443 Dothistroma septosporum 40.36 2.00e-144 506.00
IUUC-Dme-031786 Drosophila melanogaster 53.68 0.00e+00 737.00
IUUC-Eca-033677 Equus caballus 89.11 0.00e+00 1167.00
IUUC-Eeu-035310 Erinaceus europaeus 88.26 0.00e+00 937.00
IUUC-Fca-035888 Felis catus 88.70 0.00e+00 1127.00
IUUC-Fal-037438 Ficedula albicollis 69.20 0.00e+00 738.00
IUUC-Fox-037973 Fusarium oxysporum 42.70 2.00e-157 549.00
IUUC-Fso-038187 Fusarium solani 42.24 4.00e-156 545.00
IUUC-Gmo-039114 Gadus morhua 65.53 0.00e+00 830.00
IUUC-Ggr-039746 Gaeumannomyces graminis 41.76 1.00e-151 530.00
IUUC-Gga-040631 Gallus gallus 73.45 3.00e-156 544.00
IUUC-Gac-042582 Gasterosteus aculeatus 68.27 0.00e+00 893.00
IUUC-Gma-044215 Glycine max 43.22 2.00e-151 529.00
IUUC-Ggo-045587 Gorilla gorilla 99.68 0.00e+00 1236.00
IUUC-Hvu-047526 Hordeum vulgare 44.69 1.00e-145 510.00
IUUC-Itr-048683 Ictidomys tridecemlineatus 91.33 0.00e+00 1148.00
IUUC-Kpa-049221 Komagataella pastoris 40.75 1.00e-153 536.00
IUUC-Lch-049640 Latimeria chalumnae 72.64 0.00e+00 1011.00
IUUC-Lpe-051135 Leersia perrieri 42.49 2.00e-133 469.00
IUUC-Loc-051930 Lepisosteus oculatus 73.05 0.00e+00 983.00
IUUC-Lma-053290 Leptosphaeria maculans 42.95 2.00e-143 503.00
IUUC-Laf-053903 Loxodonta africana 79.10 0.00e+00 1031.00
IUUC-Mcc-055471 Macaca mulatta 96.51 0.00e+00 1291.00
IUUC-Meu-056190 Macropus eugenii 85.06 0.00e+00 1057.00
IUUC-Mor-057135 Magnaporthe oryzae 41.84 8.00e-145 507.00
IUUC-Mpo-057475 Magnaporthe poae 41.23 3.00e-140 492.00
IUUC-Mtr-058689 Medicago truncatula 40.41 5.00e-132 465.00
IUUC-Mla-059149 Melampsora laricipopulina 45.45 3.00e-170 592.00
IUUC-Mga-059645 Meleagris gallopavo 63.93 2.00e-97 348.00
IUUC-Mvi-060485 Microbotryum violaceum 44.82 5.00e-148 519.00
IUUC-Mmr-061674 Microcebus murinus 84.77 0.00e+00 1123.00
IUUC-Mdo-062973 Monodelphis domestica 81.64 0.00e+00 1080.00
IUUC-Mmu-064180 Mus musculus 87.71 0.00e+00 1138.00
IUUC-Mac-064535 Musa acuminata 41.27 1.00e-95 344.00
IUUC-Mpu-066406 Mustela putorius furo 91.05 0.00e+00 1170.00
IUUC-Mlu-067795 Myotis lucifugus 90.81 0.00e+00 1122.00
IUUC-Nfi-068516 Neosartorya fischeri 44.79 3.00e-136 479.00
IUUC-Ncr-068767 Neurospora crassa 43.06 4.00e-139 489.00
IUUC-Opr-071084 Ochotona princeps 88.21 1.00e-144 506.00
IUUC-Ont-071614 Oreochromis niloticus 69.47 0.00e+00 920.00
IUUC-Oba-075980 Oryza barthii 42.72 6.00e-134 471.00
IUUC-Obr-076799 Oryza brachyantha 44.59 6.00e-147 514.00
IUUC-Ogl-077134 Oryza glaberrima 44.37 4.00e-142 498.00
IUUC-Ogu-078655 Oryza glumaepatula 42.77 4.00e-137 481.00
IUUC-Oin-079654 Oryza indica 44.37 9.00e-142 497.00
IUUC-Olo-080706 Oryza longistaminata 42.23 3.00e-134 472.00
IUUC-Ome-081716 Oryza meridionalis 38.25 7.00e-114 404.00
IUUC-Oni-082508 Oryza nivara 42.86 1.00e-133 470.00
IUUC-Opu-083707 Oryza punctata 42.23 2.00e-133 469.00
IUUC-Oru-084453 Oryza rufipogon 42.23 3.00e-134 472.00
IUUC-Osa-085811 Oryza sativa 44.37 6.00e-142 498.00
IUUC-Ola-087361 Oryzias latipes 70.00 0.00e+00 944.00
IUUC-Oga-088015 Otolemur garnettii 87.02 0.00e+00 1183.00
IUUC-Oar-090058 Ovis aries 62.94 1.00e-117 417.00
IUUC-Ptr-090631 Pan troglodytes 98.56 2.00e-152 531.00
IUUC-Pan-092306 Papio anubis 96.90 0.00e+00 1323.00
IUUC-Pma-094622 Petromyzon marinus 72.45 0.00e+00 972.00
IUUC-Pno-094794 Phaeosphaeria nodorum 39.22 1.00e-130 460.00
IUUC-Ppa-095528 Physcomitrella patens 43.12 7.00e-96 344.00
IUUC-Pfo-096682 Poecilia formosa 70.68 0.00e+00 956.00
IUUC-Pab-097939 Pongo abelii 98.40 0.00e+00 1108.00
IUUC-Pop-099530 Populus trichocarpa 44.55 6.00e-137 481.00
IUUC-Pca-100333 Procavia capensis 84.54 0.00e+00 1140.00
IUUC-Ppe-102078 Prunus persica 43.32 4.00e-147 515.00
IUUC-Pgr-103525 Puccinia graminis 45.22 3.00e-164 572.00
IUUC-Ptt-103929 Puccinia triticina 44.83 2.00e-159 556.00
IUUC-Pte-104029 Pyrenophora teres 42.48 1.00e-151 530.00
IUUC-Pyt-104446 Pyrenophora triticirepentis 42.64 1.00e-151 530.00
IUUC-Rno-105248 Rattus norvegicus 88.80 0.00e+00 1138.00
IUUC-Sce-106381 Saccharomyces cerevisiae 41.02 5.00e-155 541.00
IUUC-Sha-106519 Sarcophilus harrisii 84.43 0.00e+00 1086.00
IUUC-Sja-107908 Schizosaccharomyces japonicus 41.86 4.00e-141 495.00
IUUC-Spo-108071 Schizosaccharomyces pombe 42.38 1.00e-141 497.00
IUUC-Smo-109604 Selaginella moellendorffii 46.48 2.00e-156 546.00
IUUC-Sit-110551 Setaria italica 44.30 3.00e-146 512.00
IUUC-Sly-110970 Solanum lycopersicum 46.11 8.00e-81 294.00
IUUC-Stu-112593 Solanum tuberosum 44.28 6.00e-151 528.00
IUUC-Sar-113123 Sorex araneus 86.03 2.00e-148 518.00
IUUC-Sbi-113945 Sorghum bicolor 43.66 1.00e-148 520.00
IUUC-Sre-115188 Sporisorium reilianum 45.07 1.00e-163 570.00
IUUC-Ssc-115352 Sus scrofa 91.90 0.00e+00 1115.00
IUUC-Tru-117685 Takifugu rubripes 70.24 0.00e+00 945.00
IUUC-Tni-119982 Tetraodon nigroviridis 70.21 0.00e+00 897.00
IUUC-Tca-121664 Theobroma cacao 44.63 2.00e-156 546.00
IUUC-Tre-122229 Trichoderma reesei 43.36 1.00e-139 490.00
IUUC-Tvi-122576 Trichoderma virens 43.36 1.00e-143 503.00
IUUC-Tae-124110 Triticum aestivum 44.28 1.00e-136 480.00
IUUC-Tur-126781 Triticum urartu 41.56 2.00e-119 423.00
IUUC-Tme-127080 Tuber melanosporum 47.24 1.00e-174 606.00
IUUC-Ttr-128514 Tursiops truncatus 88.45 0.00e+00 819.00
IUUC-Uma-129556 Ustilago maydis 43.51 6.00e-155 541.00
IUUC-Vda-129715 Verticillium dahliae 43.30 6.00e-152 531.00
IUUC-Vvi-131211 Vitis vinifera 44.44 1.00e-147 516.00
IUUC-Xma-133883 Xiphophorus maculatus 70.63 0.00e+00 924.00
IUUC-Yli-134438 Yarrowia lipolytica 42.90 2.00e-143 503.00
IUUC-Zma-135341 Zea mays 39.42 3.00e-134 472.00
Created Date 25-Jun-2017

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