iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Mmu-063503

UUCD1 version

UUC-MuM-01230

Ensembl Protein ID

ENSMUSP00000005825.6

UniProt Accession

Q8BGF7; Q3TZK5; Q68FH6; Q6ZQ63; PAN2_MOUSE

Genbank Protein ID

BAC98006.2; BAC33183.1; BAC40693.1; BAE34203.1; AAH75686.1; AAH79841.1

Protein Name

PAB-dependent poly(A)-specific ribonuclease subunit PAN2; Inactive ubiquitin carboxyl-terminal hydrolase 52; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2

Genbank Nucleotide ID

AK129196; AK047887; AK089001; AK157800; BC075686; BC079841

Gene Name

Pan2; Kiaa0710; Usp52

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000005682.8	ENSMUST00000005825.6	ENSMUSP00000005825.6

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	miRNAMap
RAID2
Protein-protein Interaction
IID	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	6.60e-21	76.0	524	909

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 9    tCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs............ 85
             Y+N+++Q+L++++++r+l+ +   + +++      + +l+++l  lf+ l  s+    + +++l+a++++ e               
   Q: 524  NAYCNCMIQVLYFLEPVRCLIQN---HLCQK------EFCLACELGFLFHMLDLSRGDPCQGSNFLRAFRTIPEASAlgliladsdeas 603
           56*********************...55654......57*************9*****************9999855655555444444 PP
   S: 86   ..gyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldl 172
             g+     q   +f+l ql++++           +e +  ++ + a  +  ++++s+i +lF  ++++   c +c+++++r ++ l +
   Q: 604  gkGSLARLIQRWNRFILTQLHQDM-----------QELEVPQAYRGAGGSFCSSGDSIIGQLFSCEMENCSLC-RCGSETVRASSTLLF 680
           444444444555566666666666...........3334445666688999*****************99999.8************** PP
   S: 173  slpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdl 261
           +l+ p++++ k+ ++ ++L+     e+ +   + +c++c+k+q + ++  +++lP++L+++    s +e+     +++ +v f+  + +
   Q: 681  TLSYPEDKTGKNYDFAQVLKRSICLEQNT---QAWCDNCEKYQPTIQTRNIRHLPDILVINCEVNSSKEADFW--RLQAEVAFK--IAV 762
           **********999**99999888766665...69****************************99976666555..599999997..777 PP
   S: 262  spfcts..............peekqke.............................................................k 275
           +++  +              +     +                                                              
   Q: 763  KKYGGEmkskefaladrkelR-----SpegflcssieelknvwlpfsirmkmtknkgldvcnwadehelsslgapsqwgparaeeelgV 846
           777776334455555555550.....055555555555555555555555566666666666666666666777777777777777779 PP
   S: 276  kkYeLiavvvHsG.slssGHYvayvkn...........ekgkWllfdDskVtevkeeevleet 326
           + Y+L+a vvH   s  +G  va++k            ++++W+lf+D  ++++++ e +++ 
   Q: 847  YVYDLMATVVHILdSRTGGSLVAHIKVgetyhqrkegvTHQQWYLFNDFLIEPIDKYEAVQFD 909
           *************9*************999988877777888************998877765 PP

Organism

Mus musculus

Functional Description
(View)

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.

Protein Sequence
(Fasta)

MNFEGLDPGL AEFSPAMHST LDPVLDAHLN PSLLQNVELD PEGVALEALP VQESVHIMEG 60
VYSELHSVVA EVGVPVSVSH FDLHEEMLWV GSHGGHATSF FGPALERYSS FQVNGGDDIR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTGCTTGGGT TAGGTTGAGC TAGAGGCGGG GGAGTAGTAG GGAAACTGGA ATTTCCCGCG 60
GAGCTGACGG CGCTTTCTCT ACCCCCTACT CGTTTGAATT CCACGCGCTC CAAAATATCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom

PROSITE

PS50235--USP_3

Pfam

PF00929--RNase_T
PF13423--UCH_1

SMART

SM00479--EXOIII

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0000932--C:P-body
GO:0031251--C:PAN complex
GO:0000175--F:3'-5'-exoribonuclease activity
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000291--P:nuclear-transcribed mRNA catabolic process, exonucleolytic
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening

KEGG

mmu:103135

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001273	Ailuropoda melanoleuca	95.37	0.00e+00	2269.00
IUUC-Apl-003500	Anas platyrhynchos	83.82	0.00e+00	1844.00
IUUC-Aca-004930	Anolis carolinensis	83.35	0.00e+00	2005.00
IUUC-Acl-008214	Aspergillus clavatus	31.36	4.00e-158	552.00
IUUC-Afu-009112	Aspergillus fumigatus	31.37	5.00e-149	522.00
IUUC-Ang-009531	Aspergillus niger	31.04	2.00e-151	530.00
IUUC-Ame-011259	Astyanax mexicanus	74.63	0.00e+00	1823.00
IUUC-Bta-012371	Bos taurus	95.27	0.00e+00	2266.00
IUUC-Bci-013684	Botrytis cinerea	43.55	3.00e-71	263.00
IUUC-Cja-019297	Callithrix jacchus	93.31	0.00e+00	2214.00
IUUC-Cfa-020489	Canis familiaris	95.68	0.00e+00	2263.00
IUUC-Cpo-022392	Cavia porcellus	95.20	0.00e+00	2292.00
IUUC-Csa-023220	Chlorocebus sabaeus	95.37	0.00e+00	2271.00
IUUC-Csv-025841	Ciona savignyi	45.32	0.00e+00	891.00
IUUC-Cgl-026534	Colletotrichum gloeosporioides	32.53	3.00e-164	573.00
IUUC-Cne-026932	Cryptococcus neoformans	42.70	4.00e-72	266.00
IUUC-Dre-028482	Danio rerio	72.13	0.00e+00	1776.00
IUUC-Dno-029398	Dasypus novemcinctus	95.02	0.00e+00	2256.00
IUUC-Dor-030307	Dipodomys ordii	88.67	0.00e+00	1278.00
IUUC-Dme-032111	Drosophila melanogaster	41.82	0.00e+00	887.00
IUUC-Eca-033985	Equus caballus	95.85	0.00e+00	2277.00
IUUC-Eeu-034928	Erinaceus europaeus	82.39	0.00e+00	758.00
IUUC-Fca-035587	Felis catus	95.70	0.00e+00	2291.00
IUUC-Fal-037587	Ficedula albicollis	84.20	0.00e+00	1984.00
IUUC-Fso-038133	Fusarium solani	29.27	8.00e-133	468.00
IUUC-Gmo-039076	Gadus morhua	72.73	0.00e+00	1738.00
IUUC-Ggr-039957	Gaeumannomyces graminis	32.62	5.00e-143	502.00
IUUC-Gga-040948	Gallus gallus	84.35	0.00e+00	2019.00
IUUC-Gac-042396	Gasterosteus aculeatus	73.68	0.00e+00	1798.00
IUUC-Ggo-045412	Gorilla gorilla	95.53	0.00e+00	2274.00
IUUC-Hsa-046076	Homo sapiens	95.53	0.00e+00	2277.00
IUUC-Itr-048143	Ictidomys tridecemlineatus	90.47	0.00e+00	2100.00
IUUC-Kpa-049178	Komagataella pastoris	31.68	3.00e-85	310.00
IUUC-Lch-050279	Latimeria chalumnae	72.30	0.00e+00	1711.00
IUUC-Loc-052872	Lepisosteus oculatus	75.94	0.00e+00	1823.00
IUUC-Lma-052986	Leptosphaeria maculans	31.40	1.00e-94	342.00
IUUC-Laf-054181	Loxodonta africana	94.68	0.00e+00	2267.00
IUUC-Mcc-054812	Macaca mulatta	95.85	0.00e+00	2281.00
IUUC-Meu-056325	Macropus eugenii	90.98	0.00e+00	2160.00
IUUC-Mor-057246	Magnaporthe oryzae	29.60	6.00e-124	439.00
IUUC-Mpo-057464	Magnaporthe poae	32.21	2.00e-145	510.00
IUUC-Mla-058911	Melampsora laricipopulina	40.77	1.00e-69	258.00
IUUC-Mga-059335	Meleagris gallopavo	84.58	0.00e+00	1973.00
IUUC-Mvi-060461	Microbotryum violaceum	32.87	5.00e-146	512.00
IUUC-Mmr-060636	Microcebus murinus	95.85	0.00e+00	2274.00
IUUC-Mpu-066670	Mustela putorius furo	95.93	0.00e+00	2278.00
IUUC-Mlu-068119	Myotis lucifugus	94.36	0.00e+00	2301.00
IUUC-Nfi-068398	Neosartorya fischeri	31.87	8.00e-159	555.00
IUUC-Ncr-068927	Neurospora crassa	30.10	2.00e-131	463.00
IUUC-Nle-069651	Nomascus leucogenys	91.74	0.00e+00	2180.00
IUUC-Opr-070614	Ochotona princeps	94.64	0.00e+00	2232.00
IUUC-Ont-072433	Oreochromis niloticus	74.88	0.00e+00	1851.00
IUUC-Oan-073283	Ornithorhynchus anatinus	73.92	0.00e+00	1421.00
IUUC-Ocu-074401	Oryctolagus cuniculus	95.93	0.00e+00	2287.00
IUUC-Ola-087522	Oryzias latipes	73.71	0.00e+00	1785.00
IUUC-Oga-088226	Otolemur garnettii	95.69	0.00e+00	2306.00
IUUC-Oar-089241	Ovis aries	94.87	0.00e+00	2283.00
IUUC-Pan-092297	Papio anubis	95.87	0.00e+00	2033.00
IUUC-Psi-094043	Pelodiscus sinensis	81.07	0.00e+00	1883.00
IUUC-Pma-094394	Petromyzon marinus	68.55	0.00e+00	1559.00
IUUC-Pno-095053	Phaeosphaeria nodorum	31.18	3.00e-135	476.00
IUUC-Ppa-095188	Physcomitrella patens	32.02	4.00e-159	555.00
IUUC-Pfo-097517	Poecilia formosa	74.80	0.00e+00	1849.00
IUUC-Pca-100471	Procavia capensis	94.61	0.00e+00	2123.00
IUUC-Pva-102805	Pteropus vampyrus	91.02	0.00e+00	1779.00
IUUC-Pte-104021	Pyrenophora teres	31.97	2.00e-163	570.00
IUUC-Pyt-104682	Pyrenophora triticirepentis	30.68	5.00e-95	342.00
IUUC-Rno-105471	Rattus norvegicus	97.92	0.00e+00	2349.00
IUUC-Sce-106235	Saccharomyces cerevisiae	38.55	5.00e-60	226.00
IUUC-Sha-106883	Sarcophilus harrisii	90.77	0.00e+00	2010.00
IUUC-Spo-108169	Schizosaccharomyces pombe	32.49	3.00e-145	509.00
IUUC-Sar-113323	Sorex araneus	93.54	0.00e+00	1659.00
IUUC-Sre-115075	Sporisorium reilianum	29.32	1.00e-67	252.00
IUUC-Ssc-116363	Sus scrofa	95.44	0.00e+00	2301.00
IUUC-Tru-118427	Takifugu rubripes	74.06	0.00e+00	1860.00
IUUC-Tni-120218	Tetraodon nigroviridis	74.33	0.00e+00	1867.00
IUUC-Tre-122177	Trichoderma reesei	31.28	4.00e-153	535.00
IUUC-Tme-127176	Tuber melanosporum	32.14	3.00e-141	496.00
IUUC-Tbe-127641	Tupaia belangeri	86.61	0.00e+00	790.00
IUUC-Ttr-128888	Tursiops truncatus	93.78	0.00e+00	1410.00
IUUC-Uma-129361	Ustilago maydis	38.12	9.00e-63	236.00
IUUC-Xtr-132811	Xenopus tropicalis	78.12	0.00e+00	1880.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence