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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063849
Ensembl Protein ID ENSMUSP00000106534.2
UniProt Accession Q9ES28; O08757; Q3UTS5; Q6XPA5; Q6ZQI5; Q8C750; Q91ZZ6; Q9ES27; ARHG7_MOUSE
Genbank Protein ID BAC97874.1; AAO65479.1; BAC35033.1; BAE23905.1; AAH44838.1; AAG18017.1; AAG18018.1; AAK97363.1; AAB57691.1
Protein Name Rho guanine nucleotide exchange factor 7; Beta-Pix; PAK-interacting exchange factor beta; p85SPR
Genbank Nucleotide ID AK129064; AY220301; AK052545; AK139156; BC044838; AF247654; AF247655; AF343877; U96634
Gene Name Arhgef7; Kiaa0142; Pak3bp
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000031511.15 ENSMUST00000110909.8 ENSMUSP00000106534.2
ENSMUSG00000031511.15 ENSMUST00000074856.12 ENSMUSP00000074399.6
ENSMUSG00000031511.15 ENSMUST00000098938.8 ENSMUSP00000096538.2
ENSMUSG00000031511.15 ENSMUST00000211409.1 ENSMUSP00000148111.1
ENSMUSG00000031511.15 ENSMUST00000110904.1 ENSMUSP00000106529.2
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Phospho.ELMUniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 1.90e-14 54.4 167 221
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +v++ ++++ +n+deL++ kGdv++v     +++gW++g  + +g+ G fP+n+v++++
   Q: 167  VVRAKFNFQQTNEDELSFSKGDVIHVT--RVEEGGWWEG--THNGRTGWFPSNYVREIK 221
           78999*********************7..999*******..8**************996 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. May function as a positive regulator of apoptosis. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons (By similarity).
 Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. May function as a positive regulator of apoptosis. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons (By similarity).
Protein Sequence
(Fasta)
MNSAEQTVTW LITLGVLESP KKTISDPEVF LQASLKDGVV LCRLLERLLP GTIEKVYPEP 60
RNESECLSNI REFLRACGAS LRLETFDAND LYQGQNFNKV LSSLVTLNKV TADIGLGSDS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063849|UBD,SH3|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGAGCATGTG CGTGCCATCC CCGCCGGCTG GCGAGGTGGC GAAGAGACGC CCGCGCCCCG 60
CAGTCGGCGG GCTAGCTCAA GAGAGCATTC TGGGAAGCGC TTACTAATCG CGCGCCGCCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063849|UBD,SH3|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0024--Alternative initiation
KW-0025--Alternative splicing
KW-0965--Cell junction
KW-0966--Cell projection
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0344--Guanine-nucleotide releasing factor
KW-0524--Neurogenesis
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0728--SH3 domain
Interpro

IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR032409--GEF_CC
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR011511--SH3_2
IPR001452--SH3_domain
PROSITE

PS50021--CH
PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50002--SH3
Pfam

PF16523--betaPIX_CC
PF00307--CH
PF00169--PH
PF00621--RhoGEF
PF07653--SH3_2
PRINTS

PR00452--SH3DOMAIN
SMART

SM00033--CH
SM00233--PH
SM00325--RhoGEF
SM00326--SH3
Gene Ontology

GO:0005938--C:cell cortex
GO:0005829--C:cytosol
GO:0005925--C:focal adhesion
GO:0030027--C:lamellipodium
GO:0043005--C:neuron projection
GO:0043025--C:neuronal cell body
GO:0005886--C:plasma membrane
GO:0043234--C:protein complex
GO:0001726--C:ruffle
GO:0000322--C:storage vacuole
GO:0005085--F:guanyl-nucleotide exchange factor activity
GO:0019901--F:protein kinase binding
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0048041--P:focal adhesion assembly
GO:0007030--P:Golgi organization
GO:0002244--P:hematopoietic progenitor cell differentiation
GO:0035556--P:intracellular signal transduction
GO:0030032--P:lamellipodium assembly
GO:0007399--P:nervous system development
GO:0043065--P:positive regulation of apoptotic process
GO:0010763--P:positive regulation of fibroblast migration
GO:0060124--P:positive regulation of growth hormone secretion
GO:0043547--P:positive regulation of GTPase activity
GO:2000394--P:positive regulation of lamellipodium morphogenesis
GO:0032092--P:positive regulation of protein binding
GO:1900026--P:positive regulation of substrate adhesion-dependent cell spreading
GO:1904424--P:regulation of GTP binding
GO:0035023--P:regulation of Rho protein signal transduction
KEGG mmu:54126
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001259 Ailuropoda melanoleuca 90.95 0.00e+00 1285.00
IUUC-Aca-004591 Anolis carolinensis 90.53 0.00e+00 1220.00
IUUC-Ame-010759 Astyanax mexicanus 76.35 0.00e+00 1126.00
IUUC-Bta-013328 Bos taurus 91.57 0.00e+00 1288.00
IUUC-Cja-018742 Callithrix jacchus 93.17 0.00e+00 1169.00
IUUC-Cfa-020756 Canis familiaris 93.49 0.00e+00 1101.00
IUUC-Cpo-021284 Cavia porcellus 93.83 0.00e+00 1271.00
IUUC-Csa-023162 Chlorocebus sabaeus 94.29 0.00e+00 1316.00
IUUC-Cho-024736 Choloepus hoffmanni 72.42 6.00e-165 574.00
IUUC-Cin-025535 Ciona intestinalis 40.70 1.00e-95 343.00
IUUC-Cgl-026676 Colletotrichum gloeosporioides 44.29 8.00e-12 66.60
IUUC-Cne-026866 Cryptococcus neoformans 50.79 6.00e-13 70.50
IUUC-Dre-028646 Danio rerio 76.49 0.00e+00 1113.00
IUUC-Dno-029461 Dasypus novemcinctus 93.90 0.00e+00 1307.00
IUUC-Dor-030623 Dipodomys ordii 82.89 0.00e+00 1083.00
IUUC-Dse-031165 Dothistroma septosporum 37.97 1.00e-11 65.50
IUUC-Dme-032219 Drosophila melanogaster 46.25 1.00e-97 351.00
IUUC-Ete-032236 Echinops telfairi 78.62 0.00e+00 762.00
IUUC-Eca-034137 Equus caballus 94.33 0.00e+00 1145.00
IUUC-Fca-035742 Felis catus 91.50 0.00e+00 1101.00
IUUC-Fal-037205 Ficedula albicollis 91.53 0.00e+00 976.00
IUUC-Fox-037757 Fusarium oxysporum 41.67 8.00e-12 66.60
IUUC-Fso-038433 Fusarium solani 41.67 8.00e-12 66.60
IUUC-Gmo-039475 Gadus morhua 75.98 0.00e+00 977.00
IUUC-Gga-040539 Gallus gallus 90.99 0.00e+00 929.00
IUUC-Gac-042615 Gasterosteus aculeatus 73.18 0.00e+00 915.00
IUUC-Ggo-044470 Gorilla gorilla 92.18 0.00e+00 1151.00
IUUC-Hsa-046398 Homo sapiens 92.03 0.00e+00 1324.00
IUUC-Loc-052146 Lepisosteus oculatus 84.72 0.00e+00 1189.00
IUUC-Laf-053891 Loxodonta africana 89.88 0.00e+00 1252.00
IUUC-Mcc-055483 Macaca mulatta 91.78 0.00e+00 1321.00
IUUC-Mga-059410 Meleagris gallopavo 89.66 0.00e+00 1117.00
IUUC-Mmr-060758 Microcebus murinus 94.37 0.00e+00 1281.00
IUUC-Mdo-061900 Monodelphis domestica 91.71 0.00e+00 1236.00
IUUC-Mpu-065876 Mustela putorius furo 93.03 0.00e+00 1095.00
IUUC-Mlu-067970 Myotis lucifugus 94.19 0.00e+00 1146.00
IUUC-Nle-069685 Nomascus leucogenys 90.27 0.00e+00 985.00
IUUC-Opr-071132 Ochotona princeps 63.61 0.00e+00 721.00
IUUC-Ont-071815 Oreochromis niloticus 77.23 0.00e+00 1113.00
IUUC-Oan-073057 Ornithorhynchus anatinus 90.55 0.00e+00 991.00
IUUC-Ola-086663 Oryzias latipes 74.58 0.00e+00 940.00
IUUC-Oga-088103 Otolemur garnettii 93.22 0.00e+00 1094.00
IUUC-Ptr-091162 Pan troglodytes 91.08 0.00e+00 1216.00
IUUC-Pan-092093 Papio anubis 84.56 0.00e+00 1181.00
IUUC-Pma-094701 Petromyzon marinus 63.37 6.00e-134 470.00
IUUC-Pfo-096736 Poecilia formosa 72.50 0.00e+00 1008.00
IUUC-Pab-097641 Pongo abelii 93.96 0.00e+00 1256.00
IUUC-Pva-102819 Pteropus vampyrus 91.43 0.00e+00 1268.00
IUUC-Rno-106099 Rattus norvegicus 98.96 0.00e+00 1363.00
IUUC-Sha-106845 Sarcophilus harrisii 90.66 0.00e+00 1075.00
IUUC-Ssc-116036 Sus scrofa 92.54 0.00e+00 1077.00
IUUC-Tgu-117498 Taeniopygia guttata 88.20 0.00e+00 1210.00
IUUC-Tru-118278 Takifugu rubripes 73.47 0.00e+00 945.00
IUUC-Tsy-118990 Tarsius syrichta 92.26 0.00e+00 925.00
IUUC-Tni-120852 Tetraodon nigroviridis 74.93 0.00e+00 984.00
IUUC-Tre-121917 Trichoderma reesei 44.12 1.00e-11 65.90
IUUC-Tvi-122534 Trichoderma virens 44.12 1.00e-11 66.20
IUUC-Ttr-128922 Tursiops truncatus 86.75 0.00e+00 1108.00
IUUC-Xtr-132012 Xenopus tropicalis 84.72 0.00e+00 1073.00
Created Date 25-Jun-2017

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