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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046238
UUCD1 version UUC-HoS-00332
Ensembl Protein ID ENSP00000305161.6
UniProt Accession Q9BRZ2; Q6PJS5; Q86VT6; Q8N2H8; Q8NAC0; Q9H031; TRI56_HUMAN
Genbank Protein ID BAC11500.1; AAH05847.3; AAH11882.1; AAH48194.1; CAC21676.1
Protein Name E3 ubiquitin-protein ligase TRIM56; RING finger protein 109; RING-type E3 ubiquitin transferase TRIM56; Tripartite motif-containing protein 56
Genbank Nucleotide ID AK075255; AK092927; BC011882; BC048194; AL512757
Gene Name TRIM56; RNF109
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000169871.12 ENST00000306085.10 ENSP00000305161.6
ENSG00000169871.12 ENST00000412507.1 ENSP00000404186.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBaseCircNetmiRTarBase
microRNATRANSFACTargetScanRepTar
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRID
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 21074459; 21289118
Classification
Family E-value Score Start End
E3 activity/RING/RING 9.70e-06 27.7 21 60
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iCle ++  p++lpC H++++dCl ++        ++ rCP Cr
   Q: 21   CKICLEQLRA-PKTLPCLHTYCQDCLAQL-----ADGGRVRCPECR 60
           99******99.***************555.....499999*****8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity (PubMed:21289118). In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets TMEM173/STING to 'Lys-63'-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta (By similarity). Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling. Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES. Promotes establishment of an antiviral state by TLR3 ligand and TLR3-mediated chemokine induction following infection by hepatitis C virus (PubMed:22948160).
 E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity (PubMed:21289118). In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets TMEM173/STING to 'Lys-63'-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta (By similarity). Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling. Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES. Promotes establishment of an antiviral state by TLR3 ligand and TLR3-mediated chemokine induction following infection by hepatitis C virus (PubMed:22948160).
Protein Sequence
(Fasta)
MVSHGSSPSL LEALSSDFLA CKICLEQLRA PKTLPCLHTY CQDCLAQLAD GGRVRCPECR 60
ETVPVPPEGV ASFKTNFFVN GLLDLVKARA CGDLRAGKPA CALCPLVGGT STGGPATARC 120
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Protein Fasta Sequence


>IUUC-Hsa-046238|E3,RING|Homo sapiens
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Nucleotide Sequence
(Fasta)
CCTGGCTGGG ACGGAAGTTG CACCACAAGT ACAATTAGTT TCAGTTTTGT TTCTTTTCCA 60
GGCACCCAGC AACGGCGGCC TCCAGGCCTC AGGCCCCCTC ACCATCCTAG AGGTCAAGAT 120
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Nucleotide Fasta Sequence


>IUUC-Hsa-046238|E3,RING|Homo sapiens
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Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0051--Antiviral defense
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0391--Immunity
KW-0399--Innate immunity
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00643--zf-B_box
PF13445--zf-RING_UBOX
SMART

SM00336--BBOX
SM00184--RING
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0051607--P:defense response to virus
GO:0032608--P:interferon-beta production
GO:0070534--P:protein K63-linked ubiquitination
GO:0032479--P:regulation of type I interferon production
GO:0034340--P:response to type I interferon
KEGG hsa:81844
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001496 Ailuropoda melanoleuca 90.01 0.00e+00 1159.00
IUUC-Aca-004996 Anolis carolinensis 53.76 1.00e-75 278.00
IUUC-Bta-012368 Bos taurus 86.89 0.00e+00 1172.00
IUUC-Cja-019698 Callithrix jacchus 94.57 0.00e+00 1278.00
IUUC-Csa-023090 Chlorocebus sabaeus 97.09 0.00e+00 1231.00
IUUC-Dno-030051 Dasypus novemcinctus 80.33 0.00e+00 981.00
IUUC-Ete-032312 Echinops telfairi 88.94 5.00e-94 336.00
IUUC-Eca-033253 Equus caballus 92.65 6.00e-107 380.00
IUUC-Eeu-034772 Erinaceus europaeus 81.16 2.00e-52 199.00
IUUC-Fca-036198 Felis catus 84.27 0.00e+00 916.00
IUUC-Ggo-045486 Gorilla gorilla 98.94 0.00e+00 1259.00
IUUC-Itr-048481 Ictidomys tridecemlineatus 86.62 0.00e+00 1103.00
IUUC-Loc-052915 Lepisosteus oculatus 29.62 5.00e-68 252.00
IUUC-Laf-053640 Loxodonta africana 85.05 0.00e+00 1066.00
IUUC-Mcc-055540 Macaca mulatta 97.22 0.00e+00 1244.00
IUUC-Mmr-060840 Microcebus murinus 90.33 0.00e+00 1163.00
IUUC-Mmu-064375 Mus musculus 80.69 0.00e+00 1057.00
IUUC-Mpu-066797 Mustela putorius furo 88.59 0.00e+00 1147.00
IUUC-Mlu-067996 Myotis lucifugus 88.07 0.00e+00 1149.00
IUUC-Nle-069238 Nomascus leucogenys 99.26 5.00e-127 446.00
IUUC-Oga-089156 Otolemur garnettii 85.45 0.00e+00 1153.00
IUUC-Oar-090056 Ovis aries 81.93 0.00e+00 1035.00
IUUC-Ptr-090837 Pan troglodytes 98.48 0.00e+00 778.00
IUUC-Psi-093493 Pelodiscus sinensis 45.49 3.00e-59 223.00
IUUC-Pab-097607 Pongo abelii 98.41 0.00e+00 1283.00
IUUC-Pva-102758 Pteropus vampyrus 86.36 0.00e+00 1128.00
Created Date 25-Jun-2017

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