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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046490
UUCD1 version UUC-HoS-01184
Ensembl Protein ID ENSP00000261427.5
UniProt Accession P61086; A6NJC1; A8K5Y9; B2RDF8; C9JGP1; O54806; P27924; Q16721; Q9CVV9; Q9Y2D3; UBE2K_HUMAN
Genbank Protein ID AAC50633.1; BAA78555.1; BAA78556.1; BAF84143.1; BAG37905.1; EAW92948.1; AAH22804.1; AAH50600.1
Protein Name Ubiquitin-conjugating enzyme E2 K; E2 ubiquitin-conjugating enzyme K; Huntingtin-interacting protein 2; Ubiquitin carrier protein; Ubiquitin-conjugating enzyme E2-25 kDa; Ubiquitin-protein ligase
Genbank Nucleotide ID U58522; AB022435; AB022436; BX339118; AK315524; AC105287; BC022804; BC050600
Gene Name UBE2K; HIP2; LIG
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000078140.13 ENST00000261427.9 ENSP00000261427.5
ENSG00000078140.13 ENST00000510934.5 ENSP00000425301.1
ENSG00000078140.13 ENST00000503368.5 ENSP00000421203.1
ENSG00000078140.13 ENST00000445950.2 ENSP00000390483.2
ENSG00000078140.13 ENST00000510719.1 ENSP00000421422.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkTargetScanRepTarmiRNAMap
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtBioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/UBC-like/UBD_UBC UBD_UBC 21281599
UBD/Alpha-Helix/UBA UBA 21281599
E2/UBC E2_UBC 19252184; 16714285; 15773819
Classification
Family E-value Score Start End
E2/UBC 1.10e-45 156.4 8 146
UBD/Alpha-Helix/UBA 1.50e-10 42.5 161 199
UBD/UBC-like/UBD_UBC 1.80e-72 243.6 8 149
Active Site
Position(s) Description Evidence
92 Glycyl thioester intermediate {ECO:0000255|PROSITE-ProRule:PRU00388,
ECO:0000255|PROSITE-ProRule:PRU10133}
Domain Profile

   E2/UBC
   S: 1    Rlkkelkel...ekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyen.GkvClsilke 88
           R+k+e+ke+   e++++++i++++vde ++te++ +i Gp+dtpYegg ++lei++pe+YPf+PPkv+f+tki+hPn+++  G++Cl+ilk 
   Q: 8    RIKREFKEVlksEETSKNQIKVDLVDE-NFTELRGEIAGPPDTPYEGGRYQLEIKIPETYPFNPPKVRFITKIWHPNISSVtGAICLDILK- 97
           7888888873335556699********.9***************************************************99********9. PP
   S: 89   eekWspalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
            ++W +a+++++vlls+q+lla ++p++p+++ +a+++k+n+e++k+++r
   Q: 98   -DQWAAAMTLRTVLLSLQALLAAAEPDDPQDAVVANQYKQNPEMFKQTAR 146
           .**********************************************986 PP
   

   UBD/Alpha-Helix/UBA
   S: 2    ededkleqlveMGFdreealqaLraannnleaAveyLld 40
           e++ k+e+l++MGFdr++++ aL + ++++e A+e+Ll+
   Q: 161  EYTKKIENLCAMGFDRNAVIVALSSKSWDVETATELLLS 199
           6789*********************************97 PP
   

   UBD/UBC-like/UBD_UBC
   S: 1    rikkelkdllrdeea...qisadlvdddlfelratiagppdspyeggvffltiklptdypfkppkvafitkiyhpnins.ngsicldilrsq 88
           rik+e+k++l++ee+   qi++dlvd++++elr++iagppd+pyegg+++l+ik+p++ypf+ppkv+fitki+hpni+s +g+icldil++q
   Q: 8    RIKREFKEVLKSEETsknQIKVDLVDENFTELRGEIAGPPDTPYEGGRYQLEIKIPETYPFNPPKVRFITKIWHPNISSvTGAICLDILKDQ 99
           8*************9999************************************************************************** PP
   S: 89   wsaaltlskvllslcslladaepddplvaeiariyktdkekykriarewt 138
           w+aa+tl++vllsl++lla+aepddp++a++a++yk+++e++k++ar+w+
   Q: 100  WAAAMTLRTVLLSLQALLAAAEPDDPQDAVVANQYKQNPEMFKQTARLWA 149
           *************************************************7 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein-dependent degradation of RB1.
 Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein-dependent degradation of RB1.
Protein Sequence
(Fasta)
MANIAVQRIK REFKEVLKSE ETSKNQIKVD LVDENFTELR GEIAGPPDTP YEGGRYQLEI 60
KIPETYPFNP PKVRFITKIW HPNISSVTGA ICLDILKDQW AAAMTLRTVL LSLQALLAAA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046490|UBD,UBD_UBC;UBD,UBA;E2,E2/UBC|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACGCGAGCTC GTGGCTCGGG CGTATGGGGG CTCCAACGGG AGCGGCTGCG CCGCCCGGCC 60
GGGTCAACGT CGTGCGCATG CGCCGACCCG GCGCCATTTT GGTGGCCGGG CGCGGAGGTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046490|UBD,UBD_UBC;UBD,UBA;E2,E2/UBC|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-1017--Isopeptide bond
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR015940--UBA
IPR009060--UBA-like
IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD
PROSITE

PS50030--UBA
PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2
Pfam

PF00627--UBA
PF00179--UQ_con
SMART

SM00165--UBA
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0032433--C:filopodium tip
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0035458--P:cellular response to interferon-beta
GO:0010994--P:free ubiquitin chain polymerization
GO:0070059--P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0010800--P:positive regulation of peptidyl-threonine phosphorylation
GO:0060340--P:positive regulation of type I interferon-mediated signaling pathway
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0016567--P:protein ubiquitination
GO:0032434--P:regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG hsa:3093
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000621 Aegilops tauschii 51.55 4.00e-28 117.00
IUUC-Aml-001286 Ailuropoda melanoleuca 100.00 5.00e-110 389.00
IUUC-Atr-003063 Amborella trichopoda 47.94 1.00e-39 155.00
IUUC-Apl-004122 Anas platyrhynchos 91.50 1.00e-96 345.00
IUUC-Aca-004565 Anolis carolinensis 94.74 3.00e-99 353.00
IUUC-Aly-006390 Arabidopsis lyrata 47.72 5.00e-44 170.00
IUUC-Ath-006637 Arabidopsis thaliana 46.86 3.00e-41 161.00
IUUC-Ago-007714 Ashbya gossypii 44.62 7.00e-38 150.00
IUUC-Acl-008189 Aspergillus clavatus 49.68 8.00e-28 117.00
IUUC-Afl-008489 Aspergillus flavus 41.40 4.00e-28 118.00
IUUC-Afu-008850 Aspergillus fumigatus 40.65 1.00e-28 119.00
IUUC-Ani-009361 Aspergillus nidulans 50.68 1.00e-26 113.00
IUUC-Ang-009548 Aspergillus niger 48.39 3.00e-26 112.00
IUUC-Aor-010105 Aspergillus oryzae 41.40 4.00e-28 118.00
IUUC-Ate-010389 Aspergillus terreus 40.55 1.00e-27 116.00
IUUC-Ame-011454 Astyanax mexicanus 97.00 2.00e-107 380.00
IUUC-Bgr-012255 Blumeria graminis 48.41 9.00e-34 136.00
IUUC-Bta-012992 Bos taurus 100.00 5.00e-110 389.00
IUUC-Bci-013806 Botrytis cinerea 40.09 3.00e-36 144.00
IUUC-Bdi-015024 Brachypodium distachyon 48.22 1.00e-40 159.00
IUUC-Bol-015985 Brassica oleracea 48.22 2.00e-44 172.00
IUUC-Bra-016805 Brassica rapa 48.22 7.00e-45 173.00
IUUC-Cel-018353 Caenorhabditis elegans 52.26 1.00e-56 212.00
IUUC-Cja-019051 Callithrix jacchus 99.50 4.00e-109 386.00
IUUC-Cfa-020016 Canis familiaris 100.00 5.00e-110 389.00
IUUC-Cpo-022026 Cavia porcellus 100.00 5.00e-110 389.00
IUUC-Cre-022987 Chlamydomonas reinhardtii 48.98 7.00e-42 163.00
IUUC-Csa-023059 Chlorocebus sabaeus 100.00 5.00e-110 389.00
IUUC-Cho-024276 Choloepus hoffmanni 96.60 1.00e-73 268.00
IUUC-Cin-025598 Ciona intestinalis 60.71 4.00e-56 210.00
IUUC-Csv-025831 Ciona savignyi 62.24 2.00e-54 205.00
IUUC-Cgl-026449 Colletotrichum gloeosporioides 44.51 3.00e-34 138.00
IUUC-Cne-027068 Cryptococcus neoformans 41.38 4.00e-41 160.00
IUUC-Dre-028139 Danio rerio 97.00 2.00e-107 381.00
IUUC-Dno-029169 Dasypus novemcinctus 93.50 4.00e-102 363.00
IUUC-Dor-030382 Dipodomys ordii 86.00 2.00e-88 318.00
IUUC-Dse-031335 Dothistroma septosporum 50.96 7.00e-37 147.00
IUUC-Dme-032003 Drosophila melanogaster 68.34 2.00e-71 261.00
IUUC-Ete-032868 Echinops telfairi 91.00 2.00e-88 317.00
IUUC-Eca-033428 Equus caballus 100.00 5.00e-110 389.00
IUUC-Eeu-035103 Erinaceus europaeus 73.44 3.00e-49 186.00
IUUC-Fca-035366 Felis catus 100.00 5.00e-110 389.00
IUUC-Fal-037016 Ficedula albicollis 100.00 5.00e-110 389.00
IUUC-Fox-037969 Fusarium oxysporum 42.62 4.00e-34 137.00
IUUC-Fso-038296 Fusarium solani 44.26 5.00e-36 144.00
IUUC-Gmo-039135 Gadus morhua 96.00 5.00e-106 376.00
IUUC-Ggr-039768 Gaeumannomyces graminis 46.25 9.00e-26 110.00
IUUC-Gga-041018 Gallus gallus 99.50 1.00e-109 388.00
IUUC-Gac-041503 Gasterosteus aculeatus 96.50 7.00e-107 379.00
IUUC-Gma-042779 Glycine max 50.26 4.00e-43 167.00
IUUC-Ggo-045032 Gorilla gorilla 100.00 5.00e-110 389.00
IUUC-Itr-048373 Ictidomys tridecemlineatus 100.00 5.00e-110 389.00
IUUC-Kpa-049297 Komagataella pastoris 49.02 7.00e-34 137.00
IUUC-Lch-050588 Latimeria chalumnae 68.25 6.00e-76 276.00
IUUC-Lpe-051070 Leersia perrieri 48.22 1.00e-32 132.00
IUUC-Loc-052549 Lepisosteus oculatus 97.50 8.00e-108 382.00
IUUC-Lma-052949 Leptosphaeria maculans 49.36 7.00e-37 147.00
IUUC-Laf-053688 Loxodonta africana 92.16 4.00e-100 357.00
IUUC-Mcc-055606 Macaca mulatta 100.00 5.00e-110 389.00
IUUC-Mor-056946 Magnaporthe oryzae 37.44 7.00e-23 100.00
IUUC-Mpo-057441 Magnaporthe poae 49.04 9.00e-26 110.00
IUUC-Mtr-058002 Medicago truncatula 49.74 8.00e-43 166.00
IUUC-Mla-059007 Melampsora laricipopulina 43.52 1.00e-37 149.00
IUUC-Mga-059254 Meleagris gallopavo 98.89 1.00e-97 348.00
IUUC-Mvi-060346 Microbotryum violaceum 41.50 1.00e-33 135.00
IUUC-Mmr-061211 Microcebus murinus 100.00 5.00e-110 389.00
IUUC-Mdo-062458 Monodelphis domestica 99.00 2.00e-107 381.00
IUUC-Mmu-063648 Mus musculus 100.00 5.00e-110 389.00
IUUC-Mac-065447 Musa acuminata 48.22 4.00e-41 160.00
IUUC-Mpu-066407 Mustela putorius furo 100.00 3.00e-109 387.00
IUUC-Mlu-067682 Myotis lucifugus 92.93 3.00e-100 357.00
IUUC-Nfi-068517 Neosartorya fischeri 40.65 1.00e-28 120.00
IUUC-Ncr-068749 Neurospora crassa 48.08 2.00e-38 152.00
IUUC-Nle-069712 Nomascus leucogenys 98.89 1.00e-97 348.00
IUUC-Opr-070651 Ochotona princeps 100.00 5.00e-110 389.00
IUUC-Ont-071595 Oreochromis niloticus 96.50 7.00e-107 379.00
IUUC-Oan-073058 Ornithorhynchus anatinus 100.00 8.00e-79 285.00
IUUC-Ocu-074939 Oryctolagus cuniculus 100.00 5.00e-110 389.00
IUUC-Oba-075530 Oryza barthii 48.99 8.00e-32 129.00
IUUC-Obr-076838 Oryza brachyantha 48.48 3.00e-31 127.00
IUUC-Ogl-077606 Oryza glaberrima 48.99 8.00e-32 129.00
IUUC-Ogu-078238 Oryza glumaepatula 48.99 8.00e-32 129.00
IUUC-Oin-079643 Oryza indica 48.99 2.00e-31 128.00
IUUC-Ome-081274 Oryza meridionalis 48.99 8.00e-32 129.00
IUUC-Oni-082651 Oryza nivara 48.99 8.00e-32 129.00
IUUC-Opu-083933 Oryza punctata 48.99 2.00e-31 129.00
IUUC-Oru-085054 Oryza rufipogon 48.99 2.00e-31 129.00
IUUC-Osa-085716 Oryza sativa 48.99 2.00e-31 128.00
IUUC-Ola-087043 Oryzias latipes 96.50 7.00e-107 379.00
IUUC-Olu-087846 Ostreococcus lucimarinus 46.63 8.00e-42 162.00
IUUC-Oga-088897 Otolemur garnettii 93.94 3.00e-100 357.00
IUUC-Oar-089673 Ovis aries 92.93 1.00e-100 358.00
IUUC-Ptr-091295 Pan troglodytes 100.00 5.00e-110 389.00
IUUC-Pan-092034 Papio anubis 100.00 1.00e-97 348.00
IUUC-Psi-093498 Pelodiscus sinensis 100.00 5.00e-110 389.00
IUUC-Pma-094115 Petromyzon marinus 82.91 1.00e-89 322.00
IUUC-Pno-095102 Phaeosphaeria nodorum 40.76 8.00e-38 150.00
IUUC-Ppa-095326 Physcomitrella patens 46.19 8.00e-40 156.00
IUUC-Pfo-096940 Poecilia formosa 96.50 5.00e-107 379.00
IUUC-Pab-098279 Pongo abelii 100.00 5.00e-110 389.00
IUUC-Pop-099543 Populus trichocarpa 49.24 3.00e-44 171.00
IUUC-Pca-100782 Procavia capensis 99.50 6.00e-108 382.00
IUUC-Ppe-101789 Prunus persica 47.94 5.00e-37 147.00
IUUC-Pva-102147 Pteropus vampyrus 71.02 6.00e-58 216.00
IUUC-Pgr-103643 Puccinia graminis 45.06 1.00e-37 150.00
IUUC-Ptt-103772 Puccinia triticina 47.95 3.00e-36 145.00
IUUC-Pte-104370 Pyrenophora teres 49.36 1.00e-36 146.00
IUUC-Pyt-104592 Pyrenophora triticirepentis 40.74 1.00e-36 146.00
IUUC-Rno-104984 Rattus norvegicus 100.00 5.00e-110 389.00
IUUC-Sce-106394 Saccharomyces cerevisiae 43.01 3.00e-35 141.00
IUUC-Sha-106624 Sarcophilus harrisii 93.50 6.00e-104 369.00
IUUC-Ssl-108609 Sclerotinia sclerotiorum 42.86 1.00e-40 159.00
IUUC-Smo-109656 Selaginella moellendorffii 48.47 3.00e-40 157.00
IUUC-Sit-110639 Setaria italica 47.98 2.00e-39 155.00
IUUC-Sly-110978 Solanum lycopersicum 48.22 7.00e-44 169.00
IUUC-Stu-112088 Solanum tuberosum 48.22 3.00e-44 171.00
IUUC-Sar-113285 Sorex araneus 84.36 3.00e-76 277.00
IUUC-Sbi-113986 Sorghum bicolor 47.98 3.00e-39 154.00
IUUC-Sre-115046 Sporisorium reilianum 46.71 9.00e-37 146.00
IUUC-Ssc-116314 Sus scrofa 100.00 5.00e-110 389.00
IUUC-Tgu-117427 Taeniopygia guttata 99.44 7.00e-98 349.00
IUUC-Tru-118196 Takifugu rubripes 84.44 5.00e-102 363.00
IUUC-Tsy-119208 Tarsius syrichta 97.98 1.00e-106 378.00
IUUC-Tni-119667 Tetraodon nigroviridis 97.00 2.00e-107 380.00
IUUC-Tca-121446 Theobroma cacao 49.75 4.00e-45 174.00
IUUC-Tre-122053 Trichoderma reesei 38.12 1.00e-31 129.00
IUUC-Tvi-122533 Trichoderma virens 36.00 5.00e-31 127.00
IUUC-Tae-124726 Triticum aestivum 48.73 2.00e-33 135.00
IUUC-Tme-127024 Tuber melanosporum 49.38 4.00e-39 154.00
IUUC-Tbe-127752 Tupaia belangeri 96.50 6.00e-105 372.00
IUUC-Ttr-128287 Tursiops truncatus 100.00 1.00e-97 348.00
IUUC-Uma-129512 Ustilago maydis 39.22 3.00e-36 144.00
IUUC-Vda-129947 Verticillium dahliae 37.20 3.00e-31 128.00
IUUC-Vpa-130481 Vicugna pacos 100.00 6.00e-108 382.00
IUUC-Vvi-131429 Vitis vinifera 46.19 3.00e-41 160.00
IUUC-Xtr-132710 Xenopus tropicalis 83.17 2.00e-95 341.00
IUUC-Xma-134308 Xiphophorus maculatus 96.00 1.00e-106 378.00
IUUC-Yli-134523 Yarrowia lipolytica 44.00 6.00e-34 137.00
IUUC-Zma-135733 Zea mays 47.14 1.00e-37 149.00
Created Date 25-Jun-2017

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