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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064247
UUCD1 version UUC-MuM-00265
Ensembl Protein ID ENSMUSP00000069259.9
UniProt Accession O54714; Q80WF8; Q8R598; PIAS3_MOUSE
Genbank Protein ID BAC30647.1; BAC36858.1; AAH23128.1; AAH51252.1; AAB88902.3
Protein Name E3 SUMO-protein ligase PIAS3; Protein inhibitor of activated STAT protein 3
Genbank Nucleotide ID AK040619; AK077551; BC023128; BC051252; AF034080
Gene Name Pias3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000028101.18 ENSMUST00000162934.7 ENSMUSP00000125747.1
ENSMUSG00000028101.18 ENSMUST00000064900.15 ENSMUSP00000069259.9
ENSMUSG00000028101.18 ENSMUST00000107077.3 ENSMUSP00000102692.3
ENSMUSG00000028101.18 ENSMUST00000176302.7 ENSMUSP00000134835.1
ENSMUSG00000028101.18 ENSMUST00000162156.2 ENSMUSP00000135843.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 96.97 0.00e+00 1092.00 IUUC-Hsa-045973
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Repressor of STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Repressor of MITF transcriptional activity. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Sumoylates CCAR2 which promotes its interaction with SIRT1 (By similarity). Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus (By similarity).
 Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Repressor of STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Repressor of MITF transcriptional activity. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Sumoylates CCAR2 which promotes its interaction with SIRT1 (By similarity). Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus (By similarity).
Protein Sequence
(Fasta)
MAELGELKHM VMSFRVSELQ VLLGFAGRNK SGRKHELLAK ALHLLKSSCA PSVQMKIKEL 60
YRRRFPRKTL GPSDLSLLSL PPGTSPVGSP GPLAPIPPTL LTPGTLLGPK REVDMHPPLP 120
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Protein Fasta Sequence


>IUUC-Mmu-064247|E3,RING|Mus musculus
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Nucleotide Sequence
(Fasta)
AGCAGCAACG CTTGGCCGGG CGGAGCTCAG GCCCGGGCGG TGCTGCGGCT GCAGCGTCCA 60
GCTGCCCGAC TGAACTCCAG CCGTGCAGCA GACTGCCGGA GCTGCGCGAG CCCTTTCTGC 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-064247|E3,RING|Mus musculus
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Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0436--Ligase
KW-0479--Metal-binding
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR027226--PIAS3
IPR023321--PINIT
IPR003034--SAP_dom
IPR004181--Znf_MIZ
PROSITE

PS51466--PINIT
PS50800--SAP
PS51044--ZF_SP_RING
Pfam

PF14324--PINIT
PF02891--zf-MIZ
SMART

SM00513--SAP
Gene Ontology

GO:0005737--C:cytoplasm
GO:0030425--C:dendrite
GO:0016607--C:nuclear speck
GO:0005634--C:nucleus
GO:0045202--C:synapse
GO:0019899--F:enzyme binding
GO:0016874--F:ligase activity
GO:0015459--F:potassium channel regulator activity
GO:0008022--F:protein C-terminus binding
GO:0019789--F:SUMO transferase activity
GO:0008270--F:zinc ion binding
GO:0033234--P:negative regulation of protein sumoylation
GO:0010628--P:positive regulation of gene expression
GO:0045838--P:positive regulation of membrane potential
GO:0033235--P:positive regulation of protein sumoylation
GO:0016925--P:protein sumoylation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0009725--P:response to hormone
GO:0006351--P:transcription, DNA-templated
KEGG mmu:229615
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002142 Ailuropoda melanoleuca 95.44 0.00e+00 1093.00
IUUC-Aca-004903 Anolis carolinensis 69.71 0.00e+00 825.00
IUUC-Ago-007762 Ashbya gossypii 26.92 6.00e-18 86.70
IUUC-Bta-013566 Bos taurus 96.97 0.00e+00 1102.00
IUUC-Bol-015575 Brassica oleracea 24.63 1.00e-17 85.50
IUUC-Cja-019111 Callithrix jacchus 95.87 0.00e+00 1085.00
IUUC-Cfa-020209 Canis familiaris 96.02 0.00e+00 1110.00
IUUC-Cpo-022188 Cavia porcellus 95.38 0.00e+00 1115.00
IUUC-Csa-024163 Chlorocebus sabaeus 96.86 0.00e+00 948.00
IUUC-Cin-025791 Ciona intestinalis 45.49 8.00e-93 334.00
IUUC-Dno-029139 Dasypus novemcinctus 96.61 0.00e+00 1040.00
IUUC-Dor-030842 Dipodomys ordii 94.03 0.00e+00 1071.00
IUUC-Eca-034115 Equus caballus 96.66 0.00e+00 1092.00
IUUC-Eeu-034486 Erinaceus europaeus 91.11 0.00e+00 730.00
IUUC-Fca-035527 Felis catus 92.49 0.00e+00 1105.00
IUUC-Ggo-045185 Gorilla gorilla 97.13 0.00e+00 1097.00
IUUC-Hsa-045973 Homo sapiens 96.97 0.00e+00 1092.00
IUUC-Itr-049072 Ictidomys tridecemlineatus 95.58 0.00e+00 1080.00
IUUC-Kpa-049203 Komagataella pastoris 30.52 2.00e-22 102.00
IUUC-Lch-050349 Latimeria chalumnae 69.38 0.00e+00 823.00
IUUC-Lma-053196 Leptosphaeria maculans 28.39 4.00e-30 126.00
IUUC-Laf-054406 Loxodonta africana 95.38 0.00e+00 1105.00
IUUC-Mcc-054886 Macaca mulatta 96.82 0.00e+00 1093.00
IUUC-Meu-055949 Macropus eugenii 85.85 0.00e+00 943.00
IUUC-Mmr-060659 Microcebus murinus 96.97 0.00e+00 1097.00
IUUC-Mdo-062925 Monodelphis domestica 86.26 0.00e+00 962.00
IUUC-Mpu-066833 Mustela putorius furo 95.56 0.00e+00 1078.00
IUUC-Mlu-067384 Myotis lucifugus 93.57 0.00e+00 1013.00
IUUC-Ocu-074264 Oryctolagus cuniculus 96.48 0.00e+00 837.00
IUUC-Oga-088281 Otolemur garnettii 96.30 0.00e+00 1085.00
IUUC-Oar-090090 Ovis aries 96.49 0.00e+00 1093.00
IUUC-Ptr-090687 Pan troglodytes 90.13 0.00e+00 979.00
IUUC-Pan-091813 Papio anubis 96.97 0.00e+00 1096.00
IUUC-Psi-092943 Pelodiscus sinensis 76.87 0.00e+00 870.00
IUUC-Pab-097650 Pongo abelii 97.25 0.00e+00 1081.00
IUUC-Pop-099241 Populus trichocarpa 26.79 8.00e-12 66.20
IUUC-Pca-100372 Procavia capensis 93.26 0.00e+00 929.00
IUUC-Pva-103134 Pteropus vampyrus 95.98 0.00e+00 988.00
IUUC-Pte-104331 Pyrenophora teres 29.74 1.00e-30 127.00
IUUC-Pyt-104673 Pyrenophora triticirepentis 30.29 7.00e-29 122.00
IUUC-Rno-105009 Rattus norvegicus 98.25 0.00e+00 1115.00
IUUC-Sha-107250 Sarcophilus harrisii 85.96 0.00e+00 991.00
IUUC-Ssc-115626 Sus scrofa 96.82 0.00e+00 1102.00
IUUC-Tvi-122408 Trichoderma virens 31.66 1.00e-29 124.00
IUUC-Tbe-127583 Tupaia belangeri 96.79 0.00e+00 772.00
Created Date 25-Jun-2017

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