iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000183826.16	ENST00000481247.5	ENSP00000418751.1
ENSG00000183826.16	ENST00000419706.6	ENSP00000415365.2
ENSG00000183826.16	ENST00000328403.10	ENSP00000328328.6
ENSG00000183826.16	ENST00000408958.5	ENSP00000386211.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/BCR/BTB_3-box	BTB_3-box	23455037

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	1.00e-20	75.5	37	103

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 2    DvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklden 68
           Dv++vv++++f+ah+++Laa++++F+al++++++es+++ ++ ++d  +e+f  llk++Ytg+++++
   Q: 37   DVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQPEAEIPLQDTTAEAFTMLLKYIYTGRATLT 103
           9**************************************************************9875 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MSNSHPLRPF TAVGEIDHVH ILSEHIGALL IGEEYGDVTF VVEKKRFPAH RVILAARCQY 60
FRALLYGGMR ESQPEAEIPL QDTTAEAFTM LLKYIYTGRA TLTDEKEEVL LDFLSLAHKY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAGCCAGGT GCCGGCAGGG CAGCCACACC CTGGGGCCCC CTGTTCTGGA GGGGCAGAGG 60
GTCGGGCCGA TGCGAAAAAG CCGCGGAAGC TGCCTTAGGC GACTTTCTGG GCCTGCATCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR011705--BACK
IPR000210--BTB/POZ_dom
IPR034091--BTBD9_BACK-like_dom
IPR000421--FA58C
IPR008979--Galactose-bd-like
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF00754--F5_F8_type_C

SMART

SM00875--BACK
SM00225--BTB

Gene Ontology

GO:0005737--C:cytoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0031625--F:ubiquitin protein ligase binding
GO:0008344--P:adult locomotory behavior
GO:0048512--P:circadian behavior
GO:0042748--P:circadian sleep/wake cycle, non-REM sleep
GO:0007616--P:long-term memory
GO:0050804--P:modulation of synaptic transmission
GO:0060586--P:multicellular organismal iron ion homeostasis
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030162--P:regulation of proteolysis
GO:1900242--P:regulation of synaptic vesicle endocytosis
GO:0050951--P:sensory perception of temperature stimulus
GO:0042428--P:serotonin metabolic process

KEGG

hsa:114781

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001333	Ailuropoda melanoleuca	99.22	0.00e+00	798.00
IUUC-Apl-003275	Anas platyrhynchos	91.69	0.00e+00	1148.00
IUUC-Aca-004407	Anolis carolinensis	92.19	0.00e+00	1142.00
IUUC-Ani-009467	Aspergillus nidulans	30.12	9.00e-08	51.20
IUUC-Ame-011645	Astyanax mexicanus	76.13	0.00e+00	885.00
IUUC-Bta-012635	Bos taurus	99.22	0.00e+00	798.00
IUUC-Bci-013715	Botrytis cinerea	25.60	4.00e-06	45.80
IUUC-Cel-018453	Caenorhabditis elegans	40.04	8.00e-116	410.00
IUUC-Cja-019564	Callithrix jacchus	99.48	0.00e+00	803.00
IUUC-Cfa-020412	Canis familiaris	99.74	0.00e+00	801.00
IUUC-Cpo-022116	Cavia porcellus	97.45	0.00e+00	1170.00
IUUC-Cre-022671	Chlamydomonas reinhardtii	41.00	1.00e-04	41.60
IUUC-Csa-023458	Chlorocebus sabaeus	99.74	0.00e+00	801.00
IUUC-Cho-024472	Choloepus hoffmanni	88.19	0.00e+00	666.00
IUUC-Cin-025433	Ciona intestinalis	55.99	0.00e+00	657.00
IUUC-Csv-025875	Ciona savignyi	55.14	1.00e-179	622.00
IUUC-Cne-026822	Cryptococcus neoformans	32.08	1.70e-01	31.60
IUUC-Dre-028362	Danio rerio	71.79	0.00e+00	887.00
IUUC-Dno-029542	Dasypus novemcinctus	98.97	0.00e+00	803.00
IUUC-Dor-030108	Dipodomys ordii	94.75	1.00e-166	580.00
IUUC-Dme-031643	Drosophila melanogaster	53.97	3.00e-171	595.00
IUUC-Ete-033062	Echinops telfairi	99.26	2.00e-159	556.00
IUUC-Eca-034168	Equus caballus	99.15	0.00e+00	1198.00
IUUC-Eeu-035231	Erinaceus europaeus	100.00	3.00e-107	382.00
IUUC-Fca-035540	Felis catus	64.44	0.00e+00	645.00
IUUC-Fal-037629	Ficedula albicollis	91.91	0.00e+00	1137.00
IUUC-Gmo-038968	Gadus morhua	73.99	2.00e-149	521.00
IUUC-Gga-040297	Gallus gallus	91.53	0.00e+00	1145.00
IUUC-Gac-042219	Gasterosteus aculeatus	74.57	2.00e-143	501.00
IUUC-Ggo-045584	Gorilla gorilla	99.35	0.00e+00	1188.00
IUUC-Itr-047909	Ictidomys tridecemlineatus	99.22	0.00e+00	797.00
IUUC-Lch-050280	Latimeria chalumnae	87.65	0.00e+00	941.00
IUUC-Loc-052601	Lepisosteus oculatus	78.86	0.00e+00	970.00
IUUC-Laf-053474	Loxodonta africana	97.94	0.00e+00	794.00
IUUC-Mcc-055501	Macaca mulatta	99.67	0.00e+00	1196.00
IUUC-Meu-056851	Macropus eugenii	94.24	2.00e-175	608.00
IUUC-Mga-059540	Meleagris gallopavo	94.87	0.00e+00	968.00
IUUC-Mmr-061009	Microcebus murinus	98.29	0.00e+00	1211.00
IUUC-Mdo-061824	Monodelphis domestica	94.43	0.00e+00	1120.00
IUUC-Mmu-064408	Mus musculus	96.75	0.00e+00	1190.00
IUUC-Mpu-065943	Mustela putorius furo	99.74	0.00e+00	802.00
IUUC-Mlu-067349	Myotis lucifugus	98.71	0.00e+00	798.00
IUUC-Nle-069794	Nomascus leucogenys	99.18	0.00e+00	1188.00
IUUC-Opr-070569	Ochotona princeps	97.15	0.00e+00	905.00
IUUC-Ont-071668	Oreochromis niloticus	76.94	0.00e+00	948.00
IUUC-Oan-072886	Ornithorhynchus anatinus	95.05	0.00e+00	979.00
IUUC-Ocu-074010	Oryctolagus cuniculus	99.48	0.00e+00	800.00
IUUC-Ola-086345	Oryzias latipes	68.89	2.00e-68	251.00
IUUC-Oga-088389	Otolemur garnettii	97.80	0.00e+00	1185.00
IUUC-Oar-089674	Ovis aries	99.48	0.00e+00	800.00
IUUC-Ptr-091004	Pan troglodytes	99.35	0.00e+00	1188.00
IUUC-Pan-092824	Papio anubis	96.41	0.00e+00	1150.00
IUUC-Psi-093770	Pelodiscus sinensis	92.03	0.00e+00	1152.00
IUUC-Pma-094226	Petromyzon marinus	68.59	0.00e+00	779.00
IUUC-Pfo-096112	Poecilia formosa	76.67	0.00e+00	954.00
IUUC-Pab-098462	Pongo abelii	95.32	0.00e+00	1177.00
IUUC-Pca-100966	Procavia capensis	74.77	0.00e+00	754.00
IUUC-Pva-102618	Pteropus vampyrus	98.98	0.00e+00	1194.00
IUUC-Pte-104211	Pyrenophora teres	33.04	1.00e-06	47.40
IUUC-Rno-105840	Rattus norvegicus	97.09	0.00e+00	1197.00
IUUC-Sha-106785	Sarcophilus harrisii	94.16	0.00e+00	1096.00
IUUC-Sar-113661	Sorex araneus	98.97	0.00e+00	1000.00
IUUC-Sre-115044	Sporisorium reilianum	34.38	4.00e-03	37.00
IUUC-Ssc-115629	Sus scrofa	94.74	1.00e-114	405.00
IUUC-Tgu-117110	Taeniopygia guttata	91.57	0.00e+00	1134.00
IUUC-Tru-117672	Takifugu rubripes	75.99	0.00e+00	926.00
IUUC-Tsy-119176	Tarsius syrichta	98.64	0.00e+00	1192.00
IUUC-Tni-120213	Tetraodon nigroviridis	76.90	0.00e+00	922.00
IUUC-Tbe-128031	Tupaia belangeri	94.13	0.00e+00	1120.00
IUUC-Ttr-129304	Tursiops truncatus	78.10	0.00e+00	892.00
IUUC-Uma-129493	Ustilago maydis	32.81	3.00e-03	37.40
IUUC-Vpa-130638	Vicugna pacos	85.78	0.00e+00	1040.00
IUUC-Xtr-132304	Xenopus tropicalis	87.28	0.00e+00	1043.00
IUUC-Xma-133520	Xiphophorus maculatus	76.50	0.00e+00	954.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence