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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064350
UUCD1 version UUC-MuM-00865
Ensembl Protein ID ENSMUSP00000120496.1
UniProt Accession Q99JP4; CDC26_MOUSE
Genbank Protein ID BAC25372.1; AAH05775.1; AAI14351.1
Protein Name Anaphase-promoting complex subunit CDC26; Cell division cycle protein 26 homolog
Genbank Nucleotide ID AK012627; BC005775; BC114350
Gene Name Cdc26
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000066149.11 ENSMUST00000134727.7 ENSMUSP00000120496.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDiRefIndexMentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 adaptor/Cullin RING/APC_C/APC_C 88.24 6.00e-37 149.00 IUUC-Hsa-046899
E3 adaptor/Cullin RING/APC_C/APC_C 35.19 5.70e-02 30.40 IUUC-Sce-106324
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex (By similarity).
 Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex (By similarity).
Protein Sequence
(Fasta)
MLRRKPTRLE LKLDDIEEFE SIRKDLEARK KQKEDVEGVG TSDGEGAAGL SSDPKSREQM 60
INDRIGYKPQ LKSNNRTSQF GNFEF 85
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Protein Fasta Sequence


>IUUC-Mmu-064350|E3,APC_C|Mus musculus
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Nucleotide Sequence
(Fasta)
AGAGCAGCCT GGGAGGTGTA GTTTGGGCTG CGCAGCAATG GAGTCATGGT GGGAGTTGAG 60
GTTCTGGGGA ACTGCAGAGG CCTGAAAAGA GGTAGGTTTG CGGATCGCAA CCATAATCTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064350|E3,APC_C|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0498--Mitosis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR018860--APC_suCDC26
Pfam

PF10471--ANAPC_CDC26
Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:0070979--P:protein K11-linked ubiquitination
GO:0030071--P:regulation of mitotic metaphase/anaphase transition
KEGG mmu:66440
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001456 Ailuropoda melanoleuca 88.24 8.00e-39 150.00
IUUC-Atr-002458 Amborella trichopoda 37.14 6.00e-04 35.00
IUUC-Aca-004376 Anolis carolinensis 78.82 4.00e-34 135.00
IUUC-Ago-007754 Ashbya gossypii 50.00 5.20e-01 26.20
IUUC-Acl-008116 Aspergillus clavatus 52.17 9.40e-02 28.10
IUUC-Ani-009376 Aspergillus nidulans 46.67 3.50e-01 26.20
IUUC-Ame-011022 Astyanax mexicanus 59.77 3.00e-22 95.90
IUUC-Bta-012581 Bos taurus 90.59 2.00e-39 153.00
IUUC-Bci-013595 Botrytis cinerea 50.00 2.10e+00 25.00
IUUC-Cja-019622 Callithrix jacchus 87.06 3.00e-38 149.00
IUUC-Cfa-021044 Canis familiaris 88.24 8.00e-39 150.00
IUUC-Cpo-022441 Cavia porcellus 84.71 1.00e-32 130.00
IUUC-Csa-024091 Chlorocebus sabaeus 89.41 1.00e-31 127.00
IUUC-Cho-025001 Choloepus hoffmanni 81.03 2.00e-21 93.20
IUUC-Csv-025958 Ciona savignyi 27.47 7.00e-06 41.60
IUUC-Dre-027369 Danio rerio 62.50 2.00e-26 109.00
IUUC-Dno-029137 Dasypus novemcinctus 87.06 3.00e-38 149.00
IUUC-Dor-030181 Dipodomys ordii 89.41 1.00e-39 153.00
IUUC-Ete-032555 Echinops telfairi 87.06 1.00e-37 146.00
IUUC-Eca-033227 Equus caballus 89.41 1.00e-31 127.00
IUUC-Eeu-034615 Erinaceus europaeus 84.21 2.00e-23 99.80
IUUC-Fca-035838 Felis catus 87.06 4.00e-38 148.00
IUUC-Fal-036994 Ficedula albicollis 89.66 1.00e-09 54.30
IUUC-Gga-040675 Gallus gallus 64.71 4.00e-22 95.50
IUUC-Ggo-044779 Gorilla gorilla 84.48 5.00e-16 75.10
IUUC-Hsa-046899 Homo sapiens 88.24 4.00e-31 125.00
IUUC-Itr-048643 Ictidomys tridecemlineatus 88.24 1.00e-33 134.00
IUUC-Lch-049544 Latimeria chalumnae 65.88 6.00e-29 118.00
IUUC-Loc-052390 Lepisosteus oculatus 60.23 9.00e-22 94.40
IUUC-Laf-053681 Loxodonta africana 90.59 3.00e-32 129.00
IUUC-Mcc-054912 Macaca mulatta 89.41 1.00e-31 127.00
IUUC-Meu-056222 Macropus eugenii 74.14 1.00e-20 90.50
IUUC-Mor-057242 Magnaporthe oryzae 34.38 3.00e-01 28.10
IUUC-Mmr-061790 Microcebus murinus 88.24 4.00e-39 152.00
IUUC-Mlu-067848 Myotis lucifugus 88.24 7.00e-34 134.00
IUUC-Nle-069077 Nomascus leucogenys 88.24 4.00e-31 125.00
IUUC-Opr-071004 Ochotona princeps 87.06 1.00e-33 133.00
IUUC-Ont-071525 Oreochromis niloticus 47.42 7.00e-16 74.70
IUUC-Oan-073200 Ornithorhynchus anatinus 87.06 5.00e-38 148.00
IUUC-Ocu-074476 Oryctolagus cuniculus 88.24 3.00e-39 152.00
IUUC-Oba-075520 Oryza barthii 65.00 4.30e-02 28.90
IUUC-Obr-076249 Oryza brachyantha 65.00 2.80e-01 28.90
IUUC-Ogu-078445 Oryza glumaepatula 65.00 4.30e-02 28.90
IUUC-Ola-087554 Oryzias latipes 48.39 1.00e-17 80.90
IUUC-Oga-088195 Otolemur garnettii 89.41 2.00e-30 122.00
IUUC-Oar-089399 Ovis aries 89.41 6.00e-39 151.00
IUUC-Ptr-090822 Pan troglodytes 88.24 4.00e-31 125.00
IUUC-Pan-092857 Papio anubis 89.41 1.00e-31 127.00
IUUC-Ppa-095794 Physcomitrella patens 75.00 5.00e-03 32.30
IUUC-Pfo-097147 Poecilia formosa 48.94 1.00e-14 70.90
IUUC-Pab-098774 Pongo abelii 88.24 4.00e-31 125.00
IUUC-Pca-100745 Procavia capensis 89.41 4.00e-31 125.00
IUUC-Pva-102647 Pteropus vampyrus 88.24 7.00e-34 134.00
IUUC-Pte-104296 Pyrenophora teres 54.17 7.80e-02 28.10
IUUC-Pyt-104747 Pyrenophora triticirepentis 54.17 5.80e-02 28.50
IUUC-Rno-106085 Rattus norvegicus 97.65 3.00e-44 169.00
IUUC-Sce-106324 Saccharomyces cerevisiae 35.19 3.50e-02 30.40
IUUC-Sha-107235 Sarcophilus harrisii 84.71 3.00e-37 145.00
IUUC-Spo-108195 Schizosaccharomyces pombe 28.21 4.60e-01 25.80
IUUC-Ssl-108598 Sclerotinia sclerotiorum 50.00 2.10e+00 24.60
IUUC-Sar-113299 Sorex araneus 84.48 3.00e-16 76.30
IUUC-Ssc-115650 Sus scrofa 80.00 4.00e-28 115.00
IUUC-Tgu-117309 Taeniopygia guttata 59.30 5.00e-22 95.50
IUUC-Tsy-119267 Tarsius syrichta 90.59 3.00e-32 129.00
IUUC-Tni-120675 Tetraodon nigroviridis 49.41 2.00e-17 79.70
IUUC-Tvi-122490 Trichoderma virens 50.00 3.90e-01 26.90
IUUC-Ttr-129250 Tursiops truncatus 87.06 8.00e-33 130.00
IUUC-Vpa-130562 Vicugna pacos 89.41 2.00e-39 152.00
Created Date 25-Jun-2017

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