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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046214
Ensembl Protein ID ENSP00000428924.1
UniProt Accession P07948; A0AVQ5; LYN_HUMAN
Genbank Protein ID AAA59540.1; AAB50019.1; AAH75001.1; AAH75002.1; AAI26457.1; AAI26459.1
Protein Name Tyrosine-protein kinase Lyn; Lck/Yes-related novel protein tyrosine kinase; V-yes-1 Yamaguchi sarcoma viral related oncogene homolog; p53Lyn; p56Lyn
Genbank Nucleotide ID M16038; M79321; BC075001; BC075002; BC126456; BC126458
Gene Name LYN; JTK8
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000254087.7 ENST00000519728.5 ENSP00000428924.1
ENSG00000254087.7 ENST00000520220.6 ENSP00000428424.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACmiRWalk
RepTarSomamiRmiRcodeRAID2
LncRNADisease
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
GWASdbOMIM
Drug and target
TTDGRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 6.10e-16 59.8 66 122
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 4    ekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           + v +ly+y++ + d+L++kkG++++v+   e+ ++W+k+++ l++k+G++P+n+v+kl+
   Q: 66   DIVVALYPYDGIHPDDLSFKKGEKMKVL---EEHGEWWKAKSLLTKKEGFIPSNYVAKLN 122
           5799************************...999***********************997 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, PTK2B/PYK2, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Mediates phosphorylation of the BCR-ABL fusion protein. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on 'Tyr-72'. Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation.
 Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, PTK2B/PYK2, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Mediates phosphorylation of the BCR-ABL fusion protein. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on 'Tyr-72'. Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation.
Protein Sequence
(Fasta)
MGCIKSKGKD SLSDDGVDLK TQPVRNTERT IYVRDPTSNK QQRPVPESQL LPGQRFQTKD 60
PEEQGDIVVA LYPYDGIHPD DLSFKKGEKM KVLEEHGEWW KAKSLLTKKE GFIPSNYVAK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046214|UBD,SH3|Homo sapiens
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Nucleotide Sequence
(Fasta)
TCGGCCGAGC CCAGAGACAG CCAGTTCCTC TCCCGCCGCG CCGGGCCGCG CTGCCGCTCG 60
CTCCCCGGCC GTGGCGCCTC CGGGCCAGAC GCGCTGCAGC CTCCAGCCCG CGGCAAGCGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046214|UBD,SH3|Homo sapiens
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Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-1064--Adaptive immunity
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0333--Golgi apparatus
KW-0945--Host-virus interaction
KW-0391--Immunity
KW-0395--Inflammatory response
KW-0399--Innate immunity
KW-0418--Kinase
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0519--Myristate
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0564--Palmitate
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase
KW-0832--Ubl conjugation
Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom
PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3
Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1
PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE
SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc
Gene Ontology

GO:0005913--C:cell-cell adherens junction
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005794--C:Golgi apparatus
GO:0034666--C:integrin alpha2-beta1 complex
GO:0043231--C:intracellular membrane-bounded organelle
GO:0042629--C:mast cell granule
GO:0045121--C:membrane raft
GO:0030061--C:mitochondrial crista
GO:0005758--C:mitochondrial intermembrane space
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0014069--C:postsynaptic density
GO:0005524--F:ATP binding
GO:0019899--F:enzyme binding
GO:0043208--F:glycosphingolipid binding
GO:0044325--F:ion channel binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0004713--F:protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0004716--F:signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0002250--P:adaptive immune response
GO:0001782--P:B cell homeostasis
GO:0050853--P:B cell receptor signaling pathway
GO:0007596--P:blood coagulation
GO:0006974--P:cellular response to DNA damage stimulus
GO:0031668--P:cellular response to extracellular stimulus
GO:0034605--P:cellular response to heat
GO:0071300--P:cellular response to retinoic acid
GO:0007417--P:central nervous system development
GO:0050663--P:cytokine secretion
GO:0097028--P:dendritic cell differentiation
GO:0048013--P:ephrin receptor signaling pathway
GO:0030218--P:erythrocyte differentiation
GO:0002774--P:Fc receptor mediated inhibitory signaling pathway
GO:0002431--P:Fc receptor mediated stimulatory signaling pathway
GO:0038095--P:Fc-epsilon receptor signaling pathway
GO:0038096--P:Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0002553--P:histamine secretion by mast cell
GO:0002768--P:immune response-regulating cell surface receptor signaling pathway
GO:0006954--P:inflammatory response
GO:0045087--P:innate immune response
GO:0060397--P:JAK-STAT cascade involved in growth hormone signaling pathway
GO:0050900--P:leukocyte migration
GO:0031663--P:lipopolysaccharide-mediated signaling pathway
GO:0030889--P:negative regulation of B cell proliferation
GO:0008285--P:negative regulation of cell proliferation
GO:0070373--P:negative regulation of ERK1 and ERK2 cascade
GO:0050777--P:negative regulation of immune response
GO:1902532--P:negative regulation of intracellular signal transduction
GO:0043407--P:negative regulation of MAP kinase activity
GO:0070667--P:negative regulation of mast cell proliferation
GO:0002762--P:negative regulation of myeloid leukocyte differentiation
GO:0001933--P:negative regulation of protein phosphorylation
GO:0034136--P:negative regulation of toll-like receptor 2 signaling pathway
GO:0034144--P:negative regulation of toll-like receptor 4 signaling pathway
GO:0031175--P:neuron projection development
GO:0014003--P:oligodendrocyte development
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0018108--P:peptidyl-tyrosine phosphorylation
GO:0030168--P:platelet activation
GO:0002576--P:platelet degranulation
GO:0050861--P:positive regulation of B cell receptor signaling pathway
GO:0030335--P:positive regulation of cell migration
GO:0008284--P:positive regulation of cell proliferation
GO:0051272--P:positive regulation of cellular component movement
GO:2000670--P:positive regulation of dendritic cell apoptotic process
GO:0060369--P:positive regulation of Fc receptor mediated stimulatory signaling pathway
GO:0060252--P:positive regulation of glial cell proliferation
GO:0070668--P:positive regulation of mast cell proliferation
GO:0010976--P:positive regulation of neuron projection development
GO:0070447--P:positive regulation of oligodendrocyte progenitor proliferation
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0070304--P:positive regulation of stress-activated protein kinase signaling cascade
GO:0042531--P:positive regulation of tyrosine phosphorylation of STAT protein
GO:0046777--P:protein autophosphorylation
GO:0006468--P:protein phosphorylation
GO:0002902--P:regulation of B cell apoptotic process
GO:0050855--P:regulation of B cell receptor signaling pathway
GO:0033628--P:regulation of cell adhesion mediated by integrin
GO:0001817--P:regulation of cytokine production
GO:0050707--P:regulation of cytokine secretion
GO:0070372--P:regulation of ERK1 and ERK2 cascade
GO:0045646--P:regulation of erythrocyte differentiation
GO:0050727--P:regulation of inflammatory response
GO:0033003--P:regulation of mast cell activation
GO:0043304--P:regulation of mast cell degranulation
GO:0090025--P:regulation of monocyte chemotaxis
GO:0090330--P:regulation of platelet aggregation
GO:0001932--P:regulation of protein phosphorylation
GO:0051279--P:regulation of release of sequestered calcium ion into cytosol
GO:0043200--P:response to amino acid
GO:0048678--P:response to axon injury
GO:0009743--P:response to carbohydrate
GO:0042493--P:response to drug
GO:0009725--P:response to hormone
GO:0032868--P:response to insulin
GO:0014070--P:response to organic cyclic compound
GO:0006991--P:response to sterol depletion
GO:0009636--P:response to toxic substance
GO:0007165--P:signal transduction
GO:0002223--P:stimulatory C-type lectin receptor signaling pathway
GO:0031295--P:T cell costimulation
GO:0002513--P:tolerance induction to self antigen
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway
GO:0016032--P:viral process
KEGG hsa:4067
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001812 Ailuropoda melanoleuca 97.27 0.00e+00 1043.00
IUUC-Apl-004139 Anas platyrhynchos 88.01 0.00e+00 943.00
IUUC-Aca-004333 Anolis carolinensis 86.60 0.00e+00 924.00
IUUC-Ame-011257 Astyanax mexicanus 76.31 0.00e+00 820.00
IUUC-Bta-013257 Bos taurus 96.88 0.00e+00 1041.00
IUUC-Cja-018827 Callithrix jacchus 98.63 0.00e+00 1055.00
IUUC-Cfa-020816 Canis familiaris 97.07 0.00e+00 1040.00
IUUC-Cpo-021423 Cavia porcellus 96.29 0.00e+00 1034.00
IUUC-Csa-024244 Chlorocebus sabaeus 99.41 0.00e+00 1060.00
IUUC-Dre-028518 Danio rerio 75.97 0.00e+00 807.00
IUUC-Dno-029322 Dasypus novemcinctus 97.27 0.00e+00 1039.00
IUUC-Dor-030706 Dipodomys ordii 86.91 0.00e+00 909.00
IUUC-Eca-034193 Equus caballus 96.88 0.00e+00 1039.00
IUUC-Fal-037273 Ficedula albicollis 88.50 0.00e+00 952.00
IUUC-Gmo-039677 Gadus morhua 74.44 0.00e+00 718.00
IUUC-Gga-040417 Gallus gallus 84.18 0.00e+00 895.00
IUUC-Gac-042490 Gasterosteus aculeatus 72.09 0.00e+00 791.00
IUUC-Ggo-045096 Gorilla gorilla 100.00 0.00e+00 1066.00
IUUC-Itr-048354 Ictidomys tridecemlineatus 97.07 0.00e+00 1046.00
IUUC-Lch-049991 Latimeria chalumnae 81.36 0.00e+00 863.00
IUUC-Loc-052309 Lepisosteus oculatus 78.10 0.00e+00 841.00
IUUC-Laf-053568 Loxodonta africana 95.90 0.00e+00 1031.00
IUUC-Mcc-054849 Macaca mulatta 99.41 0.00e+00 1060.00
IUUC-Meu-056170 Macropus eugenii 78.71 0.00e+00 804.00
IUUC-Mmr-061519 Microcebus murinus 97.27 0.00e+00 1044.00
IUUC-Mdo-062090 Monodelphis domestica 81.45 0.00e+00 883.00
IUUC-Mmu-063760 Mus musculus 96.09 0.00e+00 1033.00
IUUC-Mpu-065677 Mustela putorius furo 96.88 0.00e+00 1041.00
IUUC-Mlu-067386 Myotis lucifugus 95.70 0.00e+00 1031.00
IUUC-Nle-069742 Nomascus leucogenys 99.41 0.00e+00 1060.00
IUUC-Ont-071537 Oreochromis niloticus 73.15 0.00e+00 790.00
IUUC-Oan-073193 Ornithorhynchus anatinus 93.19 0.00e+00 1001.00
IUUC-Ocu-074501 Oryctolagus cuniculus 97.46 0.00e+00 1043.00
IUUC-Ola-086726 Oryzias latipes 70.57 0.00e+00 779.00
IUUC-Oga-088069 Otolemur garnettii 96.50 0.00e+00 1037.00
IUUC-Oar-090091 Ovis aries 97.07 0.00e+00 1041.00
IUUC-Ptr-091409 Pan troglodytes 100.00 0.00e+00 1066.00
IUUC-Pan-092268 Papio anubis 99.41 0.00e+00 1060.00
IUUC-Psi-093685 Pelodiscus sinensis 87.43 0.00e+00 941.00
IUUC-Pfo-096217 Poecilia formosa 72.18 0.00e+00 789.00
IUUC-Pab-098601 Pongo abelii 99.80 0.00e+00 1064.00
IUUC-Pva-102160 Pteropus vampyrus 85.19 0.00e+00 887.00
IUUC-Rno-105557 Rattus norvegicus 96.09 0.00e+00 1036.00
IUUC-Sha-106643 Sarcophilus harrisii 92.41 0.00e+00 999.00
IUUC-Sar-113555 Sorex araneus 94.44 7.00e-173 600.00
IUUC-Ssc-116317 Sus scrofa 90.25 0.00e+00 957.00
IUUC-Tgu-116865 Taeniopygia guttata 88.69 0.00e+00 954.00
IUUC-Tru-118284 Takifugu rubripes 72.37 0.00e+00 787.00
IUUC-Tsy-119440 Tarsius syrichta 92.77 0.00e+00 978.00
IUUC-Tni-120005 Tetraodon nigroviridis 71.35 0.00e+00 776.00
IUUC-Ttr-128481 Tursiops truncatus 82.62 0.00e+00 848.00
IUUC-Xtr-131907 Xenopus tropicalis 76.21 0.00e+00 796.00
Created Date 25-Jun-2017

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