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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-045726
UUCD1 version UUC-HoS-00972
Ensembl Protein ID ENSP00000367075.4
UniProt Accession Q9NR64; A8K5X0; Q5VZ64; Q9H4X4; Q9NR65; Q9P238; KLHL1_HUMAN
Genbank Protein ID AAF81719.1; AAF81716.1; BAA96014.1; BAF84124.1; CAH70258.2; CAH70258.2; CAH70258.2; CAH70258.2; CAH73330.2; CAH73330.2; CAH73330.2; CAH73330.2; CAH71287.2; CAH71287.2; CAH71287.2; CAH71287.2; CAH73834.2; CAH73834.2; CAH73834.2; CAH73834.2; EAW80503.1
Protein Name Kelch-like protein 1
Genbank Nucleotide ID AF252283; AF252279; AB040923; AK291435; AL160391; AL162378; AL353738; AL356384; AL162378; AL160391; AL353738; AL356384; AL353738; AL160391; AL162378; AL356384; AL356384; AL160391; AL162378; AL353738; CH471093
Gene Name KLHL1; KIAA1490
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000150361.11 ENST00000377844.8 ENSP00000367075.4
ENSG00000150361.11 ENST00000545028.2 ENSP00000439602.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarmiRNAMapSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexMentha
Disease-associated Variation
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusBioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB 4.20e-18 67.1 212 279
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box 8.10e-07 28.4 311 337
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgkldene 69
           +Dvil+vg+++++ah++vL++ S++F a+f+++  e k ++++++++++p ++ +l++F Ytg l+++e
   Q: 212  CDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAK-QEEIKMEGIDPNALWDLVQFAYTGCLELKE 279
           9************************************9.**************************9986 PP
   

   E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box
   S: 1    leNclgilrfAdlydcpdLkdaaldfi 27
           ++Nclgi++fAd+ +c +L+++a++++
   Q: 311  PSNCLGIRAFADAQGCIELMKVAHSYT 337
           89***********************95 PP
   
Organism Homo sapiens
Protein Sequence
(Fasta)
MSGSGRKDFD VKHILRLRWK LFSHPSPSTG GPAGGGCLQQ DGSGSFEHWG PSQSRLLKSQ 60
ERSGVSTFWK KPSSSSSSSS SPSSSSSSFN PLNGTLLPVA TRLQQGAPGQ GTQQPARTLF 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045726|E3,BTB_3-box|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACTTACAGGG GAGGAGGAGG CGCTGAGGCA GAGAGAAAAT TGTACTGTGA GGACCTTGAC 60
AGCTTCACAG GCGGGCTTTT TCTTTTGCCT CCCTATATGC GCTAGAATAT CTATTTTTCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045726|E3,BTB_3-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0009--Actin-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat
Interpro

IPR011705--BACK
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1
SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch
Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0030425--C:dendrite
GO:0043025--C:neuronal cell body
GO:0003779--F:actin binding
GO:0030036--P:actin cytoskeleton organization
GO:0007628--P:adult walking behavior
GO:0021680--P:cerebellar Purkinje cell layer development
GO:0016358--P:dendrite development
GO:0016567--P:protein ubiquitination
KEGG hsa:57626
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001478 Ailuropoda melanoleuca 96.40 0.00e+00 1351.00
IUUC-Apl-003408 Anas platyrhynchos 95.89 0.00e+00 1109.00
IUUC-Aca-004384 Anolis carolinensis 86.41 0.00e+00 1251.00
IUUC-Bta-012684 Bos taurus 98.63 0.00e+00 1136.00
IUUC-Cja-019103 Callithrix jacchus 99.20 0.00e+00 1379.00
IUUC-Cfa-020670 Canis familiaris 98.05 0.00e+00 1199.00
IUUC-Cpo-021951 Cavia porcellus 98.80 0.00e+00 1138.00
IUUC-Csa-023607 Chlorocebus sabaeus 99.66 0.00e+00 1143.00
IUUC-Cho-024648 Choloepus hoffmanni 87.93 0.00e+00 1142.00
IUUC-Dno-029854 Dasypus novemcinctus 95.99 0.00e+00 1318.00
IUUC-Dor-030497 Dipodomys ordii 80.06 0.00e+00 987.00
IUUC-Eca-033525 Equus caballus 97.06 0.00e+00 1383.00
IUUC-Fca-035490 Felis catus 98.80 0.00e+00 1134.00
IUUC-Fal-037099 Ficedula albicollis 97.68 0.00e+00 1106.00
IUUC-Gga-041081 Gallus gallus 86.50 0.00e+00 1194.00
IUUC-Gma-043533 Glycine max 32.64 1.00e-38 154.00
IUUC-Ggo-044717 Gorilla gorilla 100.00 0.00e+00 1382.00
IUUC-Itr-048921 Ictidomys tridecemlineatus 98.40 0.00e+00 1365.00
IUUC-Lpe-051276 Leersia perrieri 27.39 1.00e-39 159.00
IUUC-Loc-052321 Lepisosteus oculatus 76.50 0.00e+00 1094.00
IUUC-Laf-054378 Loxodonta africana 96.53 0.00e+00 1339.00
IUUC-Mcc-054985 Macaca mulatta 99.47 0.00e+00 1377.00
IUUC-Mmr-061255 Microcebus murinus 82.53 0.00e+00 1108.00
IUUC-Mdo-062369 Monodelphis domestica 93.99 0.00e+00 1336.00
IUUC-Mmu-063334 Mus musculus 95.21 0.00e+00 1329.00
IUUC-Nle-069856 Nomascus leucogenys 99.87 0.00e+00 1381.00
IUUC-Ocu-074469 Oryctolagus cuniculus 96.66 0.00e+00 1338.00
IUUC-Ogl-077595 Oryza glaberrima 25.93 2.00e-34 141.00
IUUC-Oin-080100 Oryza indica 29.51 4.00e-34 139.00
IUUC-Olo-080536 Oryza longistaminata 31.35 5.00e-34 140.00
IUUC-Opu-083716 Oryza punctata 31.02 2.00e-32 134.00
IUUC-Olu-087696 Ostreococcus lucimarinus 36.36 9.00e-33 133.00
IUUC-Oga-088528 Otolemur garnettii 98.06 0.00e+00 1193.00
IUUC-Oar-089603 Ovis aries 98.46 0.00e+00 1132.00
IUUC-Ptr-090657 Pan troglodytes 99.60 0.00e+00 1379.00
IUUC-Psi-092962 Pelodiscus sinensis 96.23 0.00e+00 1115.00
IUUC-Pab-097812 Pongo abelii 99.33 0.00e+00 1349.00
IUUC-Pva-103042 Pteropus vampyrus 96.63 0.00e+00 1338.00
IUUC-Sbi-114612 Sorghum bicolor 28.81 2.00e-34 141.00
IUUC-Ssc-115880 Sus scrofa 98.63 0.00e+00 1135.00
IUUC-Tgu-116624 Taeniopygia guttata 94.79 0.00e+00 979.00
IUUC-Tsy-119339 Tarsius syrichta 90.91 0.00e+00 1223.00
IUUC-Tbe-127398 Tupaia belangeri 100.00 0.00e+00 680.00
IUUC-Ttr-129024 Tursiops truncatus 96.27 0.00e+00 1403.00
Created Date 25-Jun-2017

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