iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC
DNA & RNA Element
UTRdb	microRNA	TRANSFAC	TargetScan
RepTar	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
InWeb_IM
Disease-associated Variation
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	UniProt
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	8.20e-07	30.8	543	563

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 4    dsvtclaf.sd.tllvsGsdD 22
           ++vtc++  s+ +l+v+Gs+ 
   Q: 543  SPVTCCDVsSNnRLVVTGSGE 563
           79******9555999****86 PP

Organism

Homo sapiens

Functional Description
(View)

As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions.

Protein Sequence
(Fasta)

MTSRDQPRPK GPPKSTSPCP GISNSESSPT LNYQGILNRL KQFPRFSPHF AAELESIYYS 60
LHKIQQDVAE HHKQIGNVLQ IVESCSQLQG FQSEEVSPAE PASPGTPQQV KDKTLQESSF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTGATCTGC TTCGCGGTCC AGGTGGCGGC TGGGTGGGGC CTGGGCGGGA CGGGGCGGGG 60
ACAAGGCGGG ACGAGGCGGG GCCCGATGGG TCAAATGGCC CCCGGTGGGG GAAGGAGGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR009146--Groucho_enhance
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50294--WD_REPEATS_REGION

PRINTS

PR01850--GROUCHOFAMLY

SMART

Gene Ontology

GO:0005938--C:cell cortex
GO:0005634--C:nucleus
GO:0043234--C:protein complex
GO:0045666--P:positive regulation of neuron differentiation
GO:0006355--P:regulation of transcription, DNA-templated

KEGG

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002169	Ailuropoda melanoleuca	64.76	2.00e-148	519.00
IUUC-Bta-012704	Bos taurus	60.00	1.00e-142	499.00
IUUC-Cfa-020822	Canis familiaris	72.35	7.00e-118	416.00
IUUC-Cpo-021589	Cavia porcellus	53.22	3.00e-103	368.00
IUUC-Csa-023760	Chlorocebus sabaeus	91.46	0.00e+00	983.00
IUUC-Dno-029434	Dasypus novemcinctus	45.53	2.00e-75	276.00
IUUC-Dor-030782	Dipodomys ordii	57.49	1.00e-111	395.00
IUUC-Eca-033556	Equus caballus	73.46	2.00e-139	488.00
IUUC-Fca-035421	Felis catus	61.03	4.00e-151	527.00
IUUC-Ggo-044650	Gorilla gorilla	94.06	0.00e+00	1021.00
IUUC-Itr-048864	Ictidomys tridecemlineatus	61.79	3.00e-71	261.00
IUUC-Laf-053971	Loxodonta africana	63.93	1.00e-108	385.00
IUUC-Mcc-055698	Macaca mulatta	91.64	0.00e+00	987.00
IUUC-Mmr-061647	Microcebus murinus	62.41	0.00e+00	704.00
IUUC-Mmu-064062	Mus musculus	51.00	7.00e-114	404.00
IUUC-Mpu-066131	Mustela putorius furo	61.68	8.00e-158	550.00
IUUC-Mlu-068020	Myotis lucifugus	63.24	3.00e-158	551.00
IUUC-Oga-088838	Otolemur garnettii	73.00	2.00e-101	361.00
IUUC-Oar-090417	Ovis aries	58.59	2.00e-140	492.00
IUUC-Ptr-090523	Pan troglodytes	97.73	0.00e+00	1054.00
IUUC-Pan-092275	Papio anubis	90.77	0.00e+00	1001.00
IUUC-Pab-097952	Pongo abelii	97.61	2.00e-158	551.00
IUUC-Pva-102968	Pteropus vampyrus	65.34	6.00e-168	583.00
IUUC-Rno-105186	Rattus norvegicus	42.66	4.00e-108	385.00
IUUC-Ssc-116390	Sus scrofa	60.93	4.00e-149	521.00

Created Date

25-Jun-2017

Functional Description